SG11202013020YA - Tissue potency determination through quantitative histomorphology analysis - Google Patents

Tissue potency determination through quantitative histomorphology analysis

Info

Publication number
SG11202013020YA
SG11202013020YA SG11202013020YA SG11202013020YA SG11202013020YA SG 11202013020Y A SG11202013020Y A SG 11202013020YA SG 11202013020Y A SG11202013020Y A SG 11202013020YA SG 11202013020Y A SG11202013020Y A SG 11202013020YA SG 11202013020Y A SG11202013020Y A SG 11202013020YA
Authority
SG
Singapore
Prior art keywords
potency determination
quantitative
tissue
analysis
tissue potency
Prior art date
Application number
SG11202013020YA
Other languages
English (en)
Inventor
Alex Tracy
Kristin Marks
Michael Thomas Johnson
Thomas Villani
Original Assignee
Enzyvant Therapeutics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzyvant Therapeutics Gmbh filed Critical Enzyvant Therapeutics Gmbh
Publication of SG11202013020YA publication Critical patent/SG11202013020YA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A61B5/7267—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems involving training the classification device
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/065—Thymocytes
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/214—Generating training patterns; Bootstrap methods, e.g. bagging or boosting
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/23—Clustering techniques
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/23—Clustering techniques
    • G06F18/231—Hierarchical techniques, i.e. dividing or merging pattern sets so as to obtain a dendrogram
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G06T7/0014—Biomedical image inspection using an image reference approach
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/40—Extraction of image or video features
    • G06V10/50—Extraction of image or video features by performing operations within image blocks; by using histograms, e.g. histogram of oriented gradients [HoG]; by summing image-intensity values; Projection analysis
    • G06V10/507—Summing image-intensity values; Histogram projection analysis
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/762—Arrangements for image or video recognition or understanding using pattern recognition or machine learning using clustering, e.g. of similar faces in social networks
    • G06V10/7625—Hierarchical techniques, i.e. dividing or merging patterns to obtain a tree-like representation; Dendograms
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/38—Pediatrics
    • G01N2800/385—Congenital anomalies
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20081—Training; Learning
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Molecular Biology (AREA)
  • Artificial Intelligence (AREA)
  • Multimedia (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Evolutionary Computation (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Quality & Reliability (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
SG11202013020YA 2018-07-06 2019-07-02 Tissue potency determination through quantitative histomorphology analysis SG11202013020YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862694829P 2018-07-06 2018-07-06
PCT/US2019/040275 WO2020010067A1 (en) 2018-07-06 2019-07-02 Tissue potency determination through quantitative histomorphology analysis

Publications (1)

Publication Number Publication Date
SG11202013020YA true SG11202013020YA (en) 2021-01-28

Family

ID=69060606

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202013020YA SG11202013020YA (en) 2018-07-06 2019-07-02 Tissue potency determination through quantitative histomorphology analysis

Country Status (12)

Country Link
US (2) US10977479B2 (pt)
EP (1) EP3817652A4 (pt)
JP (3) JP6984050B2 (pt)
KR (2) KR20220019069A (pt)
CN (1) CN113164046A (pt)
AU (1) AU2019298235A1 (pt)
BR (1) BR112020026363A2 (pt)
CA (1) CA3104679A1 (pt)
IL (3) IL279968B (pt)
MX (1) MX2020014048A (pt)
SG (1) SG11202013020YA (pt)
WO (1) WO2020010067A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11819520B2 (en) 2018-02-23 2023-11-21 Duke University Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants
EP4018365A1 (en) 2019-08-23 2022-06-29 Memorial Sloan Kettering Cancer Center Identifying regions of interest from whole slide images
WO2024042488A1 (en) 2022-08-24 2024-02-29 Enzyvant Therapeutics Gmbh Thymic exosome assays, and methods of producing t cell depleted thymus tissue and uses thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766944A (en) * 1996-12-31 1998-06-16 Ruiz; Margaret Eileen T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments
US20060154236A1 (en) * 2004-11-11 2006-07-13 Altschuler Steven J Computer-assisted analysis
PL1971681T3 (pl) 2005-12-16 2018-01-31 Depuy Synthes Products Inc Kompozycje oraz sposoby do hamowania niepożądanej odpowiedzi immunologicznej w przypadku transplantacji z brakiem zgodności tkankowej
WO2009098698A2 (en) * 2008-02-07 2009-08-13 Shahar Cohen Compartmental extract compositions for tissue engineering
US8488863B2 (en) * 2008-11-06 2013-07-16 Los Alamos National Security, Llc Combinational pixel-by-pixel and object-level classifying, segmenting, and agglomerating in performing quantitative image analysis that distinguishes between healthy non-cancerous and cancerous cell nuclei and delineates nuclear, cytoplasm, and stromal material objects from stained biological tissue materials
US9495515B1 (en) * 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
MX346624B (es) * 2011-09-13 2017-03-27 Koninklijke Philips Nv Sistema y metodo para la deteccion de anormalidades en una muestra biologica.
AU2012318445A1 (en) * 2011-10-05 2014-05-01 Cireca Theranostics, Llc Method and system for analyzing biological specimens by spectral imaging
WO2013113707A1 (en) * 2012-02-01 2013-08-08 Ventana Medical Systems, Inc. System for detecting genes in tissue samples
EP3108446B1 (en) * 2014-02-21 2019-03-20 Ventana Medical Systems, Inc. Medical image analysis for identifying biomarker-positive tumor cells
WO2015170183A2 (en) * 2014-05-05 2015-11-12 Dako Denmark A/S Method and apparatus for image scoring and analysis
EP3175389B1 (en) * 2014-07-28 2024-05-15 Ventana Medical Systems, Inc. Automatic glandular and tubule detection in histological grading of breast cancer
AU2015331579A1 (en) * 2014-10-17 2017-05-25 Cireca Theranostics, Llc Methods and systems for classifying biological samples, including optimization of analyses and use of correlation
EP3212057B1 (en) * 2014-10-29 2021-12-01 Spectral MD, Inc. Reflective mode multi-spectral time-resolved optical imaging methods and apparatuses for tissue classification
JP6800152B2 (ja) * 2014-11-10 2020-12-16 ベンタナ メディカル システムズ， インコーポレイテッド 組織学画像中の核の分類
WO2016120440A1 (en) * 2015-01-29 2016-08-04 Ventana Medical Systems, Inc. Dot detection, color classification of dots and counting of color classified dots
EP3308327A4 (en) * 2015-06-11 2019-01-23 University of Pittsburgh - Of the Commonwealth System of Higher Education SYSTEMS AND METHODS FOR FINDING REGIONS OF INTEREST IN HEMATOXYLIN AND EOSIN (H & E) DYED TISSUE IMAGES AND QUANTIFYING INTRATUMORAL CELLULAR HORIZONTAL HETEROGENICITY IN MULTIPLEXED / HYPERPLEXED FLUORESCENT TISSUE IMAGES
US9613254B1 (en) * 2015-09-30 2017-04-04 General Electric Company Quantitative in situ characterization of heterogeneity in biological samples
US10943345B2 (en) * 2015-11-17 2021-03-09 The Board Of Trustees Of The Leland Stanford Junior University Profiling of pathology images for clinical applications
US10957041B2 (en) * 2018-05-14 2021-03-23 Tempus Labs, Inc. Determining biomarkers from histopathology slide images

Also Published As

Publication number Publication date
JP2022031786A (ja) 2022-02-22
JP2021524039A (ja) 2021-09-09
AU2019298235A1 (en) 2021-01-21
US20200012845A1 (en) 2020-01-09
US20210279442A1 (en) 2021-09-09
IL285609B (en) 2022-04-01
CA3104679A1 (en) 2020-01-09
MX2020014048A (es) 2021-03-09
JP6984050B2 (ja) 2021-12-17
WO2020010067A1 (en) 2020-01-09
KR20210024645A (ko) 2021-03-05
IL291503A (en) 2022-05-01
JP7317929B2 (ja) 2023-07-31
EP3817652A4 (en) 2021-08-25
CN113164046A (zh) 2021-07-23
JP2023153848A (ja) 2023-10-18
US20200285830A9 (en) 2020-09-10
US10977479B2 (en) 2021-04-13
KR20220019069A (ko) 2022-02-15
EP3817652A1 (en) 2021-05-12
KR102357952B1 (ko) 2022-02-08
IL279968A (en) 2021-03-01
IL279968B (en) 2022-01-01
IL285609A (en) 2021-09-30
BR112020026363A2 (pt) 2021-03-30

Similar Documents

Publication Publication Date Title
CA185208S (en) Medical probe
IL291503A (en) Determination of tissue strength through quantitative histomorphology analysis
GB202015400D0 (en) Adverse drug reaction analysis
GB201813449D0 (en) Skin cell analysis
GB201608781D0 (en) Non-invasive blood analysis
SG11201910487QA (en) Blood sampling device
EP3813710A4 (en) IMPLANT FIT ANALYSIS
GB2570742B (en) Optical-interference analysis
GB201708835D0 (en) Direct tissue analysis
GB201908045D0 (en) Object analysis
IL284421A (en) Foxvirus is defective in M2
GB201811477D0 (en) Runtime analysis
GB201815799D0 (en) Skin analysis device
PT3750457T (pt) Canudo descartável
SG11202009797UA (en) Analysis system
GB2579810B (en) Assay Analysis
EP3786639A4 (en) BLOOD ANALYSIS DEVICE
GB201809702D0 (en) Content analysis
GB2612914B (en) Tissue analysis
EP3405095C0 (en) TISSUE SAMPLE ANALYSIS
SG11202103186SA (en) Analysis system
GB201818285D0 (en) Sweat analysis
GB201817485D0 (en) Protein tablets
GB201811451D0 (en) Blood analysis
GB2585410B (en) Analysis