SG11202012748TA - Decreasing phasing with unlabeled nucleotides during sequencing - Google Patents
Decreasing phasing with unlabeled nucleotides during sequencingInfo
- Publication number
- SG11202012748TA SG11202012748TA SG11202012748TA SG11202012748TA SG11202012748TA SG 11202012748T A SG11202012748T A SG 11202012748TA SG 11202012748T A SG11202012748T A SG 11202012748TA SG 11202012748T A SG11202012748T A SG 11202012748TA SG 11202012748T A SG11202012748T A SG 11202012748TA
- Authority
- SG
- Singapore
- Prior art keywords
- phasing
- decreasing
- during sequencing
- unlabeled nucleotides
- nucleotides during
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/146—Concentration of target or template
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/149—Sequential reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Fluid Mechanics (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862779609P | 2018-12-14 | 2018-12-14 | |
| PCT/EP2019/083175 WO2020120179A1 (en) | 2018-12-14 | 2019-11-29 | Decreasing phasing with unlabeled nucleotides during sequencing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202012748TA true SG11202012748TA (en) | 2021-01-28 |
Family
ID=68806732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202012748TA SG11202012748TA (en) | 2018-12-14 | 2019-11-29 | Decreasing phasing with unlabeled nucleotides during sequencing |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11767558B2 (zh) |
| EP (1) | EP3894598B1 (zh) |
| JP (1) | JP7542444B2 (zh) |
| KR (1) | KR20210103931A (zh) |
| CN (1) | CN112639126A (zh) |
| AU (1) | AU2019400090A1 (zh) |
| CA (1) | CA3103520A1 (zh) |
| ES (1) | ES2973302T3 (zh) |
| SG (1) | SG11202012748TA (zh) |
| WO (1) | WO2020120179A1 (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3157457A1 (en) | 2019-11-27 | 2021-06-03 | Xiaolin Wu | Cyclooctatetraene containing dyes and compositions |
| JP2024520279A (ja) * | 2021-05-26 | 2024-05-24 | イルミナ インコーポレイテッド | ３’－ブロック化ヌクレオチドの精製及び重合 |
| US20230096386A1 (en) * | 2021-09-30 | 2023-03-30 | Illumina Cambridge Limited | Polynucleotide sequencing |
| WO2024216163A1 (en) * | 2023-04-13 | 2024-10-17 | Esbiolab Llc | Methods and compositions for nucleic acid sequencing using predominantly unlabeled nucleotides |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| WO1991006678A1 (en) | 1989-10-26 | 1991-05-16 | Sri International | Dna sequencing |
| US5386023A (en) | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5644048A (en) | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
| US5637684A (en) | 1994-02-23 | 1997-06-10 | Isis Pharmaceuticals, Inc. | Phosphoramidate and phosphorothioamidate oligomeric compounds |
| US5681702A (en) | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
| WO1997043611A1 (en) | 1996-05-16 | 1997-11-20 | Affymetrix, Inc. | Systems and methods for detection of labeled materials |
| US5754291A (en) | 1996-09-19 | 1998-05-19 | Molecular Dynamics, Inc. | Micro-imaging system |
| EP3034626A1 (en) | 1997-04-01 | 2016-06-22 | Illumina Cambridge Limited | Method of nucleic acid sequencing |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6429027B1 (en) | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
| JP2004513619A (ja) | 2000-07-07 | 2004-05-13 | ヴィジゲン バイオテクノロジーズ インコーポレイテッド | リアルタイム配列決定 |
| WO2002102578A1 (en) | 2000-11-16 | 2002-12-27 | Schott Glas | Method of forming an ordered array of fibers |
| AU2002227156A1 (en) | 2000-12-01 | 2002-06-11 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
| AR031640A1 (es) | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| EP1992706B1 (en) | 2002-02-21 | 2014-11-19 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| DK3363809T3 (da) | 2002-08-23 | 2020-05-04 | Illumina Cambridge Ltd | Modificerede nukleotider til polynukleotidsekvensering |
| AU2004253882B2 (en) | 2003-06-20 | 2010-06-10 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
| AU2005296200B2 (en) | 2004-09-17 | 2011-07-14 | Pacific Biosciences Of California, Inc. | Apparatus and method for analysis of molecules |
| WO2006064199A1 (en) * | 2004-12-13 | 2006-06-22 | Solexa Limited | Improved method of nucleotide detection |
| GB0514936D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Preparation of templates for nucleic acid sequencing |
| WO2007033176A2 (en) | 2005-09-14 | 2007-03-22 | Illumina, Inc. | Continuous polymer synthesizer |
| US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| US7329860B2 (en) | 2005-11-23 | 2008-02-12 | Illumina, Inc. | Confocal imaging methods and apparatus |
| EP3722409A1 (en) | 2006-03-31 | 2020-10-14 | Illumina, Inc. | Systems and devices for sequence by synthesis analysis |
| US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
| CA2666517A1 (en) | 2006-10-23 | 2008-05-02 | Pacific Biosciences Of California, Inc. | Polymerase enzymes and reagents for enhanced nucleic acid sequencing |
| WO2008069973A2 (en) | 2006-12-01 | 2008-06-12 | The Trustees Of Columbia University In The City Of New York | Four-color dna sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators |
| EP2121983A2 (en) * | 2007-02-02 | 2009-11-25 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
| WO2008157640A2 (en) | 2007-06-18 | 2008-12-24 | Illumina, Inc. | Microfabrication methods for the optimal patterning of substrates |
| US20090226975A1 (en) | 2008-03-10 | 2009-09-10 | Illumina, Inc. | Constant cluster seeding |
| US9017973B2 (en) | 2008-03-19 | 2015-04-28 | Intelligent Biosystems, Inc. | Methods and compositions for incorporating nucleotides |
| US8772473B2 (en) | 2009-03-30 | 2014-07-08 | The Regents Of The University Of California | Mostly natural DNA sequencing by synthesis |
| WO2012068454A2 (en) * | 2010-11-19 | 2012-05-24 | University Of Rochester | Nrf2 deficiency influences susceptibility to steroid resistance via hdac2 reduction |
| WO2012162429A2 (en) | 2011-05-23 | 2012-11-29 | The Trustees Of Columbia University In The City Of New York | Dna sequencing by synthesis using raman and infrared spectroscopy detection |
| ES2639938T5 (es) | 2011-09-23 | 2021-05-07 | Illumina Inc | Métodos y composiciones para la secuenciación de ácidos nucleicos |
| EP2971070B2 (en) * | 2013-03-14 | 2021-03-03 | Illumina, Inc. | Modified polymerases for improved incorporation of nucleotide analogues |
| GB201414098D0 (en) | 2014-08-08 | 2014-09-24 | Illumina Cambridge Ltd | Modified nucleotide linkers |
| US10428378B2 (en) | 2016-08-15 | 2019-10-01 | Omniome, Inc. | Sequencing method for rapid identification and processing of cognate nucleotide pairs |
| EP3596099B1 (en) * | 2017-03-06 | 2024-07-24 | Singular Genomics Systems, Inc. | Nucleic acid sequencing-by-synthesis (sbs) methods that combine sbs cycle steps |
-
2019
- 2019-11-29 CN CN201980042752.5A patent/CN112639126A/zh active Pending
- 2019-11-29 ES ES19816247T patent/ES2973302T3/es active Active
- 2019-11-29 KR KR1020207036776A patent/KR20210103931A/ko active Search and Examination
- 2019-11-29 EP EP19816247.1A patent/EP3894598B1/en active Active
- 2019-11-29 CA CA3103520A patent/CA3103520A1/en active Pending
- 2019-11-29 WO PCT/EP2019/083175 patent/WO2020120179A1/en unknown
- 2019-11-29 AU AU2019400090A patent/AU2019400090A1/en active Pending
- 2019-11-29 JP JP2020572430A patent/JP7542444B2/ja active Active
- 2019-11-29 SG SG11202012748TA patent/SG11202012748TA/en unknown
- 2019-12-05 US US16/704,345 patent/US11767558B2/en active Active
-
2023
- 2023-08-09 US US18/232,127 patent/US20240084379A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20210103931A (ko) | 2021-08-24 |
| EP3894598A1 (en) | 2021-10-20 |
| US20200190576A1 (en) | 2020-06-18 |
| CA3103520A1 (en) | 2020-06-18 |
| JP2022512263A (ja) | 2022-02-03 |
| US20240084379A1 (en) | 2024-03-14 |
| ES2973302T3 (es) | 2024-06-19 |
| CN112639126A (zh) | 2021-04-09 |
| US11767558B2 (en) | 2023-09-26 |
| AU2019400090A1 (en) | 2021-01-07 |
| WO2020120179A1 (en) | 2020-06-18 |
| EP3894598B1 (en) | 2024-01-03 |
| JP7542444B2 (ja) | 2024-08-30 |
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