SG11202010744YA - Antibodies with modulated glycan profiles - Google Patents
Antibodies with modulated glycan profilesInfo
- Publication number
- SG11202010744YA SG11202010744YA SG11202010744YA SG11202010744YA SG11202010744YA SG 11202010744Y A SG11202010744Y A SG 11202010744YA SG 11202010744Y A SG11202010744Y A SG 11202010744YA SG 11202010744Y A SG11202010744Y A SG 11202010744YA SG 11202010744Y A SG11202010744Y A SG 11202010744YA
- Authority
- SG
- Singapore
- Prior art keywords
- antibodies
- modulated
- glycan profiles
- glycan
- profiles
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862665045P | 2018-05-01 | 2018-05-01 | |
| PCT/US2019/029850 WO2019213043A1 (en) | 2018-05-01 | 2019-04-30 | Antibodies with modulated glycan profiles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202010744YA true SG11202010744YA (en) | 2020-11-27 |
Family
ID=66542532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202010744YA SG11202010744YA (en) | 2018-05-01 | 2019-04-30 | Antibodies with modulated glycan profiles |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US12084686B2 (ru) |
| EP (2) | EP3788076A1 (ru) |
| JP (1) | JP7536651B2 (ru) |
| KR (1) | KR20210005689A (ru) |
| CN (1) | CN112074537A (ru) |
| AU (1) | AU2019263008A1 (ru) |
| BR (1) | BR112020022166A2 (ru) |
| CA (1) | CA3099163A1 (ru) |
| CL (1) | CL2020002810A1 (ru) |
| EA (1) | EA202092576A1 (ru) |
| IL (2) | IL307155A (ru) |
| MA (1) | MA52490A (ru) |
| MX (1) | MX2020011614A (ru) |
| SG (1) | SG11202010744YA (ru) |
| TW (1) | TW202003574A (ru) |
| WO (1) | WO2019213043A1 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR129727A1 (es) * | 2022-06-28 | 2024-09-25 | Amgen Inc | Configuraciones flexibles de instalaciones para la fabricación de productos terapéuticos |
| CN117825686A (zh) * | 2024-03-05 | 2024-04-05 | 军科正源（北京）药物研究有限责任公司 | 用于检测地诺单抗抗药性抗体的样品预处理方法及其应用 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US159259A (en) * | 1875-02-02 | Improvement in reservoir cooking-stoves | ||
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| US4499064A (en) | 1982-06-03 | 1985-02-12 | Clayton Foundation For Research | Assessment of nutritional status of individuals |
| AU588819B2 (en) | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| US5075222A (en) | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
| AU643427B2 (en) | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
| US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| EP1132471A3 (de) | 1989-09-12 | 2001-11-28 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
| US6204363B1 (en) | 1989-10-16 | 2001-03-20 | Amgen Inc. | Stem cell factor |
| US5272064A (en) | 1989-12-19 | 1993-12-21 | Amgen Inc. | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
| US5149792A (en) | 1989-12-19 | 1992-09-22 | Amgen Inc. | Platelet-derived growth factor B chain analogs |
| WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
| US5350683A (en) | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
| GB9118664D0 (en) | 1991-08-30 | 1991-10-16 | Celltech Ltd | Cell culture |
| PT672141E (pt) | 1992-10-23 | 2003-09-30 | Immunex Corp | Metodos de preparacao de proteinas oligomericas soluveis |
| JPH06292592A (ja) | 1993-02-09 | 1994-10-21 | Snow Brand Milk Prod Co Ltd | 糖蛋白質の生産方法 |
| US5554512A (en) | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
| US6310185B1 (en) | 1994-03-08 | 2001-10-30 | Memorial Sloan Kettering Cancer Center | Recombinant human anti-Lewis Y antibodies |
| US5856179A (en) | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
| US5981713A (en) | 1994-10-13 | 1999-11-09 | Applied Research Systems Ars Holding N.V. | Antibodies to intereleukin-1 antagonists |
| EP0835305B1 (en) | 1995-06-29 | 2005-11-23 | Immunex Corporation | Cytokine that induces apoptosis |
| US6613544B1 (en) | 1995-12-22 | 2003-09-02 | Amgen Inc. | Osteoprotegerin |
| US6096728A (en) | 1996-02-09 | 2000-08-01 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
| US20020012991A1 (en) | 1997-04-07 | 2002-01-31 | Florence Chua Nee Ho Kit Fong | Cell culture media for enhanced protein production |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| DK1036179T4 (da) | 1997-12-03 | 2014-03-31 | Roche Diagnostics Gmbh | Fremgangsmåde til fremstilling af polypeptider med egnet glycosilering |
| US6337072B1 (en) | 1998-04-03 | 2002-01-08 | Hyseq, Inc. | Interleukin-1 receptor antagonist and recombinant production thereof |
| US6210924B1 (en) | 1998-08-11 | 2001-04-03 | Amgen Inc. | Overexpressing cyclin D 1 in a eukaryotic cell line |
| AU1920301A (en) | 1999-11-17 | 2001-05-30 | Immunex Corporation | Receptor activator of nf-kappa b |
| US6544424B1 (en) | 1999-12-03 | 2003-04-08 | Refined Technology Company | Fluid filtration system |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| PT1543106E (pt) | 2002-07-15 | 2007-05-31 | Immunex Corp | Métodos e meios para controlar a sialilação de proteínas produzidas por células de mamíferos |
| ATE488600T1 (de) | 2002-12-23 | 2010-12-15 | Bristol Myers Squibb Co | Produktqualitätsverbesserung in säugerzellkulturverfahrenzur proteinproduktion |
| US7294484B2 (en) | 2004-08-27 | 2007-11-13 | Wyeth Research Ireland Limited | Production of polypeptides |
| US7691611B2 (en) | 2005-06-03 | 2010-04-06 | Ares Trading S.A. | Production of recombinant IL-18 binding protein |
| US20070190057A1 (en) | 2006-01-23 | 2007-08-16 | Jian Wu | Methods for modulating mannose content of recombinant proteins |
| US7846724B2 (en) * | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
| US8580554B2 (en) | 2009-07-31 | 2013-11-12 | Baxter International Inc. | Method of producing a polypeptide or virus of interest in a continuous cell culture |
| WO2012145682A1 (en) | 2011-04-21 | 2012-10-26 | Amgen Inc. | A method for culturing mammalian cells to improve recombinant protein production |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| KR102558247B1 (ko) | 2011-07-01 | 2023-07-24 | 암젠 인크 | 포유동물 세포 배양 |
| WO2013181575A2 (en) * | 2012-06-01 | 2013-12-05 | Momenta Pharmaceuticals, Inc. | Methods related to denosumab |
| US8956830B2 (en) * | 2013-03-14 | 2015-02-17 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| TWI625390B (zh) * | 2013-03-14 | 2018-06-01 | 安美基公司 | 用於增加重組蛋白質之甘露糖含量之方法 |
| US9481901B2 (en) | 2013-05-30 | 2016-11-01 | Amgen Inc. | Methods for increasing mannose content of recombinant proteins |
| WO2015009259A2 (en) * | 2013-07-19 | 2015-01-22 | Kaynakli Ömer | A simple ripper for roll papers |
| US11427627B2 (en) | 2013-09-05 | 2022-08-30 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
| MX2016005572A (es) | 2013-10-31 | 2016-12-09 | Amgen Inc | Uso de monensina para regular la glicosilacion de proteinas recombinantes. |
| KR102519540B1 (ko) | 2014-01-29 | 2023-04-10 | 암젠 인크 | 재조합 단백질의 글리코실화를 조절하기 위한 n-글리코실화 경로 조절자의 과발현 |
-
2019
- 2019-04-30 KR KR1020207033991A patent/KR20210005689A/ko not_active Application Discontinuation
- 2019-04-30 AU AU2019263008A patent/AU2019263008A1/en active Pending
- 2019-04-30 CN CN201980029448.7A patent/CN112074537A/zh active Pending
- 2019-04-30 EP EP19724307.4A patent/EP3788076A1/en active Pending
- 2019-04-30 WO PCT/US2019/029850 patent/WO2019213043A1/en unknown
- 2019-04-30 EP EP23200813.6A patent/EP4316519A3/en active Pending
- 2019-04-30 EA EA202092576A patent/EA202092576A1/ru unknown
- 2019-04-30 JP JP2020560390A patent/JP7536651B2/ja active Active
- 2019-04-30 BR BR112020022166-0A patent/BR112020022166A2/pt unknown
- 2019-04-30 MA MA052490A patent/MA52490A/fr unknown
- 2019-04-30 SG SG11202010744YA patent/SG11202010744YA/en unknown
- 2019-04-30 US US17/051,528 patent/US12084686B2/en active Active
- 2019-04-30 IL IL307155A patent/IL307155A/en unknown
- 2019-04-30 CA CA3099163A patent/CA3099163A1/en active Pending
- 2019-04-30 MX MX2020011614A patent/MX2020011614A/es unknown
- 2019-04-30 IL IL278211A patent/IL278211B1/en unknown
- 2019-05-01 TW TW108115162A patent/TW202003574A/zh unknown
-
2020
- 2020-10-29 CL CL2020002810A patent/CL2020002810A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021521854A (ja) | 2021-08-30 |
| IL307155A (en) | 2023-11-01 |
| EP4316519A3 (en) | 2024-04-24 |
| EA202092576A1 (ru) | 2021-02-05 |
| WO2019213043A1 (en) | 2019-11-07 |
| TW202003574A (zh) | 2020-01-16 |
| CL2020002810A1 (es) | 2021-02-19 |
| CN112074537A (zh) | 2020-12-11 |
| CA3099163A1 (en) | 2019-11-07 |
| IL278211B1 (en) | 2023-10-01 |
| MX2020011614A (es) | 2020-12-09 |
| EP4316519A2 (en) | 2024-02-07 |
| MA52490A (fr) | 2021-03-10 |
| KR20210005689A (ko) | 2021-01-14 |
| BR112020022166A2 (pt) | 2021-01-26 |
| EP3788076A1 (en) | 2021-03-10 |
| US12084686B2 (en) | 2024-09-10 |
| US20210062156A1 (en) | 2021-03-04 |
| IL278211A (en) | 2020-11-30 |
| JP7536651B2 (ja) | 2024-08-20 |
| AU2019263008A1 (en) | 2020-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL279321A (en) | Anti-SIRPalpha antibody | |
| IL280780A (en) | Anti-TIGIT antibodies | |
| EP3589313A4 (en) | ANTI-TIGITE ANTIBODY | |
| IL280013A (en) | Anti-IL36R antibodies | |
| EP3569709A4 (en) | ANTI-GPC3 ANTIBODIES | |
| IL279352A (en) | IL-11RA antibodies | |
| EP3661558A4 (en) | ANTI-IL1RAP ANTIBODIES | |
| IL278010A (en) | Antibodies to galectin 10 | |
| EP3606961B8 (en) | Garp-tgf-beta antibodies | |
| EP3684806A4 (en) | NEW ANTI-CD3EPSILON ANTIBODIES | |
| IL277030A (en) | Antibodies | |
| EP3691447A4 (en) | ANTI-TRANSTHYRETINE ANTIBODIES | |
| SG11202106171WA (en) | Anti-btla antibodies | |
| EP3596126A4 (en) | NEW ANTI-TRKB ANTIBODIES | |
| ZA202101177B (en) | Anti-btla antibody | |
| GB201811368D0 (en) | Antibody | |
| GB201811403D0 (en) | Antibody molecules | |
| AU2019361253A1 (en) | Anti-synuclein antibodies | |
| GB201817172D0 (en) | Antibody | |
| EP3579879A4 (en) | ANTI-BODY ANTI-KIR3DL1 | |
| IL281594A (en) | Antibodies against KLRG1 | |
| IL278211A (en) | Antibodies with a modulated glycan profile | |
| GB201806084D0 (en) | Antibodies | |
| EP3720492A4 (en) | ANTI-RSPO3 ANTIBODIES | |
| TWI860014B (zh) | 抗體 |