SG11202007073SA - Glypican 3 antibodies and conjugates thereof - Google Patents
Glypican 3 antibodies and conjugates thereofInfo
- Publication number
- SG11202007073SA SG11202007073SA SG11202007073SA SG11202007073SA SG11202007073SA SG 11202007073S A SG11202007073S A SG 11202007073SA SG 11202007073S A SG11202007073S A SG 11202007073SA SG 11202007073S A SG11202007073S A SG 11202007073SA SG 11202007073S A SG11202007073S A SG 11202007073SA
- Authority
- SG
- Singapore
- Prior art keywords
- glypican
- conjugates
- antibodies
- Prior art date
Links
- 102000010956 Glypican Human genes 0.000 title 1
- 108050001154 Glypican Proteins 0.000 title 1
- 108050007237 Glypican-3 Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6859—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from liver or pancreas cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862631353P | 2018-02-15 | 2018-02-15 | |
PCT/US2019/018182 WO2019161174A1 (fr) | 2018-02-15 | 2019-02-15 | Anticorps de glypicane 3 et leurs conjugués |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202007073SA true SG11202007073SA (en) | 2020-08-28 |
Family
ID=67620075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202007073SA SG11202007073SA (en) | 2018-02-15 | 2019-02-15 | Glypican 3 antibodies and conjugates thereof |
Country Status (13)
Country | Link |
---|---|
US (1) | US11819553B2 (fr) |
EP (1) | EP3752534A4 (fr) |
JP (2) | JP7402807B2 (fr) |
KR (1) | KR20200121317A (fr) |
CN (1) | CN111712520A (fr) |
AR (1) | AR114112A1 (fr) |
AU (1) | AU2019220700A1 (fr) |
CA (1) | CA3090251A1 (fr) |
IL (1) | IL276514A (fr) |
MX (1) | MX2020008030A (fr) |
SG (1) | SG11202007073SA (fr) |
TW (1) | TW201938587A (fr) |
WO (1) | WO2019161174A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201900699QA (en) | 2016-08-09 | 2019-02-27 | Seattle Genetics Inc | Drug conjugates with self-stabilizing linkers having improved physiochemical properties |
AR114112A1 (es) | 2018-02-15 | 2020-07-22 | Seattle Genetics Inc | Anticuerpos de glipicano 3 y conjugados de los mismos |
CN115955980A (zh) | 2020-04-10 | 2023-04-11 | 思进公司 | 电荷可变接头 |
JP2023525991A (ja) * | 2020-05-07 | 2023-06-20 | フェインズ セラピューティクス,インコーポレーテッド | 抗腫瘍関連抗原抗体及びその使用 |
CN112921005B (zh) * | 2021-04-14 | 2023-07-07 | 中国农业科学院兰州兽医研究所 | 一株杂交瘤细胞株及其产生的犬细小病毒vp2蛋白单克隆抗体和应用 |
EP4346906A1 (fr) | 2021-05-28 | 2024-04-10 | Seagen Inc. | Conjugués d'anticorps d'anthracycline |
WO2023045151A1 (fr) * | 2021-09-24 | 2023-03-30 | Zhejiang Shimai Pharmaceutical Co., Ltd. | Anticorps anti-gpc3 et leurs utilisations |
WO2023178289A2 (fr) | 2022-03-17 | 2023-09-21 | Seagen Inc. | Conjugués de camptothécine |
WO2023207475A1 (fr) * | 2022-04-24 | 2023-11-02 | 昱言科技(北京)有限公司 | Anticorps monoclonal ciblant gpc3 et conjugué anticorps-médicament le comprenant |
WO2024061305A1 (fr) * | 2022-09-22 | 2024-03-28 | 上海美雅珂生物技术有限责任公司 | Conjugué anticorps-médicament gpc3 et son utilisation |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7361336B1 (en) | 1997-09-18 | 2008-04-22 | Ivan Bergstein | Methods of cancer therapy targeted against a cancer stem line |
EP1780273B1 (fr) | 2001-06-22 | 2010-10-06 | Chugai Seiyaku Kabushiki Kaisha | Inhibiteurs de prolifération de cellules contenant un anticorps anti-glypican 3 |
AU2002338020A1 (en) | 2002-09-04 | 2004-03-29 | Chugai Seiyaku Kabushiki Kaisha | Antibody against blood-solubilized n-terminal peptide in gpc3 |
AU2005256113B2 (en) * | 2004-07-09 | 2011-02-10 | Chugai Seiyaku Kabushiki Kaisha | Anti-glypican 3 antibody |
BR112012012917A2 (pt) | 2009-11-30 | 2016-10-25 | Biotest Ag | anticorpo, ácido nucleico, vetor, célula hospedeira, método para a produção de um anticorpo ou um fragmento do mesmo, composição farmacêutica, método para tratar ou prevenir uma condição médica em um indivíduo, uso de um anticorpo ou fragmento do mesmo, e, métodos in vitro para neutralizar il-10 em uma amostra, in vitro para detectar a presença de il-10 em uma amostra e para diagnosticar lúpus eritematoso sistêmico (sle) em um indivíduo |
JP6827319B2 (ja) * | 2014-05-08 | 2021-02-10 | 中外製薬株式会社 | Gpc3標的治療剤療法が有効である患者に投与されるgpc3標的治療剤 |
MX2016015162A (es) * | 2014-05-22 | 2017-03-03 | Genentech Inc | Anticuerpos anti - gpc3 e inmunoconjugados. |
EP2963057A1 (fr) | 2014-07-02 | 2016-01-06 | Calypso Biotech SA | Anticorps pour IL-15 |
SG11201701311YA (en) * | 2014-09-11 | 2017-03-30 | Seattle Genetics Inc | Targeted delivery of tertiary amine-containing drug substances |
WO2017181109A1 (fr) * | 2016-04-15 | 2017-10-19 | Michael Molloy | Anticorps anti-vista humain et leur utilisation |
US20170326249A1 (en) | 2016-05-10 | 2017-11-16 | Bristol-Myers Squibb Company | Antibody-drug conjugate of an anti-glypican-3 antibody and a tubulysin analog, preparation and uses |
AR114112A1 (es) | 2018-02-15 | 2020-07-22 | Seattle Genetics Inc | Anticuerpos de glipicano 3 y conjugados de los mismos |
-
2019
- 2019-02-14 AR ARP190100366A patent/AR114112A1/es unknown
- 2019-02-15 MX MX2020008030A patent/MX2020008030A/es unknown
- 2019-02-15 TW TW108105041A patent/TW201938587A/zh unknown
- 2019-02-15 WO PCT/US2019/018182 patent/WO2019161174A1/fr unknown
- 2019-02-15 SG SG11202007073SA patent/SG11202007073SA/en unknown
- 2019-02-15 CN CN201980012811.4A patent/CN111712520A/zh active Pending
- 2019-02-15 AU AU2019220700A patent/AU2019220700A1/en active Pending
- 2019-02-15 JP JP2020543351A patent/JP7402807B2/ja active Active
- 2019-02-15 EP EP19755133.6A patent/EP3752534A4/fr active Pending
- 2019-02-15 KR KR1020207025196A patent/KR20200121317A/ko unknown
- 2019-02-15 US US16/970,095 patent/US11819553B2/en active Active
- 2019-02-15 CA CA3090251A patent/CA3090251A1/fr active Pending
-
2020
- 2020-08-05 IL IL276514A patent/IL276514A/en unknown
-
2023
- 2023-04-17 JP JP2023067166A patent/JP2023089195A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3090251A1 (fr) | 2019-08-22 |
KR20200121317A (ko) | 2020-10-23 |
EP3752534A4 (fr) | 2021-12-01 |
JP2023089195A (ja) | 2023-06-27 |
MX2020008030A (es) | 2020-09-10 |
AR114112A1 (es) | 2020-07-22 |
AU2019220700A1 (en) | 2020-09-24 |
IL276514A (en) | 2020-09-30 |
WO2019161174A1 (fr) | 2019-08-22 |
EP3752534A1 (fr) | 2020-12-23 |
JP2021513844A (ja) | 2021-06-03 |
TW201938587A (zh) | 2019-10-01 |
JP7402807B2 (ja) | 2023-12-21 |
CN111712520A (zh) | 2020-09-25 |
US20210361776A1 (en) | 2021-11-25 |
US11819553B2 (en) | 2023-11-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL276514A (en) | Glypican 3 antibodies and their conjugates | |
IL276950A (en) | Anti-CD73 antibodies and uses thereof | |
IL282968A (en) | Anti-NKG2A antibodies and their use | |
IL276978A (en) | Antibodies against IL-6 and their fusions and conjugates | |
IL284974A (en) | Anti-cd228 antibodies and antibody-drug conjugates | |
IL275826A (en) | Anti-mct1 antibodies and their uses | |
IL282736A (en) | Interleukin 10 conjugates and their use | |
IL281297A (en) | Anti-NPR1 antibodies and uses thereof | |
SG11202101517PA (en) | Isoquinoline-steroid conjugates and uses thereof | |
ZA202002207B (en) | Antibodies and antibody-drug conjugates specific for cd123 and uses thereof | |
EP3877416A4 (fr) | Anticorps anti-cd45 et leurs conjugués | |
SG11202009625WA (en) | Anti-trem-1 antibodies and uses thereof | |
IL280321A (en) | Antibodies against CXCR2 and their uses | |
IL277330A (en) | Anti-IL-27 antibodies and uses thereof | |
IL283942A (en) | Tubulysins and protein-tubulysin conjugation | |
IL283875A (en) | Anti-il-27 antibodies and uses thereof | |
IL281202A (en) | Anti-TNFRSF9 antibodies and uses thereof | |
IL266112A (en) | Antibodies against edb and antibody-drug conjugates | |
IL277075A (en) | Anti-PHF-tau antibodies and uses thereof | |
IL276548A (en) | Binding antibodies - BCMA and their uses | |
EP4069297A4 (fr) | Anticorps anti-avb6 et conjugués anticorps-médicament | |
IL286483A (en) | Claudin-6 antibodies and drug conjugates | |
IL284027A (en) | Antibodies to pmel17 and their conjugates | |
IL283926A (en) | Antibodies against alpha-synuclein and their uses | |
SG11202011232VA (en) | Anti-cd63 antibodies, conjugates, and uses thereof |