SG11202006837XA - Dihydroindolizinone derivative - Google Patents
Dihydroindolizinone derivativeInfo
- Publication number
- SG11202006837XA SG11202006837XA SG11202006837XA SG11202006837XA SG11202006837XA SG 11202006837X A SG11202006837X A SG 11202006837XA SG 11202006837X A SG11202006837X A SG 11202006837XA SG 11202006837X A SG11202006837X A SG 11202006837XA SG 11202006837X A SG11202006837X A SG 11202006837XA
- Authority
- SG
- Singapore
- Prior art keywords
- dihydroindolizinone
- derivative
- dihydroindolizinone derivative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/73—Hydrolases (EC 3.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018006269 | 2018-01-18 | ||
PCT/JP2019/001364 WO2019142883A1 (ja) | 2018-01-18 | 2019-01-18 | ジヒドロインドリジノン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202006837XA true SG11202006837XA (en) | 2020-08-28 |
Family
ID=67302218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202006837XA SG11202006837XA (en) | 2018-01-18 | 2019-01-18 | Dihydroindolizinone derivative |
Country Status (12)
Country | Link |
---|---|
US (1) | US11530211B2 (de) |
EP (1) | EP3741757B1 (de) |
JP (1) | JP7359697B2 (de) |
KR (1) | KR20200110338A (de) |
CN (1) | CN111630052B (de) |
AU (1) | AU2019208634B2 (de) |
CA (1) | CA3088968C (de) |
ES (1) | ES2958118T3 (de) |
IL (1) | IL276125A (de) |
SG (1) | SG11202006837XA (de) |
TW (1) | TWI818948B (de) |
WO (1) | WO2019142883A1 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021006268A1 (ja) * | 2019-07-08 | 2021-01-14 | 国立大学法人東京工業大学 | ジヒドロインドリジノン誘導体を用いたインスリン産生細胞の作製法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR039059A1 (es) | 2001-08-06 | 2005-02-09 | Sanofi Aventis | Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios |
JP2003128551A (ja) * | 2001-08-15 | 2003-05-08 | Sankyo Co Ltd | 新規抗糖尿病医薬組成物 |
WO2007022506A2 (en) * | 2005-08-18 | 2007-02-22 | University Of Massachusetts | Methods and compositions for treating neurological disease |
EP2650359B1 (de) | 2006-03-02 | 2022-05-04 | Viacyte, Inc. | Endokrine Vorläuferzellen, pankreashormon-exprimierende Zellen und Herstellungsverfahren |
US8623648B2 (en) * | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
WO2010077686A1 (en) * | 2008-12-08 | 2010-07-08 | Sirtris Pharmaceuticals, Inc. | Isoindolinone and related analogs as sirtuin modulators |
WO2012056997A1 (ja) | 2010-10-28 | 2012-05-03 | 国立大学法人熊本大学 | 多能性幹細胞の分化誘導効率を改善するための方法及び培地 |
WO2012121168A1 (ja) * | 2011-03-04 | 2012-09-13 | 国立大学法人京都大学 | キナーゼ阻害剤 |
SI2844739T1 (sl) | 2012-04-30 | 2019-11-29 | Univ Health Network | Postopki in sestavki za ustvarjanje pankreatičnih prednikov in funkcionalnih beta-celic iz hPSC-jev |
JP2014161257A (ja) | 2013-02-22 | 2014-09-08 | Univ Of Tokyo | 多能性幹細胞から膵ランゲルハンス島を製造する方法 |
US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
EP3031905A4 (de) | 2013-08-07 | 2017-04-26 | Kyoto University | Verfahren zur herstellung bauchspeicheldrüsenhormon-produzierender zellen |
US20160208215A1 (en) | 2013-08-30 | 2016-07-21 | Novo Nordisk A/S | Generation of Endocrine Progenitor Cells from Human Pluripotent Stem Cells Using Small Molecules |
WO2015125662A1 (ja) | 2014-02-21 | 2015-08-27 | 国立大学法人熊本大学 | アミノ酸組成変更培地を用いた幹細胞の分化促進方法、及び該方法を用いて処理された幹細胞、並びに培地 |
JP6094516B2 (ja) | 2014-03-19 | 2017-03-15 | 三菱電機株式会社 | エレベーター装置 |
EP3143127B1 (de) | 2014-05-16 | 2021-07-14 | Janssen Biotech, Inc. | Verwendung kleiner moleküle zur verstärkung der mafa-expression in endokrinen pankreaszellen |
EP3147356B1 (de) | 2014-05-20 | 2024-03-13 | Tokyo Institute of Technology | Verfahren zur herstellung von insulinproduzierenden zellen |
WO2016019228A1 (en) * | 2014-07-31 | 2016-02-04 | Merck Patent Gmbh | Indolizine derivatives which are applicable to neurodegenerative diseases |
WO2016100930A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived b cells and methods of use thereof |
US20160175363A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived beta cells and uses thereof |
WO2016100925A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING AUGMENTED STEM CELL-DERIVED β CELLS AND USES THEREOF |
WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
EP3234110B1 (de) | 2014-12-18 | 2024-02-28 | President and Fellows of Harvard College | Verfahren zur generierung von stammzell-abgeleiteten beta-zellen und verwendungen davon |
CA2979293C (en) | 2015-03-11 | 2022-01-04 | Timothy J. Kieffer | Pancreatic endocrine progenitor cell therapies for the treatment of obesity and type 2 diabetes (t2d) |
-
2019
- 2019-01-18 CN CN201980008987.2A patent/CN111630052B/zh active Active
- 2019-01-18 EP EP19741238.0A patent/EP3741757B1/de active Active
- 2019-01-18 TW TW108101951A patent/TWI818948B/zh active
- 2019-01-18 ES ES19741238T patent/ES2958118T3/es active Active
- 2019-01-18 JP JP2019566511A patent/JP7359697B2/ja active Active
- 2019-01-18 KR KR1020207020768A patent/KR20200110338A/ko active IP Right Grant
- 2019-01-18 SG SG11202006837XA patent/SG11202006837XA/en unknown
- 2019-01-18 US US16/960,308 patent/US11530211B2/en active Active
- 2019-01-18 WO PCT/JP2019/001364 patent/WO2019142883A1/ja unknown
- 2019-01-18 AU AU2019208634A patent/AU2019208634B2/en not_active Expired - Fee Related
- 2019-01-18 CA CA3088968A patent/CA3088968C/en active Active
-
2020
- 2020-07-16 IL IL276125A patent/IL276125A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN111630052B (zh) | 2023-04-18 |
IL276125A (en) | 2020-08-31 |
ES2958118T3 (es) | 2024-02-01 |
WO2019142883A1 (ja) | 2019-07-25 |
CN111630052A (zh) | 2020-09-04 |
JPWO2019142883A1 (ja) | 2021-01-14 |
AU2019208634A1 (en) | 2020-08-06 |
CA3088968A1 (en) | 2019-07-25 |
KR20200110338A (ko) | 2020-09-23 |
JP7359697B2 (ja) | 2023-10-11 |
US20210053965A1 (en) | 2021-02-25 |
CA3088968C (en) | 2023-10-17 |
TW201938156A (zh) | 2019-10-01 |
AU2019208634A2 (en) | 2020-09-24 |
AU2019208634B2 (en) | 2024-06-13 |
US11530211B2 (en) | 2022-12-20 |
EP3741757A4 (de) | 2021-11-03 |
EP3741757B1 (de) | 2023-07-26 |
EP3741757A1 (de) | 2020-11-25 |
TWI818948B (zh) | 2023-10-21 |
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