SG11202005983TA - Heterocycle compounds as tyro3, axl and mertk (tam) family of receptor tyrosine kinase inhibitors - Google Patents

Heterocycle compounds as tyro3, axl and mertk (tam) family of receptor tyrosine kinase inhibitors

Info

Publication number
SG11202005983TA
SG11202005983TA SG11202005983TA SG11202005983TA SG11202005983TA SG 11202005983T A SG11202005983T A SG 11202005983TA SG 11202005983T A SG11202005983T A SG 11202005983TA SG 11202005983T A SG11202005983T A SG 11202005983TA SG 11202005983T A SG11202005983T A SG 11202005983TA
Authority
SG
Singapore
Prior art keywords
mertk
tyro3
axl
tam
family
Prior art date
Application number
SG11202005983TA
Other languages
English (en)
Inventor
Shih-Chieh Yen
Chu-Bin Liao
Hui-Chen Wang
Po-Ting Chen
Yu-Chih Pan
Tsung-Hui Li
bo-rong Chen
Shian-Yi Chiou
Original Assignee
Dev Ct Biotechnology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dev Ct Biotechnology filed Critical Dev Ct Biotechnology
Publication of SG11202005983TA publication Critical patent/SG11202005983TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG11202005983TA 2017-12-28 2018-12-26 Heterocycle compounds as tyro3, axl and mertk (tam) family of receptor tyrosine kinase inhibitors SG11202005983TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762610994P 2017-12-28 2017-12-28
PCT/US2018/067532 WO2019133629A1 (fr) 2017-12-28 2018-12-26 Composés hétérocycliques en tant que famille (tam) tyro3, axl et mertk d'inhibiteurs de récepteur tyrosine kinase

Publications (1)

Publication Number Publication Date
SG11202005983TA true SG11202005983TA (en) 2020-07-29

Family

ID=67068139

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202005983TA SG11202005983TA (en) 2017-12-28 2018-12-26 Heterocycle compounds as tyro3, axl and mertk (tam) family of receptor tyrosine kinase inhibitors

Country Status (10)

Country Link
US (1) US11407757B2 (fr)
EP (1) EP3731845A4 (fr)
JP (1) JP2021510729A (fr)
KR (1) KR20200104336A (fr)
CN (1) CN112203659A (fr)
AU (1) AU2018397483A1 (fr)
CA (1) CA3086714A1 (fr)
SG (1) SG11202005983TA (fr)
TW (1) TWI691500B (fr)
WO (1) WO2019133629A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023043836A1 (fr) * 2021-09-15 2023-03-23 Metacrine, Inc. Inhibiteurs de hsd17b13 et utilisations de ceux-ci
WO2023049270A1 (fr) * 2021-09-24 2023-03-30 Halia Therapeutics, Inc. Dérivés de pyrrole[2,3-b]pyridine utilisés comme inhibiteurs de tyro3

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009511528A (ja) * 2005-10-13 2009-03-19 グラクソ グループ リミテッド Ｓｙｋ阻害物質としてのピロロピリミジン誘導体群
US7981903B2 (en) * 2007-08-08 2011-07-19 Glaxosmithkline Llc 2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer
WO2009049028A1 (fr) * 2007-10-09 2009-04-16 Targegen Inc. Composés de pyrrolopyrimidine et leur utilisation en tant qu'inhibiteurs des janus kinases
TW201041892A (en) * 2009-02-09 2010-12-01 Supergen Inc Pyrrolopyrimidinyl Axl kinase inhibitors
JP2014532060A (ja) * 2011-10-03 2014-12-04 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 癌を治療するためのピロロピリミジン化合物
ES2638179T3 (es) * 2013-01-16 2017-10-19 Signal Pharmaceuticals, Llc Compuestos de pirrolopirimidina sustituidos, composiciones de los mismos, y métodos de tratamiento con los mismos
CN106458914B (zh) * 2014-03-28 2020-01-14 常州捷凯医药科技有限公司 作为axl抑制剂的杂环化合物
KR20170024120A (ko) * 2014-07-14 2017-03-06 시그날 파마소티칼 엘엘씨 치환된 피롤로피리미딘 화합물을 사용한 암의 치료방법, 이의 조성물
CN105646496B (zh) * 2016-01-20 2018-07-20 华侨大学 一种7H-吡咯并[2,3-d]嘧啶衍生物、其合成方法及应用

Also Published As

Publication number Publication date
US20210009597A1 (en) 2021-01-14
EP3731845A4 (fr) 2021-10-06
CN112203659A (zh) 2021-01-08
US11407757B2 (en) 2022-08-09
AU2018397483A1 (en) 2020-08-13
TW201930306A (zh) 2019-08-01
WO2019133629A8 (fr) 2020-01-16
EP3731845A1 (fr) 2020-11-04
KR20200104336A (ko) 2020-09-03
JP2021510729A (ja) 2021-04-30
CA3086714A1 (fr) 2019-07-04
WO2019133629A1 (fr) 2019-07-04
TWI691500B (zh) 2020-04-21

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