WO2014193696A3 - Dérivés d'acide benzimidazole-carboxylique, compositions et procédés d'utilisation en tant qu'inhibiteurs de kinase aurora - Google Patents

Dérivés d'acide benzimidazole-carboxylique, compositions et procédés d'utilisation en tant qu'inhibiteurs de kinase aurora Download PDF

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Publication number
WO2014193696A3
WO2014193696A3 PCT/US2014/038737 US2014038737W WO2014193696A3 WO 2014193696 A3 WO2014193696 A3 WO 2014193696A3 US 2014038737 W US2014038737 W US 2014038737W WO 2014193696 A3 WO2014193696 A3 WO 2014193696A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
aurora kinase
carboxylic acid
acid derivatives
compositions
Prior art date
Application number
PCT/US2014/038737
Other languages
English (en)
Other versions
WO2014193696A2 (fr
Inventor
Dharma Rao Polisetti
Santhosh Kalpathy
William Kenneth Banner
Muralidhar Bondlela
Robert Carl Andrews
Stephen Thomas Davis
Original Assignee
Transtech Pharma, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transtech Pharma, Llc filed Critical Transtech Pharma, Llc
Publication of WO2014193696A2 publication Critical patent/WO2014193696A2/fr
Publication of WO2014193696A3 publication Critical patent/WO2014193696A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des dérivés d'acide benzimidazole-carboxylique qui inhibent la kinase Aurora, des compositions pharmaceutiques comprenant des composés qui inhibent la kinase Aurora et des procédés de traitement utilisant les composés de la présente invention ou des compositions pharmaceutiques comprenant des composés de la présente invention.
PCT/US2014/038737 2013-05-28 2014-05-20 Dérivés d'acide benzimidazole-carboxylique, compositions et procédés d'utilisation en tant qu'inhibiteurs de kinase aurora WO2014193696A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361828040P 2013-05-28 2013-05-28
US61/828,040 2013-05-28

Publications (2)

Publication Number Publication Date
WO2014193696A2 WO2014193696A2 (fr) 2014-12-04
WO2014193696A3 true WO2014193696A3 (fr) 2015-03-19

Family

ID=50983160

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/038737 WO2014193696A2 (fr) 2013-05-28 2014-05-20 Dérivés d'acide benzimidazole-carboxylique, compositions et procédés d'utilisation en tant qu'inhibiteurs de kinase aurora

Country Status (1)

Country Link
WO (1) WO2014193696A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107739391A (zh) * 2017-11-16 2018-02-27 浙江普洛得邦制药有限公司 噁唑烷酮药物单脱苄基杂质及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007050732A1 (fr) * 2005-10-28 2007-05-03 Abbott Laboratories DERIVES D’INDAZOLE INHIBANT LE RECEPTEUR TRPVl
WO2007095124A2 (fr) * 2006-02-10 2007-08-23 Transtech Pharma, Inc. Derives, compositions de benzazole et procedes d'utilisation en tant qu'inhibiteurs de la kinase aurora

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007050732A1 (fr) * 2005-10-28 2007-05-03 Abbott Laboratories DERIVES D’INDAZOLE INHIBANT LE RECEPTEUR TRPVl
WO2007095124A2 (fr) * 2006-02-10 2007-08-23 Transtech Pharma, Inc. Derives, compositions de benzazole et procedes d'utilisation en tant qu'inhibiteurs de la kinase aurora

Also Published As

Publication number Publication date
WO2014193696A2 (fr) 2014-12-04

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