SG11202004370WA - Method for separating eight components in chinese traditional medicine composition - Google Patents

Method for separating eight components in chinese traditional medicine composition

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Publication number
SG11202004370WA
SG11202004370WA SG11202004370WA SG11202004370WA SG11202004370WA SG 11202004370W A SG11202004370W A SG 11202004370WA SG 11202004370W A SG11202004370W A SG 11202004370WA SG 11202004370W A SG11202004370W A SG 11202004370WA SG 11202004370W A SG11202004370W A SG 11202004370WA
Authority
SG
Singapore
Prior art keywords
separating
components
medicine composition
chinese traditional
traditional medicine
Prior art date
Application number
SG11202004370WA
Inventor
chuangfeng Zhang
Shuo Shen
Lianqiang Song
Original Assignee
Shijiazhuang Yiling Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shijiazhuang Yiling Pharmaceutical Co Ltd filed Critical Shijiazhuang Yiling Pharmaceutical Co Ltd
Publication of SG11202004370WA publication Critical patent/SG11202004370WA/en

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/265—Adsorption chromatography
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
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    • B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
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    • A61K2236/10—Preparation or pretreatment of starting material
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
SG11202004370WA 2017-11-10 2018-10-25 Method for separating eight components in chinese traditional medicine composition SG11202004370WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201711103420.2A CN109776635B (en) 2017-11-10 2017-11-10 Method for separating eight components in traditional Chinese medicine composition
PCT/CN2018/111846 WO2019091287A1 (en) 2017-11-10 2018-10-25 Method for separating eight components in chinese traditional medicine composition

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SG11202004370WA true SG11202004370WA (en) 2020-06-29

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US (1) US11564966B2 (en)
EP (1) EP3705130A4 (en)
JP (1) JP6976429B2 (en)
KR (1) KR102532345B1 (en)
CN (1) CN109776635B (en)
CA (1) CA3081627C (en)
RU (1) RU2769512C2 (en)
SG (1) SG11202004370WA (en)
WO (1) WO2019091287A1 (en)

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CN112946094B (en) * 2020-11-27 2023-03-31 吉林修正药业新药开发有限公司 Heart-nourishing and sleep-improving capsule HPLC characteristic spectrum construction method
CN113105388B (en) * 2021-04-07 2023-02-28 沈阳药科大学 Euphorbia lathyris diterpene alkyl compound and extraction method and application thereof
CN113244791B (en) * 2021-05-12 2022-06-17 佳木斯大学 Preparation method of emodin-blended phenolphthalein polyethersulfone ultrafiltration membrane
CN113624881B (en) * 2021-08-14 2022-09-27 昆明理工大学 Method for simultaneously detecting contents of six components in Sanwu capsule
CN114264737B (en) * 2021-12-08 2023-04-28 中国中医科学院中药研究所 Separation method of water-soluble compounds in kuh-seng
CN114184719B (en) * 2021-12-13 2023-05-09 江西和盈药业有限公司 Dual-wavelength fingerprint spectrum establishment method of Baoyuan decoction and standard fingerprint spectrum thereof
CN114516893B (en) * 2022-03-09 2022-07-26 广西壮族自治区中国科学院广西植物研究所 Fructus momordicae neoflavonoid compound, preparation method thereof and application thereof in bee attractant
CN114634534B (en) * 2022-04-07 2024-03-19 陕西富捷药业有限公司 Method for separating monoammonium glycyrrhizinate and glycyrrhizin from monoammonium glycyrrhizinate mother liquor
CN114965748A (en) * 2022-04-28 2022-08-30 陕西科技大学 Method for simultaneously detecting barbaloin, aloe-emodin and indirubin in new compound aloe capsule
CN115480011A (en) * 2022-09-20 2022-12-16 广州白云山潘高寿药业股份有限公司 Method for detecting contents of six components in astragalus and cassia twig five-component decoction material standard
CN116124945B (en) * 2023-01-18 2024-01-30 广州白云山明兴制药有限公司 A method for analyzing and identifying chemical components in traditional Chinese medicine preparations based on UPLC-Q-TOF-MS technology

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