SG11202004116QA - T cell manufacturing compositions and methods - Google Patents

T cell manufacturing compositions and methods

Info

Publication number
SG11202004116QA
SG11202004116QA SG11202004116QA SG11202004116QA SG11202004116QA SG 11202004116Q A SG11202004116Q A SG 11202004116QA SG 11202004116Q A SG11202004116Q A SG 11202004116QA SG 11202004116Q A SG11202004116Q A SG 11202004116QA SG 11202004116Q A SG11202004116Q A SG 11202004116QA
Authority
SG
Singapore
Prior art keywords
methods
cell manufacturing
manufacturing compositions
compositions
cell
Prior art date
Application number
SG11202004116QA
Other languages
English (en)
Inventor
Buuren Marit M Van
Divya Reddy Lenkala
Den Berg Joost Huibert Van
Jessica Kohler
Matthew Goldstein
Ed Fritsch
Renate Deboer
Ton Schumacher
Noor Bakker
Original Assignee
Biontech Us Inc
Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biontech Us Inc, Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis filed Critical Biontech Us Inc
Publication of SG11202004116QA publication Critical patent/SG11202004116QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464401—Neoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/46449—Melanoma antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/876—Skin, melanoma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2307—Interleukin-7 (IL-7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2315—Interleukin-15 (IL-15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1121—Dendritic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
SG11202004116QA 2017-11-08 2018-11-08 T cell manufacturing compositions and methods SG11202004116QA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762583229P 2017-11-08 2017-11-08
US201762588590P 2017-11-20 2017-11-20
US201862618445P 2018-01-17 2018-01-17
US201862737625P 2018-09-27 2018-09-27
PCT/US2018/059896 WO2019094642A1 (fr) 2017-11-08 2018-11-08 Compositions et procédés de production de lymphocytes t

Publications (1)

Publication Number Publication Date
SG11202004116QA true SG11202004116QA (en) 2020-06-29

Family

ID=66438061

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202004116QA SG11202004116QA (en) 2017-11-08 2018-11-08 T cell manufacturing compositions and methods

Country Status (9)

Country Link
US (2) US11162072B2 (fr)
EP (1) EP3706784A4 (fr)
JP (3) JP7054418B2 (fr)
KR (2) KR102484433B1 (fr)
CN (1) CN111867618A (fr)
BR (1) BR112020008927A2 (fr)
CA (1) CA3081840A1 (fr)
SG (1) SG11202004116QA (fr)
WO (1) WO2019094642A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102484433B1 (ko) 2017-11-08 2023-01-03 바이오엔테크 유에스 인크. T 세포 제조 조성물 및 방법
AU2020253368A1 (en) 2019-03-30 2021-11-18 Biontech Us Inc. Compositions and methods for preparing T cell compositions and uses thereof
TWI777160B (zh) * 2019-05-08 2022-09-11 美商百歐恩泰美國公司 T細胞製備組合物及方法
GB201911066D0 (en) 2019-08-02 2019-09-18 Achilles Therapeutics Ltd T cell therapy
CN110514845B (zh) * 2019-08-22 2022-09-27 深圳新合睿恩生物医疗科技有限公司 一种肿瘤新生抗原免疫原性检测方法及检测平台
CA3162703A1 (fr) * 2019-11-27 2021-06-03 Myst Therapeutics, Llc Procede de production d'une composition de lymphocytes t reactifs a une tumeur faisant appel a des agents modulateurs
GB201918290D0 (en) 2019-12-12 2020-01-29 Achilles Therapeutics Ltd Method
WO2021116714A1 (fr) 2019-12-12 2021-06-17 Achilles Therapeutics Uk Limited Procédé d'obtention d'un acide nucléique pour séquençage
IL297594A (en) 2020-04-28 2022-12-01 Achilles Therapeutics Uk Ltd t cell therapy
BR112023002733A2 (pt) 2020-08-13 2023-05-02 Biontech Us Inc Composições e métodos de fabricação de células t
IL300565A (en) 2020-08-13 2023-04-01 Biontech Us Inc RAS neoantigens and their uses
EP4251177A2 (fr) * 2020-11-25 2023-10-04 Geneius Biotechnology, Inc. Lymphocytes t spécifiques d'un antigène et méthodes de fabrication et d'utilisation associées
AU2021400424A1 (en) 2020-12-14 2023-07-06 Biontech Us Inc. Tissue-specific antigens for cancer immunotherapy
GB202109886D0 (en) 2021-07-08 2021-08-25 Achilles Therapeutics Uk Ltd Assay
US20220323500A1 (en) 2021-04-09 2022-10-13 Achilles Therapeutics Uk Limited Cancer immunotherapy
IL312121A (en) * 2021-10-15 2024-06-01 Biontech Us Inc Preparations and methods for the production of T cells
GB202210006D0 (en) 2022-07-07 2022-08-24 Achilles Therapeutics Uk Ltd Analysis of T cell samples
WO2024190864A1 (fr) * 2023-03-15 2024-09-19 株式会社ガイアバイオメディシン Solution pour la mise en suspension de cellules et son utilisation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022788D0 (en) 1990-10-19 1990-12-05 Cortecs Ltd Pharmaceutical formulations
CA2133409C (fr) 1992-04-01 2011-05-24 Ralph M. Steinman Methode de proliferation in vitro de precurseurs de cellules dendritiques et facon d'utiliser lesdits precurseurs pour produire des immunogenes
AU4998993A (en) 1992-08-07 1994-03-03 Epimmune, Inc. Hla binding peptides and their uses
KR960700739A (ko) 1993-03-05 1996-02-24 카린 이스텀 Hla-a2. 1 결합 펩티드 및 그의 용도(hla-a2. 1 binding peptides and their uses)
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
EP1670501A2 (fr) * 2003-09-25 2006-06-21 ZymoGenetics, Inc. Procedes de traitement de maladies auto-immunes utilisant l'interleukine-21
WO2006015497A1 (fr) * 2004-08-13 2006-02-16 Val-Chum, S.E.C. Procedes d'utilisation d'une proteine dkk1, de polypeptides immunogenes de ladite proteine, d'acides nucleiques codant la proteine dkk1 ou des polypeptides, ou de ligands de ladite proteine, pour detecter des tumeurs et pour eliciter une reponse immunitaire contre des tumeurs
WO2006110582A1 (fr) * 2005-04-08 2006-10-19 Xcyte Therapies, Inc. Compositions et methodes de traitement des brulures et de la sepsie
WO2009045308A2 (fr) 2007-10-03 2009-04-09 Fred Hutchinson Cancer Research Center Production améliorée de lymphocytes t cytotoxiques par suppression de foxp3 à médiation assurée par il-21
WO2012159643A1 (fr) 2011-05-24 2012-11-29 Biontech Ag Vaccins individualisés pour le cancer
EP3082853A2 (fr) 2013-12-20 2016-10-26 The Broad Institute, Inc. Polythérapie comprenant un vaccin à base de néoantigènes
EP3134512B1 (fr) * 2014-04-24 2019-01-02 Miltenyi Biotec GmbH Procédé de production automatisée de cellules t génétiquement modifiées
CN103923880B (zh) 2014-05-08 2016-03-30 成都百赛泰科生物科技有限公司 一种高效增殖、靶向杀伤肿瘤的ctl制备方法
WO2016180852A1 (fr) * 2015-05-12 2016-11-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de préparation de cellules t spécifiques de l'antigène à partir d'un échantillon de sang de cordon ombilical
KR102484433B1 (ko) 2017-11-08 2023-01-03 바이오엔테크 유에스 인크. T 세포 제조 조성물 및 방법

Also Published As

Publication number Publication date
BR112020008927A2 (pt) 2020-10-20
RU2020118338A3 (fr) 2022-03-31
RU2020118338A (ru) 2021-12-08
WO2019094642A8 (fr) 2019-11-28
EP3706784A1 (fr) 2020-09-16
US20220177840A1 (en) 2022-06-09
JP2022106722A (ja) 2022-07-20
KR20230008254A (ko) 2023-01-13
CA3081840A1 (fr) 2019-05-16
CN111867618A (zh) 2020-10-30
JP7054418B2 (ja) 2022-04-13
US11162072B2 (en) 2021-11-02
JP2021502414A (ja) 2021-01-28
WO2019094642A1 (fr) 2019-05-16
EP3706784A4 (fr) 2021-12-01
US20200165567A1 (en) 2020-05-28
KR102484433B1 (ko) 2023-01-03
JP2024041873A (ja) 2024-03-27
KR20200109301A (ko) 2020-09-22
JP7420856B2 (ja) 2024-01-23

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