SG11202003614WA - Method for production of recombinant e. coli asparaginase - Google Patents
Method for production of recombinant e. coli asparaginaseInfo
- Publication number
- SG11202003614WA SG11202003614WA SG11202003614WA SG11202003614WA SG11202003614WA SG 11202003614W A SG11202003614W A SG 11202003614WA SG 11202003614W A SG11202003614W A SG 11202003614WA SG 11202003614W A SG11202003614W A SG 11202003614WA SG 11202003614W A SG11202003614W A SG 11202003614WA
- Authority
- SG
- Singapore
- Prior art keywords
- recombinant
- production
- coli asparaginase
- asparaginase
- coli
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/78—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01001—Asparaginase (3.5.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C12N9/82—Asparaginase (3.5.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/38—Pseudomonas
- C12R2001/39—Pseudomonas fluorescens
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762578302P | 2017-10-27 | 2017-10-27 | |
| PCT/US2018/056375 WO2019083794A1 (en) | 2017-10-27 | 2018-10-17 | PROCESS FOR PRODUCING EAR ASPARAGINASE. RECOMBINED COLI |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202003614WA true SG11202003614WA (en) | 2020-05-28 |
Family
ID=66243528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202003614WA SG11202003614WA (en) | 2017-10-27 | 2018-10-17 | Method for production of recombinant e. coli asparaginase |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10662433B2 (https=) |
| EP (1) | EP3701036A4 (https=) |
| JP (1) | JP7358347B2 (https=) |
| CN (1) | CN111278979B (https=) |
| AU (1) | AU2018354068C1 (https=) |
| SG (1) | SG11202003614WA (https=) |
| WO (1) | WO2019083794A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019083794A1 (en) * | 2017-10-27 | 2019-05-02 | Pfenex Inc. | PROCESS FOR PRODUCING EAR ASPARAGINASE. RECOMBINED COLI |
| JP7784804B2 (ja) * | 2017-10-27 | 2025-12-12 | フェネックス インク． | 組み換えｅｒｗｉｎｉａアスパラギナーゼの製造のための方法 |
| GB201912020D0 (en) * | 2019-08-21 | 2019-10-02 | Porton Biopharma Ltd | Therapeutic Conjugate |
| JP2022553399A (ja) * | 2019-10-25 | 2022-12-22 | ジャズ ファーマシューティカルズ アイルランド リミテッド | 組換えｌ－アスパラギナーゼ |
| CN110904085B (zh) * | 2019-12-26 | 2021-04-16 | 常州千红生化制药股份有限公司 | 一种发酵法制备门冬酰胺酶的方法 |
| CN118440925B (zh) * | 2023-03-14 | 2024-12-24 | 医图生科(苏州)生命科学技术有限公司 | 一种低免疫原性门冬酰胺酶突变体及其制备方法和应用 |
| WO2025157811A1 (fr) * | 2024-01-23 | 2025-07-31 | Asfalia Biologics | Promoteurs inductibles par des molecules pharmacologiques |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4551433A (en) | 1981-05-18 | 1985-11-05 | Genentech, Inc. | Microbial hybrid promoters |
| US4755465A (en) | 1983-04-25 | 1988-07-05 | Genentech, Inc. | Secretion of correctly processed human growth hormone in E. coli and Pseudomonas |
| US5281532A (en) | 1983-07-27 | 1994-01-25 | Mycogen Corporation | Pseudomas hosts transformed with bacillus endotoxin genes |
| US4695462A (en) | 1985-06-28 | 1987-09-22 | Mycogen Corporation | Cellular encapsulation of biological pesticides |
| US4695455A (en) | 1985-01-22 | 1987-09-22 | Mycogen Corporation | Cellular encapsulation of pesticides produced by expression of heterologous genes |
| GB8517071D0 (en) | 1985-07-05 | 1985-08-14 | Hoffmann La Roche | Gram-positive expression control sequence |
| GB8519753D0 (en) * | 1985-08-06 | 1985-09-11 | Health Lab Service Board | Production of 1-asparaginase |
| US5128130A (en) | 1988-01-22 | 1992-07-07 | Mycogen Corporation | Hybrid Bacillus thuringiensis gene, plasmid and transformed Pseudomonas fluorescens |
| US5055294A (en) | 1988-03-03 | 1991-10-08 | Mycogen Corporation | Chimeric bacillus thuringiensis crystal protein gene comprising hd-73 and berliner 1715 toxin genes, transformed and expressed in pseudomonas fluorescens |
| US5169760A (en) | 1989-07-27 | 1992-12-08 | Mycogen Corporation | Method, vectors, and host cells for the control of expression of heterologous genes from lac operated promoters |
| GB9017002D0 (en) | 1990-08-02 | 1990-09-19 | Health Lab Service Board | Improved method for the purification of erwina l-asparaginase |
| US9453251B2 (en) * | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| CA2545610C (en) | 2003-11-19 | 2014-03-25 | Dow Global Technolgies Inc. | Auxotrophic pseudomonas fluorescens bacteria for recombinant protein expression |
| AU2004317306B2 (en) | 2003-11-21 | 2010-09-02 | Pelican Technology Holdings, Inc. | Improved expression systems with Sec-system secretion |
| US8603824B2 (en) * | 2004-07-26 | 2013-12-10 | Pfenex, Inc. | Process for improved protein expression by strain engineering |
| EP2021489A2 (en) | 2006-05-30 | 2009-02-11 | Dow Global Technologies Inc. | Codon optimization method |
| MX2009000284A (es) * | 2006-06-30 | 2009-01-26 | Enzon Pharmaceuticals Inc | Hospedero recombinante para produccion de l-asparaginasa ii. |
| JP5714230B2 (ja) | 2007-01-31 | 2015-05-07 | フェネックス インコーポレイテッド | 発現上昇のための細菌リーダー配列 |
| WO2008128975A1 (en) | 2007-04-20 | 2008-10-30 | Dsm Ip Assets B.V. | Novel asparaginases and uses thereof |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| JP5444553B2 (ja) * | 2007-04-27 | 2014-03-19 | フェネックス インコーポレイテッド | 微生物宿主を迅速にスクリーニングして、異種タンパク質発現の収率および／または質が改善されている特定の株を同定する方法 |
| WO2011003633A1 (en) | 2009-07-06 | 2011-01-13 | Alize Pharma Ii | Pegylated l-asparaginase |
| EP2553102B1 (en) * | 2010-03-30 | 2015-12-09 | Pfenex Inc. | High level expression of recombinant toxin proteins |
| CN103060299B (zh) * | 2011-10-19 | 2017-05-03 | 北京安百胜生物科技有限公司 | 活性提高的l‑天冬酰胺酶变体 |
| BR102014000585B1 (pt) | 2014-01-10 | 2021-01-12 | Coppe/Ufrj-Instituto Alberto Luiz Coimbra De Pós-Graduação | l-asparaginase recombinante de zymomonas |
| KR102092225B1 (ko) | 2014-04-30 | 2020-03-23 | 주식회사 엘지화학 | 고효율 분비능을 가지는 단백질 분비 인자 및 이를 포함하는 발현 벡터 |
| JP6817939B2 (ja) | 2014-12-01 | 2021-01-20 | フェネックス インク． | ペプチド産生のための融合パートナー |
| JP7784804B2 (ja) * | 2017-10-27 | 2025-12-12 | フェネックス インク． | 組み換えｅｒｗｉｎｉａアスパラギナーゼの製造のための方法 |
| WO2019083794A1 (en) * | 2017-10-27 | 2019-05-02 | Pfenex Inc. | PROCESS FOR PRODUCING EAR ASPARAGINASE. RECOMBINED COLI |
-
2018
- 2018-10-17 WO PCT/US2018/056375 patent/WO2019083794A1/en not_active Ceased
- 2018-10-17 CN CN201880069962.9A patent/CN111278979B/zh active Active
- 2018-10-17 US US16/163,398 patent/US10662433B2/en active Active
- 2018-10-17 AU AU2018354068A patent/AU2018354068C1/en active Active
- 2018-10-17 JP JP2020523340A patent/JP7358347B2/ja active Active
- 2018-10-17 EP EP18870109.8A patent/EP3701036A4/en active Pending
- 2018-10-17 SG SG11202003614WA patent/SG11202003614WA/en unknown
-
2020
- 2020-04-15 US US16/849,532 patent/US11046964B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3701036A4 (en) | 2021-09-01 |
| CN111278979B (zh) | 2024-05-31 |
| US11046964B2 (en) | 2021-06-29 |
| AU2018354068A1 (en) | 2020-06-11 |
| AU2018354068B9 (en) | 2022-11-24 |
| EP3701036A1 (en) | 2020-09-02 |
| AU2018354068B2 (en) | 2022-11-10 |
| JP7358347B2 (ja) | 2023-10-10 |
| JP2021500892A (ja) | 2021-01-14 |
| CN111278979A (zh) | 2020-06-12 |
| AU2018354068C1 (en) | 2023-03-23 |
| US10662433B2 (en) | 2020-05-26 |
| US20190127743A1 (en) | 2019-05-02 |
| WO2019083794A1 (en) | 2019-05-02 |
| US20200248193A1 (en) | 2020-08-06 |
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