SG11202002886PA - Fused ring derivative as a2a receptor inhibitor - Google Patents
Fused ring derivative as a2a receptor inhibitorInfo
- Publication number
- SG11202002886PA SG11202002886PA SG11202002886PA SG11202002886PA SG11202002886PA SG 11202002886P A SG11202002886P A SG 11202002886PA SG 11202002886P A SG11202002886P A SG 11202002886PA SG 11202002886P A SG11202002886P A SG 11202002886PA SG 11202002886P A SG11202002886P A SG 11202002886PA
- Authority
- SG
- Singapore
- Prior art keywords
- fused ring
- receptor inhibitor
- ring derivative
- derivative
- receptor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710900542 | 2017-09-28 | ||
CN201810239824 | 2018-03-21 | ||
PCT/CN2018/107899 WO2019062803A1 (fr) | 2017-09-28 | 2018-09-27 | Dérivé à cycle fusionné utilisé en tant qu'inhibiteur du récepteur a2a |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202002886PA true SG11202002886PA (en) | 2020-04-29 |
Family
ID=65900821
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202002886PA SG11202002886PA (en) | 2017-09-28 | 2018-09-27 | Fused ring derivative as a2a receptor inhibitor |
Country Status (16)
Country | Link |
---|---|
US (1) | US11312715B2 (fr) |
EP (1) | EP3686199B9 (fr) |
JP (1) | JP6836693B2 (fr) |
KR (1) | KR102254660B1 (fr) |
CN (1) | CN111542520B (fr) |
AU (1) | AU2018341781B2 (fr) |
BR (1) | BR112020006185A2 (fr) |
CA (1) | CA3077267C (fr) |
ES (1) | ES2927086T3 (fr) |
IL (1) | IL273606B (fr) |
MX (1) | MX2020003732A (fr) |
RU (1) | RU2748993C1 (fr) |
SA (1) | SA520411635B1 (fr) |
SG (1) | SG11202002886PA (fr) |
TW (1) | TWI788424B (fr) |
WO (1) | WO2019062803A1 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110655509B (zh) * | 2018-06-29 | 2023-01-24 | 江苏恒瑞医药股份有限公司 | 2-胺基嘧啶类衍生物、其制备方法及其在医药上的应用 |
CN111094254B (zh) * | 2018-07-12 | 2022-07-26 | 江苏恒瑞医药股份有限公司 | 杂芳基类衍生物、其制备方法及其在医药上的应用 |
CN111377873B (zh) * | 2018-12-28 | 2023-03-28 | 四川科伦博泰生物医药股份有限公司 | 氨基嘧啶化合物及其制备方法和用途 |
EP3950694A4 (fr) * | 2019-03-28 | 2022-12-07 | Cstone Pharmaceuticals (Suzhou) Co., Ltd. | Forme de sel et forme cristalline d'a2a un antagoniste du récepteur aet son procédé de préparation |
US20230339936A1 (en) * | 2020-07-23 | 2023-10-26 | Cytosinlab Therapeutics Co. Ltd. | Compound having kinase inhibitory activity |
CN116514803A (zh) * | 2022-01-21 | 2023-08-01 | 上海赛岚生物科技有限公司 | 一种激酶抑制剂的盐晶型和自由碱晶型 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL184020B1 (pl) | 1995-04-21 | 2002-08-30 | Neurosearch As | Nowe związki benzimidazolowe i kompozycje farmaceutyczne zawierające takie związki |
DE69820866T2 (de) | 1997-03-24 | 2004-12-30 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE |
KR100571161B1 (ko) | 2000-06-21 | 2006-04-17 | 에프. 호프만-라 로슈 아게 | 벤조티아졸 유도체 |
NZ523998A (en) * | 2000-08-11 | 2005-07-29 | Eisai Co Ltd | 2-aminopyridine compounds and use thereof as drugs |
CA2563038C (fr) * | 2004-04-02 | 2013-10-29 | Gaik Beng Kok | Composes neurologiquement actifs |
ES2241496B1 (es) | 2004-04-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridina. |
ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
EP1903044A1 (fr) | 2006-09-14 | 2008-03-26 | Novartis AG | Derivés de l'adénosine en tant qu' agonistes du récepteur A2A |
SI2408775T1 (sl) | 2009-03-20 | 2015-08-31 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Oksidirani derivati triazolilpurinov, ki so uprabni kot ligandi receptorja adenozina A2A, in njihova uporaba kot zdravila |
DE102012019369A1 (de) | 2012-10-02 | 2014-04-03 | Merck Patent Gmbh | 7-Azaindolderivat |
CN105025899B (zh) | 2012-12-28 | 2017-08-18 | 默沙东公司 | 具有A2A拮抗剂性质的杂二环取代的‑[1,2,4]三唑并[1,5‑c]喹唑啉‑5‑胺化合物 |
WO2014101120A1 (fr) * | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Composés de 7-méthoxy-[1,2,4]triazolo[1,5-c]quinazoline-5-amine à substitution hétérobicyclo présentant des propriétés d'antagoniste d'a2a |
RU2534804C1 (ru) | 2013-08-05 | 2014-12-10 | Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") | ЗАМЕЩЕННЫЕ [1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ, ПРОЯВЛЯЮЩИЕ СВОЙСТВА АНТАГОНИСТОВ АДЕНОЗИНОВЫХ А2А РЕЦЕПТОРОВ, И ИХ ПРИМЕНЕНИЕ |
JP6275410B2 (ja) | 2013-08-06 | 2018-02-07 | 大和ハウス工業株式会社 | 固定具 |
WO2015027431A1 (fr) | 2013-08-29 | 2015-03-05 | Merck Sharp & Dohme Corp. | Antagonistes 2,2-difluorodioxolo du récepteur a2a |
JP7154221B2 (ja) * | 2017-03-30 | 2022-10-17 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Hpk1の阻害剤としてのナフチリジン |
-
2018
- 2018-09-27 JP JP2020517949A patent/JP6836693B2/ja active Active
- 2018-09-27 BR BR112020006185-9A patent/BR112020006185A2/pt unknown
- 2018-09-27 SG SG11202002886PA patent/SG11202002886PA/en unknown
- 2018-09-27 CA CA3077267A patent/CA3077267C/fr active Active
- 2018-09-27 RU RU2020114314A patent/RU2748993C1/ru active
- 2018-09-27 MX MX2020003732A patent/MX2020003732A/es unknown
- 2018-09-27 EP EP18861150.3A patent/EP3686199B9/fr active Active
- 2018-09-27 WO PCT/CN2018/107899 patent/WO2019062803A1/fr unknown
- 2018-09-27 US US16/650,967 patent/US11312715B2/en active Active
- 2018-09-27 ES ES18861150T patent/ES2927086T3/es active Active
- 2018-09-27 CN CN201880062761.6A patent/CN111542520B/zh active Active
- 2018-09-27 KR KR1020207012498A patent/KR102254660B1/ko active IP Right Grant
- 2018-09-27 AU AU2018341781A patent/AU2018341781B2/en active Active
- 2018-09-28 TW TW107134271A patent/TWI788424B/zh active
-
2020
- 2020-03-25 IL IL273606A patent/IL273606B/en active IP Right Grant
- 2020-03-27 SA SA520411635A patent/SA520411635B1/ar unknown
Also Published As
Publication number | Publication date |
---|---|
CA3077267C (fr) | 2021-02-16 |
TWI788424B (zh) | 2023-01-01 |
JP6836693B2 (ja) | 2021-03-03 |
EP3686199A4 (fr) | 2021-04-07 |
EP3686199A1 (fr) | 2020-07-29 |
KR102254660B1 (ko) | 2021-05-24 |
IL273606B (en) | 2021-05-31 |
CN111542520A (zh) | 2020-08-14 |
CN111542520B (zh) | 2022-04-15 |
US20200239465A1 (en) | 2020-07-30 |
AU2018341781A1 (en) | 2020-04-30 |
TW201920171A (zh) | 2019-06-01 |
KR20200055126A (ko) | 2020-05-20 |
BR112020006185A2 (pt) | 2020-10-13 |
RU2748993C1 (ru) | 2021-06-02 |
EP3686199B1 (fr) | 2022-08-03 |
JP2020535196A (ja) | 2020-12-03 |
ES2927086T3 (es) | 2022-11-02 |
US11312715B2 (en) | 2022-04-26 |
MX2020003732A (es) | 2021-06-29 |
SA520411635B1 (ar) | 2022-05-24 |
AU2018341781A8 (en) | 2020-05-07 |
IL273606A (en) | 2020-05-31 |
AU2018341781B2 (en) | 2023-03-30 |
CA3077267A1 (fr) | 2019-04-04 |
WO2019062803A1 (fr) | 2019-04-04 |
EP3686199B9 (fr) | 2022-12-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL249261B (en) | Implications of a compressed dihydropyrimido ring as an hbv inhibitor | |
HK1255045A1 (zh) | 取代的氧代吡啶衍生物 | |
IL273606B (en) | A fused ring derivative as an a2a receptor inhibitor | |
IL271607A (en) | New azaquinoline histories | |
PL3279187T3 (pl) | Pochodna z 9-członowym skondensowanym pierścieniem | |
IL277744A (en) | Pyrazolotriazolopyrimidine derivatives as A2A receptor inhibitors | |
IL271799A (en) | New transmuted xanthine histories | |
IL271290A (en) | Dihydro-pyrrolo-pyridine derivatives | |
HK1243705A1 (zh) | 吲哚衍生物 | |
GB201711154D0 (en) | Setting sleeve | |
IL265182A (en) | proinsulin derivatives | |
HK1245796A1 (zh) | 黃嘌呤衍生物 | |
GB2533395B (en) | Fire protective sleeve | |
GB201720684D0 (en) | Protective sleeve | |
GB201701207D0 (en) | Sleeve | |
PT3319956T (pt) | Derivados de oxopiridina substituída | |
GB201601016D0 (en) | Sleeve |