SG11202002116YA - Methods of preventing methionine oxidation in immunoconjugates - Google Patents
Methods of preventing methionine oxidation in immunoconjugatesInfo
- Publication number
- SG11202002116YA SG11202002116YA SG11202002116YA SG11202002116YA SG11202002116YA SG 11202002116Y A SG11202002116Y A SG 11202002116YA SG 11202002116Y A SG11202002116Y A SG 11202002116YA SG 11202002116Y A SG11202002116Y A SG 11202002116YA SG 11202002116Y A SG11202002116Y A SG 11202002116YA
- Authority
- SG
- Singapore
- Prior art keywords
- immunoconjugates
- methods
- methionine oxidation
- preventing
- preventing methionine
- Prior art date
Links
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title 1
- 229940127121 immunoconjugate Drugs 0.000 title 1
- 229930182817 methionine Natural products 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000003647 oxidation Effects 0.000 title 1
- 238000007254 oxidation reaction Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762562049P | 2017-09-22 | 2017-09-22 | |
US201762573322P | 2017-10-17 | 2017-10-17 | |
US201862712584P | 2018-07-31 | 2018-07-31 | |
PCT/US2018/052197 WO2019060707A1 (en) | 2017-09-22 | 2018-09-21 | METHODS FOR PREVENTING OXIDATION OF METHIONINE IN IMMUNOCONJUGATES |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202002116YA true SG11202002116YA (en) | 2020-04-29 |
Family
ID=63794732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202002116YA SG11202002116YA (en) | 2017-09-22 | 2018-09-21 | Methods of preventing methionine oxidation in immunoconjugates |
Country Status (12)
Country | Link |
---|---|
US (2) | US20190111147A1 (zh) |
EP (2) | EP3684412B1 (zh) |
JP (2) | JP7203834B2 (zh) |
KR (1) | KR20200070254A (zh) |
CN (2) | CN117065043A (zh) |
AU (1) | AU2018335780A1 (zh) |
CA (1) | CA3075896A1 (zh) |
IL (2) | IL273384B2 (zh) |
MA (1) | MA50266A (zh) |
SG (1) | SG11202002116YA (zh) |
TW (1) | TW201919711A (zh) |
WO (1) | WO2019060707A1 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3313884B9 (en) * | 2015-06-29 | 2021-05-19 | ImmunoGen, Inc. | Anti-cd123 antibodies and conjugates and derivatives thereof |
CA3137454A1 (en) | 2019-04-29 | 2020-11-05 | Immunogen, Inc. | Therapeutic combinations comprising anti-cd123 immunoconjugates |
CN114401744A (zh) * | 2019-06-26 | 2022-04-26 | 纪念斯隆凯特琳癌症中心 | 用于治疗癌症的抗cd33抗体 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
AU2003285878B2 (en) | 2002-11-07 | 2011-04-28 | Immunogen, Inc. | Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same |
US20100030670A1 (en) * | 2008-08-04 | 2010-02-04 | Mastercard International, Inc. | Method of monitoring different debit card transactions associated with a single funding source |
KR20110076918A (ko) | 2008-09-10 | 2011-07-06 | 제넨테크, 인크. | 단백질의 산화성 분해를 방지하기 위한 조성물 및 방법 |
JP2010241718A (ja) | 2009-04-03 | 2010-10-28 | Kyowa Hakko Kirin Co Ltd | 安定な抗体の水溶液製剤 |
CN105073136A (zh) | 2013-03-15 | 2015-11-18 | 葛兰素史克知识产权第二有限公司 | 低浓度抗体制剂 |
JP6517468B2 (ja) * | 2014-01-10 | 2019-05-22 | 日本電気株式会社 | 情報処理システム、情報処理装置、監視装置、監視方法、及び、プログラム |
EP3313884B9 (en) | 2015-06-29 | 2021-05-19 | ImmunoGen, Inc. | Anti-cd123 antibodies and conjugates and derivatives thereof |
WO2017091745A1 (en) | 2015-11-25 | 2017-06-01 | Immunogen, Inc. | Pharmaceutical formulations and methods of use thereof |
-
2018
- 2018-09-21 MA MA050266A patent/MA50266A/fr unknown
- 2018-09-21 IL IL273384A patent/IL273384B2/en unknown
- 2018-09-21 JP JP2020516662A patent/JP7203834B2/ja active Active
- 2018-09-21 US US16/138,158 patent/US20190111147A1/en not_active Abandoned
- 2018-09-21 CA CA3075896A patent/CA3075896A1/en active Pending
- 2018-09-21 EP EP18783303.3A patent/EP3684412B1/en active Active
- 2018-09-21 WO PCT/US2018/052197 patent/WO2019060707A1/en unknown
- 2018-09-21 CN CN202310589494.0A patent/CN117065043A/zh active Pending
- 2018-09-21 CN CN201880075572.2A patent/CN111372610B/zh active Active
- 2018-09-21 TW TW107133293A patent/TW201919711A/zh unknown
- 2018-09-21 KR KR1020207011137A patent/KR20200070254A/ko not_active Application Discontinuation
- 2018-09-21 SG SG11202002116YA patent/SG11202002116YA/en unknown
- 2018-09-21 EP EP24156669.4A patent/EP4374850A2/en active Pending
- 2018-09-21 AU AU2018335780A patent/AU2018335780A1/en active Pending
-
2021
- 2021-12-13 US US17/549,327 patent/US20220202947A1/en not_active Abandoned
-
2022
- 2022-12-27 JP JP2022209534A patent/JP2023036874A/ja active Pending
-
2023
- 2023-07-18 IL IL304551A patent/IL304551A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA3075896A1 (en) | 2019-03-28 |
IL273384B2 (en) | 2023-12-01 |
CN111372610B (zh) | 2023-05-30 |
RU2020113280A3 (zh) | 2022-04-11 |
RU2020113280A (ru) | 2021-10-25 |
CN111372610A (zh) | 2020-07-03 |
EP3684412B1 (en) | 2024-02-14 |
CN117065043A (zh) | 2023-11-17 |
JP2023036874A (ja) | 2023-03-14 |
JP7203834B2 (ja) | 2023-01-13 |
IL273384B1 (en) | 2023-08-01 |
MA50266A (fr) | 2020-07-29 |
US20220202947A1 (en) | 2022-06-30 |
JP2020534326A (ja) | 2020-11-26 |
KR20200070254A (ko) | 2020-06-17 |
EP3684412A1 (en) | 2020-07-29 |
EP4374850A2 (en) | 2024-05-29 |
WO2019060707A1 (en) | 2019-03-28 |
US20190111147A1 (en) | 2019-04-18 |
TW201919711A (zh) | 2019-06-01 |
IL273384A (en) | 2020-05-31 |
AU2018335780A1 (en) | 2020-03-26 |
IL304551A (en) | 2023-09-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL261428A (en) | Antibody-drug conjugates based on eribulin and methods of use | |
HK1250646A1 (zh) | 納米粒子免疫偶聯物 | |
IL250461A0 (en) | Anti-cll-1 antibodies and immunoconjugates | |
AU201710083S (en) | Bowl and Covered Bowl | |
ZA201805805B (en) | Formulations and methods | |
HK1255141A1 (zh) | 包含抗folr1免疫綴合物的治療組合 | |
GB201507908D0 (en) | IL2 and TNF immunoconjugates | |
EP3334429C0 (en) | HYPERPHENYLALANINEMIA AND TREATMENTS THEREFOR | |
HK1255483A1 (zh) | 抗體和免疫結合物 | |
IL248281A0 (en) | The composition for oral care containing silica and zinc citrate | |
IL304551A (en) | Methods to prevent methionine oxidation in immune conjugates | |
GB201421163D0 (en) | Formulations of metal complexes | |
HK1254987A1 (zh) | 水性化妝品組合物 | |
HK1258409A1 (zh) | 抗cd22抗體-美登木素綴合物及其使用方法 | |
GB201519200D0 (en) | Skin care composition and method thereof | |
HK1256368A1 (zh) | 加利車黴素-抗體-藥物綴合物和使用方法 | |
IL266721A (en) | Anti-gp73 antibodies and immunoconjugates | |
HK1259451A1 (zh) | 護膚組合物及其方法 | |
EP3256098C0 (en) | DENTAL COMPOSITION AND USE | |
GB201611406D0 (en) | Skin care composition and method thereof | |
GB201515194D0 (en) | Nappy and insert therefor | |
ZA201904626B (en) | Cancer treatment method and composition | |
GB201713009D0 (en) | Methods for reducing oxidation | |
GB201608716D0 (en) | Bioorthogonal compounds and methods | |
GB201611362D0 (en) | Skin care composition and method thereof |