SG11202002014PA - Particle sorting in a microfluidic system - Google Patents

Particle sorting in a microfluidic system

Info

Publication number
SG11202002014PA
SG11202002014PA SG11202002014PA SG11202002014PA SG11202002014PA SG 11202002014P A SG11202002014P A SG 11202002014PA SG 11202002014P A SG11202002014P A SG 11202002014PA SG 11202002014P A SG11202002014P A SG 11202002014PA SG 11202002014P A SG11202002014P A SG 11202002014PA
Authority
SG
Singapore
Prior art keywords
microfluidic system
particle sorting
sorting
particle
microfluidic
Prior art date
Application number
SG11202002014PA
Other languages
English (en)
Inventor
Raphael Clément Li-Ming Doineau
Arnaud Reitz
Marcel Reichen
Original Assignee
Hifibio Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hifibio Sas filed Critical Hifibio Sas
Publication of SG11202002014PA publication Critical patent/SG11202002014PA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1413—Hydrodynamic focussing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1415—Control of particle position
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SG11202002014PA 2017-09-19 2018-09-19 Particle sorting in a microfluidic system SG11202002014PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17191962 2017-09-19
PCT/EP2018/075393 WO2019057794A1 (en) 2017-09-19 2018-09-19 SORTING PARTICLES IN A MICROFLUIDIC SYSTEM

Publications (1)

Publication Number Publication Date
SG11202002014PA true SG11202002014PA (en) 2020-04-29

Family

ID=59914402

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202002014PA SG11202002014PA (en) 2017-09-19 2018-09-19 Particle sorting in a microfluidic system

Country Status (8)

Country Link
US (1) US11738344B2 (zh)
EP (1) EP3684507B1 (zh)
JP (1) JP7332586B2 (zh)
CN (1) CN111132765B (zh)
AU (1) AU2018335223A1 (zh)
CA (1) CA3076194A1 (zh)
SG (1) SG11202002014PA (zh)
WO (1) WO2019057794A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2482055A3 (en) * 2007-04-16 2013-10-30 The General Hospital Corporation d/b/a Massachusetts General Hospital Systems and methods for particle focusing in microchannels
CN111235085A (zh) * 2020-01-20 2020-06-05 丁林 基于静态液滴阵列分离单个细胞的方法
WO2021188838A1 (en) * 2020-03-18 2021-09-23 Chan Zuckerberg Biohub, Inc. Single-cell combinatorial indexed cytometry sequencing
CN113275047A (zh) * 2021-04-30 2021-08-20 北京机械设备研究所 微流控芯片及其用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6541596A (en) * 1995-06-16 1997-01-15 University Of Washington Microfabricated differential extraction device and method
US6454945B1 (en) 1995-06-16 2002-09-24 University Of Washington Microfabricated devices and methods
JP2004500562A (ja) * 1999-12-29 2004-01-08 ユニオン　バイオメトリカ　インコーポレイテッド フローサイトメトリーのための高粘度シース試薬
US20010048900A1 (en) * 2000-05-24 2001-12-06 Bardell Ronald L. Jet vortex mixer
US7901939B2 (en) * 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
US7347617B2 (en) * 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
JP4341372B2 (ja) * 2003-10-30 2009-10-07 コニカミノルタホールディングス株式会社 液体の混合方法および混合装置ならびに混合システム
EP1711796A1 (de) * 2004-02-04 2006-10-18 Evotec Technologies GmbH Mikrofluidisches system und zugehoriges betriebsverfahren
JP2005224775A (ja) * 2004-02-16 2005-08-25 Fuji Xerox Co Ltd 微粒子の処理方法及び処理装置
US7442339B2 (en) * 2004-03-31 2008-10-28 Intel Corporation Microfluidic apparatus, Raman spectroscopy systems, and methods for performing molecular reactions
US7315374B2 (en) * 2004-06-24 2008-01-01 Intel Corporation Real-time monitoring optically trapped carbon nanotubes
GB2436616A (en) * 2006-03-29 2007-10-03 Inverness Medical Switzerland Assay device and method
EP2482055A3 (en) * 2007-04-16 2013-10-30 The General Hospital Corporation d/b/a Massachusetts General Hospital Systems and methods for particle focusing in microchannels
JP2009162664A (ja) * 2008-01-08 2009-07-23 Sony Corp 流路を用いた検出方法及び相互作用検出方法、並びに検出装置
US8855103B2 (en) * 2008-01-17 2014-10-07 Blackberry Limited Personal network access control system and method
JP2009180684A (ja) * 2008-01-31 2009-08-13 Canon Inc 流体の制御方法
WO2010040103A1 (en) * 2008-10-03 2010-04-08 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching
DK2440941T3 (en) * 2009-06-10 2017-08-28 Cynvenio Biosystems Inc Sheath flow devices and methods
JP5869482B2 (ja) * 2009-09-02 2016-02-24 プレジデント アンド フェローズ オブ ハーバード カレッジ ジェッティングおよび他の技術を使用して生成された多重エマルジョン
FR2972117B1 (fr) * 2011-03-04 2013-12-20 Centre Nat Rech Scient Systeme microfluidique pour controler un profil de concentration de molecules susceptibles de stimuler une cible
CN103765068B (zh) * 2011-03-30 2016-09-07 努拜欧有限公司 将多个体积注入或注出液滴
WO2013158737A1 (en) * 2012-04-17 2013-10-24 Regents Of The University Of Minnesota Inlet and outlet geometries for a vertical three-stream microfluidic device
SG2013090790A (en) * 2013-12-04 2015-07-30 Clearbridge Mfluidics Pte Ltd A microfluidic device
WO2015088299A1 (en) * 2013-12-09 2015-06-18 Vilnius University Method for production of biopolymer-based droplets and particles in a microfluidic system
CN103667057B (zh) * 2013-12-30 2015-10-28 中国科学院苏州纳米技术与纳米仿生研究所 基于微流控芯片的细胞受创后细胞迁移生物学行为的监控方法
JP6838969B2 (ja) * 2014-06-26 2021-03-03 １０エックス ジェノミクス， インコーポレイテッド 個々の細胞または細胞集団由来の核酸の分析方法
FR3024738B1 (fr) * 2014-08-11 2018-06-15 Genes Diffusion Dispostif et procede de selection de cellules eucaryotes dans un canal de transport par alteration des cellules eucaryotes au moyen d'un rayonnemement electromagnetique
CN105688721B (zh) * 2016-01-06 2018-01-12 中国计量学院 用于生成球状微气泡的微流控芯片

Also Published As

Publication number Publication date
JP2020534142A (ja) 2020-11-26
AU2018335223A1 (en) 2020-04-23
EP3684507A1 (en) 2020-07-29
EP3684507B1 (en) 2023-06-07
CN111132765A (zh) 2020-05-08
WO2019057794A1 (en) 2019-03-28
US11738344B2 (en) 2023-08-29
CA3076194A1 (en) 2019-03-28
US20200215545A1 (en) 2020-07-09
JP7332586B2 (ja) 2023-08-23
CN111132765B (zh) 2022-05-13
EP3684507C0 (en) 2023-06-07

Similar Documents

Publication Publication Date Title
HK1243669A1 (zh) 分選微流體裝置中的顆粒
HK1251660A1 (zh) 微流控微滴檢測和分選
IL281001A (en) Methods and systems for multiple taxonomic classification
EP3592670C0 (en) PARCEL AND ARTICLE SORTING SYSTEM
IL264306B1 (en) Sorting of t-lymphocytes in a microfluidic device
EP3322544A4 (en) MATERIAL GRADING SYSTEM
SG10202003786VA (en) Microfluidic particle manipulation
GB201511130D0 (en) Parcel sorter system and method
ZA201800573B (en) Nozzle device and system for sorting objects
PL3113883T3 (pl) Układ sortujący komórki z wykorzystaniem mikrofabrykowanych składowych
HK1258244A1 (zh) 流體的分析和分離
SG10201801287YA (en) Connectors For Pneumatic Devices In Microfluidic Systems
GB2550369B (en) Sorting waste materials
GB201720754D0 (en) Systems and methods for providing content in a content list
GB201512725D0 (en) Polymeric particles
SG11202002014PA (en) Particle sorting in a microfluidic system
GB201603088D0 (en) Cell sorting
SG11201709867PA (en) System for sorting objects in bags
IL267581A (en) Sorting gems
EP3426403A4 (en) MICROFLUIDIC PARTICLE SORTIER
EP3209436A4 (en) A sorting and distribution system
GB2571889B (en) Systems and methods for sorting mechanisms at a terminal
SG10201702344RA (en) A Core-Shell Particle
GB201700983D0 (en) Polymeric particles
TWI560641B (en) A handwriting grading system and the method thereof