FR2972117B1 - Systeme microfluidique pour controler un profil de concentration de molecules susceptibles de stimuler une cible - Google Patents

Systeme microfluidique pour controler un profil de concentration de molecules susceptibles de stimuler une cible

Info

Publication number
FR2972117B1
FR2972117B1 FR1100660A FR1100660A FR2972117B1 FR 2972117 B1 FR2972117 B1 FR 2972117B1 FR 1100660 A FR1100660 A FR 1100660A FR 1100660 A FR1100660 A FR 1100660A FR 2972117 B1 FR2972117 B1 FR 2972117B1
Authority
FR
France
Prior art keywords
microfluidic channel
target
chamber
microporous membrane
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1100660A
Other languages
English (en)
Other versions
FR2972117A1 (fr
Inventor
Maxime Dahan
Mathieu Morel
Jean Christophe Galas
Vincent Studer
Denis Bartolo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ecole Superieure De Physique Et Chimie Industr Fr
Centre National de la Recherche Scientifique CNRS
Universite Pierre et Marie Curie Paris 6
Ecole Normale Superieure
Universite Bordeaux Segalen
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Pierre et Marie Curie Paris 6
Ecole Normale Superieure
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1100660A priority Critical patent/FR2972117B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS, Universite Pierre et Marie Curie Paris 6, Ecole Normale Superieure filed Critical Centre National de la Recherche Scientifique CNRS
Priority to CA2829028A priority patent/CA2829028A1/fr
Priority to PCT/IB2012/051001 priority patent/WO2012120424A1/fr
Priority to CN201280021743.6A priority patent/CN103732325B/zh
Priority to JP2013557199A priority patent/JP5937114B2/ja
Priority to US14/003,206 priority patent/US9404914B2/en
Priority to EP12708969.6A priority patent/EP2680971A1/fr
Publication of FR2972117A1 publication Critical patent/FR2972117A1/fr
Application granted granted Critical
Publication of FR2972117B1 publication Critical patent/FR2972117B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/163—Biocompatibility
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
FR1100660A 2011-03-04 2011-03-04 Systeme microfluidique pour controler un profil de concentration de molecules susceptibles de stimuler une cible Active FR2972117B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR1100660A FR2972117B1 (fr) 2011-03-04 2011-03-04 Systeme microfluidique pour controler un profil de concentration de molecules susceptibles de stimuler une cible
PCT/IB2012/051001 WO2012120424A1 (fr) 2011-03-04 2012-03-02 Systeme microfluidique pour controler un profil de concentration de molecules susceptibles de stimuler une cible
CN201280021743.6A CN103732325B (zh) 2011-03-04 2012-03-02 用于可靠地控制分子的浓度分布以刺激目标的微流体系统
JP2013557199A JP5937114B2 (ja) 2011-03-04 2012-03-02 標的を刺激すると考えられる分子の濃度プロファイルを制御するためのマイクロ流体システム
CA2829028A CA2829028A1 (fr) 2011-03-04 2012-03-02 Systeme microfluidique pour controler un profil de concentration de molecules susceptibles de stimuler une cible
US14/003,206 US9404914B2 (en) 2011-03-04 2012-03-02 Microfluidic system for controlling a concentration profile of molecules capable of stimulating a target
EP12708969.6A EP2680971A1 (fr) 2011-03-04 2012-03-02 Systeme microfluidique pour controler un profil de concentration de molecules susceptibles de stimuler une cible

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1100660A FR2972117B1 (fr) 2011-03-04 2011-03-04 Systeme microfluidique pour controler un profil de concentration de molecules susceptibles de stimuler une cible

Publications (2)

Publication Number Publication Date
FR2972117A1 FR2972117A1 (fr) 2012-09-07
FR2972117B1 true FR2972117B1 (fr) 2013-12-20

Family

ID=44544063

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1100660A Active FR2972117B1 (fr) 2011-03-04 2011-03-04 Systeme microfluidique pour controler un profil de concentration de molecules susceptibles de stimuler une cible

Country Status (7)

Country Link
US (1) US9404914B2 (fr)
EP (1) EP2680971A1 (fr)
JP (1) JP5937114B2 (fr)
CN (1) CN103732325B (fr)
CA (1) CA2829028A1 (fr)
FR (1) FR2972117B1 (fr)
WO (1) WO2012120424A1 (fr)

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US10533207B2 (en) * 2014-10-16 2020-01-14 Quantamatrix Inc. Bioactivity testing structure for single cell tracking using gelling agents
CN104498327B (zh) * 2014-12-17 2017-06-20 华中科技大学 一种高通量微流控芯片、细胞分析装置及方法
CA2995088A1 (fr) * 2015-08-07 2017-02-16 President And Fellows Of Harvard College Dispositifs fluidiques contenant du tissu musculaire fonctionnel et procedes d'utilisation
US11384328B2 (en) 2015-11-18 2022-07-12 President And Fellows Of Harvard College Cartridge-based system for long term culture of cell clusters
FR3044685B1 (fr) * 2015-12-02 2020-11-27 Univ Grenoble 1 Puce microfluidique pour la cristallisation de molecules, procede de preparation, dispositif la comprenant et procede de cristallisation de molecules
CN107238573A (zh) * 2016-03-29 2017-10-10 光宝电子(广州)有限公司 流体检测装置
IT201700004017A1 (it) * 2017-01-16 2018-07-16 React4Life Srl Bioreattore e metodo di utilizzo di detto bioreattore
WO2018204257A1 (fr) * 2017-05-01 2018-11-08 The Texas A&M University System Modèle de corrosion microfluidique influencée par voie microbiologique : m-mic
EP3684507B1 (fr) * 2017-09-19 2023-06-07 HiFiBiO SAS Tri de particules dans un système microfluidique
WO2019079681A1 (fr) 2017-10-20 2019-04-25 President And Fellows Of Harvard College Procédés de production d'adipocytes matures et leurs procédés d'utilisation
DE102018206463A1 (de) * 2018-04-26 2019-10-31 Robert Bosch Gmbh Verfahren zum Verdünnen, Mischen und/oder Aliquotieren von zwei Flüssigkeiten in einem mikrofluidisches System

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Also Published As

Publication number Publication date
CN103732325A (zh) 2014-04-16
US20140080206A1 (en) 2014-03-20
JP5937114B2 (ja) 2016-06-22
WO2012120424A1 (fr) 2012-09-13
JP2014508529A (ja) 2014-04-10
US9404914B2 (en) 2016-08-02
EP2680971A1 (fr) 2014-01-08
CA2829028A1 (fr) 2012-09-13
FR2972117A1 (fr) 2012-09-07
CN103732325B (zh) 2016-02-24

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