SG11202001549UA - Dynamic human antibody light chain libraries - Google Patents

Dynamic human antibody light chain libraries

Info

Publication number
SG11202001549UA
SG11202001549UA SG11202001549UA SG11202001549UA SG11202001549UA SG 11202001549U A SG11202001549U A SG 11202001549UA SG 11202001549U A SG11202001549U A SG 11202001549UA SG 11202001549U A SG11202001549U A SG 11202001549UA SG 11202001549U A SG11202001549U A SG 11202001549UA
Authority
SG
Singapore
Prior art keywords
light chain
human antibody
antibody light
dynamic human
chain libraries
Prior art date
Application number
SG11202001549UA
Other languages
English (en)
Inventor
Yan Li
Fangyong Du
Peter Peizhi Luo
Original Assignee
Adagene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adagene Inc filed Critical Adagene Inc
Publication of SG11202001549UA publication Critical patent/SG11202001549UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11202001549UA 2017-08-21 2017-08-21 Dynamic human antibody light chain libraries SG11202001549UA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2017/098333 WO2019036856A1 (fr) 2017-08-21 2017-08-21 Banques dynamiques de chaîne légère d'anticorps humain

Publications (1)

Publication Number Publication Date
SG11202001549UA true SG11202001549UA (en) 2020-03-30

Family

ID=65439735

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202001549UA SG11202001549UA (en) 2017-08-21 2017-08-21 Dynamic human antibody light chain libraries

Country Status (12)

Country Link
US (2) US11585014B2 (fr)
EP (1) EP3673100A4 (fr)
JP (2) JP7324744B2 (fr)
KR (2) KR20200054209A (fr)
CN (1) CN111566262A (fr)
AU (1) AU2017428934B2 (fr)
BR (1) BR112020003459A2 (fr)
CA (1) CA3072111A1 (fr)
IL (1) IL272699A (fr)
SG (1) SG11202001549UA (fr)
WO (1) WO2019036856A1 (fr)
ZA (1) ZA202001112B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111511762A (zh) 2017-08-21 2020-08-07 天演药业公司 抗cd137分子及其用途
BR112020003622A2 (pt) 2017-08-21 2020-09-01 Adagene Inc. cadeia pesada de anticorpo, anticorpo, bibliotecas, kit, método de preparo de uma biblioteca, método de produção de uma biblioteca de anticorpos, fago, método de geração de um anticorpo biespecífico e anticorpo biespecífico
WO2019148445A1 (fr) 2018-02-02 2019-08-08 Adagene Inc. Anticorps activables dépendant de la précision/du contexte, et leurs procédés de fabrication et d'utilisation
WO2019148444A1 (fr) 2018-02-02 2019-08-08 Adagene Inc. Anticorps anti-ctla4 et leurs procédés de fabrication et d'utilisation

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
AU633698B2 (en) 1990-01-12 1993-02-04 Amgen Fremont Inc. Generation of xenogeneic antibodies
DE4002897A1 (de) 1990-02-01 1991-08-08 Behringwerke Ag Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken")
WO1992003918A1 (fr) 1990-08-29 1992-03-19 Genpharm International, Inc. Animaux non humains transgeniques capables de produire des anticorps heterologues
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
EP0861893A3 (fr) 1991-09-19 1999-11-10 Genentech, Inc. Expression de haut niveau d'immunoglobulines
WO1993008829A1 (fr) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions induisant la destruction de cellules infectees par l'hiv
US5866344A (en) 1991-11-15 1999-02-02 Board Of Regents, The University Of Texas System Antibody selection methods using cell surface expressed libraries
US20030036092A1 (en) 1991-11-15 2003-02-20 Board Of Regents, The University Of Texas System Directed evolution of enzymes and antibodies
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
EP1978033A3 (fr) 1995-04-27 2008-12-24 Amgen Fremont Inc. Anticorps humains dérivés à partir de xénosouris immunisée
CA2219486A1 (fr) 1995-04-28 1996-10-31 Abgenix, Inc. Anticorps humains derives de xeno-souris immunisees
CA2616914C (fr) 1996-12-03 2012-05-29 Abgenix, Inc. Anticorps de liaison de recepteur d'egf
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
KR100797667B1 (ko) 1999-10-04 2008-01-23 메디카고 인코포레이티드 외래 유전자의 전사를 조절하는 방법
EP1457559B1 (fr) 2001-11-22 2008-01-16 Keio University Banque d'anticorps artificiels dotee d'un super repertoire
US7785903B2 (en) * 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
AU2006245734C1 (en) 2005-05-12 2012-05-24 Crucell Holland B.V. Host cell specific binding molecules capable of neutralizing viruses and uses thereof
EP2465870A1 (fr) * 2005-11-07 2012-06-20 Genentech, Inc. Polypeptides de liaison dotés de séquences hypvervariables VH/VL diversifiées et consensuelles
PL2274008T3 (pl) * 2008-03-27 2014-07-31 Zymogenetics Inc Kompozycje i sposoby hamowania PDGFRbeta i VEGF-A
AU2011279073B2 (en) 2010-07-16 2016-06-09 Adimab, Llc Antibody libraries
ES2537207T3 (es) 2010-08-16 2015-06-03 Novimmune S.A. Métodos para la generación de anticuerpos multiespecíficos y multivalentes
CN105247050B (zh) 2013-03-14 2020-06-16 天演药业 用于文库构建、亲和力结合剂筛选和其表达的整合系统
CN103603057B (zh) 2013-07-03 2016-01-06 深圳大学 基于可感染病毒颗粒型抗体重链库/轻链库的抗体筛选和制备方法
EP3209776A1 (fr) 2014-10-22 2017-08-30 Crescendo Biologics Limited Échafaudages de domaine vh humain
US11078286B2 (en) 2015-09-20 2021-08-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal antibodies specific for fibroblast growth factor receptor 4 (FGFR4) and methods of their use
BR112020003622A2 (pt) 2017-08-21 2020-09-01 Adagene Inc. cadeia pesada de anticorpo, anticorpo, bibliotecas, kit, método de preparo de uma biblioteca, método de produção de uma biblioteca de anticorpos, fago, método de geração de um anticorpo biespecífico e anticorpo biespecífico

Also Published As

Publication number Publication date
CN111566262A (zh) 2020-08-21
CA3072111A1 (fr) 2019-02-28
KR20200054209A (ko) 2020-05-19
AU2017428934A1 (en) 2020-03-05
ZA202001112B (en) 2024-06-26
US20200362019A1 (en) 2020-11-19
US20230287597A1 (en) 2023-09-14
US11585014B2 (en) 2023-02-21
EP3673100A4 (fr) 2021-04-21
JP2022033762A (ja) 2022-03-02
EP3673100A1 (fr) 2020-07-01
WO2019036856A1 (fr) 2019-02-28
JP2020537633A (ja) 2020-12-24
KR20230119260A (ko) 2023-08-16
IL272699A (en) 2020-04-30
AU2017428934A8 (en) 2020-03-12
AU2017428934B2 (en) 2023-07-20
JP7324744B2 (ja) 2023-08-10
BR112020003459A2 (pt) 2020-08-25

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