SG11201912962RA - Purification of factor viii subspecies - Google Patents

Purification of factor viii subspecies

Info

Publication number
SG11201912962RA
SG11201912962RA SG11201912962RA SG11201912962RA SG11201912962RA SG 11201912962R A SG11201912962R A SG 11201912962RA SG 11201912962R A SG11201912962R A SG 11201912962RA SG 11201912962R A SG11201912962R A SG 11201912962RA SG 11201912962R A SG11201912962R A SG 11201912962RA
Authority
SG
Singapore
Prior art keywords
subspecies
purification
factor viii
viii
factor
Prior art date
Application number
SG11201912962RA
Other languages
English (en)
Inventor
Meinhard Hasslacher
Martin Feichtinger
Philipp Michael Bärnthaler
Christa Mayer
Birgit Reipert
Mantas Malisauskas
Julia Anzengruber
Original Assignee
Baxalta Inc
Baxalta GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Inc, Baxalta GmbH filed Critical Baxalta Inc
Publication of SG11201912962RA publication Critical patent/SG11201912962RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11201912962RA 2017-06-23 2018-06-22 Purification of factor viii subspecies SG11201912962RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17177749 2017-06-23
PCT/EP2018/066753 WO2018234543A1 (en) 2017-06-23 2018-06-22 PURIFICATION OF FACTOR VIII SUBSPECIES

Publications (1)

Publication Number Publication Date
SG11201912962RA true SG11201912962RA (en) 2020-01-30

Family

ID=59337429

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201912962RA SG11201912962RA (en) 2017-06-23 2018-06-22 Purification of factor viii subspecies

Country Status (8)

Country Link
US (2) US11299533B2 (ja)
EP (1) EP3642225A1 (ja)
JP (2) JP7253505B2 (ja)
CN (1) CN111183151B (ja)
BR (1) BR112019027377A2 (ja)
CA (1) CA3068121A1 (ja)
SG (1) SG11201912962RA (ja)
WO (1) WO2018234543A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115541777B (zh) * 2022-11-23 2023-06-30 天津外泌体科技有限公司 一种基于二维液相评价外泌体纯度的方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2857166T1 (de) 1977-11-17 1980-12-04 Atomic Energy Authority Uk Purification of factor viii
DE3279292D1 (en) 1981-04-08 1989-01-26 Atomic Energy Authority Uk Blood fractionation improvement
ES2042138T3 (es) * 1989-05-24 1993-12-01 Miles Inc. Filtracion en gel del factor viii tratado termicamente.
SE503424C2 (sv) * 1994-11-14 1996-06-10 Pharmacia Ab Process för rening av rekombinant koagulationsfaktor VIII
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US6596526B1 (en) 2000-06-09 2003-07-22 Baxter Aktiengesellschaft Furin polypeptides with improved characteristics
RU2324495C1 (ru) 2006-08-31 2008-05-20 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации Способ получения препарата фактора свертывания viii крови человека
KR100772053B1 (ko) 2006-11-13 2007-10-31 율촌화학 주식회사 원료의 정량 공급 장치 및 방법
CN101679496B (zh) 2007-05-18 2013-03-13 巴克斯特国际公司 用于由vwf前肽制备成熟vwf的方法
EP2167526B1 (en) 2007-07-11 2011-03-30 Novo Nordisk A/S Purification of factor viii using a mixed-mode or multimodal resin
BRPI0821467B8 (pt) 2007-12-31 2021-05-25 Baxalta GmbH composição de furina recombinante, método para produzir a composição de furina recombinante, e, método para produzir uma proteína madura utilizando a composição de furina recombinante
ES2298096B1 (es) 2008-01-08 2009-01-01 Grifols, S.A. Procedimiento para la obtencion de un concentrado de factor von willebrand o del complejo de factor viii/factor von willebrand y utilizacionde los mismos.
SI2300497T1 (sl) 2008-06-24 2013-02-28 Octapharma Ag Postopek za äťiĺˇäťenje koagulacijskega faktorja viii
RU2012132470A (ru) 2009-12-29 2014-02-10 Йейл Юниверсити Ингибиторы рецепторов фактора роста эндотелия сосудов (vegf) и способы их применения
EP2536753B1 (en) * 2010-02-16 2017-12-20 Novo Nordisk A/S Factor viii molecules with reduced vwf binding
US9611310B2 (en) * 2010-07-09 2017-04-04 Bioverativ Therapeutics Inc. Systems for factor VIII processing and methods thereof
US20130345403A1 (en) * 2010-12-16 2013-12-26 Novo Nordisk A/S Aqueous factor viii solution
SG195261A1 (en) 2011-06-02 2013-12-30 Baxter Int Formulations of recombinant furin
CA2837995A1 (en) 2011-06-03 2012-12-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
LT3564260T (lt) * 2012-02-15 2023-01-10 Bioverativ Therapeutics Inc. Viii faktoriaus kompozicijos ir jų gamybos bei panaudojimo būdai
WO2015107222A1 (en) 2014-01-20 2015-07-23 Octapharma Ag A process for manufacturing factor viii having an improved ratio of fviii:c/fviii:ag
AR102048A1 (es) 2014-08-12 2017-02-01 Baxalta Inc Producción del factor x completamente procesado y funcional en un sistema de expresión de mamífero de secreción de furina

Also Published As

Publication number Publication date
EP3642225A1 (en) 2020-04-29
US20220275058A1 (en) 2022-09-01
US11299533B2 (en) 2022-04-12
JP2022123035A (ja) 2022-08-23
US12071468B2 (en) 2024-08-27
RU2020102459A (ru) 2021-07-23
JP7253505B2 (ja) 2023-04-06
BR112019027377A2 (pt) 2020-07-14
CA3068121A1 (en) 2018-12-27
CN111183151A (zh) 2020-05-19
JP2020524688A (ja) 2020-08-20
CN111183151B (zh) 2024-06-07
WO2018234543A1 (en) 2018-12-27
US20190062403A1 (en) 2019-02-28

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