SG11201909652WA - Neoantigen identification, manufacture, and use - Google Patents
Neoantigen identification, manufacture, and useInfo
- Publication number
- SG11201909652WA SG11201909652WA SG11201909652WA SG11201909652WA SG 11201909652W A SG11201909652W A SG 11201909652WA SG 11201909652W A SG11201909652W A SG 11201909652WA SG 11201909652W A SG11201909652W A SG 11201909652WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- gritstone
- emeryville
- suite
- oncology
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 108700028369 Alleles Proteins 0.000 abstract 1
- 241001635598 Enicostema Species 0.000 abstract 1
- 206010027626 Milia Diseases 0.000 abstract 1
- 229940022399 cancer vaccine Drugs 0.000 abstract 1
- 238000009566 cancer vaccine Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
- 230000000392 somatic effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
- G16B50/40—Encryption of genetic data
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464401—Neoantigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/30—Detection of binding sites or motifs
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medical Informatics (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Bioethics (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762487469P | 2017-04-19 | 2017-04-19 | |
| PCT/US2018/028438 WO2018195357A1 (en) | 2017-04-19 | 2018-04-19 | Neoantigen identification, manufacture, and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201909652WA true SG11201909652WA (en) | 2019-11-28 |
Family
ID=63857025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201909652W SG11201909652WA (en) | 2017-04-19 | 2018-04-19 | Neoantigen identification, manufacture, and use |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20210113673A1 (ru) |
| EP (1) | EP3612965A4 (ru) |
| JP (2) | JP7217711B2 (ru) |
| KR (1) | KR20190140935A (ru) |
| CN (1) | CN110636852A (ru) |
| AU (2) | AU2018254526B2 (ru) |
| BR (1) | BR112019021782A2 (ru) |
| CA (1) | CA3060569A1 (ru) |
| CO (1) | CO2019012345A2 (ru) |
| IL (1) | IL269855B2 (ru) |
| MX (1) | MX2019012433A (ru) |
| RU (1) | RU2019136762A (ru) |
| SG (1) | SG11201909652WA (ru) |
| WO (1) | WO2018195357A1 (ru) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
| WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
| RU2729116C2 (ru) | 2015-12-16 | 2020-08-04 | Гритстоун Онколоджи, Инк. | Идентификация, производство и применение неоантигенов |
| JP7370861B2 (ja) | 2017-02-12 | 2023-10-30 | ビオンテック ユーエス インコーポレイテッド | Ｈｌａに基づく方法および組成物ならびにそれらの使用 |
| AU2018298971A1 (en) * | 2017-07-14 | 2020-01-16 | Cancer Research Technology Limited | Analysis of HLA alleles in tumours and the uses thereof |
| AU2018348165A1 (en) | 2017-10-10 | 2020-05-21 | Gritstone Bio, Inc. | Neoantigen identification using hotspots |
| US11885815B2 (en) | 2017-11-22 | 2024-01-30 | Gritstone Bio, Inc. | Reducing junction epitope presentation for neoantigens |
| SG11202006400UA (en) | 2018-01-04 | 2020-08-28 | Iconic Therapeutics Inc | Anti-tissue factor antibodies, antibody-drug conjugates, and related methods |
| US20210181188A1 (en) * | 2018-08-24 | 2021-06-17 | The Regents Of The University Of California | Mhc-ii genotype restricts the oncogenic mutational landscape |
| US10936768B2 (en) * | 2018-10-15 | 2021-03-02 | Aible, Inc. | Interface for visualizing and improving model performance |
| US20220125919A1 (en) * | 2018-11-07 | 2022-04-28 | Gritstone Bio, Inc. | Alphavirus neoantigen vectors and interferon inhibitors |
| CA3124905A1 (en) | 2019-01-03 | 2020-07-09 | Jens KRINGELUM | Vaccines targeting neoepitopes |
| CN111621564B (zh) * | 2019-02-28 | 2022-03-25 | 武汉大学 | 一种鉴定有效肿瘤新抗原的方法 |
| CA3132041A1 (en) * | 2019-03-06 | 2020-09-10 | Gritstone Bio, Inc. | Identification of neoantigens with mhc class ii model |
| CA3131824A1 (en) | 2019-03-11 | 2020-09-17 | Birgitte Rono | Nucleic acid vaccination using neo-epitope encoding constructs |
| WO2020185010A1 (ko) * | 2019-03-12 | 2020-09-17 | (주)신테카바이오 | 인공지능모델기반 분자동역학 빅데이터를 활용한 신생항원 면역치료정보 제공 시스템 및 방법 |
| EP4198513A1 (en) * | 2019-05-03 | 2023-06-21 | Epivax Therapeutics, Inc. | Neoantigens in cancer |
| EP3993829A4 (en) * | 2019-07-02 | 2024-01-03 | Gritstone bio, Inc. | HIV ANTIGENS AND MHC COMPLEXES |
| CA3145791A1 (en) | 2019-07-16 | 2021-01-21 | Gilead Sciences, Inc. | Hiv vaccines and methods of making and using |
| US20220334129A1 (en) | 2019-09-13 | 2022-10-20 | Evaxion Biotech A/S | Method for identifying T-cell epitopes |
| AU2020407905A1 (en) | 2019-12-18 | 2022-07-28 | Evaxion Biotech A/S | Nucleic acid vaccination using neo-epitope encoding constructs |
| JP2023509540A (ja) * | 2020-01-07 | 2023-03-08 | コリア アドバンスド インスティテュート オブ サイエンス アンド テクノロジー | 新生抗原をスクリーニングする方法、システム及びその用途 |
| EP4132959A1 (en) | 2020-04-07 | 2023-02-15 | Evaxion Biotech A/S | Neoepitope immunotherapy with apc targeting unit |
| WO2021257879A1 (en) * | 2020-06-18 | 2021-12-23 | Personalis Inc. | Machine-learning techniques for predicting surface-presenting peptides |
| EP4181949A1 (en) | 2020-07-14 | 2023-05-24 | Evaxion Biotech A/S | Apc targeting units for immunotherapy |
| EP4002383A3 (en) | 2020-11-13 | 2022-08-03 | Tokyo Institute of Technology | Information processing device, information processing method, recording medium recording information processing program, and information processing system |
| JP7057003B1 (ja) | 2021-02-26 | 2022-04-19 | 国立大学法人東京工業大学 | 予測装置、学習済みモデルの生成装置、予測方法、学習済みモデルの生成方法、予測プログラム、及び学習済みモデルの生成プログラム |
| JP7057004B1 (ja) | 2021-03-05 | 2022-04-19 | 国立大学法人東京工業大学 | 予測装置、学習済みモデルの生成装置、予測方法、学習済みモデルの生成方法、予測プログラム、及び学習済みモデルの生成プログラム |
| WO2022229966A1 (en) | 2021-04-29 | 2022-11-03 | Yeda Research And Development Co. Ltd. | T cell receptors directed against ras-derived recurrent neoantigens and methods of identifying same |
| CN113762416B (zh) * | 2021-10-15 | 2023-05-30 | 南京澄实生物科技有限公司 | 基于多模态深度编码的抗原免疫原性预测方法和系统 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102447139B1 (ko) * | 2010-05-14 | 2022-09-23 | 더 제너럴 하스피톨 코포레이션 | 종양 특이적 신생항원을 확인하는 조성물 및 방법 |
| CN105377292A (zh) * | 2013-04-07 | 2016-03-02 | 博德研究所 | 用于个性化瘤形成疫苗的组合物和方法 |
| WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
| RU2729116C2 (ru) * | 2015-12-16 | 2020-08-04 | Гритстоун Онколоджи, Инк. | Идентификация, производство и применение неоантигенов |
| US20190346442A1 (en) * | 2016-04-18 | 2019-11-14 | The Broad Institute, Inc. | Improved hla epitope prediction |
| TWI672503B (zh) * | 2017-03-31 | 2019-09-21 | 行動基因生技股份有限公司 | 致免疫性之癌症特異抗原決定位的排名系統 |
-
2018
- 2018-04-19 WO PCT/US2018/028438 patent/WO2018195357A1/en unknown
- 2018-04-19 US US16/606,577 patent/US20210113673A1/en not_active Abandoned
- 2018-04-19 RU RU2019136762A patent/RU2019136762A/ru not_active Application Discontinuation
- 2018-04-19 BR BR112019021782-7A patent/BR112019021782A2/pt not_active Application Discontinuation
- 2018-04-19 AU AU2018254526A patent/AU2018254526B2/en active Active
- 2018-04-19 EP EP18787958.0A patent/EP3612965A4/en active Pending
- 2018-04-19 MX MX2019012433A patent/MX2019012433A/es unknown
- 2018-04-19 JP JP2019556988A patent/JP7217711B2/ja active Active
- 2018-04-19 CA CA3060569A patent/CA3060569A1/en active Pending
- 2018-04-19 CN CN201880026206.8A patent/CN110636852A/zh active Pending
- 2018-04-19 SG SG11201909652W patent/SG11201909652WA/en unknown
- 2018-04-19 KR KR1020197031349A patent/KR20190140935A/ko not_active Application Discontinuation
-
2019
- 2019-10-06 IL IL269855A patent/IL269855B2/en unknown
- 2019-11-01 CO CONC2019/0012345A patent/CO2019012345A2/es unknown
-
2023
- 2023-01-24 JP JP2023008973A patent/JP2023055775A/ja active Pending
-
2024
- 2024-05-02 AU AU2024202903A patent/AU2024202903A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023055775A (ja) | 2023-04-18 |
| IL269855B1 (en) | 2023-01-01 |
| BR112019021782A2 (pt) | 2020-08-18 |
| AU2024202903A1 (en) | 2024-05-23 |
| IL269855A (en) | 2019-11-28 |
| JP2020519246A (ja) | 2020-07-02 |
| CN110636852A (zh) | 2019-12-31 |
| WO2018195357A1 (en) | 2018-10-25 |
| AU2018254526A1 (en) | 2019-11-14 |
| JP7217711B2 (ja) | 2023-02-03 |
| EP3612965A1 (en) | 2020-02-26 |
| MX2019012433A (es) | 2019-12-11 |
| RU2019136762A (ru) | 2021-05-19 |
| EP3612965A4 (en) | 2021-01-13 |
| IL269855B2 (en) | 2023-05-01 |
| US20210113673A1 (en) | 2021-04-22 |
| AU2018254526B2 (en) | 2024-02-15 |
| CO2019012345A2 (es) | 2020-01-17 |
| KR20190140935A (ko) | 2019-12-20 |
| CA3060569A1 (en) | 2018-10-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201909652WA (en) | Neoantigen identification, manufacture, and use | |
| SG11201804957VA (en) | Neoantigen identification, manufacture, and use | |
| SG11201903882VA (en) | Il-2 variants for the treatment of autoimmune diseases | |
| SG11201908719QA (en) | Biomarkers and car t cell therapies with enhanced efficacy | |
| SG11201909955XA (en) | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies | |
| SG11201804086VA (en) | Methods and compositions for nucleic acid analysis | |
| SG11201808990QA (en) | Compositions for topical application of compounds | |
| SG11201807538PA (en) | Crispr-cpf1-related methods, compositions and components for cancer immunotherapy | |
| SG11201804814YA (en) | Materials and methods for delivering nucleic acids to cochlear and vestibular cells | |
| SG11201808622SA (en) | Chimeric receptors to flt3 and methods of use thereof | |
| SG11201805709RA (en) | Anti-pro/latent myostatin antibodies and methods of use thereof | |
| SG11201909344SA (en) | Anti-lag3 antibodies | |
| SG11201807025SA (en) | Crispr/cas systems for c-1 fixing bacteria | |
| SG11201806496SA (en) | Antigen binding proteins that bind pd-l1 | |
| SG11201806282XA (en) | High-throughput identification of patient-specific neoepitopes as therapeutic targets for cancer immunotherapies | |
| SG11201806639VA (en) | New streptococcal proteases | |
| SG11201407669QA (en) | Methods for improving safety of blood-brain barrier transport | |
| SG11201809751XA (en) | Egfr inhibitor compounds | |
| SG11201908296VA (en) | Biomarkers for cancer therapeutics | |
| SG11201900546UA (en) | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof | |
| SG11201900551WA (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
| SG11201805149XA (en) | Compositions comprising 15-hepe and methods of using the same | |
| SG11201808713YA (en) | Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier | |
| SG11201901228QA (en) | Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide | |
| SG11201810019RA (en) | Methods of human leukocyte antigen typing |