SG11201909113VA - Dna methylation and mutational analysis methods for bladder cancer surveillance - Google Patents
Dna methylation and mutational analysis methods for bladder cancer surveillanceInfo
- Publication number
- SG11201909113VA SG11201909113VA SG11201909113VA SG11201909113VA SG 11201909113V A SG11201909113V A SG 11201909113VA SG 11201909113V A SG11201909113V A SG 11201909113VA SG 11201909113V A SG11201909113V A SG 11201909113VA
- Authority
- SG
- Singapore
- Prior art keywords
- california
- international
- penobscot
- redwood city
- drive
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
1 0.2 0.3 OA 0.5 0.6 0.7 0.8 0.9 P091.444oD quantile speciriCitc , 52 .41 ?•i , 77.9% (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 November 2018 (22.11.2018) WIP0 I PCT Hu omit VIII °nolo olotill ommoolio iflo oimIE (10) International Publication Number WO 2018/213550 Al (51) International Patent Classification: C12Q 1/6886 (2018.01) (21) International Application Number: PCT/US2018/033146 (22) International Filing Date: 17 May 2018 (17.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/508,274 18 May 2017 (18.05.2017) US (71) Applicant: GENOMIC HEALTH, INC. [US/US]; 301 Penobscot Drive, Redwood City, California 94063 (US). (72) Inventors: LOPATIN, Margarita; 301 Penobscot Dri- ve, Redwood City, California 94603 (US). TSIATIS, Athanasios; 301 Penobscot Drive, Redwood City, Califor- nia 94603 (US). SILK, Christopher N.; 301 Penobscot Drive, Redwood City, California 94603 (US). MILLER, David P.; 1080 Peralta Avenue, Albany, California 94706 (US). CRAGER, Michael; 301 Penobscot Drive, Red- wood City, California 94603 (US). FEBBO, Phillip; 301 Penobscot Drive, Redwood City, California 94603 (US). KNEZEVIC, Dej an; 301 Penobscot Drive, Redwood City, California 94603 (US). (74) Agent: DOHERTY, Elizabeth A. et al.; 125 Cambridge Park Drive, Suite 301, Cambridge, Massachusetts 02140 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: DNA METHYLATION AND MUTATIONAL ANALYSIS METHODS FOR BLADDER CANCER SURVEILLANCE 1.00 099 0.98 0.97 0.96 High Risk Recur t11 1 \"I 1.0 0.8 0.6 0.4 02 99 . 7% 98.8% 0.05 0.0 0.1 0.2 0.3 0.4 0.5 0.8 0.7 0.8 69 0.0 Population qthar669 Sensith.My 1.0 0.6 0.8 0.6 0.6 0.4 0) 0.2 w. a2 04 96.596 0.0 0.0 \" 0.0 0.1 02 0.3 04 0.5 D.6 0.7 0.8 0.9 1.0 popw.ation qumUe 0.0 01 0.2 201 0.4 6.5 OA 0.7 0.6 0.9 1.0 Popti;aton quantilt., Fig. 1 00 (57) : The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for O presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence. C [Continued on next page] WO 2018/213550 Al MIDEDIMOHNIIME1010010ElliOMMINUMEHOIS EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762508274P | 2017-05-18 | 2017-05-18 | |
PCT/US2018/033146 WO2018213550A1 (en) | 2017-05-18 | 2018-05-17 | Dna methylation and mutational analysis methods for bladder cancer surveillance |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201909113VA true SG11201909113VA (en) | 2019-10-30 |
Family
ID=62528860
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201912359XA SG10201912359XA (en) | 2017-05-18 | 2018-05-17 | Dna methylation and mutational analysis methods for bladder cancer surveillance |
SG11201909113V SG11201909113VA (en) | 2017-05-18 | 2018-05-17 | Dna methylation and mutational analysis methods for bladder cancer surveillance |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201912359XA SG10201912359XA (en) | 2017-05-18 | 2018-05-17 | Dna methylation and mutational analysis methods for bladder cancer surveillance |
Country Status (12)
Country | Link |
---|---|
US (2) | US11649506B2 (en) |
EP (1) | EP3625369B1 (en) |
JP (1) | JP2020519296A (en) |
CN (1) | CN110621788A (en) |
AU (1) | AU2018269030A1 (en) |
BR (1) | BR112019022360A2 (en) |
CA (1) | CA3057440A1 (en) |
ES (1) | ES2973607T3 (en) |
IL (1) | IL269707A (en) |
MX (1) | MX2019012260A (en) |
SG (2) | SG10201912359XA (en) |
WO (1) | WO2018213550A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114634982A (en) * | 2020-12-15 | 2022-06-17 | 广州市基准医疗有限责任公司 | Method for detecting polynucleotide variation |
CN113621691A (en) * | 2021-09-27 | 2021-11-09 | 广东省妇幼保健院 | Method and kit for directly detecting CpG methylation of KLF1 gene promoter region based on first-generation sequencing technology |
CN116013528B (en) * | 2023-01-10 | 2023-11-24 | 中山大学孙逸仙纪念医院 | Bladder cancer postoperative recurrence risk prediction method, device and medium combining with FISH detection |
CN116987787A (en) * | 2023-06-09 | 2023-11-03 | 北京泛生子基因科技有限公司 | Apparatus for detecting recurrence of bladder cancer and computer readable storage medium |
CN117604101A (en) * | 2023-09-11 | 2024-02-27 | 北京橡鑫生物科技有限公司 | Gene marker combination, kit and detection method |
CN118006781A (en) * | 2024-02-27 | 2024-05-10 | 广州中鑫基因医学科技有限公司 | Marker, primer set, high-sensitivity and high-specificity kit and detection method for detecting urothelial cancer |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1896180B1 (en) | 2005-06-23 | 2011-11-23 | Biocartis SA | Cartridge, system and method for automated medical diagnostics |
EP3048176B1 (en) * | 2009-04-20 | 2019-03-06 | Erasmus University Medical Center Rotterdam | Method of diagnosing bladder cancer |
WO2010149782A1 (en) * | 2009-06-26 | 2010-12-29 | Epigenomics Ag | Methods and nucleic acids for analysis of bladder cell proliferative disorders |
CN103417983A (en) * | 2012-05-18 | 2013-12-04 | 北京大学 | Novel apoptosis-related molecule TMEM106A and applications thereof |
US20150292030A1 (en) * | 2012-11-27 | 2015-10-15 | Board Of Regents, The University Of Texas System | Methods of characterizing and treating molecular subset of muscle-invasive bladder cancer |
WO2014183093A1 (en) * | 2013-05-10 | 2014-11-13 | University Of Southern California | Dna methylation biomarkers for bladder cancer |
EP3099822A4 (en) * | 2014-01-30 | 2017-08-30 | The Regents of the University of California | Methylation haplotyping for non-invasive diagnosis (monod) |
GB201511152D0 (en) * | 2015-06-24 | 2015-08-05 | Ucl Business Plc | Method of diagnosing bladder cancer |
-
2018
- 2018-05-17 BR BR112019022360A patent/BR112019022360A2/en not_active IP Right Cessation
- 2018-05-17 MX MX2019012260A patent/MX2019012260A/en unknown
- 2018-05-17 ES ES18729258T patent/ES2973607T3/en active Active
- 2018-05-17 WO PCT/US2018/033146 patent/WO2018213550A1/en unknown
- 2018-05-17 CN CN201880032698.1A patent/CN110621788A/en active Pending
- 2018-05-17 CA CA3057440A patent/CA3057440A1/en active Pending
- 2018-05-17 AU AU2018269030A patent/AU2018269030A1/en not_active Abandoned
- 2018-05-17 JP JP2019562614A patent/JP2020519296A/en not_active Withdrawn
- 2018-05-17 EP EP18729258.6A patent/EP3625369B1/en active Active
- 2018-05-17 SG SG10201912359XA patent/SG10201912359XA/en unknown
- 2018-05-17 SG SG11201909113V patent/SG11201909113VA/en unknown
- 2018-05-17 US US16/612,926 patent/US11649506B2/en active Active
-
2019
- 2019-09-26 IL IL26970719A patent/IL269707A/en unknown
-
2023
- 2023-04-04 US US18/130,547 patent/US20230374604A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2018269030A1 (en) | 2019-10-17 |
ES2973607T3 (en) | 2024-06-20 |
WO2018213550A1 (en) | 2018-11-22 |
US11649506B2 (en) | 2023-05-16 |
CA3057440A1 (en) | 2018-11-22 |
EP3625369B1 (en) | 2024-02-14 |
BR112019022360A2 (en) | 2020-05-19 |
MX2019012260A (en) | 2020-01-27 |
JP2020519296A (en) | 2020-07-02 |
IL269707A (en) | 2019-11-28 |
US20230374604A1 (en) | 2023-11-23 |
EP3625369A1 (en) | 2020-03-25 |
SG10201912359XA (en) | 2020-02-27 |
CN110621788A (en) | 2019-12-27 |
US20200165686A1 (en) | 2020-05-28 |
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