SG11201908418RA - Compositions and methods for selective elimination and replacement of hematopoietic stem cells - Google Patents
Compositions and methods for selective elimination and replacement of hematopoietic stem cellsInfo
- Publication number
- SG11201908418RA SG11201908418RA SG11201908418RA SG11201908418RA SG 11201908418R A SG11201908418R A SG 11201908418RA SG 11201908418R A SG11201908418R A SG 11201908418RA SG 11201908418R A SG11201908418R A SG 11201908418RA
- Authority
- SG
- Singapore
- Prior art keywords
- cells
- international
- hscs
- california
- car
- Prior art date
Links
- 210000003958 hematopoietic stem cell Anatomy 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000008030 elimination Effects 0.000 title abstract 2
- 238000003379 elimination reaction Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 8
- 210000002865 immune cell Anatomy 0.000 abstract 4
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 238000002679 ablation Methods 0.000 abstract 2
- 210000000601 blood cell Anatomy 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 238000002054 transplantation Methods 0.000 abstract 2
- 206010065553 Bone marrow failure Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N9/1241—Nucleotidyltransferases (2.7.7)
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- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
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- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/22055—Caspase-2 (3.4.22.55)
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- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/22062—Caspase-9 (3.4.22.62)
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- C12Y502/00—Cis-trans-isomerases (5.2)
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- C12Y502/01008—Peptidylprolyl isomerase (5.2.1.8), i.e. cyclophilin
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
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- C12N2510/00—Genetically modified cells
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- C12N2800/00—Nucleic acids vectors
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Abstract
Mature Blood Cells ® Progenitors ( ) ( 1 54 HSC Niche • •+s +.s •ks• : : FIGURE 3 e* S 4 ' \"•••• Total Body Irradiation or Busuffan Ablation of Progenitors + HSCs HSC Engraftment with Transplantation Myelosuppression CAR-T Cells Specific Ablation Clearance of . . . P : r\") Targeted to HSCs of HSCs CAR-T Cells ffi 4.1 0 Zt 1 O c e t , * 00 Antigen Targets 1 e 2 us 3 CAR-T Cells Selective to 1 — `s. Combination of 411 I HSC Antigens 1+2+3 CAR-T Cells Un reactive to Other Tissue Antigens 2 3 s 3 \ (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIPOIPCT ill 1111u°11111DIVIIl °nolo om IIIII o!moIIHE111110 DIIIIII (10) International Publication Number WO 2018/169948 Al (51) International Patent Classification: A61K 35/17 (2015.01) C12N 5/0783 (2010.01) A61K 35/28 (2015.01) C12N 15/09 (2006.01) A61K 48/00 (2006.01) (21) International Application Number: PCT/US2018/022169 (22) International Filing Date: 13 March 2018 (13.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/470,814 13 March 2017 (13.03.2017) US 62/596,062 07 December 2017 (07.12.2017) US (71) Applicant: POSEIDA THERAPEUTICS, INC. [US/US]; 4242 Campus Point Court, Suite 700, San Diego, California 92121 (US). (72) Inventors: OSTERTAG, Eric; 4242 Campus Point Court, Suite 700, San Diego, California 92121 (US). SHED- LOCK, Devon; 4242 Campus Point Court, Suite 700, San Diego, California 92121 (US). DOWN, Julian David; 4242 Campus Pont Drive, San Diego, California 92121 (US). (74) Agent: MILLER, Katherine J. et al.; Cooley LLP, 1299 Pennsylvania Avenue, NW, 7th Floor, Washington, District of Columbia 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (54) Title: COMPOSITIONS AND METHODS FOR SELECTIVE ELIMINATION AND REPLACEMENT OF HEMATOPOIETIC = STEM CELLS HSC Transplantation \ \ ,4km ‘If Engraftment with Maintenance of Blood Cell Production q) 2 • •,,e40,,,Ckr-. ... : GC 71- 00 O O (57) : Disclosed are methods of eliminating at least one target cell in a subject, comprising administering to the subject an effective amount of a composition comprising a plurality of immune cells, wherein each immune cell of the plurality expresses one or more chimeric ligand receptor(s) (CLR(s)) that each specifically bind to a target ligand on the at least one target cell, wherein specifically binding of the one or more CLR(s) to the target activates the immune cell, and wherein the activated immune cell induces death of the target cell. Exemplary target cells include, but are not limited to, hematopoietic stem cells (HSCs). [Continued on next page] WO 2018/169948 Al MIDEDIMOMOIDEIREEMOMOHIMEIMOIEHIMEN UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201762470814P | 2017-03-13 | 2017-03-13 | |
US201762596062P | 2017-12-07 | 2017-12-07 | |
PCT/US2018/022169 WO2018169948A1 (en) | 2017-03-13 | 2018-03-13 | Compositions and methods for selective elimination and replacement of hematopoietic stem cells |
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SG11201908418RA true SG11201908418RA (en) | 2019-10-30 |
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SG11201908418R SG11201908418RA (en) | 2017-03-13 | 2018-03-13 | Compositions and methods for selective elimination and replacement of hematopoietic stem cells |
SG10202109731Y SG10202109731YA (en) | 2017-03-13 | 2018-03-13 | Compositions and methods for selective elimination and replacement of hematopoietic stem cells |
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SG10202109731Y SG10202109731YA (en) | 2017-03-13 | 2018-03-13 | Compositions and methods for selective elimination and replacement of hematopoietic stem cells |
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EP (1) | EP3595682A1 (en) |
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CN (1) | CN110650743B (en) |
AU (1) | AU2018235756A1 (en) |
CA (1) | CA3056227A1 (en) |
IL (1) | IL269203A (en) |
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WO2018169948A1 (en) | 2018-09-20 |
CN110650743B (en) | 2023-12-29 |
CN110650743A (en) | 2020-01-03 |
JP2020510101A (en) | 2020-04-02 |
US20200078402A1 (en) | 2020-03-12 |
JP7206227B2 (en) | 2023-01-17 |
SG10202109731YA (en) | 2021-10-28 |
IL269203A (en) | 2019-11-28 |
CA3056227A1 (en) | 2018-09-20 |
KR20190124304A (en) | 2019-11-04 |
US11744861B2 (en) | 2023-09-05 |
AU2018235756A1 (en) | 2019-10-10 |
EP3595682A1 (en) | 2020-01-22 |
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