SG11201906295RA - Method and apparatus for providing a quantitative volumetric map of an organ or an assessment of organ health - Google Patents

Abstract

WO 18/ 13 4357 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) WIP0 I PCT oimitia °nolo VIII D VIII ioo Imo oimIE (10) International Publication Number WO 2018/134357 Al 100 105 stare 110 Obtain volumetric map of liver health 115 Align volumetric map to functional liver model 120 Display graphical representation of functional liver model 125 (51) International Patent Classification: A61B 5/00 (2006.01) A61B 5/055 (2006.01) G06T 7/00 (2017.01) A61B 6/00 (2006.01) (21) International Application Number: PCT/EP2018/051321 (22) International Filing Date: 19 January 2018 (19.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1701005.9 20 January 2017 (20.01.2017) GB (71) Applicant: PERSPECTUM DIAGNOSTICS LTD [GB/GB]; Oxford Centre for Innovation, New Road, Oxford Oxfordshire OX1 1BY (GB). (72) Inventors; and (71) Applicants (for US only): KELLY, Matthew [GB/GB]; 4 Laburnum Road, Oxford Oxfordshire OX2 9EL (GB). BRADY, Michael [GB/GB]; 23 Sandfield Road, Ox- ford Oxfordshire OX3 7RN (GB). HARAMIJA, Marija [HR/GB]; 19 Nickleby House, George Row, London SE16 4UW (GB). (74) Agent: TRELEVEN, Colin; Optimus Patents Limited, Peak Hill House, Steventon, Basingstoke Hampshire RG25 3AZ (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: METHOD AND APPARATUS FOR PROVIDING A QUANTITATIVE VOLUMETRIC MAP OF AN ORGAN OR AN ASSESSMENT OF ORGAN HEALTH (57) : A method of providing a quantitative volumetric assessment of organ health or a quantitative map of an organ. The method comprises obtaining a volu- metric map of organ health comprising information defining a state of tissue health across at least part of an organ, receiving an input defining at least one organ section, determining an assessment organ volume based at least partly on the at least one de- fined organ section, calculating an organ-viability measure for the assessment organ volume based at least partly on information within the volumetric map defining the state of tissue health across the organ volume, and outputting an indication of the organ-viability measure. Receive input from user deli ing at least one liver section 130 Determine assessment liver volume 135 Calculate liver-viability measure for assessment liver volume 140 Provide Indication to user of calculated liver-viability measure Yes 150-, Output defined section(s) of liver and calculated liver-viability measure 155 End Figure 1 [Continued on next page] WO 2018/134357 Al MIDEDIMOHNOBEIE30111100111110EMERVOIS Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — with international search report (Art. 21(3))