SG11201903195YA - Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders - Google Patents
Substituted pyrido[3,4-b]indoles for the treatment of cartilage disordersInfo
- Publication number
- SG11201903195YA SG11201903195YA SG11201903195YA SG11201903195YA SG11201903195YA SG 11201903195Y A SG11201903195Y A SG 11201903195YA SG 11201903195Y A SG11201903195Y A SG 11201903195YA SG 11201903195Y A SG11201903195Y A SG 11201903195YA SG 11201903195Y A SG11201903195Y A SG 11201903195YA
- Authority
- SG
- Singapore
- Prior art keywords
- sanofi
- frankfurt
- main
- international
- aventis
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 May 2018 (11.05.2018) WIPO I PCT omit IIl °nolo OH voila° oimIE (10) International Publication Number WO 2018/083157 Al (51) International Patent Classification: CO7D 471/04 (2006.01) A61K 31/437 (2006.01) CO7D 519/00 (2006.01) A61P 19/02 (2006.01) (21) International Application Number: PCT/EP2017/078026 (22) International Filing Date: 02 November 2017 (02.11.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16306452.0 07 November 2016 (07.11.2016) EP (71) Applicant: SANOFI [FR/FR]; 54 me La Boetie, 75008 Paris (FR). (72) Inventors: GRETZKE, Dirk; c/o Sanofi-Aventis Deutsch- land GmbH, 65926 Frankfurt am Main (DE). RITZEL- ER, Olaf; c/o Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main (DE). HEINELT, Uwe; c/o Sanofi- Aventis Deutschland GmbH, 65926 Frankfurt am Main (DE). WEHNER, Volkmar; c/o Sanofi-Aventis Deutsch- land GmbH, 65926 Frankfurt am Main (DE). SCHMIDT, Friedemann; c/o Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main (DE). (74) Agent: VENNE-DUNKER, Sabine; c/o Sanofi-Aventis Deutschland GmbH, Global Intellectual Property Depart- ment, Industriepark Hochst, Geb. K 703, 65926 Frankfurt am Main (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 2 I (3)) = (54) Title: SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS 1-1 R io 1-1 00 © (57) : The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula G O (I), in which A, E, G, R 1 to R 6 and R 10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example N Joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula 0 (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them. (I)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16306452.0A EP3318563A1 (en) | 2016-11-07 | 2016-11-07 | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders |
| PCT/EP2017/078026 WO2018083157A1 (en) | 2016-11-07 | 2017-11-02 | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201903195YA true SG11201903195YA (en) | 2019-05-30 |
Family
ID=57286428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201903195YA SG11201903195YA (en) | 2016-11-07 | 2017-11-02 | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US11130755B2 (en) |
| EP (3) | EP3318563A1 (en) |
| JP (1) | JP7046063B2 (en) |
| KR (1) | KR102490199B1 (en) |
| CN (1) | CN110382496B (en) |
| AR (1) | AR110136A1 (en) |
| AU (2) | AU2017353381B2 (en) |
| BR (1) | BR112019007901A2 (en) |
| CA (1) | CA3042332A1 (en) |
| CL (1) | CL2019001251A1 (en) |
| CO (1) | CO2019005090A2 (en) |
| CR (1) | CR20190217A (en) |
| DK (1) | DK3535263T3 (en) |
| DO (1) | DOP2019000112A (en) |
| EA (1) | EA038365B1 (en) |
| EC (1) | ECSP19031458A (en) |
| ES (1) | ES2837765T3 (en) |
| HR (1) | HRP20201754T1 (en) |
| HU (1) | HUE052187T2 (en) |
| IL (1) | IL265982B (en) |
| LT (1) | LT3535263T (en) |
| MA (1) | MA45803B1 (en) |
| MX (1) | MX2019005308A (en) |
| MY (1) | MY189589A (en) |
| PE (1) | PE20191032A1 (en) |
| PH (1) | PH12019500997A1 (en) |
| PT (1) | PT3535263T (en) |
| RS (1) | RS61172B1 (en) |
| SG (1) | SG11201903195YA (en) |
| SI (1) | SI3535263T1 (en) |
| TN (1) | TN2019000143A1 (en) |
| TW (1) | TWI753966B (en) |
| UY (1) | UY37473A (en) |
| WO (1) | WO2018083157A1 (en) |
| ZA (1) | ZA201902111B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3318563A1 (en) | 2016-11-07 | 2018-05-09 | Sanofi | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders |
| US11547712B2 (en) | 2017-11-20 | 2023-01-10 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
| US11788064B2 (en) | 2018-01-05 | 2023-10-17 | Icahn School Of Medicine At Mount Sinai | Method of increasing proliferation of pancreatic beta cells, treatment method, and composition |
| CA3093340A1 (en) | 2018-03-20 | 2019-09-26 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
| US11485734B2 (en) | 2018-10-02 | 2022-11-01 | Northwestern University | Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2C (5-HT2C) |
| JP2022543460A (en) * | 2019-08-06 | 2022-10-12 | ドメイン・セラピューティクス | 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists |
| CN114763347A (en) * | 2021-01-15 | 2022-07-19 | 华东师范大学 | Compound for inducing mesenchymal stem cells to differentiate towards cartilage and application thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4631149A (en) | 1983-07-25 | 1986-12-23 | University Of Illinois | Antiviral eudistomins from a marine tunicate |
| CA2140722A1 (en) | 1994-01-24 | 1995-07-25 | Joseph A. Jakubowski | Beta-carboline thromboxane synthase inhibitors |
| ECSP951529A (en) | 1995-09-05 | 1997-05-16 | PHARMACEUTICAL COMPOUNDS | |
| EP1134221A1 (en) * | 2000-03-15 | 2001-09-19 | Aventis Pharma Deutschland GmbH | Substituted beta-carbolines as lkB kinase inhibitors |
| EP1268477B1 (en) | 2000-03-15 | 2010-04-21 | Sanofi-Aventis Deutschland GmbH | Substituted beta-carbolines with ikb-kinase inhibiting activity |
| JP4599501B2 (en) | 2001-11-07 | 2010-12-15 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | Carboline derivatives as inhibitors of IκB in the treatment of multiple myeloma and other cancers |
| FR2838123B1 (en) * | 2002-04-04 | 2005-06-10 | Sanofi Synthelabo | NOVEL SUBSTITUTED INDOLOZIN-1,2,3 DERIVATIVES, SELECTIVE B-FGF INHIBITORS |
| WO2006013739A1 (en) * | 2004-08-04 | 2006-02-09 | Konica Minolta Holdings, Inc. | Organic electroluminescent device, illuminating device and display |
| JP5815206B2 (en) | 2006-08-25 | 2015-11-17 | アレス トレーディング ソシエテ アノニム | Treatment of cartilage disorders using FGF-18 |
| WO2008132454A1 (en) | 2007-04-26 | 2008-11-06 | Ge Healthcare Limited | Carbolines and their use as imaging agents |
| WO2010038153A1 (en) | 2008-10-01 | 2010-04-08 | The University Of British Columbia | Use of sox transcription factor acti\ators for stimulating chondrogenesis |
| EP2455378A1 (en) * | 2010-11-03 | 2012-05-23 | Philip Morris Products S.A. | Carbazole and carboline derivatives, and preparation and therapeutic applications thereof |
| JP5854492B2 (en) | 2011-02-24 | 2016-02-09 | 国立大学法人 岡山大学 | Chondrocyte differentiation inducer |
| UY35809A (en) | 2013-11-05 | 2015-05-29 | Bayer Pharma AG | (AZA) PIRIDOPIRAZOLOPIRIMIDINONAS AND INDAZOLOPIRIMIDINONAS AND ITS USES |
| JP2015107945A (en) | 2013-12-05 | 2015-06-11 | 国立大学法人京都大学 | Compound and pharmaceutical composition relating to neurogenesis |
| EP3318563A1 (en) | 2016-11-07 | 2018-05-09 | Sanofi | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders |
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2016
- 2016-11-07 EP EP16306452.0A patent/EP3318563A1/en not_active Withdrawn
-
2017
- 2017-11-02 EP EP17794307.3A patent/EP3535263B1/en active Active
- 2017-11-02 SG SG11201903195YA patent/SG11201903195YA/en unknown
- 2017-11-02 RS RS20201512A patent/RS61172B1/en unknown
- 2017-11-02 BR BR112019007901A patent/BR112019007901A2/en unknown
- 2017-11-02 LT LTEP17794307.3T patent/LT3535263T/en unknown
- 2017-11-02 MY MYPI2019001925A patent/MY189589A/en unknown
- 2017-11-02 TN TNP/2019/000143A patent/TN2019000143A1/en unknown
- 2017-11-02 HU HUE17794307A patent/HUE052187T2/en unknown
- 2017-11-02 US US16/347,386 patent/US11130755B2/en active Active
- 2017-11-02 KR KR1020197016225A patent/KR102490199B1/en active IP Right Grant
- 2017-11-02 EA EA201991144A patent/EA038365B1/en unknown
- 2017-11-02 DK DK17794307.3T patent/DK3535263T3/en active
- 2017-11-02 EP EP20198613.0A patent/EP3792262A1/en active Pending
- 2017-11-02 CN CN201780081846.4A patent/CN110382496B/en active Active
- 2017-11-02 JP JP2019522912A patent/JP7046063B2/en active Active
- 2017-11-02 CA CA3042332A patent/CA3042332A1/en active Pending
- 2017-11-02 PT PT177943073T patent/PT3535263T/en unknown
- 2017-11-02 ES ES17794307T patent/ES2837765T3/en active Active
- 2017-11-02 MX MX2019005308A patent/MX2019005308A/en unknown
- 2017-11-02 AU AU2017353381A patent/AU2017353381B2/en active Active
- 2017-11-02 MA MA45803A patent/MA45803B1/en unknown
- 2017-11-02 CR CR20190217A patent/CR20190217A/en unknown
- 2017-11-02 PE PE2019000879A patent/PE20191032A1/en unknown
- 2017-11-02 SI SI201730476T patent/SI3535263T1/en unknown
- 2017-11-02 WO PCT/EP2017/078026 patent/WO2018083157A1/en unknown
- 2017-11-03 TW TW106138038A patent/TWI753966B/en active
- 2017-11-07 UY UY0001037473A patent/UY37473A/en not_active Application Discontinuation
- 2017-11-07 AR ARP170103083A patent/AR110136A1/en unknown
-
2019
- 2019-04-04 ZA ZA2019/02111A patent/ZA201902111B/en unknown
- 2019-04-11 IL IL265982A patent/IL265982B/en active IP Right Grant
- 2019-05-02 DO DO2019000112A patent/DOP2019000112A/en unknown
- 2019-05-06 PH PH12019500997A patent/PH12019500997A1/en unknown
- 2019-05-06 EC ECSENADI201931458A patent/ECSP19031458A/en unknown
- 2019-05-07 CL CL2019001251A patent/CL2019001251A1/en unknown
- 2019-05-17 CO CONC2019/0005090A patent/CO2019005090A2/en unknown
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2020
- 2020-10-30 HR HRP20201754TT patent/HRP20201754T1/en unknown
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2021
- 2021-08-23 US US17/409,513 patent/US11827633B2/en active Active
- 2021-08-24 AU AU2021221468A patent/AU2021221468B2/en active Active
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