SG11201901611YA - Methods for the identification, targeting and isolation of human dendritic cell (dc) precursors "pre-dc" and their uses thereof - Google Patents
Methods for the identification, targeting and isolation of human dendritic cell (dc) precursors "pre-dc" and their uses thereofInfo
- Publication number
- SG11201901611YA SG11201901611YA SG11201901611YA SG11201901611YA SG11201901611YA SG 11201901611Y A SG11201901611Y A SG 11201901611YA SG 11201901611Y A SG11201901611Y A SG 11201901611YA SG 11201901611Y A SG11201901611Y A SG 11201901611YA SG 11201901611Y A SG11201901611Y A SG 11201901611YA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- singapore
- methods
- identification
- disease
- Prior art date
Links
- 210000004443 dendritic cell Anatomy 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 4
- 239000002243 precursor Substances 0.000 title abstract 3
- 238000002955 isolation Methods 0.000 title abstract 2
- 230000008685 targeting Effects 0.000 title abstract 2
- 102220240796 rs553605556 Human genes 0.000 abstract 5
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 239000000090 biomarker Substances 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30 CD40 or CD95
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Developmental Biology & Embryology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 March 2018 (08.03.2018) WIPO I PCT mu °million °nolo olomomiollionoiflo ois (10) International Publication Number WO 2018/044238 Al (51) International Patent Classification: G01N 33/50 (2006.01) A61P 31/12 (2006.01) G01N 33/68 (2006.01) A61P 3/04 (2006.01) G01N 33/564 (2006.01) A61P 29/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61K 35/15 (2015.01) A61P 37/00 (2006.01) (21) International Application Number: PCT/SG2017/050435 (22) International Filing Date: Immunology Network, 8A Biomedical Grove, #04-06 Im- munos, Singapore 138648 (SG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 31 August 2017 (31.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201607246S 31 August 2016 (31.08.2016) SG 10201703621Q 03 May 2017 (03.05.2017) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). = (72) Inventors: GINHOUX, Florent; c/o Singapore Immunol- ogy Network, 8A Biomedical Grove, #04-06 Immunos, Sin- gapore 138648 (SG). SEE, Chi Ee Peter; c/o Singapore (54) Title: METHODS FOR THE IDENTIFICATION, TARGETING AND ISOLATION OF HUMAN DENDRITIC CELL (DC) PRECURSORS \"PRE-DC\" AND THEIR USES THEREOF FIG. 31 (57) : Biomarkers for the detection and identification of a pre- cursor of conventional dendritic cell (cDC) (pre-DC) and its cell sub- sets (pre-cDC1 or pre-cDC2), are defined, which include CD169, CD327, AXL, CD271, CD324 and combinations thereof for detecting pre-DCs. Methods for detecting a disease or condition, prognosis of an existing disease or condition comprising determining the number of pre-DC cells in sample from a subject as compared to control, as well as methods of treating a patient comprising administration of antibodies against CD169, CD327, AXL, CD271, CD324 and combinations thereof are also dis- closed. In addition, an immunogenic composition comprising one or more binding molecules specific for one or more biomarkers or antigen of a target disease and/or one or more cells selected from the group consisting of early pre-DC, pre-cDC1 and pre-cDC2 are also disclosed for eliciting an immune response against an infectious disease or cancer. W O 20 18/0 44238 Al [Continued on next page] WO 2018/044238 Al MIDEDIMOMMIDIRMOINNHOEHOMMOMEEM TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SG10201607246S | 2016-08-31 | ||
SG10201703621Q | 2017-05-03 | ||
PCT/SG2017/050435 WO2018044238A1 (en) | 2016-08-31 | 2017-08-31 | Methods for the identification, targeting and isolation of human dendritic cell (dc) precursors "pre-dc" and their uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201901611YA true SG11201901611YA (en) | 2019-03-28 |
Family
ID=61309054
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201901611YA SG11201901611YA (en) | 2016-08-31 | 2017-08-31 | Methods for the identification, targeting and isolation of human dendritic cell (dc) precursors "pre-dc" and their uses thereof |
SG10202101958YA SG10202101958YA (en) | 2016-08-31 | 2017-08-31 | Methods for the identification, targeting and isolation of human dendritic cell (dc) precursors "pre-dc" and their uses thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202101958YA SG10202101958YA (en) | 2016-08-31 | 2017-08-31 | Methods for the identification, targeting and isolation of human dendritic cell (dc) precursors "pre-dc" and their uses thereof |
Country Status (5)
Country | Link |
---|---|
US (1) | US11249081B2 (en) |
EP (1) | EP3507601B1 (en) |
CN (1) | CN109906381B (en) |
SG (2) | SG11201901611YA (en) |
WO (1) | WO2018044238A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2020005128A (en) * | 2017-11-17 | 2020-07-27 | Merck Sharp & Dohme | Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof. |
CN110389221B (en) * | 2019-08-30 | 2021-03-16 | 广州中科蓝华生物科技有限公司 | Combined formula kit for analyzing phenotype and function of CD1c + dendritic cell subset and application thereof |
CN110922478B (en) * | 2019-12-07 | 2021-07-30 | 中国人民解放军军事科学院军事医学研究院 | Fully human monoclonal antibody against chikungunya fever and application thereof |
CN113218848B (en) * | 2021-04-30 | 2022-08-12 | 天津深析智能科技发展有限公司 | Method for judging non-specific cell population |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050013810A1 (en) | 2001-05-08 | 2005-01-20 | Waller Edmund K | Regulating immune response using dendritic cells |
WO2005124358A2 (en) | 2004-06-09 | 2005-12-29 | Tanox, Inc. | Diagnosis and treatment of siglec-6 associated diseases |
CN101035807A (en) | 2004-06-09 | 2007-09-12 | 泰勒公司 | Diagnosis and treatment of SIGLEC-6 associated diseases |
TW201204388A (en) * | 2010-06-18 | 2012-02-01 | Genentech Inc | Anti-Axl antibodies and methods of use |
SG10201506959SA (en) | 2010-09-03 | 2015-10-29 | Stemcentrx Inc | Novel modulators and methods of use |
GB201104469D0 (en) * | 2011-03-17 | 2011-04-27 | Univ Gent | Control of phagocytosis |
US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
EP2606897A1 (en) | 2011-12-22 | 2013-06-26 | Laboratorios Del. Dr. Esteve, S.A. | Methods and compositions for the treatment of diseases caused by enveloped viruses |
EP2950095B1 (en) | 2014-05-28 | 2018-08-29 | Technische Universität Dresden | Cell-based assay and screening methods for modulators of p75NTR signaling |
AU2015286569B2 (en) * | 2014-07-11 | 2021-04-15 | Genmab A/S | Antibodies binding AXL |
KR102659538B1 (en) * | 2014-09-28 | 2024-04-22 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | Modulation of stimulatory and non-stimulatory myeloid cells |
EP3256850A4 (en) * | 2015-02-09 | 2018-10-10 | Slingshot Biosciences, Inc. | Hydrogel particles with tunable optical properties and methods for using the same |
US11630103B2 (en) * | 2016-08-17 | 2023-04-18 | The Broad Institute, Inc. | Product and methods useful for modulating and evaluating immune responses |
-
2017
- 2017-08-31 SG SG11201901611YA patent/SG11201901611YA/en unknown
- 2017-08-31 WO PCT/SG2017/050435 patent/WO2018044238A1/en active Search and Examination
- 2017-08-31 SG SG10202101958YA patent/SG10202101958YA/en unknown
- 2017-08-31 CN CN201780066143.4A patent/CN109906381B/en active Active
- 2017-08-31 EP EP17847100.9A patent/EP3507601B1/en active Active
- 2017-08-31 US US16/329,751 patent/US11249081B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3507601B1 (en) | 2023-08-16 |
EP3507601A1 (en) | 2019-07-10 |
US11249081B2 (en) | 2022-02-15 |
US20190324038A1 (en) | 2019-10-24 |
CN109906381A (en) | 2019-06-18 |
EP3507601A4 (en) | 2020-08-05 |
SG10202101958YA (en) | 2021-03-30 |
WO2018044238A1 (en) | 2018-03-08 |
CN109906381B (en) | 2023-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201809879WA (en) | Novel antibodies specifically binding to zika virus epitopes and uses thereof | |
SG11201809913PA (en) | Methods for detecting target nucleic acids in a sample | |
SG11201908396PA (en) | Methods of treating tumor | |
SG11201807334SA (en) | Methods, compositions, and devices for information storage | |
SG11201901126UA (en) | Combination therapy for cancer | |
SG11201803703UA (en) | Anti-complement factor c1q fab fragments and uses thereof | |
SG11201901834WA (en) | Micrornas as biomarkers for endometriosis | |
SG11201809344QA (en) | Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde | |
SG11201901371XA (en) | Methods for the detection of genomic copy changes in dna samples | |
SG11201901611YA (en) | Methods for the identification, targeting and isolation of human dendritic cell (dc) precursors "pre-dc" and their uses thereof | |
SG11201407580YA (en) | Composition comprising two antibodies engineered to have reduced and increased effector function | |
SG11201903771XA (en) | Binding molecules specific for asct2 and uses thereof | |
SG11201900442PA (en) | Sorting of t lymphocytes in a microfluidic device | |
SG11201408385TA (en) | Methods of detecting diseases or conditions | |
SG11201408780XA (en) | Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof | |
SG11201811408PA (en) | Adoptive cell transfer and oncolytic virus combination therapy | |
SG11201901597UA (en) | Macrophage stimulating protein receptor (or ron - recepteur d' origine nantais) antibodies and uses thereof | |
SG11201809996QA (en) | Ribonucleic acid (rna) interactions | |
SG11201808573YA (en) | Nucleic acid stabilization reagent, kits, and methods of use thereof | |
SG11201806946VA (en) | Epigenomic profiling reveals the somatic promoter landscape of primary gastric adenocarcinoma | |
SG11201908767QA (en) | Method for accurate diagnosis of a disease targeting biomarkers in liquid biopsy | |
SG11201408434QA (en) | Targeted rna-seq methods and materials for the diagnosis of prostate cancer | |
SG11201910195WA (en) | Methods for trapping and barcoding discrete biological units in hydrogel | |
SG11201807596YA (en) | Gitr antibodies, methods, and uses | |
SG11201910206QA (en) | Methods and compositions for treating inflammatory gastrointestinal disorders |