SG11201811493UA - Crystal of amino acid salt of 3-hydroxyisovaleric acid and production method thereof - Google Patents
Crystal of amino acid salt of 3-hydroxyisovaleric acid and production method thereofInfo
- Publication number
- SG11201811493UA SG11201811493UA SG11201811493UA SG11201811493UA SG11201811493UA SG 11201811493U A SG11201811493U A SG 11201811493UA SG 11201811493U A SG11201811493U A SG 11201811493UA SG 11201811493U A SG11201811493U A SG 11201811493UA SG 11201811493U A SG11201811493U A SG 11201811493UA
- Authority
- SG
- Singapore
- Prior art keywords
- amino acid
- acid salt
- crystal
- hmb
- production method
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/06—Purification or separation of guanidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016125280 | 2016-06-24 | ||
| PCT/JP2017/023174 WO2017222043A1 (fr) | 2016-06-24 | 2017-06-23 | Cristal de sel d'acide aminé d'acide β-hydroxy β-méthylbutyrique et son procédé de production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201811493UA true SG11201811493UA (en) | 2019-01-30 |
Family
ID=60784321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201811493UA SG11201811493UA (en) | 2016-06-24 | 2017-06-23 | Crystal of amino acid salt of 3-hydroxyisovaleric acid and production method thereof |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11098007B2 (fr) |
| EP (1) | EP3476825A4 (fr) |
| JP (1) | JP7144320B2 (fr) |
| KR (1) | KR20190028441A (fr) |
| CN (1) | CN109476578A (fr) |
| AU (1) | AU2017282515A1 (fr) |
| CA (1) | CA3028608A1 (fr) |
| PH (1) | PH12018502693A1 (fr) |
| RU (1) | RU2018145506A (fr) |
| SG (1) | SG11201811493UA (fr) |
| WO (1) | WO2017222043A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10647653B2 (en) | 2015-11-19 | 2020-05-12 | Kyowa Hakko Bio Co., Ltd. | Crystal of monovalent cation salt of 3-hydroxyisovaleric acid and process for producing the crystal |
| CN108558707A (zh) * | 2018-04-13 | 2018-09-21 | 太仓运通新材料科技有限公司 | 一种三肌酸hmb盐的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57128653A (en) * | 1981-02-03 | 1982-08-10 | Mitsubishi Gas Chem Co Inc | Preparation of alpha-oxyisobutyric acid |
| FR2521857B1 (fr) | 1982-02-23 | 1985-10-31 | Solvay | Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee |
| AU673002B2 (en) | 1992-09-16 | 1996-10-24 | Iowa State University Research Foundation Inc. | Method of reducing blood levels of total cholesterol and low-density lipoprotein cholesterol |
| US6090978A (en) | 1996-07-19 | 2000-07-18 | Met-Rx Usa, Inc. | Process for manufacturing 3-hydroxy-3-methylbutanoic acid |
| US6031000A (en) | 1998-06-23 | 2000-02-29 | Iowa State University Research Foundation, Inc. | Composition comprising β-hydroxy-β-methylbutyric acid and at least one amino acid and methods of use |
| DE10032017A1 (de) | 2000-07-01 | 2002-01-10 | Clariant Gmbh | Verfahren zur Herstellung hochreiner Formylphenylboronsäuren |
| US7026507B2 (en) | 2001-05-18 | 2006-04-11 | Lonza Ag | Method for the production of solid formulations of sodium 3-hydroxy-3-methylbutyrate |
| CN1216037C (zh) * | 2003-02-21 | 2005-08-24 | 华东师范大学 | 3－羟基－3－甲基丁酸（hmb）氨基酸盐制备方法 |
| US6812249B2 (en) | 2003-03-04 | 2004-11-02 | Sal Abraham | Process for preparing a 3-hydroxy-3-methylbutyrate amino acid salt and method of use |
| MX355742B (es) | 2011-02-14 | 2018-04-26 | Concert Pharmaceuticals Inc | Análogos deuterados del ácido 4-hidroxibutírico. |
| CN103857390A (zh) | 2011-08-15 | 2014-06-11 | 雅培制药有限公司 | 用于制备hmb及其盐的方法 |
| CN104098461B (zh) | 2013-04-12 | 2017-06-16 | 江阴技源药业有限公司 | 一种β‑羟基‑β‑甲基丁酸的纯化方法 |
| JP2015028006A (ja) | 2013-06-27 | 2015-02-12 | 日産化学工業株式会社 | イソキサゾリン化合物の結晶性多形体およびその製造方法 |
| JP6431375B2 (ja) | 2015-01-06 | 2018-11-28 | 日精株式会社 | 循環式駐車装置 |
| US10647653B2 (en) | 2015-11-19 | 2020-05-12 | Kyowa Hakko Bio Co., Ltd. | Crystal of monovalent cation salt of 3-hydroxyisovaleric acid and process for producing the crystal |
-
2017
- 2017-06-23 RU RU2018145506A patent/RU2018145506A/ru not_active Application Discontinuation
- 2017-06-23 WO PCT/JP2017/023174 patent/WO2017222043A1/fr unknown
- 2017-06-23 US US16/311,061 patent/US11098007B2/en active Active
- 2017-06-23 SG SG11201811493UA patent/SG11201811493UA/en unknown
- 2017-06-23 CA CA3028608A patent/CA3028608A1/fr not_active Abandoned
- 2017-06-23 KR KR1020197001526A patent/KR20190028441A/ko unknown
- 2017-06-23 AU AU2017282515A patent/AU2017282515A1/en not_active Abandoned
- 2017-06-23 JP JP2018524179A patent/JP7144320B2/ja active Active
- 2017-06-23 EP EP17815508.1A patent/EP3476825A4/fr active Pending
- 2017-06-23 CN CN201780038774.5A patent/CN109476578A/zh active Pending
-
2018
- 2018-12-19 PH PH12018502693A patent/PH12018502693A1/en unknown
-
2021
- 2021-03-03 US US17/190,981 patent/US20210261493A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20190210958A1 (en) | 2019-07-11 |
| WO2017222043A1 (fr) | 2017-12-28 |
| US11098007B2 (en) | 2021-08-24 |
| RU2018145506A (ru) | 2020-07-27 |
| JP7144320B2 (ja) | 2022-09-29 |
| JPWO2017222043A1 (ja) | 2019-06-20 |
| CN109476578A (zh) | 2019-03-15 |
| CA3028608A1 (fr) | 2017-12-28 |
| EP3476825A1 (fr) | 2019-05-01 |
| AU2017282515A1 (en) | 2019-01-17 |
| PH12018502693A1 (en) | 2019-10-14 |
| EP3476825A4 (fr) | 2020-02-26 |
| US20210261493A1 (en) | 2021-08-26 |
| KR20190028441A (ko) | 2019-03-18 |
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