SG11201811440QA - Apparatus and method for detecting cells or particles in a fluid container - Google Patents

Apparatus and method for detecting cells or particles in a fluid container

Info

Publication number
SG11201811440QA
SG11201811440QA SG11201811440QA SG11201811440QA SG11201811440QA SG 11201811440Q A SG11201811440Q A SG 11201811440QA SG 11201811440Q A SG11201811440Q A SG 11201811440QA SG 11201811440Q A SG11201811440Q A SG 11201811440QA SG 11201811440Q A SG11201811440Q A SG 11201811440QA
Authority
SG
Singapore
Prior art keywords
international
fluid
sub
fluid container
freiburg
Prior art date
Application number
SG11201811440QA
Inventor
Jonas Schöndube
Andre Gross
Original Assignee
Cytena Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytena Gmbh filed Critical Cytena Gmbh
Publication of SG11201811440QA publication Critical patent/SG11201811440QA/en

Links

Classifications

    • G01N15/1433—
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1425—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its control arrangement
    • G01N15/1427—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its control arrangement with the synchronisation of components, a time gate for operation of components, or suppression of particle coincidences
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111011111111111111111111111111111111111111011111100111111101111111111011111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/220509 Al 28 December 2017 (28.12.2017) WI P0 I PC T (51) International Patent Classification: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, G01N 35/10 (2006.01) GO1N 15/10 (2006.01) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (21) International Application Number: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, PCT/EP2017/064969 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (22) International Filing Date: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 19 June 2017 (19.06.2017) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (30) Priority Data: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 10 2016 211 038.1 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 21 June 2016 (21.06.2016) DE EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (71) Applicant: CYTENA GMBH [DE/DE]; Georges- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Koehler-Allee 103, 79110 Freiburg (DE). KM, ML, MR, NE, SN, TD, TG). (72) Inventors: SCHONDUBE, Jonas; Niemensstrasse 11, 79098 Freiburg (DE). GROSS, Andre; SautierstraBe 67, Published: 79104 Freiburg (DE). — with international search report (Art. 21(3)) (74) Agent: STOCKELER, Ferdinand et al.; Schoppe, Zim- mermann, Stockeler, Zinkler, Schenk & Partner mbB, - = Radlkoferstr. 2, 81373 Mfichen (DE). (81) Designated States (unless otherwise indicated, for every = _ kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = = (54) Title: APPARATUS AND METHOD FOR DETECTING CELLS OR PARTICLES IN A FLUID CONTAINER = = 14 ( (57) : A apparatus for detecting cells or particles in a fluid container comprises a dispenser configured to dispense at least one cell or at least one particle into a defmed sub-volume of a fluid with which the fluid container is at least partially filled, and a detection apparatus configured to, in a time- coordinated manner with dispensing the at least one cell or the at least one 1 particle by the dispenser, perform a detection in the defmed sub-volume and/ or in one or several sub-volumes underneath the defmed sub-volume in order to sense the at least one cell or the at least one particle when entering the fluid — = = = = = = — = 20 or immediately after entering the fluid. i = = 12 ( = = I 10— 18 24----1 r — 1-1 C:r © kr) .._; 0 ei ei IN 1-1 ! 22 0 ei Fig. 1 O
SG11201811440QA 2016-06-21 2017-06-19 Apparatus and method for detecting cells or particles in a fluid container SG11201811440QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102016211038.1A DE102016211038A1 (en) 2016-06-21 2016-06-21 Apparatus and method for detecting cells or particles in a fluid container
PCT/EP2017/064969 WO2017220509A1 (en) 2016-06-21 2017-06-19 Apparatus and method for detecting cells or particles in a fluid container

Publications (1)

Publication Number Publication Date
SG11201811440QA true SG11201811440QA (en) 2019-01-30

Family

ID=59093412

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201811440QA SG11201811440QA (en) 2016-06-21 2017-06-19 Apparatus and method for detecting cells or particles in a fluid container

Country Status (13)

Country Link
US (2) US11112346B2 (en)
EP (3) EP3751290A1 (en)
JP (1) JP6795628B2 (en)
KR (1) KR102216684B1 (en)
CN (1) CN109642913B (en)
AU (1) AU2017283128B2 (en)
CA (1) CA3028538C (en)
DE (3) DE102016211038A1 (en)
DK (1) DK3472627T3 (en)
ES (1) ES2813563T3 (en)
IL (1) IL263844B (en)
SG (1) SG11201811440QA (en)
WO (1) WO2017220509A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017009804A1 (en) * 2017-10-20 2019-04-25 Vermicon Ag Method for evaluating microscopic samples and apparatus for carrying out this method
LU100778B1 (en) 2018-04-23 2019-10-23 Cytena Gmbh Dispensing device with a dispenser for dispensing a liquid containing at least one cell and / or at least one particle
LU100777B1 (en) * 2018-04-23 2019-10-23 Cytena Gmbh A method of assaying a liquid containing at least one cell and / or at least one particle
US20230028492A1 (en) * 2021-07-20 2023-01-26 Cytena Gmbh Method for detecting a particle in a container filled with liquid
LU501093B1 (en) 2021-12-27 2023-06-27 Cytena Gmbh Method for determining a lower interface and/or an upper interface of a liquid in a container

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Also Published As

Publication number Publication date
DE202017003180U1 (en) 2017-07-12
CN109642913B (en) 2023-03-14
US20210364414A1 (en) 2021-11-25
CA3028538A1 (en) 2017-12-28
WO2017220509A1 (en) 2017-12-28
JP6795628B2 (en) 2020-12-02
DK3472627T3 (en) 2020-08-31
IL263844B (en) 2022-04-01
IL263844A (en) 2019-01-31
KR20190038792A (en) 2019-04-09
CA3028538C (en) 2021-07-20
US20170363534A1 (en) 2017-12-21
US11112346B2 (en) 2021-09-07
US11946853B2 (en) 2024-04-02
EP3260870A1 (en) 2017-12-27
EP3472627B1 (en) 2020-06-03
AU2017283128B2 (en) 2020-02-06
EP3751290A1 (en) 2020-12-16
CN109642913A (en) 2019-04-16
DE102016211038A1 (en) 2017-12-21
JP2019522480A (en) 2019-08-15
AU2017283128A1 (en) 2019-01-24
KR102216684B1 (en) 2021-02-17
ES2813563T3 (en) 2021-03-24
DE202017003181U1 (en) 2017-07-12
EP3472627A1 (en) 2019-04-24

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