SG11201810323RA - Pharmaceutical formulation - Google Patents

Pharmaceutical formulation

Info

Publication number
SG11201810323RA
SG11201810323RA SG11201810323RA SG11201810323RA SG11201810323RA SG 11201810323R A SG11201810323R A SG 11201810323RA SG 11201810323R A SG11201810323R A SG 11201810323RA SG 11201810323R A SG11201810323R A SG 11201810323RA SG 11201810323R A SG11201810323R A SG 11201810323RA
Authority
SG
Singapore
Prior art keywords
international
pheny1
manchester
lankro
obh
Prior art date
Application number
SG11201810323RA
Inventor
Derek Law
Graham Edward Morris Sibley
Original Assignee
F2G Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F2G Ltd filed Critical F2G Ltd
Publication of SG11201810323RA publication Critical patent/SG11201810323RA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111 010111010 11111 0 01 010 11111 001 010 1110 110 111110 1111 0111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/203270 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: A61K 31/506 (2006.01) A61P 31/10 (2006.01) A61K 9/16 (2006.01) (21) International Application Number: PCT/GB2017/051494 (22) International Filing Date: 25 May 2017 (25.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1609222.3 25 May 2016 (25.05.2016) GB (71) Applicant: F2G LIMITED [GB/GB]; Lankro Way, Ec- cles, Manchester Greater Manchester M30 OBH (GB). (72) Inventors: LAW, Derek; c/o F2G Limited, P 0 Box 1, Lankro Way, Manchester M30 OBH (GB). SIBLEY, Gra- ham Edward Morris; c/o F2G Limited, P 0 Box 1, Lankro Way, Manchester M30 OBH (GB). Agent: SIMONS, Amanda Louise; 14 South Square, Gray's Inn, London Greater London WC1R 5JJ (GB). (74) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (84) Published: ,- 1 — with international search report (Art. 21(3)) © IN ei O © (54) Title: PHARMACEUTICAL FORMULATION ei ---- (57) : A pharmaceutical composition suitable for oral administration comprising particles of 2-(1,5-dimethy1-3-pheny1-1H- IN pyrrol-2-y1)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin- 1 -yl)pheny1)-2-oxoacetamide is provided. Also provided is a pharmaceutical 0 composition suitable for parenteral administration wherein the composition comprises 2-(1,5-dimethyl- 3-pheny1-1H-pyrrol-2-y1)-N- e •1 (4-(4-(5-fluoropyrimidin-2-yl)piperazin- 1 -yl)pheny1)-2-oxoacetamide. The compositions are useful in the treatment of fungal infection 0 in a subject in need thereof.
SG11201810323RA 2016-05-25 2017-05-25 Pharmaceutical formulation SG11201810323RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1609222.3A GB201609222D0 (en) 2016-05-25 2016-05-25 Pharmaceutical formulation
PCT/GB2017/051494 WO2017203270A1 (en) 2016-05-25 2017-05-25 Pharmaceutical formulation

Publications (1)

Publication Number Publication Date
SG11201810323RA true SG11201810323RA (en) 2018-12-28

Family

ID=56369959

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201810323RA SG11201810323RA (en) 2016-05-25 2017-05-25 Pharmaceutical formulation

Country Status (26)

Country Link
US (2) US10973821B2 (en)
EP (1) EP3463365B1 (en)
JP (1) JP7141108B2 (en)
KR (1) KR102464150B1 (en)
CN (1) CN109982704B (en)
AU (1) AU2017270942B2 (en)
BR (1) BR112018074162A2 (en)
CA (1) CA3024771A1 (en)
CY (1) CY1124733T1 (en)
DK (1) DK3463365T3 (en)
ES (1) ES2888951T3 (en)
GB (1) GB201609222D0 (en)
HR (1) HRP20211795T1 (en)
HU (1) HUE056129T2 (en)
IL (1) IL263167B (en)
LT (1) LT3463365T (en)
MA (1) MA45126A (en)
MX (1) MX2018014232A (en)
MY (1) MY197663A (en)
PL (1) PL3463365T3 (en)
PT (1) PT3463365T (en)
RU (1) RU2760681C2 (en)
SG (1) SG11201810323RA (en)
SI (1) SI3463365T1 (en)
WO (1) WO2017203270A1 (en)
ZA (1) ZA201807851B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201609222D0 (en) * 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection
CN113429396A (en) * 2021-06-08 2021-09-24 深圳市祥根生物医药有限公司 Five-membered heteroaromatic ring derivative and preparation method and application thereof

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1051723A (en) 1962-04-27
US3202654A (en) 1962-04-27 1965-08-24 Bristol Myers Co 6-[alpha-hydroxy-and alpha-amino-alpha-pyrrolylacetamido] penicillanic acids and salts thereof
US3252970A (en) 1963-02-27 1966-05-24 Ciba Geigy Corp Aromatization
BE631632A (en) 1963-04-26
US3268558A (en) 1964-11-05 1966-08-23 Ortho Pharma Corp 1-r-2, 4-dinitropyrroles
US3458515A (en) 1966-07-21 1969-07-29 American Home Prod Piperazine substituted pyrroles
GB1208014A (en) 1967-03-23 1970-10-07 Glaxo Lab Ltd Cephalosporins
US3573294A (en) 1968-03-14 1971-03-30 Glaxo Lab Ltd 7 - (arylglyoxamido)cephalosporanic acids and their salts and alpha-carbonyl derivatives
BE790747A (en) 1971-10-30 1973-02-15 Whitefin Holding Sa 1- (1 '- (0-CHLORO-BENZYL) -PYRROL-2'-YL) -2-DIBUTYL SEC.-AMINO-ETHANOL STEREO-ISOMERS AND PROCESS FOR THEIR PREPARATION
GB1476503A (en) 1973-06-21 1977-06-16 Sterling Drug Inc 1-arylamino-and 1-arylimino-pyrroles and preparation thereof
BE848465A (en) 1976-11-18 1977-03-16 1- (1'-BENZYL-2 'PYRRYL) -2-DISEC.BUTYLAMINOETHANOLS STEREO-ISOMERS WITH ANALGESIC ACTIVITY AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
US4316900A (en) 1977-10-05 1982-02-23 Ciba-Geigy Corporation Piperazinopyrrolobenzodiazepines
JPS57142966A (en) 1981-02-27 1982-09-03 Sagami Chem Res Center (1-alkyl-2-pyrrolyl)glyoxylic acid amide derivative
JPS57144255A (en) 1981-03-03 1982-09-06 Sagami Chem Res Center Alpha-methylthio(1-alkyl-2-pyrrolyl)acetamide derivative
US4761424A (en) 1985-10-01 1988-08-02 Warner-Lambert Company Enolamides, pharmaceutical compositions and methods for treating inflammation
FR2601368B1 (en) 1986-07-08 1989-04-07 Synthelabo NITROFURAN DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
US5637592A (en) 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
US6645976B1 (en) 1994-07-21 2003-11-11 Eli Lilly And Company Indolizine SPLA2inhibitors
WO1996033973A1 (en) 1995-04-28 1996-10-31 Banyu Pharmaceutical Co., Ltd. 1,4-disubstituted piperidine derivatives
EP0747756B1 (en) 1995-06-06 2000-05-24 Agfa-Gevaert N.V. Photographic materials
JPH09249669A (en) 1996-03-13 1997-09-22 Ono Pharmaceut Co Ltd Condensed pyrrole derivatives, and medicines containing the derivatives as active ingredients
AU750207B2 (en) 1997-06-13 2002-07-11 Cydex Pharmaceuticals, Inc. Polar drug or prodrug compositions with extended shelf-life storage and a method of making thereof
DK0901786T3 (en) 1997-08-11 2007-10-08 Pfizer Prod Inc Solid pharmaceutical dispersions with increased bioavailability
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
CA2333963C (en) 1998-06-03 2010-02-02 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of n-heterocyclic compounds
ES2310164T3 (en) 1999-02-10 2009-01-01 Pfizer Products Inc. LIBERATION DEVICE CONTROLLED BY THE MATRIX.
ID30409A (en) 1999-05-04 2001-11-29 Jannsen Pharmaceutica N V ETER ANTI MUSHROOM
WO2001008572A1 (en) 1999-07-30 2001-02-08 Norbert Heske Cannula system for introducing endoscopic tools in a human or animal body
JP2003518485A (en) 1999-12-23 2003-06-10 ファイザー・プロダクツ・インク Pharmaceutical composition giving improved drug concentration
GB0011089D0 (en) 2000-05-08 2000-06-28 Black James Foundation Gastrin and cholecystokinin receptor ligands (11)
US7202239B2 (en) 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US6825201B2 (en) 2001-04-25 2004-11-30 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic amidopiperazine derivatives
WO2002098876A1 (en) 2001-06-06 2002-12-12 Vertex Pharmaceuticals Incorporated Cak inhibitors and uses thereof
WO2003000680A1 (en) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
CN1309370C (en) 2002-02-01 2007-04-11 辉瑞产品公司 Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus
KR100758045B1 (en) 2002-02-01 2007-09-11 화이자 프로덕츠 인크. Method for Making Homogeneous Spray-dried Solid Amorphous Drug Dispersions Using Pressure Nozzles
EP1476163A4 (en) 2002-02-23 2009-05-27 Bristol Myers Squibb Co Method of treating hiv infection by preventing interaction of cd4 and gp120
JP2006500387A (en) 2002-08-15 2006-01-05 雲清 劉 Solid nanomedicine and preparation method thereof
US20050032871A1 (en) 2002-09-03 2005-02-10 Sugen, Inc. Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors
JP2006520385A (en) 2003-03-13 2006-09-07 シンタ ファーマスーティカルズ コーポレイション Condensed pyrrole compounds
FR2854079B1 (en) 2003-04-25 2007-11-30 Pf Medicament PROCESS FOR THE PREPARATION OF MOLECULAR COMPLEXES
CL2004001884A1 (en) 2003-08-04 2005-06-03 Pfizer Prod Inc DRYING PROCEDURE FOR SPRAYING FOR THE FORMATION OF SOLID DISPERSIONS AMORPHES OF A PHARMACO AND POLYMERS.
CA2541460A1 (en) 2003-10-24 2005-05-06 Schering Aktiengesellschaft Indolinone derivatives and their use in treating disease-states such as cancer
WO2005115330A2 (en) 2004-05-28 2005-12-08 Pfizer Products Inc. Pharmaceutical compositions with enhanced performance
US20060058286A1 (en) 2004-09-16 2006-03-16 Mark Krystal Methods of treating HIV infection
EP1844078B1 (en) 2005-02-03 2016-09-28 Bend Research, Inc Pharmaceutical compositions with enhanced performance
MX2007012234A (en) 2005-03-31 2008-03-18 Johnson & Johnson Bicyclic pyrazole compounds as antibacterial agents.
AR053713A1 (en) 2005-04-20 2007-05-16 Xenon Pharmaceuticals Inc HETEROCICLICAL COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS
ATE420639T1 (en) 2005-05-18 2009-01-15 F2G Ltd ANTIFUNGAL AGENTS
US20090176837A1 (en) 2005-07-12 2009-07-09 Sony Corporation Compounds with activity at retinoic acid receptors
WO2007015866A2 (en) 2005-07-20 2007-02-08 Kalypsys, Inc. Inhibitors of p38 kinase and methods of treating inflammatory disorders
EA018811B1 (en) 2006-03-20 2013-10-30 Вертекс Фармасьютикалз Инкорпорейтед Processes for preparing a solid dispersion of a drug and solid dispersions of a drug prepared thereby
US8343548B2 (en) 2006-08-08 2013-01-01 Shin-Etsu Chemical Co., Ltd. Solid dosage form comprising solid dispersion
US20080118500A1 (en) 2006-11-16 2008-05-22 Taiwan Liposome Company Sustained releasing composition via local injection for treating eye diseases
GB0623209D0 (en) 2006-11-21 2007-01-03 F2G Ltd Antifungal agents
EP2125938A2 (en) 2007-01-26 2009-12-02 Isp Investments Inc. Formulation process method to produce spray dried products
CN101260086B (en) 2007-03-06 2011-08-10 中国科学院上海药物研究所 Protein-tyrosine-phosphatase 1B inhibitor and its preparation method and use
GB0710121D0 (en) 2007-05-25 2007-07-04 F2G Ltd Antifungal agents
US20100215747A1 (en) 2007-07-13 2010-08-26 Corey Jay Bloom Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
EP2283006B1 (en) * 2008-04-24 2015-02-25 F2G Limited Pyrrole antifungal agents
GB0809773D0 (en) 2008-05-29 2008-07-09 F2G Ltd Antifungal combination therapy
US20100093872A1 (en) 2008-10-15 2010-04-15 Erimos Pharmaceuticals Llc Stable aqueous formulations of water insoluble or poorly soluble drugs
MX2011011290A (en) 2009-04-28 2012-02-13 Boehringer Ingelheim Int Ex-vivo treatment of immunological disorders with pkc-theta inhibitors.
MX2012014849A (en) 2010-06-14 2013-05-01 Dow Global Technologies Llc Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution.
US9084976B2 (en) 2010-09-03 2015-07-21 Bend Research, Inc. Spray-drying apparatus and methods of using the same
WO2012060448A1 (en) 2010-11-05 2012-05-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 Combined pharmaceutical composition as antifungal agent
CN102805733B (en) 2011-06-01 2016-03-09 日东电工株式会社 Granular preparation and manufacture method thereof
SG10201506273PA (en) 2011-11-29 2015-09-29 Jurox Pty Ltd Methods of preserving injectable pharmaceutical compositions comprising a cyclodextrin and a hydrophobic drug
KR20140146181A (en) 2012-04-11 2014-12-24 다우 글로벌 테크놀로지스 엘엘씨 Esterified cellulose ethers having a specific substituent distribution
WO2014031422A1 (en) 2012-08-24 2014-02-27 Dow Global Technologies Llc Novel hydroxyalkyl methyl cellulose acetate succinates
US9745387B2 (en) 2012-08-24 2017-08-29 Dow Global Technologies Llc Partially cross-linked esterified cellulose ethers
MY192032A (en) 2013-01-22 2022-07-24 Hoffmann La Roche Pharmaceutical composition with improved bioavailability
KR102455648B1 (en) 2013-07-19 2022-10-19 베링거잉겔하임베트메디카게엠베하 Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
WO2015007759A1 (en) 2013-07-19 2015-01-22 Boehringer Ingelheim Vetmedica Gmbh Etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
US20160303102A1 (en) 2013-12-05 2016-10-20 Alrise Biosystems Gmbh Process for the production of drug formulations for oral administration
PT107568B (en) 2014-03-31 2018-11-05 Hovione Farm S A ATOMIZATION DRYING PROCESS FOR PRODUCTION OF POWDER WITH IMPROVED PROPERTIES.
ES2694637T3 (en) * 2014-11-21 2018-12-26 F2G Limited Antifungal agents
GB201609222D0 (en) * 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation

Also Published As

Publication number Publication date
MA45126A (en) 2021-04-14
WO2017203270A1 (en) 2017-11-30
US20190328737A1 (en) 2019-10-31
GB201609222D0 (en) 2016-07-06
DK3463365T3 (en) 2021-09-20
BR112018074162A2 (en) 2019-03-06
EP3463365B1 (en) 2021-08-25
AU2017270942A1 (en) 2018-12-06
JP7141108B2 (en) 2022-09-22
KR102464150B1 (en) 2022-11-07
PL3463365T3 (en) 2022-01-10
RU2018142381A (en) 2020-06-25
JP2019516765A (en) 2019-06-20
ES2888951T3 (en) 2022-01-10
KR20190013865A (en) 2019-02-11
PT3463365T (en) 2021-09-28
RU2018142381A3 (en) 2020-09-30
ZA201807851B (en) 2022-04-28
CY1124733T1 (en) 2022-07-22
CN109982704B (en) 2023-10-24
AU2017270942B2 (en) 2022-07-21
RU2760681C2 (en) 2021-11-29
CA3024771A1 (en) 2017-11-30
EP3463365A1 (en) 2019-04-10
US20210186967A1 (en) 2021-06-24
IL263167A (en) 2018-12-31
MY197663A (en) 2023-06-30
IL263167B (en) 2022-07-01
HRP20211795T1 (en) 2022-03-18
HUE056129T2 (en) 2022-01-28
LT3463365T (en) 2021-11-10
US10973821B2 (en) 2021-04-13
CN109982704A (en) 2019-07-05
MX2018014232A (en) 2019-03-28
SI3463365T1 (en) 2022-01-31

Similar Documents

Publication Publication Date Title
SG11201806863WA (en) Tetracyclic pyridone compounds as antivirals
SG11201805044WA (en) Compounds useful as kinase inhibitors
SG11201810628XA (en) Nasal pharmaceutical compositions with a porous excipient
SG11201908567UA (en) Modified cyclic dinucleotide compounds
SG11201805300QA (en) Heterocyclic compounds as immunomodulators
SG11201810280YA (en) Spiro-lactam nmda receptor modulators and uses thereof
SG11201805570WA (en) Systems and methods for long term transdermal administration
SG11201809908TA (en) Stabilized glycopeptide antibiotic formulations
SG11201808566WA (en) Polymorphic form of n-{6-(2-hydroxypropan-2-yl)-2-[2-(methylsulphonyl)ethyl]-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide
SG11201903061YA (en) Combination treatments comprising administration of imidazopyrazinones
SG11201900551WA (en) Spiro-lactam nmda receptor modulators and uses thereof
SG11201900546UA (en) Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
SG11201900443VA (en) Spiro-lactam nmda receptor modulators and uses thereof
SG11201809882XA (en) Pharmaceutical combinations for treating cancer
SG11201809830WA (en) Selective reduction of cysteine-engineered antibodies
SG11201900558RA (en) Spiro-lactam nmda receptor modulators and uses thereof
SG11201906222WA (en) Jak1 selective inhibitors
SG11201808713YA (en) Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier
SG11202000333UA (en) Bicyclic ketone compounds and methods of use thereof
SG11201908691PA (en) Compounds and methods for the treatment of parasitic diseases
SG11201806393QA (en) Use of gabaa receptor modulators for treatment of itch
SG11201810318RA (en) Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses
SG11201808650QA (en) Methods of treating ocular conditions
SG11201810934TA (en) Microparticles comprising a sulphur-containing compound
SG11201909840TA (en) Treatment of epithelial cysts by intracystic injection of antineoplastic particles