SG11201806059TA - Process for producing ethylbenzene - Google Patents

Process for producing ethylbenzene

Info

Publication number
SG11201806059TA
SG11201806059TA SG11201806059TA SG11201806059TA SG11201806059TA SG 11201806059T A SG11201806059T A SG 11201806059TA SG 11201806059T A SG11201806059T A SG 11201806059TA SG 11201806059T A SG11201806059T A SG 11201806059TA SG 11201806059T A SG11201806059T A SG 11201806059TA
Authority
SG
Singapore
Prior art keywords
benzene
alkylation
international
massachusetts
ethylbenzene
Prior art date
Application number
SG11201806059TA
Inventor
Brian Maerz
Chung-Ming Chi
Raghavender Bhoomi
Original Assignee
Badger Licensing Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Badger Licensing Llc filed Critical Badger Licensing Llc
Publication of SG11201806059TA publication Critical patent/SG11201806059TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2/00—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms
    • C07C2/54—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition of unsaturated hydrocarbons to saturated hydrocarbons or to hydrocarbons containing a six-membered aromatic ring with no unsaturation outside the aromatic ring
    • C07C2/64—Addition to a carbon atom of a six-membered aromatic ring
    • C07C2/66—Catalytic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J29/00—Catalysts comprising molecular sieves
    • B01J29/03—Catalysts comprising molecular sieves not having base-exchange properties
    • B01J29/0308—Mesoporous materials not having base exchange properties, e.g. Si-MCM-41
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J29/00—Catalysts comprising molecular sieves
    • B01J29/04—Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites
    • B01J29/06—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J29/00—Catalysts comprising molecular sieves
    • B01J29/04—Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites
    • B01J29/06—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof
    • B01J29/08—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the faujasite type, e.g. type X or Y
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J29/00—Catalysts comprising molecular sieves
    • B01J29/04—Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites
    • B01J29/06—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof
    • B01J29/18—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the mordenite type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J29/00—Catalysts comprising molecular sieves
    • B01J29/04—Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites
    • B01J29/06—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof
    • B01J29/70—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of types characterised by their specific structure not provided for in groups B01J29/08 - B01J29/65
    • B01J29/7007—Zeolite Beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/02—Monocyclic hydrocarbons
    • C07C15/067—C8H10 hydrocarbons
    • C07C15/073—Ethylbenzene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C6/00—Preparation of hydrocarbons from hydrocarbons containing a different number of carbon atoms by redistribution reactions
    • C07C6/08—Preparation of hydrocarbons from hydrocarbons containing a different number of carbon atoms by redistribution reactions by conversion at a saturated carbon-to-carbon bond
    • C07C6/12—Preparation of hydrocarbons from hydrocarbons containing a different number of carbon atoms by redistribution reactions by conversion at a saturated carbon-to-carbon bond of exclusively hydrocarbons containing a six-membered aromatic ring
    • C07C6/126—Preparation of hydrocarbons from hydrocarbons containing a different number of carbon atoms by redistribution reactions by conversion at a saturated carbon-to-carbon bond of exclusively hydrocarbons containing a six-membered aromatic ring of more than one hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2529/00—Catalysts comprising molecular sieves
    • C07C2529/04—Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites, pillared clays
    • C07C2529/06—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2529/00—Catalysts comprising molecular sieves
    • C07C2529/04—Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites, pillared clays
    • C07C2529/06—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof
    • C07C2529/08—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the faujasite type, e.g. type X or Y
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2529/00—Catalysts comprising molecular sieves
    • C07C2529/04—Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites, pillared clays
    • C07C2529/06—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof
    • C07C2529/18—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the mordenite type
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2529/00—Catalysts comprising molecular sieves
    • C07C2529/04—Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites, pillared clays
    • C07C2529/06—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof
    • C07C2529/70—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of types characterised by their specific structure not provided for in groups C07C2529/08 - C07C2529/65
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101011111011111010111101111101111011111 International Bureau 0.. .... .. ..... ..or::,„, (10) International Publication Number (43) International Publication Date WO 2017/142526 Al 24 August 2017 (24.08.2017) WI P0 I P CT (51) International Patent Classification: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, C07C 2/66 (2006.01) CO7C 6/12 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (21) International Application Number: KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, PCT/US2016/018245 MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (22) International Filing Date: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 17 February 2016 (17.02.2016) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (71) Applicant: BADGER LICENSING LLC [US/US]; One GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Financial Center, Boston, Massachusetts 02111 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: MAERZ, Brian; 48 Ruthellen Road, Chelms- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, ford, Massachusetts 01824 (US). CHI, Chung-Ming; 65 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Donna Road, Needham, Massachusetts 02494 (US). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, BHOOMI, Raghavender; 50 Stonehaven Drive, South GW, KM, ML, MR, NE, SN, TD, TG). Weymouth, Massachusetts 02190 (US). Declarations under Rule 4.17: (74) Agent: ROBERTS, Peter; Roberts Mlotkowski Safran & of inventorship (Rule 4.17(N)) Cole, P.C., Suite 500, 7918 Jones Branch Drive, McLean, _ Virginia 22102 (US). Published: (81) Designated States (unless otherwise indicated, for every — with international search report (Art. 21(3)) = kind of national protection available): AE, AG, AL, AM, _ = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, = = = = = = = = = = Il ,tD ei il n (54) Title: PROCESS FOR PRODUCING ETHYLBENZENE el 71' (57) : A process for producing ethylbenzene is described in which benzene and ethylene are supplied to an alkylation reac - 11 ---- tion zone. Also added to the alkylation reaction zone is a C 3 + olefm in an amount of at least 200 ppm by weight of the ethylene sup - L . ' plied to the alkylation reaction zone. The benzene, ethylene and C3+ olefm are contacted with an alkylation catalyst in the alkylation ::::) reaction zone to alkylate at least part of the benzene and produce an alkylation effluent comprising ethylbenzene, polyethylated ben- el zene and at least one mono-C3+ alkyl benzene. The alkylation effluent is separated into a first product fraction comprising ethylben - O zene and a second fraction comprising polyethylated benzene and the at least one mono-C3+ alkyl benzene. The second fraction is ,-t then contacted with benzene in the presence of a transalkylation catalyst to convert at least part of the polyethylated benzene to ethylbenzene and produce a transalkylation effluent.
SG11201806059TA 2016-02-17 2016-02-17 Process for producing ethylbenzene SG11201806059TA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2016/018245 WO2017142526A1 (en) 2016-02-17 2016-02-17 Process for producing ethylbenzene

Publications (1)

Publication Number Publication Date
SG11201806059TA true SG11201806059TA (en) 2018-09-27

Family

ID=55453303

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201806059TA SG11201806059TA (en) 2016-02-17 2016-02-17 Process for producing ethylbenzene

Country Status (7)

Country Link
US (1) US10899683B2 (en)
EP (1) EP3416933B1 (en)
KR (1) KR102570207B1 (en)
CN (1) CN108698952B (en)
SG (1) SG11201806059TA (en)
TW (1) TWI715716B (en)
WO (1) WO2017142526A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102285489B1 (en) * 2018-12-20 2021-08-03 한화토탈 주식회사 Separating method of PDEB by Simulated Moving Bed with benzene as desorbent

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6503410A (en) 1963-02-21 1965-09-20
US3442795A (en) 1963-02-27 1969-05-06 Mobil Oil Corp Method for preparing highly siliceous zeolite-type materials and materials resulting therefrom
US3308069A (en) 1964-05-01 1967-03-07 Mobil Oil Corp Catalytic composition of a crystalline zeolite
US3293192A (en) 1965-08-23 1966-12-20 Grace W R & Co Zeolite z-14us and method of preparation thereof
US3415736A (en) 1965-09-20 1968-12-10 Mobil Oil Corp Lithium-containing crystalline aluminosilicate
US3702886A (en) 1969-10-10 1972-11-14 Mobil Oil Corp Crystalline zeolite zsm-5 and method of preparing the same
US3709979A (en) 1970-04-23 1973-01-09 Mobil Oil Corp Crystalline zeolite zsm-11
US3832449A (en) 1971-03-18 1974-08-27 Mobil Oil Corp Crystalline zeolite zsm{14 12
US3766093A (en) 1972-01-07 1973-10-16 Mobil Oil Corp Treatment of organic cationcontaining zeolites
US3950496A (en) 1973-05-29 1976-04-13 Mobil Oil Corporation Synthetic zeolite ZSM-18
US3894104A (en) 1973-08-09 1975-07-08 Mobil Oil Corp Aromatization of hetero-atom substituted hydrocarbons
US4016245A (en) 1973-09-04 1977-04-05 Mobil Oil Corporation Crystalline zeolite and method of preparing same
US3941871A (en) 1973-11-02 1976-03-02 Mobil Oil Corporation Crystalline silicates and method of preparing the same
US3923636A (en) 1974-06-03 1975-12-02 Texaco Inc Production of lubricating oils
US3972983A (en) 1974-11-25 1976-08-03 Mobil Oil Corporation Crystalline zeolite ZSM-20 and method of preparing same
US4021947A (en) 1975-10-30 1977-05-10 Shneider Aaron H Rotary display stands
US4016218A (en) 1975-05-29 1977-04-05 Mobil Oil Corporation Alkylation in presence of thermally modified crystalline aluminosilicate catalyst
CA1064890A (en) 1975-06-10 1979-10-23 Mae K. Rubin Crystalline zeolite, synthesis and use thereof
US4234231A (en) 1978-12-06 1980-11-18 Mobil Oil Corporation Method for restoring a leached formation
US4401556A (en) 1979-11-13 1983-08-30 Union Carbide Corporation Midbarrel hydrocracking
DE3117135A1 (en) 1981-04-30 1982-11-18 Bayer Ag, 5090 Leverkusen CRYSTALLINE ALUMOSILICATE, METHOD FOR THE PRODUCTION THEREOF AND THE USE THEREOF FOR CATALYTICALLY CONVERTING METHANOL AND / OR DIMETHYL ETHER IN HYDROCARBONS
US4556477A (en) 1984-03-07 1985-12-03 Mobil Oil Corporation Highly siliceous porous crystalline material ZSM-22 and its use in catalytic dewaxing of petroleum stocks
US4826667A (en) 1986-01-29 1989-05-02 Chevron Research Company Zeolite SSZ-25
US4954325A (en) 1986-07-29 1990-09-04 Mobil Oil Corp. Composition of synthetic porous crystalline material, its synthesis and use
IT1205681B (en) 1987-05-26 1989-03-31 Eniricerche Spa SYNTHETIC POROUS CRYSTALLINE MATERIAL CONTAINING SILICON AND BORON OXIDES
US5250277A (en) 1991-01-11 1993-10-05 Mobil Oil Corp. Crystalline oxide material
US5236575A (en) 1991-06-19 1993-08-17 Mobil Oil Corp. Synthetic porous crystalline mcm-49, its synthesis and use
AU5746294A (en) * 1992-12-16 1994-07-04 Mobil Oil Corporation Production of ethylbenzene
US5362697A (en) 1993-04-26 1994-11-08 Mobil Oil Corp. Synthetic layered MCM-56, its synthesis and use
CN1096025A (en) * 1993-12-16 1994-12-07 美孚石油有限公司 The production of ethylbenzene
WO1996011175A1 (en) * 1994-10-06 1996-04-18 Exxon Chemical Patents Inc. Process for manufacturing ethylbenzene or cumene
ES2124154B1 (en) 1995-11-08 1999-12-01 Univ Politecnica De Valencia C PREPARATION METHOD AND CATALYTIC PROPERTIES OF A MICROPOROUS SOLID WITH HIGH EXTERNAL SURFACE.
ES2105982B1 (en) 1995-11-23 1998-07-01 Consejo Superior Investigacion ZEOLITE ITQ-1
US5856607A (en) * 1996-05-03 1999-01-05 Amoco Corporation Process for production of ethylbenzene frome dilute ethylene streams
US6096935A (en) * 1998-07-28 2000-08-01 Uop Llc Production of alkyl aromatics by passing transalkylation effluent to alkylation zone
CN1227196C (en) * 2002-04-26 2005-11-16 中国石油化工股份有限公司 Alkylbenzene producing process with impure low-carbon olefine and benzene
US7713513B2 (en) 2003-03-21 2010-05-11 Uop Llc High silica zeolites: UZM-8HS
US6756030B1 (en) 2003-03-21 2004-06-29 Uop Llc Crystalline aluminosilicate zeolitic composition: UZM-8
US7622622B1 (en) * 2004-06-21 2009-11-24 Uop Llc Process for the high yield production of monoalkylaromatics
KR101177220B1 (en) * 2005-03-31 2012-08-24 바져 라이센싱 엘엘씨 Multiphase alkylaromatics production
US20070161835A1 (en) * 2006-01-07 2007-07-12 Fina Technology, Inc. Liquid phase alkylation system
US7652181B1 (en) * 2006-05-02 2010-01-26 Uop Llc Alkylation reactor design with effluent recycle and impure benzene regeneration
US7501547B2 (en) * 2006-05-10 2009-03-10 Exxonmobil Chemical Patents Inc. Alkylaromatics production
US20080058566A1 (en) * 2006-09-05 2008-03-06 Fina Technology, Inc. Processes for reduction of alkylation catalyst deactivation utilizing low silica to alumina ratio catalyst
CN101195556A (en) * 2006-12-04 2008-06-11 中国科学院大连化学物理研究所 Method for producing ethyl benzene by dilute benzene and low concentration ethylene hydrocarbonylation
US7713386B2 (en) * 2007-05-23 2010-05-11 Uop Llc Apparatus for producing ethylbenzene or cumene
CA2702423C (en) * 2007-10-31 2015-04-28 Exxonmobil Chemical Patents Inc. Heavy aromatics processing catalyst and process of using the same

Also Published As

Publication number Publication date
US20190016647A1 (en) 2019-01-17
KR20180113196A (en) 2018-10-15
KR102570207B1 (en) 2023-08-25
WO2017142526A1 (en) 2017-08-24
EP3416933B1 (en) 2020-06-03
TWI715716B (en) 2021-01-11
TW201800370A (en) 2018-01-01
EP3416933A1 (en) 2018-12-26
CN108698952B (en) 2021-04-27
CN108698952A (en) 2018-10-23
US10899683B2 (en) 2021-01-26

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