SG11201802073YA - Pharmaceutical composition containing anionic drug, and preparation method therefor - Google Patents
Pharmaceutical composition containing anionic drug, and preparation method thereforInfo
- Publication number
- SG11201802073YA SG11201802073YA SG11201802073YA SG11201802073YA SG11201802073YA SG 11201802073Y A SG11201802073Y A SG 11201802073YA SG 11201802073Y A SG11201802073Y A SG 11201802073YA SG 11201802073Y A SG11201802073Y A SG 11201802073YA SG 11201802073Y A SG11201802073Y A SG 11201802073YA
- Authority
- SG
- Singapore
- Prior art keywords
- preparation
- pharmaceutical composition
- composition containing
- method therefor
- containing anionic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Nanotechnology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20150130587 | 2015-09-15 | ||
KR1020160117053A KR101828877B1 (ko) | 2015-09-15 | 2016-09-12 | 음이온성 약물 함유 약제학적 조성물 및 그 제조방법 |
PCT/KR2016/010269 WO2017048018A1 (ko) | 2015-09-15 | 2016-09-12 | 음이온성 약물 함유 약제학적 조성물 및 그 제조방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201802073YA true SG11201802073YA (en) | 2018-04-27 |
Family
ID=58496160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201802073YA SG11201802073YA (en) | 2015-09-15 | 2016-09-12 | Pharmaceutical composition containing anionic drug, and preparation method therefor |
Country Status (16)
Country | Link |
---|---|
US (2) | US11253598B2 (ko) |
EP (1) | EP3357491B1 (ko) |
JP (1) | JP6638072B2 (ko) |
KR (2) | KR101828877B1 (ko) |
CN (1) | CN108024960B (ko) |
AU (1) | AU2016324450B2 (ko) |
CA (1) | CA2998092C (ko) |
DK (1) | DK3357491T3 (ko) |
ES (1) | ES2883290T3 (ko) |
HK (1) | HK1251464A1 (ko) |
IL (1) | IL257937B (ko) |
MX (1) | MX2018003096A (ko) |
PT (1) | PT3357491T (ko) |
RU (1) | RU2721558C2 (ko) |
SG (1) | SG11201802073YA (ko) |
ZA (1) | ZA201802303B (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016372321B2 (en) * | 2015-12-18 | 2019-01-24 | Samyang Holdings Corporation | Method for preparing polymeric micelle containing anionic drug |
KR102175069B1 (ko) * | 2017-11-10 | 2020-11-05 | 주식회사 삼양바이오팜 | 음이온성 약물 전달용 지질 나노입자의 동결건조 조성물 및 방법 |
KR102259513B1 (ko) * | 2017-11-16 | 2021-06-02 | 주식회사 삼양홀딩스 | 음이온성 약물 함유 약제학적 조성물의 동결건조 조성물 및 방법 |
KR20190127277A (ko) * | 2018-05-04 | 2019-11-13 | 주식회사 삼양바이오팜 | mRNA 전달용 고분자 나노입자 조성물 및 그 제조방법 |
JP7179154B2 (ja) * | 2018-08-07 | 2022-11-28 | サムヤン ホールディングス コーポレイション | ウイルス送達用ポリマーナノ粒子組成物及びその製造方法 |
CN109136271B (zh) * | 2018-09-20 | 2021-07-20 | 西北工业大学 | 阳离子聚乙烯胺线形高分子作为转基因载体的应用 |
KR20210055616A (ko) | 2019-11-07 | 2021-05-17 | 주식회사 삼양바이오팜 | 면역유도용 고분자 나노입자 조성물 및 그 제조방법 |
BR112022009773A2 (pt) * | 2019-11-22 | 2022-08-09 | Samyang Holdings Corp | Kit para preparar uma composição de nanopartículas |
WO2021125805A1 (ko) * | 2019-12-20 | 2021-06-24 | 주식회사 삼양홀딩스 | 폴리락트산염을 포함하는 약물전달용 나노입자 조성물 제조용 키트 |
US20230149288A1 (en) * | 2020-08-31 | 2023-05-18 | VAIM Co.,Ltd. | Biodegradable polymer dispersion, composition comprising same, and skin improvement system |
WO2022231375A1 (ko) * | 2021-04-30 | 2022-11-03 | 주식회사 삼양홀딩스 | 양친성 고분자를 함유하지 않는 나노입자를 포함하는 약물전달용 조성물 |
GB202108444D0 (en) * | 2021-06-14 | 2021-07-28 | Imperial College Innovations Ltd | Sub-micron particle |
CN114569577B (zh) * | 2022-03-07 | 2023-04-11 | 晟迪生物医药(苏州)有限公司 | 一种聚合物包衣纳米粒及其制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0180334B1 (ko) | 1995-09-21 | 1999-03-20 | 김윤 | 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 |
US6458382B1 (en) | 1999-11-12 | 2002-10-01 | Mirus Corporation | Nucleic acid transfer complexes |
KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Rna 간섭의 rna 서열 특이적인 매개체 |
EP1463518A2 (en) | 2001-12-28 | 2004-10-06 | Supratek Pharma, Inc. | Pharmaceutical compositions comprising polyanionic polymers and amphiphilic block copolymers and methods of use thereof to improve gene expression |
AU2003288902A1 (en) | 2002-09-06 | 2004-04-08 | Genteric, Inc. | Microcapsules and methods of use |
CN1964744B (zh) * | 2004-05-06 | 2015-06-17 | 株式会社三养生物制药 | 基于包含两亲性嵌段共聚物和聚乳酸衍生物的聚合物药物载体的生物活性剂传递系统 |
KR100949791B1 (ko) | 2007-12-18 | 2010-03-30 | 이동기 | 오프-타겟 효과를 최소화하고 RNAi 기구를 포화시키지않는 신규한 siRNA 구조 및 그 용도 |
US20090312402A1 (en) * | 2008-05-20 | 2009-12-17 | Contag Christopher H | Encapsulated nanoparticles for drug delivery |
RU2505315C2 (ru) * | 2008-07-30 | 2014-01-27 | Нитто Денко Корпорейшн | Носители лекарственных средств |
EP2376062B1 (en) * | 2008-12-26 | 2017-04-26 | Samyang Biopharmaceuticals Corporation | Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug |
US20110268772A1 (en) * | 2008-12-26 | 2011-11-03 | Samyang Corporation | Pharmaceutical composition containing an anionic drug and a production method thereof |
KR101296326B1 (ko) * | 2009-12-30 | 2013-08-14 | 주식회사 삼양바이오팜 | 폴리락트산을 포함하는 음이온성 약물 전달용 조성물 및 그 제조 방법 |
CA2804815C (en) | 2010-07-09 | 2016-06-07 | The University Of Tokyo | Nucleic acid delivery composition and carrier composition, pharmaceutical composition using the same, and method for nucleic acid delivery |
KR101308591B1 (ko) | 2010-12-30 | 2013-09-13 | 주식회사 삼양바이오팜 | 양이온성 지질을 포함하는 음이온성 약물 전달체 및 그 제조방법 |
EP2833869B1 (en) * | 2012-04-04 | 2020-10-28 | Samyang Biopharmaceuticals Corporation | Method of preparing composition for delivering an anionic drug |
KR102109188B1 (ko) * | 2013-04-01 | 2020-05-11 | 삼성전자주식회사 | 양이온성 지질을 포함하는 온도민감성 리포좀 및 그의 용도 |
WO2014169007A2 (en) | 2013-04-09 | 2014-10-16 | University Of Georgia Research Foundation Inc. | Combination therapeutic nanoparticles |
-
2016
- 2016-09-12 DK DK16846839.5T patent/DK3357491T3/da active
- 2016-09-12 CN CN201680053810.0A patent/CN108024960B/zh active Active
- 2016-09-12 PT PT168468395T patent/PT3357491T/pt unknown
- 2016-09-12 ES ES16846839T patent/ES2883290T3/es active Active
- 2016-09-12 JP JP2018533597A patent/JP6638072B2/ja active Active
- 2016-09-12 SG SG11201802073YA patent/SG11201802073YA/en unknown
- 2016-09-12 EP EP16846839.5A patent/EP3357491B1/en active Active
- 2016-09-12 RU RU2018113459A patent/RU2721558C2/ru active
- 2016-09-12 AU AU2016324450A patent/AU2016324450B2/en active Active
- 2016-09-12 MX MX2018003096A patent/MX2018003096A/es unknown
- 2016-09-12 CA CA2998092A patent/CA2998092C/en active Active
- 2016-09-12 KR KR1020160117053A patent/KR101828877B1/ko active IP Right Grant
- 2016-09-12 US US15/759,943 patent/US11253598B2/en active Active
-
2018
- 2018-01-16 KR KR1020180005600A patent/KR101948839B1/ko active IP Right Grant
- 2018-03-07 IL IL257937A patent/IL257937B/en active IP Right Grant
- 2018-04-09 ZA ZA2018/02303A patent/ZA201802303B/en unknown
- 2018-08-24 HK HK18110936.6A patent/HK1251464A1/zh unknown
-
2022
- 2022-01-10 US US17/572,195 patent/US20220125929A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR101948839B1 (ko) | 2019-02-15 |
RU2018113459A (ru) | 2019-10-18 |
RU2721558C2 (ru) | 2020-05-20 |
KR101828877B1 (ko) | 2018-02-14 |
MX2018003096A (es) | 2018-05-11 |
HK1251464A1 (zh) | 2019-02-01 |
EP3357491B1 (en) | 2021-06-02 |
IL257937A (en) | 2018-05-31 |
JP6638072B2 (ja) | 2020-01-29 |
US20220125929A1 (en) | 2022-04-28 |
US11253598B2 (en) | 2022-02-22 |
CN108024960A (zh) | 2018-05-11 |
IL257937B (en) | 2020-10-29 |
CA2998092A1 (en) | 2017-03-23 |
DK3357491T3 (da) | 2021-08-02 |
ES2883290T3 (es) | 2021-12-07 |
CA2998092C (en) | 2020-08-04 |
AU2016324450A1 (en) | 2018-04-12 |
PT3357491T (pt) | 2021-08-02 |
CN108024960B (zh) | 2020-12-29 |
RU2018113459A3 (ko) | 2019-10-18 |
EP3357491A4 (en) | 2019-05-08 |
JP2018527413A (ja) | 2018-09-20 |
US20180250409A1 (en) | 2018-09-06 |
EP3357491A1 (en) | 2018-08-08 |
AU2016324450B2 (en) | 2019-04-18 |
KR20180008854A (ko) | 2018-01-24 |
ZA201802303B (en) | 2019-01-30 |
KR20170032858A (ko) | 2017-03-23 |
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