SG11201708738YA - Mixed disulfide conjugates of thienopyridine compounds and uses thereof - Google Patents

Mixed disulfide conjugates of thienopyridine compounds and uses thereof

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Publication number
SG11201708738YA
SG11201708738YA SG11201708738YA SG11201708738YA SG11201708738YA SG 11201708738Y A SG11201708738Y A SG 11201708738YA SG 11201708738Y A SG11201708738Y A SG 11201708738YA SG 11201708738Y A SG11201708738Y A SG 11201708738YA SG 11201708738Y A SG11201708738Y A SG 11201708738YA
Authority
SG
Singapore
Prior art keywords
mixed disulfide
disulfide conjugates
thienopyridine compounds
thienopyridine
compounds
Prior art date
Application number
SG11201708738YA
Other languages
English (en)
Inventor
Haoming Zhang
Original Assignee
Univ Michigan Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan Regents filed Critical Univ Michigan Regents
Publication of SG11201708738YA publication Critical patent/SG11201708738YA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C—CHEMISTRY; METALLURGY
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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SG11201708738YA 2015-04-30 2016-04-29 Mixed disulfide conjugates of thienopyridine compounds and uses thereof SG11201708738YA (en)

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MX2020008073A (es) * 2018-01-31 2020-11-13 Univ Michigan Regents Biocatalizador y metodos para sintetizar conjugados mezclados de disulfuro de compuestos de tienopiridina.
US11642335B2 (en) * 2019-09-26 2023-05-09 Board Of Regents, The University Of Texas System Chemical synthesis of clopidogrel active metabolites and disulfide conjugate prodrugs
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US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
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US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
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US7407890B2 (en) 2006-04-21 2008-08-05 International Business Machines Corporation Patterning sub-lithographic features with variable widths
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HK1251855A1 (zh) 2019-04-18
JP6893030B2 (ja) 2021-06-23
CA2983313C (fr) 2020-08-25
JP2021121626A (ja) 2021-08-26
DK3288590T3 (da) 2021-04-06
CN107921135A (zh) 2018-04-17
MX2017013772A (es) 2018-02-21
EP3288590A1 (fr) 2018-03-07
US10173980B2 (en) 2019-01-08
KR20200043521A (ko) 2020-04-27
KR20220162885A (ko) 2022-12-08
JP2018514532A (ja) 2018-06-07
JP7448961B2 (ja) 2024-03-13
MX371538B (es) 2020-01-30
EP3288590B1 (fr) 2021-03-03
US20180155289A1 (en) 2018-06-07
KR20170141758A (ko) 2017-12-26
WO2016176644A1 (fr) 2016-11-03
EP3288590A4 (fr) 2018-10-31

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