MX2017013772A - Conjugados mezclados de disulfuro de compuestos de tienopiridina y usos de los mismos. - Google Patents

Conjugados mezclados de disulfuro de compuestos de tienopiridina y usos de los mismos.

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Publication number
MX2017013772A
MX2017013772A MX2017013772A MX2017013772A MX2017013772A MX 2017013772 A MX2017013772 A MX 2017013772A MX 2017013772 A MX2017013772 A MX 2017013772A MX 2017013772 A MX2017013772 A MX 2017013772A MX 2017013772 A MX2017013772 A MX 2017013772A
Authority
MX
Mexico
Prior art keywords
mixed disulfide
disulfide conjugates
thienopyridine compounds
thienopyridine
compounds
Prior art date
Application number
MX2017013772A
Other languages
English (en)
Other versions
MX371538B (es
Inventor
Zhang Haoming
Original Assignee
Univ Michigan Regents
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Publication date
Application filed by Univ Michigan Regents filed Critical Univ Michigan Regents
Publication of MX2017013772A publication Critical patent/MX2017013772A/es
Publication of MX371538B publication Critical patent/MX371538B/es

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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Esta invención está en el campo de la química medicinal. En particular, la invención se refiere a conjugados mezclados de disulfuro de compuestos de tienopiridina, y su uso como agentes terapéuticos para el tratamiento, mejora y prevención de enfermedades cardiovasculares.
MX2017013772A 2015-04-30 2016-04-29 Conjugados mezclados de disulfuro de compuestos de tienopiridina y usos de los mismos. MX371538B (es)

Applications Claiming Priority (2)

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US201562155231P 2015-04-30 2015-04-30
PCT/US2016/030261 WO2016176644A1 (en) 2015-04-30 2016-04-29 Mixed disulfide conjugates of thienopyridine compounds and uses thereof

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US (1) US10173980B2 (es)
EP (1) EP3288590B1 (es)
JP (3) JP6893030B2 (es)
KR (3) KR20170141758A (es)
CN (2) CN116478086A (es)
CA (1) CA2983313C (es)
DK (1) DK3288590T3 (es)
EA (1) EA201792085A1 (es)
HK (1) HK1251855A1 (es)
MX (1) MX371538B (es)
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WO (1) WO2016176644A1 (es)

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DK3288590T3 (da) * 2015-04-30 2021-04-06 Univ Michigan Regents Blandede disulfidkonjugater af thienopyridinforbindelser og anvendelser deraf
MX2020008073A (es) * 2018-01-31 2020-11-13 Univ Michigan Regents Biocatalizador y metodos para sintetizar conjugados mezclados de disulfuro de compuestos de tienopiridina.
US11642335B2 (en) * 2019-09-26 2023-05-09 Board Of Regents, The University Of Texas System Chemical synthesis of clopidogrel active metabolites and disulfide conjugate prodrugs
CN111484446A (zh) * 2020-04-02 2020-08-04 北京翼方生物科技有限责任公司 氯吡格雷代谢活性体二硫衍生物、其制备方法及医药用途

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US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4444762A (en) 1980-04-04 1984-04-24 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclopentan-2-ones
JPH03193969A (ja) * 1989-12-20 1991-08-23 Idemitsu Kosan Co Ltd 炭素繊維の電解処理方法
HU225741B1 (en) 1998-02-27 2007-07-30 Ube Industries Cyclic amino compounds, use of them for producing pharmaceutical compositions and pharmaceutical compositions containing them
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
US20080214599A1 (en) * 2005-08-19 2008-09-04 John Thomas Brandt Use of Par-1/Par-4 Inhibitors for Treating or Preventing Vascular Diseases
US7407890B2 (en) 2006-04-21 2008-08-05 International Business Machines Corporation Patterning sub-lithographic features with variable widths
CA2897407C (en) 2013-01-09 2018-05-08 The Regents Of The University Of Michigan Mixed disulfide conjugates of thienopyridine compounds and uses thereof
DK3288590T3 (da) * 2015-04-30 2021-04-06 Univ Michigan Regents Blandede disulfidkonjugater af thienopyridinforbindelser og anvendelser deraf

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MX371538B (es) 2020-01-30
JP2024059795A (ja) 2024-05-01
KR20220162885A (ko) 2022-12-08
KR20200043521A (ko) 2020-04-27
SG11201708738YA (en) 2017-11-29
DK3288590T3 (da) 2021-04-06
CA2983313A1 (en) 2016-11-03
HK1251855A1 (zh) 2019-04-18
JP6893030B2 (ja) 2021-06-23
JP2021121626A (ja) 2021-08-26
JP2018514532A (ja) 2018-06-07
WO2016176644A1 (en) 2016-11-03
EP3288590B1 (en) 2021-03-03
EP3288590A1 (en) 2018-03-07
CN116478086A (zh) 2023-07-25
CA2983313C (en) 2020-08-25
JP7448961B2 (ja) 2024-03-13
US20180155289A1 (en) 2018-06-07
CN107921135A (zh) 2018-04-17
EP3288590A4 (en) 2018-10-31
US10173980B2 (en) 2019-01-08
EA201792085A1 (ru) 2018-05-31
KR20170141758A (ko) 2017-12-26

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