SG11201708203UA - Production of oversized adeno-associated vectors - Google Patents

Production of oversized adeno-associated vectors

Info

Publication number
SG11201708203UA
SG11201708203UA SG11201708203UA SG11201708203UA SG11201708203UA SG 11201708203U A SG11201708203U A SG 11201708203UA SG 11201708203U A SG11201708203U A SG 11201708203UA SG 11201708203U A SG11201708203U A SG 11201708203UA SG 11201708203U A SG11201708203U A SG 11201708203UA
Authority
SG
Singapore
Prior art keywords
oversized
adeno
production
associated vectors
vectors
Prior art date
Application number
SG11201708203UA
Other languages
English (en)
Inventor
Sirkka Kyostio-Moore
David Souza
Karen Vincent
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56943906&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201708203U(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of SG11201708203UA publication Critical patent/SG11201708203UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10041Use of virus, viral particle or viral elements as a vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151Methods of production or purification of viral material
    • C12N2750/14152Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11201708203UA 2015-04-08 2016-04-07 Production of oversized adeno-associated vectors SG11201708203UA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562144862P 2015-04-08 2015-04-08
US201562220067P 2015-09-17 2015-09-17
PCT/US2016/026486 WO2016164609A2 (en) 2015-04-08 2016-04-07 Production of oversized adeno-associated vectors

Publications (1)

Publication Number Publication Date
SG11201708203UA true SG11201708203UA (en) 2017-11-29

Family

ID=56943906

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201909381W SG10201909381WA (en) 2015-04-08 2016-04-07 Production of oversized adeno-associated vectors
SG11201708203UA SG11201708203UA (en) 2015-04-08 2016-04-07 Production of oversized adeno-associated vectors
SG10201912912QA SG10201912912QA (en) 2015-04-08 2016-04-07 Production of oversized adeno-associated vectors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201909381W SG10201909381WA (en) 2015-04-08 2016-04-07 Production of oversized adeno-associated vectors

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201912912QA SG10201912912QA (en) 2015-04-08 2016-04-07 Production of oversized adeno-associated vectors

Country Status (27)

Country Link
US (1) US10815497B2 (enrdf_load_stackoverflow)
EP (2) EP3280799B1 (enrdf_load_stackoverflow)
JP (3) JP6878299B2 (enrdf_load_stackoverflow)
KR (1) KR20250126875A (enrdf_load_stackoverflow)
CN (1) CN107864657A (enrdf_load_stackoverflow)
AU (3) AU2016245806A1 (enrdf_load_stackoverflow)
BR (1) BR112017021505A2 (enrdf_load_stackoverflow)
CA (1) CA2982123A1 (enrdf_load_stackoverflow)
CL (1) CL2017002537A1 (enrdf_load_stackoverflow)
CO (1) CO2017011344A2 (enrdf_load_stackoverflow)
CR (1) CR20170505A (enrdf_load_stackoverflow)
DK (1) DK3280799T3 (enrdf_load_stackoverflow)
EA (1) EA201792236A1 (enrdf_load_stackoverflow)
EC (1) ECSP17074016A (enrdf_load_stackoverflow)
ES (1) ES3008382T3 (enrdf_load_stackoverflow)
GT (1) GT201700214A (enrdf_load_stackoverflow)
HU (1) HUE069779T2 (enrdf_load_stackoverflow)
IL (3) IL294965A (enrdf_load_stackoverflow)
MX (1) MX2017012935A (enrdf_load_stackoverflow)
PE (1) PE20171800A1 (enrdf_load_stackoverflow)
PH (1) PH12017501836A1 (enrdf_load_stackoverflow)
PL (1) PL3280799T3 (enrdf_load_stackoverflow)
SG (3) SG10201909381WA (enrdf_load_stackoverflow)
TN (1) TN2017000431A1 (enrdf_load_stackoverflow)
TW (1) TWI707951B (enrdf_load_stackoverflow)
UY (1) UY36611A (enrdf_load_stackoverflow)
WO (1) WO2016164609A2 (enrdf_load_stackoverflow)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2956477B2 (en) 2013-02-15 2024-01-24 Bioverativ Therapeutics Inc. Optimized factor viii gene
WO2015191508A1 (en) 2014-06-09 2015-12-17 Voyager Therapeutics, Inc. Chimeric capsids
US11008561B2 (en) 2014-06-30 2021-05-18 Bioverativ Therapeutics Inc. Optimized factor IX gene
EP3215191B1 (en) 2014-11-05 2024-08-14 Voyager Therapeutics, Inc. Aadc polynucleotides for the treatment of parkinson's disease
SG11201703419UA (en) 2014-11-14 2017-05-30 Voyager Therapeutics Inc Modulatory polynucleotides
AU2015346162B2 (en) 2014-11-14 2022-02-10 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (ALS)
US11697825B2 (en) 2014-12-12 2023-07-11 Voyager Therapeutics, Inc. Compositions and methods for the production of scAAV
TWI707951B (zh) * 2015-04-08 2020-10-21 美商健臻公司 過大腺相關載體之製造
RU2742352C2 (ru) 2015-09-24 2021-02-05 Байомарин Фармасьютикал Инк. Векторы фактора fviii на основе аденоассоциированных вирусов, соответствующие вирусные частицы и содержащие их терапевтические композиции
CN116218863A (zh) 2016-02-01 2023-06-06 比奥贝拉蒂治疗公司 优化的因子viii基因
US11326182B2 (en) 2016-04-29 2022-05-10 Voyager Therapeutics, Inc. Compositions for the treatment of disease
US11299751B2 (en) 2016-04-29 2022-04-12 Voyager Therapeutics, Inc. Compositions for the treatment of disease
MX2018014154A (es) 2016-05-18 2019-05-06 Voyager Therapeutics Inc Polinucleotidos moduladores.
KR102427379B1 (ko) 2016-05-18 2022-08-02 보이저 테라퓨틱스, 인크. 헌팅톤 질환을 치료하기 위한 조성물 및 방법
EP3506817A4 (en) 2016-08-30 2020-07-22 The Regents of The University of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
WO2018154096A1 (en) 2017-02-24 2018-08-30 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Method for re-expression of different hypermethylated genes involved in fibrosis, like hypermethylated rasal,1 and use thereof in treatment of fibrosis as well as kit of parts for re-expression of hypermethylated genes including rasal1 in a subject
EP3618839A4 (en) 2017-05-05 2021-06-09 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (als)
MX2019013172A (es) 2017-05-05 2020-09-07 Voyager Therapeutics Inc Composiciones y metodos para tratar la enfermedad de huntington.
MA49153A (fr) * 2017-05-19 2021-03-24 Encoded Therapeutics Inc Éléments régulateurs à haute activité
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
CA3070087A1 (en) 2017-07-17 2019-01-24 Voyager Therapeutics, Inc. Trajectory array guide system
AU2018311069A1 (en) 2017-08-03 2020-02-20 Voyager Therapeutics, Inc. Compositions and methods for delivery of AAV
KR20250040746A (ko) 2017-08-09 2025-03-24 바이오버라티브 테라퓨틱스 인크. 핵산 분자 및 이의 용도
MX2020003042A (es) 2017-09-29 2020-11-18 Voyager Therapeutics Inc Rescate del fenotipo neurológico central y periférico de la ataxia de friedreich mediante administración intravenosa.
US20200237799A1 (en) 2017-10-16 2020-07-30 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis (als)
EP4124658A3 (en) 2017-10-16 2023-04-19 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis (als)
CA3083765A1 (en) 2017-12-01 2019-06-06 Encoded Therapeutics, Inc. Engineered dna binding proteins
MX2020012077A (es) 2018-05-15 2021-03-09 Voyager Therapeutics Inc Composiciones y metodos para el tratamiento de la enfermedad de parkinson.
CA3106838A1 (en) * 2018-07-20 2020-01-23 University Of Utah Research Foundation Gene therapy for macular degeneration
US12364774B2 (en) 2018-08-09 2025-07-22 Bioverativ Therapeutics Inc. Nucleic acid molecules and uses thereof for non-viral gene therapy
US12281321B2 (en) 2018-09-28 2025-04-22 Voyager Therapeutics, Inc. Frataxin expression constructs having engineered promoters and methods of use thereof
JP2022504740A (ja) * 2018-10-12 2022-01-13 ジェンザイム・コーポレーション 肝臓に向けられた遺伝子補充療法によって重度のpkuを処置するための改善されたヒトpahの生成
US20220349017A1 (en) * 2019-08-29 2022-11-03 Siemens Healthcare Diagnostics Inc. Reagents and methods for detecting aav shedding
JP2022549932A (ja) 2019-09-30 2022-11-29 バイオベラティブ セラピューティクス インコーポレイテッド レンチウイルスベクター製剤
CN111218446B (zh) * 2019-12-25 2023-03-28 劲帆生物医药科技(武汉)有限公司 一种肝脏特异性启动子及其应用
IL296509A (en) * 2020-03-16 2022-11-01 Univ North Carolina Chapel Hill Compositions and methods for the selective detection of tumor-derived viral dna
BR112022026127A2 (pt) 2020-06-24 2023-01-17 Bioverativ Therapeutics Inc Métodos para remoção de fator viii livre de preparações de vetores lentivirais modificados para expressar referida proteína
AU2021319208A1 (en) 2020-07-30 2023-03-02 Shape Therapeutics Inc. Stable cell lines for inducible production of rAAV virions
IL300445A (en) 2020-08-23 2023-04-01 Bioverativ Therapeutics Inc A baculovirus system adapted to improve the production of closed-end DNA (cadna)
IL310963A (en) 2021-08-23 2024-04-01 Bioverativ Therapeutics Inc Production of closed DNA with inverted repeat sequences
JP2024534123A (ja) 2021-08-23 2024-09-18 バイオベラティブ セラピューティクス インコーポレイテッド バキュロウイルス発現システム
AU2022332276A1 (en) 2021-08-23 2024-04-04 Bioverativ Therapeutics Inc. Optimized factor viii genes
EP4408874A1 (en) 2021-09-30 2024-08-07 Bioverativ Therapeutics Inc. Nucleic acids encoding factor viii polypeptides with reduced immunogenicity
AU2022373653A1 (en) 2021-10-18 2024-05-02 Regeneron Pharmaceuticals, Inc. Eukaryotic cells comprising adenovirus-associated virus polynucleotides
AR132545A1 (es) * 2023-04-26 2025-07-16 Sanofi Sa Líneas celulares hospedadoras y métodos para identificar y usar dichas líneas celulares hospedadoras

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010088A1 (en) 1996-09-06 1998-03-12 Trustees Of The University Of Pennsylvania An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase
US6989264B2 (en) 1997-09-05 2006-01-24 Targeted Genetics Corporation Methods for generating high titer helper-free preparations of released recombinant AAV vectors
US6566118B1 (en) 1997-09-05 2003-05-20 Targeted Genetics Corporation Methods for generating high titer helper-free preparations of released recombinant AAV vectors
JP4827353B2 (ja) 1999-08-09 2011-11-30 ターゲティッド ジェネティクス コーポレイション 鎖内塩基対を形成するような配列の設計による、組換えウイルスベクターからの一本鎖の異種ヌクレオチド配列の発現の増大
WO2001027303A1 (en) 1999-10-12 2001-04-19 The University Of North Carolina At Chapel Hill Adeno-associated virus vectors encoding factor viii and methods of using the same
US7465583B2 (en) 2000-06-01 2008-12-16 The University Of North Carolina At Chapel Hill Duplexed parvovirus vectors
US6723551B2 (en) 2001-11-09 2004-04-20 The United States Of America As Represented By The Department Of Health And Human Services Production of adeno-associated virus in insect cells
MX359371B (es) 2001-11-13 2018-09-25 Univ Pennsylvania Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo.
US20040092008A1 (en) * 2002-11-12 2004-05-13 Snyder Richard O. Recombinant AAV vectors for gene therapy of hemophilia A
WO2004075861A2 (en) 2003-02-26 2004-09-10 Children's Hospital, Inc. Recombinant adeno-associated virus production
WO2004113494A2 (en) 2003-05-21 2004-12-29 Avigen, Inc. Methods for producing preparations of recombinant aav virions substantially free of empty capsids
WO2006119432A2 (en) 2005-04-29 2006-11-09 The Government Of The U.S.A., As Rep. By The Sec., Dept. Of Health & Human Services Isolation, cloning and characterization of new adeno-associated virus (aav) serotypes
US7943374B2 (en) * 2005-08-21 2011-05-17 Markus Hildinger Super-size adeno-associated viral vector harboring a recombinant genome larger than 5.7 kb
WO2007120542A2 (en) 2006-03-30 2007-10-25 The Board Of Trustees Of The Leland Stanford Junior University Aav capsid library and aav capsid proteins
RS57784B1 (sr) 2009-06-16 2018-12-31 Genzyme Corp Poboljšani postupci za prečišćavanje vektora rekombinantnog aav
US8663624B2 (en) 2010-10-06 2014-03-04 The Regents Of The University Of California Adeno-associated virus virions with variant capsid and methods of use thereof
WO2012112832A1 (en) 2011-02-17 2012-08-23 The Trustees Of The University Of Pennsylvania Compositions and methods for altering tissue specificity and improving aav9-mediated gene transfer
EP2911687B1 (en) * 2012-10-26 2019-02-13 Vrije Universiteit Brussel Vector for liver-directed gene therapy of hemophilia and methods and use thereof
SI3044231T1 (sl) * 2013-09-12 2020-12-31 Biomarin Pharmaceutical Inc. Vektorji AAV, ki vsebujejo gen, ki kodira faktor VIII
CN114231563B (zh) 2014-05-02 2024-08-16 建新公司 用于视网膜及cns基因疗法的aav载体
HUE057272T2 (hu) 2015-02-10 2022-04-28 Genzyme Corp Vírusrészecskék fokozott bevitele a csíkolt testbe és az agykéregbe
TWI707951B (zh) * 2015-04-08 2020-10-21 美商健臻公司 過大腺相關載體之製造

Also Published As

Publication number Publication date
EP4512429A2 (en) 2025-02-26
IL294965A (en) 2022-09-01
CL2017002537A1 (es) 2018-05-11
WO2016164609A2 (en) 2016-10-13
JP2021118724A (ja) 2021-08-12
IL254933B (en) 2021-06-30
PL3280799T3 (pl) 2025-04-14
EP3280799B1 (en) 2024-10-30
TN2017000431A1 (en) 2019-04-12
ES3008382T3 (en) 2025-03-24
US10815497B2 (en) 2020-10-27
CA2982123A1 (en) 2016-10-13
ECSP17074016A (es) 2018-02-28
KR20170133500A (ko) 2017-12-05
TWI707951B (zh) 2020-10-21
EP3280799A2 (en) 2018-02-14
AU2024201619A1 (en) 2024-03-28
CN107864657A (zh) 2018-03-30
MX2017012935A (es) 2018-02-12
JP6878299B2 (ja) 2021-05-26
IL283291B (en) 2022-08-01
NZ737009A (en) 2024-01-26
SG10201909381WA (en) 2019-11-28
PE20171800A1 (es) 2017-12-28
DK3280799T3 (da) 2025-01-27
KR20250126875A (ko) 2025-08-25
HK1246339A1 (en) 2018-09-07
NZ774736A (en) 2024-08-30
WO2016164609A3 (en) 2016-12-15
CO2017011344A2 (es) 2018-03-28
BR112017021505A2 (pt) 2018-07-03
EA201792236A1 (ru) 2018-03-30
CR20170505A (es) 2018-01-26
PH12017501836A1 (en) 2018-04-23
AU2022203942A1 (en) 2022-06-23
HUE069779T2 (hu) 2025-04-28
AU2016245806A1 (en) 2017-11-30
EP4512429A3 (en) 2025-05-21
TW201710498A (zh) 2017-03-16
JP2023116678A (ja) 2023-08-22
IL254933A0 (en) 2017-12-31
UY36611A (es) 2016-11-30
SG10201912912QA (en) 2020-02-27
AU2022203942B2 (en) 2023-12-14
US20190048362A1 (en) 2019-02-14
JP2018510648A (ja) 2018-04-19
GT201700214A (es) 2018-10-24
IL283291A (en) 2021-07-29

Similar Documents

Publication Publication Date Title
IL283291A (en) Production of Adno-related vectors of large size
ZA201800029B (en) Microbiome-compatible cosmetics
HUE050747T2 (hu) Poggyász
IL257026A (en) Solid state forms of eluxadoline
SG10201601042PA (en) Production of ester mixtures
GB201508727D0 (en) Polyurethane
GB201502721D0 (en) Product
GB201509578D0 (en) Vectors
PL3283506T3 (pl) Sposób wytwarzania aneksyny v
GB201518792D0 (en) Production of proteins
GB201521751D0 (en) Novel uses
GB2561109B (en) Transition structure
ZA201706282B (en) Solid forms of menaquinols
GB201511225D0 (en) Novel structure
GB201506757D0 (en) Cosmetic
GB201516363D0 (en) Enclosed Space
IL253635A0 (en) Cyclopropanebenzofuranyl pyridopyrazinedione type compounds
GB201505800D0 (en) Motion arrangement
GB201509881D0 (en) Complementary vectors
ZA201707704B (en) Production of vcl4
PL3257657T3 (pl) Struktura zapobiegająca wyciekaniu
GB201601286D0 (en) Multi-eptopic construct
PL3497407T3 (pl) Monitorowanie ruchu względnego dwóch elementów
GB201601249D0 (en) Production of manool
GB201521180D0 (en) Encapsulated moluscicide