SG11201706076QA - Novel combination of 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione with an antidepressant, and the pharmaceutical compositions containing same - Google Patents

Novel combination of 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione with an antidepressant, and the pharmaceutical compositions containing same

Info

Publication number
SG11201706076QA
SG11201706076QA SG11201706076QA SG11201706076QA SG11201706076QA SG 11201706076Q A SG11201706076Q A SG 11201706076QA SG 11201706076Q A SG11201706076Q A SG 11201706076QA SG 11201706076Q A SG11201706076Q A SG 11201706076QA SG 11201706076Q A SG11201706076Q A SG 11201706076QA
Authority
SG
Singapore
Prior art keywords
oxazino
benzotriazine
antidepressant
dione
fluorophenyl
Prior art date
Application number
SG11201706076QA
Inventor
Sylvie Bretin
Laurence Danober
Pierre Lestage
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of SG11201706076QA publication Critical patent/SG11201706076QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
SG11201706076QA 2015-03-26 2016-03-25 Novel combination of 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione with an antidepressant, and the pharmaceutical compositions containing same SG11201706076QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1552563A FR3034019B1 (en) 2015-03-26 2015-03-26 NOVEL ASSOCIATION BETWEEN 8-CYCLOPROPYL-3- [2- (3-FLUOROPHENYL) ETHYL] -7,8-DIHYDRO-3H- [1,3] OXAZINO [6,5-G] [1,2,3] BENZOTRIAZINE -4,9-DIONE AND AN ANTIDEPRESSANT AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT
PCT/FR2016/050681 WO2016151265A1 (en) 2015-03-26 2016-03-25 Novel combination of 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione with an antidepressant, and the pharmaceutical compositions containing same

Publications (1)

Publication Number Publication Date
SG11201706076QA true SG11201706076QA (en) 2017-08-30

Family

ID=53776719

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201706076QA SG11201706076QA (en) 2015-03-26 2016-03-25 Novel combination of 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione with an antidepressant, and the pharmaceutical compositions containing same

Country Status (12)

Country Link
EP (1) EP3273996A1 (en)
JP (1) JP2018509436A (en)
KR (1) KR20170125835A (en)
AU (1) AU2016238625A1 (en)
CA (1) CA2975571A1 (en)
FR (1) FR3034019B1 (en)
MA (1) MA41817A (en)
PH (1) PH12017501248A1 (en)
SG (1) SG11201706076QA (en)
TN (1) TN2017000280A1 (en)
WO (1) WO2016151265A1 (en)
ZA (1) ZA201705052B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG163545A1 (en) * 2007-01-03 2010-08-30 Servier Lab 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses

Also Published As

Publication number Publication date
FR3034019B1 (en) 2017-03-17
CA2975571A1 (en) 2016-09-29
FR3034019A1 (en) 2016-09-30
EP3273996A1 (en) 2018-01-31
TN2017000280A1 (en) 2019-01-16
ZA201705052B (en) 2019-02-27
PH12017501248A1 (en) 2017-10-30
AU2016238625A1 (en) 2017-08-03
MA41817A (en) 2018-01-30
KR20170125835A (en) 2017-11-15
WO2016151265A1 (en) 2016-09-29
JP2018509436A (en) 2018-04-05

Similar Documents

Publication Publication Date Title
IL276333B (en) Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
IL250280B (en) Spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds, derivatives thereof and pharmaceutical compositions comprising them
RS63116B1 (en) Benzazepine derivative, preparation method, pharmaceutical composition and use thereof
IL252311B (en) 4-oxo-3,4-dihydro-1,2,3-benzotriazines as modulators of gpr139
IL272638A (en) Quinoxaline derivatives, their preparation and pharmaceutical compositions containing them
IL263172A (en) Tricyclic heterocyclic derivatives, their preparation and use
ZA201807125B (en) Pharmaceutical composition of dapagliflozin
IL258977B (en) Pyperidyl derivatives, their preparation and pharmaceutical compositions containing them
HUE065010T2 (en) Benzazepine derivatives useful as medicaments
ZA201908006B (en) Targeted drug rescue with novel compositions, combinations, and methods thereof
ZA201705052B (en) Novel combination of 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione with an antidepressant, and the pharmaceutical compositions containing same
IL271513A (en) Novel pharmaceutical composition
EP3589372A4 (en) Chemotherapeutic drug composition
EP3448857A4 (en) Analogs of yohimbine and uses thereof
ZA201606873B (en) Novel combination between 8-cyclopropyl-3-[2-(3-fluorophenyl) ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione and an acetylcholinesterase inhibitor, and pharmaceutical compositions containing same
AU2016900705A0 (en) Traditional chinese medicine composition
GB201520226D0 (en) Pharmaceutical compositions comprising of hetero-bicyclic derivatives, and methodsof use thereof.
EP3191441A4 (en) Novel process for preparation of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione
HUP1500451A2 (en) Processes for the preparation of 1,4,7-triaza-cyclononane derivatives and intermediates