SG11201704862UA - Detection of nucleic acid polymerase conformational changes using a nanotube - Google Patents
Detection of nucleic acid polymerase conformational changes using a nanotubeInfo
- Publication number
- SG11201704862UA SG11201704862UA SG11201704862UA SG11201704862UA SG11201704862UA SG 11201704862U A SG11201704862U A SG 11201704862UA SG 11201704862U A SG11201704862U A SG 11201704862UA SG 11201704862U A SG11201704862U A SG 11201704862UA SG 11201704862U A SG11201704862U A SG 11201704862UA
- Authority
- SG
- Singapore
- Prior art keywords
- nanotube
- detection
- nucleic acid
- acid polymerase
- conformational changes
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 239000002071 nanotube Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07007—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/91245—Nucleotidyltransferases (2.7.7)
- G01N2333/9125—Nucleotidyltransferases (2.7.7) with a definite EC number (2.7.7.-)
- G01N2333/9126—DNA-directed DNA polymerase (2.7.7.7)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Biomedical Technology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462093671P | 2014-12-18 | 2014-12-18 | |
| PCT/US2015/066321 WO2016100635A1 (en) | 2014-12-18 | 2015-12-17 | Detection of nucleic acid polymerase conformational changes using a nanotube |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201704862UA true SG11201704862UA (en) | 2017-07-28 |
Family
ID=56127582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201704862UA SG11201704862UA (en) | 2014-12-18 | 2015-12-17 | Detection of nucleic acid polymerase conformational changes using a nanotube |
Country Status (10)
Families Citing this family (47)
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| US10712334B2 (en) | 2016-01-28 | 2020-07-14 | Roswell Biotechnologies, Inc. | Massively parallel DNA sequencing apparatus |
| US11624725B2 (en) | 2016-01-28 | 2023-04-11 | Roswell Blotechnologies, Inc. | Methods and apparatus for measuring analytes using polymerase in large scale molecular electronics sensor arrays |
| WO2017139493A2 (en) | 2016-02-09 | 2017-08-17 | Roswell Biotechnologies, Inc. | Electronic label-free dna and genome sequencing |
| US10597767B2 (en) | 2016-02-22 | 2020-03-24 | Roswell Biotechnologies, Inc. | Nanoparticle fabrication |
| US9829456B1 (en) | 2016-07-26 | 2017-11-28 | Roswell Biotechnologies, Inc. | Method of making a multi-electrode structure usable in molecular sensing devices |
| CN106244712B (zh) * | 2016-08-31 | 2019-11-19 | 北京大学 | Dna测序方法 |
| US20190376925A1 (en) * | 2016-11-22 | 2019-12-12 | Roswell Biotechnologies, Inc. | Nucleic acid sequencing device containing graphene |
| CA3052062A1 (en) | 2017-01-10 | 2018-07-19 | Roswell Biotechnologies, Inc. | Methods and systems for dna data storage |
| EP3571286A4 (en) * | 2017-01-19 | 2020-10-28 | Roswell Biotechnologies, Inc | SEMICONDUCTOR SEQUENCING DEVICES INCLUDING TWO-DIMENSIONAL LAYER MATERIALS |
| CN110546276A (zh) | 2017-04-25 | 2019-12-06 | 罗斯威尔生命技术公司 | 用于分子传感器的酶电路 |
| US10508296B2 (en) | 2017-04-25 | 2019-12-17 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
| EP4023764A3 (en) | 2017-05-09 | 2022-09-21 | Roswell Biotechnologies, Inc. | Binding probe circuits for molecular sensors |
| KR102737316B1 (ko) | 2017-08-30 | 2024-12-02 | 로스웰 엠이 아이엔씨. | Dna 데이터 저장을 위한 진행성 효소 분자 전자 센서들 |
| US12332248B2 (en) * | 2017-09-15 | 2025-06-17 | Illumina, Inc. | Sequence-detection system |
| CA3067230A1 (en) * | 2017-09-15 | 2019-03-21 | Illumina, Inc. | Tuning and calibration features of a sequence-detection system |
| EP3694990A4 (en) * | 2017-10-10 | 2022-06-15 | Roswell Biotechnologies, Inc. | METHODS, APPARATUS AND SYSTEMS FOR NON-AMPLIFICATION DNA DATA STORAGE |
| MX2020003836A (es) | 2017-10-13 | 2020-11-06 | Dicerna Pharmaceuticals Inc | Metodos y composiciones para inhibir la expresion de lactato deshidrogenasa a (ldha). |
| BR112020023494A2 (pt) * | 2018-05-17 | 2021-03-30 | Stuart Lindsay | Dispositivo, sistema e método para medição elétrica direta de atividade enzimática, bem como método para sequenciamento |
| WO2020101795A1 (en) | 2018-11-15 | 2020-05-22 | Omniome, Inc. | Electronic detection of nucleic acid structure |
| EP3891304A1 (en) | 2018-12-04 | 2021-10-13 | Omniome, Inc. | Mixed-phase fluids for nucleic acid sequencing and other analytical assays |
| EP3918329A4 (en) | 2019-01-30 | 2023-02-08 | Arizona Board of Regents on behalf of Arizona State University | Bioelectronic circuits, systems and methods for preparing and using them |
| EP3924513B1 (en) | 2019-02-14 | 2023-04-12 | Pacific Biosciences of California, Inc. | Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes |
| KR20220076416A (ko) * | 2019-03-01 | 2022-06-08 | 유니버셜 시퀀싱 테크놀로지 코퍼레이션 | 생체중합체 확인을 위한 디바이스 및 방법 |
| JP2022535746A (ja) * | 2019-05-27 | 2022-08-10 | ユニバーサル シーケンシング テクノロジー コーポレイション | 核酸配列における構成要素を同定する方法 |
| CN114728996B (zh) | 2019-09-10 | 2022-11-29 | 加利福尼亚太平洋生物科学股份有限公司 | 核苷酸的可逆修饰 |
| DE202019106694U1 (de) | 2019-12-02 | 2020-03-19 | Omniome, Inc. | System zur Sequenzierung von Nukleinsäuren in Fluidschaum |
| US20230054204A1 (en) | 2020-02-04 | 2023-02-23 | Pacific Biosciences Of California, Inc. | Flow cells and methods for their manufacture and use |
| MX2022010514A (es) * | 2020-02-28 | 2022-09-21 | Univ Arizona State | Metodos de secuenciacion de biopolimeros. |
| US12298300B2 (en) | 2020-04-17 | 2025-05-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Single-molecule electronic sequence detector and methods of use |
| EP4158063A4 (en) | 2020-05-29 | 2024-05-29 | Arizona Board of Regents on behalf of Arizona State University | BIOELECTRONIC DEVICES WITH PROGRAMMABLE ADAPTERS |
| CA3182266A1 (en) | 2020-06-11 | 2021-12-16 | Vadim Lobanov | Methods and systems for computational decoding of biological, chemical, and physical entities |
| CA3196729A1 (en) | 2020-11-11 | 2022-05-19 | Tural AKSEL | Affinity reagents having enhanced binding and detection characteristics |
| WO2022159663A1 (en) | 2021-01-21 | 2022-07-28 | Nautilus Biotechnology, Inc. | Systems and methods for biomolecule preparation |
| EP4305419A1 (en) | 2021-03-11 | 2024-01-17 | Nautilus Subsidiary, Inc. | Systems and methods for biomolecule retention |
| US20230070896A1 (en) | 2021-09-09 | 2023-03-09 | Nautilus Biotechnology, Inc. | Characterization and localization of protein modifications |
| JP2024537689A (ja) | 2021-09-22 | 2024-10-16 | ノーティラス・サブシディアリー・インコーポレイテッド | ポリペプチド相互作用を決定するための方法及びシステム |
| US20230149883A1 (en) | 2021-11-03 | 2023-05-18 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| EP4500157A1 (en) | 2022-03-29 | 2025-02-05 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
| WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| WO2024124073A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | A method comprising performing on a single-analyte array at least 50 cycles of a process |
| US20240201182A1 (en) | 2022-12-15 | 2024-06-20 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
| WO2024206122A1 (en) | 2023-03-24 | 2024-10-03 | Nautilus Subsidiary, Inc. | Improved transfer of nanoparticles to array surfaces |
| WO2024243237A1 (en) | 2023-05-24 | 2024-11-28 | Nautilus Subsidiary, Inc. | Systems and methods for machine vision |
| US20250066841A1 (en) | 2023-08-24 | 2025-02-27 | Nautilus Subsidiary, Inc. | Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions |
| WO2025128588A1 (en) | 2023-12-11 | 2025-06-19 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| WO2025137166A1 (en) | 2023-12-20 | 2025-06-26 | Nautilus Subsidiary, Inc. | Fluidic devices for single-analyte assays |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8911972B2 (en) * | 2009-12-16 | 2014-12-16 | Pacific Biosciences Of California, Inc. | Sequencing methods using enzyme conformation |
| US20110287432A1 (en) * | 2010-05-21 | 2011-11-24 | 454 Life Science Corporation | System and method for tailoring nucleotide concentration to enzymatic efficiencies in dna sequencing technologies |
| GB2481283B (en) * | 2010-06-03 | 2013-07-17 | Element Six Ltd | A method of increasing the toughness and/or wear resistance of diamond tool pieces and diamond tool pieces fabricated by said method |
| WO2012097074A2 (en) * | 2011-01-11 | 2012-07-19 | The Trustees Of Columbia University In The City Of New York | Systems and methods for single-molecule detection using nanotubes |
| US9164053B2 (en) * | 2011-09-26 | 2015-10-20 | The Regents Of The University Of California | Electronic device for monitoring single molecule dynamics |
| US9279154B2 (en) * | 2011-12-21 | 2016-03-08 | Illumina, Inc. | Apparatus and methods for kinetic analysis and determination of nucleic acid sequences |
| US9950001B2 (en) * | 2012-08-20 | 2018-04-24 | The Regents Of The University Of California | Polynucleotides having bioreversible groups |
-
2015
- 2015-12-17 SG SG11201704862UA patent/SG11201704862UA/en unknown
- 2015-12-17 WO PCT/US2015/066321 patent/WO2016100635A1/en active Application Filing
- 2015-12-17 EP EP15871053.3A patent/EP3234178A4/en not_active Withdrawn
- 2015-12-17 WO PCT/US2015/066324 patent/WO2016100637A1/en active Application Filing
- 2015-12-17 CA CA2971268A patent/CA2971268A1/en active Pending
- 2015-12-17 KR KR1020177019443A patent/KR20170091158A/ko not_active Ceased
- 2015-12-17 RU RU2017125417A patent/RU2721965C2/ru active
- 2015-12-17 JP JP2017532800A patent/JP2018500905A/ja active Pending
- 2015-12-17 US US15/537,072 patent/US20180051316A1/en not_active Abandoned
- 2015-12-17 AU AU2015364602A patent/AU2015364602B2/en not_active Ceased
- 2015-12-17 CN CN201811305798.5A patent/CN109517878A/zh active Pending
- 2015-12-17 CN CN201580072789.4A patent/CN107109466A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN109517878A (zh) | 2019-03-26 |
| RU2017125417A3 (enrdf_load_stackoverflow) | 2019-05-27 |
| EP3234178A4 (en) | 2018-07-11 |
| EP3234178A1 (en) | 2017-10-25 |
| RU2017125417A (ru) | 2019-01-23 |
| WO2016100637A1 (en) | 2016-06-23 |
| KR20170091158A (ko) | 2017-08-08 |
| CA2971268A1 (en) | 2016-06-23 |
| AU2015364602B2 (en) | 2021-12-09 |
| AU2015364602A1 (en) | 2017-07-06 |
| CN107109466A (zh) | 2017-08-29 |
| US20180051316A1 (en) | 2018-02-22 |
| WO2016100635A1 (en) | 2016-06-23 |
| RU2721965C2 (ru) | 2020-05-25 |
| JP2018500905A (ja) | 2018-01-18 |
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