SG11201702075QA - Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms) - Google Patents
Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms)Info
- Publication number
- SG11201702075QA SG11201702075QA SG11201702075QA SG11201702075QA SG11201702075QA SG 11201702075Q A SG11201702075Q A SG 11201702075QA SG 11201702075Q A SG11201702075Q A SG 11201702075QA SG 11201702075Q A SG11201702075Q A SG 11201702075QA SG 11201702075Q A SG11201702075Q A SG 11201702075QA
- Authority
- SG
- Singapore
- Prior art keywords
- kdms
- modulating
- catalytic activity
- histone lysine
- lysine demethylases
- Prior art date
Links
- IAAQUOVTPAMQCR-UHFFFAOYSA-N 1h-pyrido[3,2-d]pyrimidin-2-one Chemical class C1=CC=C2NC(=O)N=CC2=N1 IAAQUOVTPAMQCR-UHFFFAOYSA-N 0.000 title 1
- 102000008157 Histone Demethylases Human genes 0.000 title 1
- 108010074870 Histone Demethylases Proteins 0.000 title 1
- 230000003197 catalytic effect Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462069915P | 2014-10-29 | 2014-10-29 | |
| PCT/KR2015/011386 WO2016068580A2 (en) | 2014-10-29 | 2015-10-27 | Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201702075QA true SG11201702075QA (en) | 2017-04-27 |
Family
ID=55851908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201702075QA SG11201702075QA (en) | 2014-10-29 | 2015-10-27 | Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms) |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9834550B2 (ru) |
| EP (1) | EP3212647B1 (ru) |
| JP (1) | JP6505222B2 (ru) |
| KR (1) | KR101978899B1 (ru) |
| CN (1) | CN107001358A (ru) |
| AU (1) | AU2015340215B2 (ru) |
| BR (1) | BR112017008312A2 (ru) |
| CA (1) | CA2962917C (ru) |
| MX (1) | MX2017005346A (ru) |
| NZ (1) | NZ730475A (ru) |
| RU (1) | RU2684396C2 (ru) |
| SG (1) | SG11201702075QA (ru) |
| WO (1) | WO2016068580A2 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3359154B1 (en) * | 2015-10-08 | 2021-05-26 | Suzhou Yunxuan Yiyao Keji Youxian Gongsi | Wnt signaling pathway inhibitors and therapeutic applications thereof |
| SG11201804901WA (en) | 2015-12-22 | 2018-07-30 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| CA3066939A1 (en) | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| CN112119065B (zh) * | 2018-07-13 | 2024-01-23 | 四川科伦博泰生物医药股份有限公司 | 苯并二氮杂环类化合物、其制备方法及用途 |
| US20230110603A1 (en) | 2020-01-31 | 2023-04-13 | Kumiai Chemical Industry Co., Ltd. | 3-alkoxybenzamide derivative, and pest control agent |
| EP4126847A1 (en) | 2020-03-30 | 2023-02-08 | ENYO Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
| WO2021198191A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
| BR112023019511A2 (pt) * | 2021-03-31 | 2023-10-31 | Duke Street Bio Ltd | Composto inibidor de parp7, composto, composição farmacêutica, kit farmacêutico para o tratamento de um câncer, método de tratamento de uma doença e/ou uma condição e/ou um distúrbio, e, método de síntese de um composto |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5939421A (en) * | 1997-07-01 | 1999-08-17 | Signal Pharmaceuticals, Inc. | Quinazoline analogs and related compounds and methods for treating inflammatory conditions |
| GB9909135D0 (en) | 1999-04-22 | 1999-06-16 | Univ Wales Medicine | Cystic fibrosis medicaments |
| WO2003045911A1 (en) * | 2001-11-26 | 2003-06-05 | Dsm Ip Assets B.V. | Process for recovering caprolactam |
| FR2846657B1 (fr) | 2002-11-05 | 2004-12-24 | Servier Lab | Nouveaux composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2005032481A2 (en) * | 2003-09-30 | 2005-04-14 | Scios Inc. | Quinazoline derivatives as medicaments |
| NZ546477A (en) | 2006-04-07 | 2009-04-30 | Auckland Uniservices Ltd | 4-Alkylamino-2-(heterocyclic)quinazolines and their use in cancer therapy |
| AU2012284088B2 (en) | 2011-07-19 | 2015-10-08 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| BR112015007061B1 (pt) * | 2012-09-28 | 2022-10-04 | Cancer Research Technology Limited | Composto, composição farmacêutica e uso do composto |
| WO2014055634A1 (en) | 2012-10-02 | 2014-04-10 | Yale University | Identification of small molecule inhibitors of jumonji at-rich interactive domain 1a (jarid1a) and 1b (jarid1b) histone demethylase |
| ES2654143T3 (es) | 2012-10-02 | 2018-02-12 | Gilead Sciences, Inc. | Inhibidores de desmetilasas de histonas |
| WO2014087165A1 (en) * | 2012-12-06 | 2014-06-12 | University Of Bath | Tankyrase inhibitors |
| CN105263906B (zh) | 2013-02-27 | 2018-11-23 | 吉利德科学公司 | 组蛋白脱甲基酶的抑制剂 |
| CA2903473A1 (en) | 2013-03-12 | 2014-10-09 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
| BR112015022545A2 (pt) | 2013-03-13 | 2017-07-18 | Constellation Pharmaceuticals Inc | compostos de pirazolo e os usos disso |
| HUE034906T2 (hu) | 2013-03-15 | 2018-03-28 | Quanticel Pharmaceuticals Inc | Hiszton-demetiláz inhibitorok |
| MX2016002794A (es) | 2013-09-05 | 2016-09-13 | Genentech Inc | Compuestos antiproliferativos. |
| CN103694255A (zh) * | 2014-01-09 | 2014-04-02 | 华中师范大学 | 吡啶并噁嗪酮和吡啶并嘧啶酮类化合物及其制备方法与应用 |
| TWI675836B (zh) * | 2014-03-25 | 2019-11-01 | 美商伊格尼塔公司 | 非典型蛋白質激酶ｃ之氮雜喹唑啉抑制劑 |
-
2015
- 2015-10-27 CA CA2962917A patent/CA2962917C/en active Active
- 2015-10-27 NZ NZ730475A patent/NZ730475A/en unknown
- 2015-10-27 MX MX2017005346A patent/MX2017005346A/es unknown
- 2015-10-27 BR BR112017008312A patent/BR112017008312A2/pt not_active Application Discontinuation
- 2015-10-27 SG SG11201702075QA patent/SG11201702075QA/en unknown
- 2015-10-27 AU AU2015340215A patent/AU2015340215B2/en active Active
- 2015-10-27 RU RU2017113007A patent/RU2684396C2/ru active
- 2015-10-27 US US14/923,525 patent/US9834550B2/en active Active
- 2015-10-27 WO PCT/KR2015/011386 patent/WO2016068580A2/en active Application Filing
- 2015-10-27 JP JP2017523293A patent/JP6505222B2/ja active Active
- 2015-10-27 CN CN201580061545.6A patent/CN107001358A/zh active Pending
- 2015-10-27 EP EP15853996.5A patent/EP3212647B1/en not_active Not-in-force
- 2015-10-27 KR KR1020177014472A patent/KR101978899B1/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| RU2684396C2 (ru) | 2019-04-09 |
| MX2017005346A (es) | 2017-08-02 |
| CA2962917C (en) | 2019-04-30 |
| RU2017113007A (ru) | 2018-11-29 |
| RU2017113007A3 (ru) | 2018-11-29 |
| WO2016068580A2 (en) | 2016-05-06 |
| EP3212647A4 (en) | 2018-04-18 |
| AU2015340215A1 (en) | 2017-04-13 |
| US9834550B2 (en) | 2017-12-05 |
| EP3212647A2 (en) | 2017-09-06 |
| EP3212647B1 (en) | 2019-04-03 |
| WO2016068580A3 (en) | 2016-08-18 |
| KR20170072943A (ko) | 2017-06-27 |
| US20160122343A1 (en) | 2016-05-05 |
| CN107001358A (zh) | 2017-08-01 |
| KR101978899B1 (ko) | 2019-05-15 |
| CA2962917A1 (en) | 2016-05-06 |
| AU2015340215B2 (en) | 2018-11-15 |
| JP6505222B2 (ja) | 2019-04-24 |
| JP2017533215A (ja) | 2017-11-09 |
| BR112017008312A2 (pt) | 2017-12-19 |
| NZ730475A (en) | 2018-09-28 |
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