SG11201504260UA - Low acidic species compositions and methods for producing and using the same - Google Patents
Low acidic species compositions and methods for producing and using the sameInfo
- Publication number
- SG11201504260UA SG11201504260UA SG11201504260UA SG11201504260UA SG11201504260UA SG 11201504260U A SG11201504260U A SG 11201504260UA SG 11201504260U A SG11201504260U A SG 11201504260UA SG 11201504260U A SG11201504260U A SG 11201504260UA SG 11201504260U A SG11201504260U A SG 11201504260UA
- Authority
- SG
- Singapore
- Prior art keywords
- producing
- methods
- same
- acidic species
- low acidic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2013/031485 WO2013158275A1 (fr) | 2012-04-20 | 2013-03-14 | Procédés de culture cellulaire pour réduire des espèces acides |
PCT/US2013/031681 WO2013158279A1 (fr) | 2012-04-20 | 2013-03-14 | Procédés de purification de protéines pour réduire des espèces acides |
PCT/US2013/065749 WO2014158231A1 (fr) | 2013-03-14 | 2013-10-18 | Compositions d'espèces faiblement acides et leurs procédés de production et d'utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201504260UA true SG11201504260UA (en) | 2015-10-29 |
Family
ID=49517725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201504260UA SG11201504260UA (en) | 2013-03-14 | 2013-10-18 | Low acidic species compositions and methods for producing and using the same |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2836515A1 (fr) |
KR (1) | KR20150129033A (fr) |
AU (1) | AU2013384204B2 (fr) |
BR (1) | BR112015017307A2 (fr) |
CA (3) | CA2926301A1 (fr) |
HK (1) | HK1206755A1 (fr) |
SG (1) | SG11201504260UA (fr) |
WO (1) | WO2014158231A1 (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2702077A2 (fr) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Procédé de contrôle du profil de galactosylation de protéines exprimées de manière recombinante |
WO2013158279A1 (fr) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Procédés de purification de protéines pour réduire des espèces acides |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9505833B2 (en) | 2012-04-20 | 2016-11-29 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
WO2015051293A2 (fr) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Utilisation d'ions métalliques pour moduler les profils de glycosylation des protéines dans le cas de protéines recombinées |
AU2014337263B2 (en) | 2013-10-16 | 2019-12-12 | Outlook Therapeutics, Inc. | Buffer formulations for enhanced antibody stability |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
WO2015073884A2 (fr) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Compositions de protéines de liaison génétiquement glycomodifiées |
US20160039924A1 (en) * | 2014-08-05 | 2016-02-11 | Abbvie Inc. | Methods for modulating the glycosylation profile of recombinant proteins using dissolved oxygen |
US10696735B2 (en) | 2015-01-21 | 2020-06-30 | Outlook Therapeutics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
EP4056590A1 (fr) * | 2015-08-24 | 2022-09-14 | GlaxoSmithKline Intellectual Property (No.2) Limited | Compositions biopharmaceutiques |
JP7084308B2 (ja) | 2016-02-03 | 2022-06-14 | アウトルック セラピューティクス,インコーポレイティド | 抗体安定性を増大させるための緩衝液製剤 |
GB201602938D0 (en) * | 2016-02-19 | 2016-04-06 | Ucb Biopharma Sprl | Protein purification |
WO2018027195A1 (fr) * | 2016-08-05 | 2018-02-08 | Abbvie Biotherapeutics Inc. | Compositions contenant des quantités réduites d'isoformes acides de daclizumab et procédés de préparation associés |
KR102511050B1 (ko) | 2016-08-16 | 2023-03-17 | 리제너론 파아마슈티컬스, 인크. | 혼합물로부터 개별 항체들을 정량하는 방법 |
CA3036965A1 (fr) | 2016-09-16 | 2018-03-22 | Leukocare Ag | Nouveau procede de stabilisation d'un produit medicamenteux biopharmaceutique pendant le traitement |
PL3532838T3 (pl) | 2016-10-25 | 2022-10-03 | Regeneron Pharmaceuticals, Inc. | Metody i systemy analizy danych chromatograficznych |
EP3339444A1 (fr) * | 2016-12-20 | 2018-06-27 | Mabxience Research, S.L. | Procédé permettant d'obtenir une glycoprotéine ayant un pourcentage élevé de glycanes afucosylés |
GB201711481D0 (en) | 2017-07-17 | 2017-08-30 | Ucb Biopharma Sprl | Protein purification |
TW202005694A (zh) | 2018-07-02 | 2020-02-01 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
CN111693711B (zh) * | 2019-03-12 | 2023-05-05 | 上海市质量监督检验技术研究院 | 一种超高压液相色谱串联质谱同时检测鲜蛋中103种抗生素残留的方法 |
MX2022007464A (es) * | 2019-12-18 | 2022-06-27 | Tesaro Inc | Composiciones biofarmaceuticas y metodos relacionados. |
WO2022154762A1 (fr) * | 2021-01-18 | 2022-07-21 | Turgut İlaçlari A.Ş. | Procédé de production d'adalimumab |
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BR112013011699B1 (pt) | 2010-11-11 | 2019-04-24 | Abbvie Biotechnology Ltd | FORMULAÇÕES AQUOSAS LÍQUIDAS, SERINGA PRÉ-CHEIA OU DISPOSITIVO AUTOINJETOR E USO DAS DITAS FORMULAÇÕES PARA TRATAR UM DISTÚRBIO ASSOCIADO À ATIVIDADE DE TNFa COMPROMETIDA |
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-
2013
- 2013-10-18 EP EP13786072.2A patent/EP2836515A1/fr not_active Withdrawn
- 2013-10-18 AU AU2013384204A patent/AU2013384204B2/en not_active Withdrawn - After Issue
- 2013-10-18 CA CA2926301A patent/CA2926301A1/fr not_active Abandoned
- 2013-10-18 WO PCT/US2013/065749 patent/WO2014158231A1/fr active Application Filing
- 2013-10-18 SG SG11201504260UA patent/SG11201504260UA/en unknown
- 2013-10-18 KR KR1020157029562A patent/KR20150129033A/ko not_active Application Discontinuation
- 2013-10-18 CA CA2899308A patent/CA2899308C/fr not_active Expired - Fee Related
- 2013-10-18 BR BR112015017307A patent/BR112015017307A2/pt not_active IP Right Cessation
- 2013-10-18 CA CA2926384A patent/CA2926384A1/fr not_active Abandoned
-
2015
- 2015-07-30 HK HK15107319.2A patent/HK1206755A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
HK1206755A1 (en) | 2016-01-15 |
CA2926384A1 (fr) | 2014-10-02 |
CA2899308A1 (fr) | 2014-10-02 |
CA2899308C (fr) | 2017-04-18 |
CA2926301A1 (fr) | 2014-10-02 |
KR20150129033A (ko) | 2015-11-18 |
EP2836515A1 (fr) | 2015-02-18 |
AU2013384204A1 (en) | 2015-06-04 |
WO2014158231A1 (fr) | 2014-10-02 |
BR112015017307A2 (pt) | 2017-11-21 |
AU2013384204B2 (en) | 2017-03-16 |
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