SG11201503752SA - Cloned non-human animals free of selective markers - Google Patents

Cloned non-human animals free of selective markers

Info

Publication number
SG11201503752SA
SG11201503752SA SG11201503752SA SG11201503752SA SG11201503752SA SG 11201503752S A SG11201503752S A SG 11201503752SA SG 11201503752S A SG11201503752S A SG 11201503752SA SG 11201503752S A SG11201503752S A SG 11201503752SA SG 11201503752S A SG11201503752S A SG 11201503752SA
Authority
SG
Singapore
Prior art keywords
human animals
selective markers
cloned non
animals free
free
Prior art date
Application number
SG11201503752SA
Other languages
English (en)
Inventor
Guochun Gong
Ka-Man Venus Lai
David M Valenzuela
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49725406&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201503752S(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11201503752SA publication Critical patent/SG11201503752SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0273—Cloned vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8771—Bovine embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8778—Swine embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A01K2217/203—Animal model comprising inducible/conditional expression system, e.g. hormones, tet
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/007—Vectors comprising a special translation-regulating system cell or tissue specific
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2999/00—Further aspects of viruses or vectors not covered by groups C12N2710/00 - C12N2796/00 or C12N2800/00
    • C12N2999/007—Technological advancements, e.g. new system for producing known virus, cre-lox system for production of transgenic animals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Reproductive Health (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11201503752SA 2012-11-28 2013-11-26 Cloned non-human animals free of selective markers SG11201503752SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261730771P 2012-11-28 2012-11-28
PCT/US2013/072088 WO2014085501A1 (en) 2012-11-28 2013-11-26 Cloned non-human animals free of selective markers

Publications (1)

Publication Number Publication Date
SG11201503752SA true SG11201503752SA (en) 2015-06-29

Family

ID=49725406

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201503752SA SG11201503752SA (en) 2012-11-28 2013-11-26 Cloned non-human animals free of selective markers

Country Status (16)

Country Link
US (1) US20140221734A1 (es)
EP (1) EP2925122A1 (es)
JP (2) JP6154479B2 (es)
KR (1) KR20150089004A (es)
CN (1) CN104918484A (es)
AU (1) AU2013352235A1 (es)
BR (1) BR112015012408A2 (es)
CA (1) CA2891163A1 (es)
HK (1) HK1211177A1 (es)
IL (1) IL238771A0 (es)
MX (1) MX353279B (es)
MY (1) MY193790A (es)
RU (1) RU2015122802A (es)
SG (1) SG11201503752SA (es)
WO (1) WO2014085501A1 (es)
ZA (1) ZA201503305B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2877571B1 (en) 2013-09-18 2018-05-30 Kymab Limited Methods, cells and organisms
US11246299B2 (en) 2015-03-04 2022-02-15 Pormedtec Co., Ltd. Disease model pig exhibiting stable phenotype, and production method thereof
CN105200086A (zh) * 2015-10-22 2015-12-30 中国农业科学院北京畜牧兽医研究所 一种无选择标记的多基因复合性状基因工程猪的制备方法
CA3099441A1 (en) 2018-06-13 2019-12-19 Regeneron Pharmaceuticals, Inc. A rodent model of fibrodysplasia ossificans progressiva
CN109504708A (zh) * 2018-12-03 2019-03-22 江苏集萃药康生物科技有限公司 一种筛选标记自我删除的基因打靶载体及方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1375654A3 (en) * 1998-11-02 2008-01-16 GTC Biotherapeutics, Inc. Transgenic and cloned mammals
US7049480B1 (en) * 2000-09-01 2006-05-23 Avigenics, Inc. Methods of enucleating an avian oocyte or zygote using two-photon laser scanning microscopy
WO2006035741A1 (ja) * 2004-09-29 2006-04-06 Dainippon Sumitomo Pharma Co., Ltd. Ｅｓ細胞特異的発現遺伝子及びその利用
WO2009121999A1 (es) * 2008-04-04 2009-10-08 Consejo Superior De Investigaciones Científicas Promotor especifico de celulas troncales
US8354389B2 (en) * 2009-08-14 2013-01-15 Regeneron Pharmaceuticals, Inc. miRNA-regulated differentiation-dependent self-deleting cassette
CN102628061A (zh) * 2012-04-09 2012-08-08 西北农林科技大学 一种hbd3 乳腺特异性表达载体及构建的重组细胞

Also Published As

Publication number Publication date
CN104918484A (zh) 2015-09-16
JP6227747B2 (ja) 2017-11-08
RU2015122802A (ru) 2017-01-10
KR20150089004A (ko) 2015-08-04
AU2013352235A1 (en) 2015-05-28
MX2015006810A (es) 2015-09-07
MX353279B (es) 2018-01-05
BR112015012408A2 (pt) 2017-07-11
JP2017060502A (ja) 2017-03-30
EP2925122A1 (en) 2015-10-07
ZA201503305B (en) 2016-05-25
HK1211177A1 (en) 2016-05-20
CA2891163A1 (en) 2014-06-05
MY193790A (en) 2022-10-27
IL238771A0 (en) 2015-06-30
JP6154479B2 (ja) 2017-06-28
US20140221734A1 (en) 2014-08-07
JP2016502407A (ja) 2016-01-28
WO2014085501A1 (en) 2014-06-05

Similar Documents

Publication Publication Date Title
IL282472A (en) Genetically modified non-human animals and methods of their use
IL258968A (en) Genetically modified non-human animals and methods of their use
EP2887799A4 (en) FISHING LURE
HK1220990A1 (zh) 缺乏 的非人類動物
EP2749163A4 (en) FISHING ROD
EP2756753A4 (en) FISHING REEL
HK1212552A1 (zh) 基因敲入非人動物
HK1211177A1 (en) Cloned non-human animals free of selective markers
EP2868192A4 (en) LITTER FOR ANIMALS
HRP20181521T1 (hr) Pokretna životinjska staja
GB2489200B (en) Animal halter
EP2926655A4 (en) REEL FOR FISHING
IL234955A (en) Harness for an animal
GB201214337D0 (en) Transgenic animal
EP2898772A4 (en) FISHING REEL
HU4177U (en) Manger
GB201218748D0 (en) Fishing aid
GB201215190D0 (en) Fishing kite
GB2506356B (en) An animal deterrent
AU344685S (en) Leash connector - water sports
AU343316S (en) Leash connector - water sports
GB201311228D0 (en) Fishing reel
AU343607S (en) Fishing ski
GB201205891D0 (en) Fishing reel
FI10073U1 (fi) Eläinankkuri