SG11201502918RA - Elution of biomolecules from multi-modal resins using mes and mops as mobile phase modifiers - Google Patents
Elution of biomolecules from multi-modal resins using mes and mops as mobile phase modifiersInfo
- Publication number
- SG11201502918RA SG11201502918RA SG11201502918RA SG11201502918RA SG11201502918RA SG 11201502918R A SG11201502918R A SG 11201502918RA SG 11201502918R A SG11201502918R A SG 11201502918RA SG 11201502918R A SG11201502918R A SG 11201502918RA SG 11201502918R A SG11201502918R A SG 11201502918RA
- Authority
- SG
- Singapore
- Prior art keywords
- mops
- biomolecules
- mes
- elution
- mobile phase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/16—Holders for containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3847—Multimodal interactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01022—Alpha-galactosidase (3.2.1.22)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261717880P | 2012-10-24 | 2012-10-24 | |
| PCT/US2013/066319 WO2014066471A1 (fr) | 2012-10-24 | 2013-10-23 | Élution de biomolécules à partir de résines multimodales au moyen de mes et de mops en tant que modificateurs de phase mobile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201502918RA true SG11201502918RA (en) | 2015-05-28 |
Family
ID=49554488
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201502918RA SG11201502918RA (en) | 2012-10-24 | 2013-10-23 | Elution of biomolecules from multi-modal resins using mes and mops as mobile phase modifiers |
| SG10201901695RA SG10201901695RA (en) | 2012-10-24 | 2013-10-23 | Elution of biomolecules from multi-modal resins using mes and mops as mobile phase modifiers |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201901695RA SG10201901695RA (en) | 2012-10-24 | 2013-10-23 | Elution of biomolecules from multi-modal resins using mes and mops as mobile phase modifiers |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20150275195A1 (fr) |
| EP (1) | EP2911759A1 (fr) |
| CN (3) | CN105777862A (fr) |
| AU (3) | AU2013334644B2 (fr) |
| CA (1) | CA2888824C (fr) |
| HK (1) | HK1222868A1 (fr) |
| MX (1) | MX2015005313A (fr) |
| SG (2) | SG11201502918RA (fr) |
| WO (1) | WO2014066471A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2888824C (fr) * | 2012-10-24 | 2021-02-02 | Genzyme Corporation | Elution de biomolecules a partir de resines multimodales au moyen de l'acide 2-(n-morpholino)ethanosulfonique (mes) en tant que modificateursde phase mobile |
| SG11201506775VA (en) * | 2013-03-08 | 2015-09-29 | Genzyme Corp | Continuous purification of therapeutic proteins |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| TWI709570B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析法及製法 |
| JP7299896B2 (ja) * | 2017-12-29 | 2023-06-28 | 武田薬品工業株式会社 | アデノ随伴ウイルス精製方法 |
| CN108479110A (zh) * | 2018-04-10 | 2018-09-04 | 深圳市菲鹏生物制药股份有限公司 | 一种细胞培养液脱色剂及脱色方法 |
| WO2020046602A1 (fr) | 2018-08-31 | 2020-03-05 | Genzyme Corporation | Résine de chromatographie stérile et son utilisation dans des procédés de fabrication |
| DE102020214647A1 (de) | 2020-11-20 | 2022-05-25 | DIL Deutsches Institut für Lebensmitteltechnik e.V. | Anthocyanhaltiges Extraktpulver und Verfahren zur Herstellung |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4347322A (en) * | 1981-01-12 | 1982-08-31 | Nabisco Brands, Inc. | Chromatographic process for enzyme purification |
| US4663288A (en) * | 1985-05-22 | 1987-05-05 | Nabisco Brands, Inc. | Process for purification of enzymes |
| ES2458292T3 (es) | 1996-09-13 | 2014-04-30 | Shire Human Genetic Therapies, Inc. | Producción de alfa-galactosidasa A humana |
| JP2008538181A (ja) * | 2005-03-30 | 2008-10-16 | ネオス テクノロジーズ インコーポレイテッド | 昆虫細胞系において増殖させたペプチドを生産するための製造方法 |
| US20080090278A1 (en) * | 2006-03-31 | 2008-04-17 | Toyo Boseki Kabushiki Kaisha | Method for enhancing stability of a composition comprising soluble glucose dehydrogenase (gdh) |
| JP5323072B2 (ja) | 2007-07-11 | 2013-10-23 | ノボ・ノルデイスク・エー／エス | 混合方式又は多様式樹脂を使用する第ｖｉｉｉ因子の精製 |
| EP2242762B1 (fr) * | 2008-01-18 | 2015-12-16 | Bio-Rad Laboratories, Inc. | Purification améliorée d'anticorps et de fragments d'anticorps par chromatographie sur hydroxyapatite |
| SI2300497T1 (sl) | 2008-06-24 | 2013-02-28 | Octapharma Ag | Postopek za äťiĺˇäťenje koagulacijskega faktorja viii |
| US20110166332A1 (en) | 2008-09-12 | 2011-07-07 | Ge Healthcare Bio-Sciences Ab | Enhanced antibody aggregate removal with capto adhere in the presence of protein-excluded zwitterions |
| CA2697999C (fr) * | 2009-04-24 | 2013-04-30 | Werner Hoelke | Composition aqueuse stabilisee d'alpha-galactosidase et methodes connexes |
| EP2490780A4 (fr) * | 2009-10-20 | 2014-04-09 | Merck Sharp & Dohme | Utilisation de la chromatographie en mode mixte pour la capture et la purification de produits d'anticorps de base |
| JP5773454B2 (ja) * | 2010-01-15 | 2015-09-02 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | アパタイトの表面中和方法 |
| ES2740825T3 (es) | 2010-03-30 | 2020-02-06 | Octapharma Ag | Un procedimiento de purificación de proteínas dependientes de vitamina K |
| CA2793143C (fr) * | 2010-03-30 | 2020-04-28 | Gustav Gilljam | Procede de purification d'une proteine de facteur de croissance |
| WO2012059495A1 (fr) * | 2010-11-05 | 2012-05-10 | F. Hoffmann-La Roche Ag | Procédé optimisé pour la capture d'anticorps par une chromatographie en mode mixte |
| EP2638156B1 (fr) * | 2010-11-09 | 2016-01-27 | Qiagen GmbH | Procédé et dispositif pour l'isolement et la purification d'acides nucléiques double brin |
| BR112013032225A2 (pt) * | 2011-06-13 | 2016-08-16 | Merck Sharp & Dohme | método para purificar toxina de difteria, e, formulação |
| EP3527274A1 (fr) | 2011-11-02 | 2019-08-21 | F. Hoffmann-La Roche AG | Chromatographie par surcharge et élution |
| CA2888824C (fr) * | 2012-10-24 | 2021-02-02 | Genzyme Corporation | Elution de biomolecules a partir de resines multimodales au moyen de l'acide 2-(n-morpholino)ethanosulfonique (mes) en tant que modificateursde phase mobile |
| JP6035427B2 (ja) * | 2012-11-13 | 2016-11-30 | チエシイ・ファルマセウテイシイ・エス・ペー・アーＣｈｉｅｓｉ Ｆａｒｍａｃｅｕｔｉｃｉ Ｓ．Ｐ．Ａ． | 組換えヒトガラクトセレブロシドβ−ガラクトシダーゼ（ｒｈＧＡＬＣ）の精製 |
| TWI631132B (zh) * | 2013-05-06 | 2018-08-01 | 賽諾菲公司 | 用於純化抗體之連續多步驟方法 |
-
2013
- 2013-10-23 CA CA2888824A patent/CA2888824C/fr active Active
- 2013-10-23 US US14/438,401 patent/US20150275195A1/en not_active Abandoned
- 2013-10-23 AU AU2013334644A patent/AU2013334644B2/en active Active
- 2013-10-23 MX MX2015005313A patent/MX2015005313A/es unknown
- 2013-10-23 CN CN201610146521.7A patent/CN105777862A/zh active Pending
- 2013-10-23 CN CN202010027060.8A patent/CN111172135A/zh active Pending
- 2013-10-23 SG SG11201502918RA patent/SG11201502918RA/en unknown
- 2013-10-23 EP EP13789418.4A patent/EP2911759A1/fr active Pending
- 2013-10-23 CN CN201380067814.0A patent/CN104884147A/zh active Pending
- 2013-10-23 WO PCT/US2013/066319 patent/WO2014066471A1/fr active Application Filing
- 2013-10-23 SG SG10201901695RA patent/SG10201901695RA/en unknown
-
2016
- 2016-09-21 HK HK16111066.8A patent/HK1222868A1/zh unknown
-
2018
- 2018-10-08 AU AU2018241214A patent/AU2018241214B9/en active Active
-
2019
- 2019-12-23 US US16/725,879 patent/US11203747B2/en active Active
-
2020
- 2020-05-06 AU AU2020203008A patent/AU2020203008B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104884147A (zh) | 2015-09-02 |
| AU2020203008B2 (en) | 2022-06-16 |
| AU2018241214B2 (en) | 2020-02-06 |
| MX2015005313A (es) | 2016-04-06 |
| WO2014066471A1 (fr) | 2014-05-01 |
| CA2888824A1 (fr) | 2014-05-01 |
| US20200131493A1 (en) | 2020-04-30 |
| AU2020203008A1 (en) | 2020-05-28 |
| AU2018241214A1 (en) | 2018-11-01 |
| AU2013334644A1 (en) | 2015-05-07 |
| US11203747B2 (en) | 2021-12-21 |
| US20150275195A1 (en) | 2015-10-01 |
| CN105777862A (zh) | 2016-07-20 |
| CA2888824C (fr) | 2021-02-02 |
| EP2911759A1 (fr) | 2015-09-02 |
| HK1222868A1 (zh) | 2017-07-14 |
| SG10201901695RA (en) | 2019-03-28 |
| AU2018241214B9 (en) | 2020-02-20 |
| AU2013334644B2 (en) | 2018-07-12 |
| CN111172135A (zh) | 2020-05-19 |
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