SG11201501133WA - Pyrrolopyrazoles as n-type calcium channel blockers - Google Patents

Pyrrolopyrazoles as n-type calcium channel blockers

Info

Publication number
SG11201501133WA
SG11201501133WA SG11201501133WA SG11201501133WA SG11201501133WA SG 11201501133W A SG11201501133W A SG 11201501133WA SG 11201501133W A SG11201501133W A SG 11201501133WA SG 11201501133W A SG11201501133W A SG 11201501133WA SG 11201501133W A SG11201501133W A SG 11201501133WA
Authority
SG
Singapore
Prior art keywords
pyrrolopyrazoles
calcium channel
channel blockers
type calcium
type
Prior art date
Application number
SG11201501133WA
Other languages
English (en)
Inventor
Zhihua Sui
Michael P Winters
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49170857&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201501133W(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SG11201501133WA publication Critical patent/SG11201501133WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201501133WA 2012-08-16 2013-08-16 Pyrrolopyrazoles as n-type calcium channel blockers SG11201501133WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261683780P 2012-08-16 2012-08-16
PCT/US2013/055275 WO2014028805A1 (en) 2012-08-16 2013-08-16 Pyrrolopyrazoles as n-type calcium channel blockers

Publications (1)

Publication Number Publication Date
SG11201501133WA true SG11201501133WA (en) 2015-04-29

Family

ID=49170857

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201501133WA SG11201501133WA (en) 2012-08-16 2013-08-16 Pyrrolopyrazoles as n-type calcium channel blockers

Country Status (19)

Country Link
US (1) US8846949B2 (es)
EP (1) EP2885304B8 (es)
JP (1) JP6250674B2 (es)
KR (1) KR20150042271A (es)
CN (1) CN104936960B (es)
AU (1) AU2013302473B2 (es)
BR (1) BR112015003359A2 (es)
CA (1) CA2882127A1 (es)
CL (1) CL2015000359A1 (es)
CR (1) CR20150070A (es)
EA (1) EA201590379A1 (es)
ES (1) ES2607839T3 (es)
IL (1) IL237192A0 (es)
IN (1) IN2015DN01230A (es)
MX (1) MX2015002039A (es)
PE (1) PE20151139A1 (es)
PH (1) PH12015500310A1 (es)
SG (1) SG11201501133WA (es)
WO (1) WO2014028805A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9974775B2 (en) 2013-08-16 2018-05-22 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2882038A1 (en) 2012-08-16 2014-02-20 Janssen Pharmaceutica Nv Substituted pyrazoles as n-type calcium channel blockers
KR102638253B1 (ko) 2017-05-31 2024-02-16 케모센트릭스, 인크. C5a 억제제로서의 6-5 융합 고리
BR112019025230A2 (pt) * 2017-05-31 2020-06-16 Chemocentryx, Inc. Anéis 5-5 fundidos como inibidores de c5a
AU2018388655C1 (en) 2017-12-22 2023-03-23 Chemocentryx, Inc. Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors
US10759807B2 (en) * 2017-12-22 2020-09-01 Chemocentryx, Inc. Diaryl substituted 5,5-fused ring compounds as C5aR inhibitors
US11608336B2 (en) 2018-04-02 2023-03-21 Chemocentryx, Inc. Prodrugs of fused-bicyclic C5aR antagonists
CN112300169B (zh) * 2019-07-26 2022-03-04 上海美迪西生物医药股份有限公司 吡咯并吡唑类衍生物、其制备方法及其在医药上的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1287174B1 (it) * 1996-11-15 1998-08-04 Angelini Ricerche Spa Diaril-ciclometilenpirazoli farmacologicamente attivi,procedimento per prepararli e composizioni farmaceutiche che li contengono
EP1615895A4 (en) * 2003-04-03 2007-11-07 Merck & Co Inc SUBSTITUTED BIARYL PYRAZOLES AS SODIUM CHANNEL BLOCKERS
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
ATE420881T1 (de) * 2003-09-17 2009-01-15 Janssen Pharmaceutica Nv Kondensierte heterocyclische verbindungen als modulatoren des serotoninrezeptors
FR2864958B1 (fr) * 2004-01-12 2006-02-24 Sanofi Synthelabo Derive de n-[(1,5-diphenyl-1h-pyrazol-3-yl)methyl] sulfonamide, leur preparation et leur application en therapeutique.
US20070203194A1 (en) * 2004-03-08 2007-08-30 Scion Pharmaceuticals, Inc. Ion channel modulators
WO2005086902A2 (en) * 2004-03-08 2005-09-22 Wyeth Ion channel modulators

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9974775B2 (en) 2013-08-16 2018-05-22 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers

Also Published As

Publication number Publication date
IL237192A0 (en) 2015-04-30
AU2013302473B2 (en) 2017-08-10
WO2014028805A1 (en) 2014-02-20
ES2607839T3 (es) 2017-04-04
CR20150070A (es) 2015-05-18
CN104936960A (zh) 2015-09-23
US8846949B2 (en) 2014-09-30
CN104936960B (zh) 2016-12-28
EP2885304A1 (en) 2015-06-24
IN2015DN01230A (en) 2015-06-26
MX2015002039A (es) 2016-01-22
BR112015003359A2 (pt) 2017-07-04
CL2015000359A1 (es) 2015-04-24
EP2885304B1 (en) 2016-09-21
EP2885304B8 (en) 2016-12-07
JP6250674B2 (ja) 2017-12-20
EA201590379A1 (ru) 2015-06-30
KR20150042271A (ko) 2015-04-20
US20140051688A1 (en) 2014-02-20
PE20151139A1 (es) 2015-08-07
PH12015500310A1 (en) 2015-04-20
JP2015524853A (ja) 2015-08-27
AU2013302473A1 (en) 2015-02-26
CA2882127A1 (en) 2014-02-20

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