SG11201407252UA - Method for controlling the size of solid-state nanopores - Google Patents
Method for controlling the size of solid-state nanoporesInfo
- Publication number
- SG11201407252UA SG11201407252UA SG11201407252UA SG11201407252UA SG11201407252UA SG 11201407252U A SG11201407252U A SG 11201407252UA SG 11201407252U A SG11201407252U A SG 11201407252UA SG 11201407252U A SG11201407252U A SG 11201407252UA SG 11201407252U A SG11201407252U A SG 11201407252UA
- Authority
- SG
- Singapore
- Prior art keywords
- ottawa
- nanopore
- international
- kin
- ontario
- Prior art date
Links
- 239000012528 membrane Substances 0.000 abstract 2
- 230000008520 organization Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25F—PROCESSES FOR THE ELECTROLYTIC REMOVAL OF MATERIALS FROM OBJECTS; APPARATUS THEREFOR
- C25F3/00—Electrolytic etching or polishing
- C25F3/02—Etching
- C25F3/14—Etching locally
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0081—After-treatment of organic or inorganic membranes
- B01D67/009—After-treatment of organic or inorganic membranes with wave-energy, particle-radiation or plasma
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
- B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
- B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
- B81C1/00087—Holes
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25F—PROCESSES FOR THE ELECTROLYTIC REMOVAL OF MATERIALS FROM OBJECTS; APPARATUS THEREFOR
- C25F7/00—Constructional parts, or assemblies thereof, of cells for electrolytic removal of material from objects; Servicing or operating
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B7/00—Measuring arrangements characterised by the use of electric or magnetic techniques
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0095—Semiconductive materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
- B01D2321/22—Electrical effects
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/42—Details of membrane preparation apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/02—Details relating to pores or porosity of the membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/02—Details relating to pores or porosity of the membranes
- B01D2325/0282—Dynamic pores-stimuli responsive membranes, e.g. thermoresponsive or pH-responsive
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2203/00—Basic microelectromechanical structures
- B81B2203/03—Static structures
- B81B2203/0353—Holes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Biomedical Technology (AREA)
- Electrochemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Plasma & Fusion (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Steroid Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Testing Of Short-Circuits, Discontinuities, Leakage, Or Incorrect Line Connections (AREA)
Abstract
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 November 2013 (14.11.2013) WIPOIPCT (10) International Publication Number WO 2013/167952 A1 (51) International Patent Classification: B01D 67/00 (2006.01) G01B 7/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/000884 7 May 2013 (07.05.2013) English English (30) Priority Data: 61/643,651 61/781,081 7 May 2012 (07.05.2012) US 14 March 2013 (14.03.2013) US (71) Applicant: THE UNIVERSITY OF OTTAWA [CA/CA]; 3042-800 King Edward, Ottawa, Ontario KIN 6N5 (CA). (72) Inventors: GODIN, Michael; The University of Ottawa, 3042-800 King Edward, Ottawa, Ontario KIN 6N5 (CA). BEAMISH, Eric; The University of Ottawa, 3042-800 King Edward, Ottawa, Ontario KIN 6N5 (CA). TABARD- COSSA, Vincent; The University of Ottawa, 3042-800 King Edward, Ottawa, Ontario KIN 6N5 (CA). KWOK, Wing Hei; The University of Ottawa, 3042-800 King Ed ward, Ottawa, Ontario KIN 6N5 (CA). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: METHOD FOR CONTROLLING THE SIZE OF SOLID-STATE NANOPORES ^27 CJ o\ i> i-H cn i-H o CJ O £ FIG. 2 (57) Abstract: A method is provided for precisely enlarging a nanopore formed in a membrane. The method includes: applying an electric potential across the nanopore, where the electric potential has a pulsed waveform oscillating between a high value and low a value; measuring current flowing though the nanopore while the electric potential is being applied to the nanopore at a low value; determining size of the nanopore based in part on the measured current; and removing the electric potential applied the to membrane when the size of the nanopore corresponds to a desired size.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261643651P | 2012-05-07 | 2012-05-07 | |
US201361781081P | 2013-03-14 | 2013-03-14 | |
PCT/IB2013/000884 WO2013167952A1 (en) | 2012-05-07 | 2013-05-07 | Method for controlling the size of solid-state nanopores |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201407252UA true SG11201407252UA (en) | 2014-12-30 |
Family
ID=49550214
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201407252UA SG11201407252UA (en) | 2012-05-07 | 2013-05-07 | Method for controlling the size of solid-state nanopores |
SG10201606334XA SG10201606334XA (en) | 2012-05-07 | 2013-05-07 | Fabrication of nanopores using high electric fields |
SG11201407249XA SG11201407249XA (en) | 2012-05-07 | 2013-05-07 | Fabrication of nanopores using high electric fields |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201606334XA SG10201606334XA (en) | 2012-05-07 | 2013-05-07 | Fabrication of nanopores using high electric fields |
SG11201407249XA SG11201407249XA (en) | 2012-05-07 | 2013-05-07 | Fabrication of nanopores using high electric fields |
Country Status (12)
Country | Link |
---|---|
US (2) | US9777389B2 (en) |
EP (2) | EP2846901B1 (en) |
JP (3) | JP6298450B2 (en) |
KR (2) | KR102065745B1 (en) |
CN (2) | CN104411386B (en) |
AU (2) | AU2013257756B2 (en) |
BR (2) | BR112014027829B1 (en) |
CA (2) | CA2872602C (en) |
ES (2) | ES2630064T3 (en) |
MX (2) | MX357200B (en) |
SG (3) | SG11201407252UA (en) |
WO (2) | WO2013167952A1 (en) |
Families Citing this family (36)
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CA3116407C (en) * | 2013-03-15 | 2023-02-07 | President And Fellows Of Harvard College | Surface wetting method |
WO2015097765A1 (en) | 2013-12-25 | 2015-07-02 | 株式会社日立製作所 | Hole forming method, measuring apparatus, and chip set |
JP6209122B2 (en) * | 2014-04-02 | 2017-10-04 | 株式会社日立ハイテクノロジーズ | Hole forming method and measuring apparatus |
DE102014111984B3 (en) * | 2014-08-21 | 2016-01-21 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Fluidic gigaohm seal for transmembrane protein measurements |
WO2016094131A2 (en) * | 2014-12-01 | 2016-06-16 | Cornell University | Nanopore-containing substrates with aligned nanoscale electronic elements and methods of making and using same |
MX2017007833A (en) * | 2014-12-19 | 2018-03-21 | Univ Ottawa | Integrating nanopore sensors within microfluidic channel arrays using controlled breakdown. |
MX2017010824A (en) * | 2015-02-24 | 2018-05-28 | Univ Ottawa | Localizing nanopore fabrication on a membrane by laser illumination during controlled breakdown. |
CN104694649A (en) * | 2015-03-10 | 2015-06-10 | 北京大学 | Nanopore sequencing method for nucleic acid molecules with low perforation rate and special nanopore device thereof |
WO2016142925A1 (en) * | 2015-03-12 | 2016-09-15 | Ecole Polytechnique Federale De Lausanne (Epfl) | Nanopore forming method and uses thereof |
EP3067693A1 (en) | 2015-03-12 | 2016-09-14 | Ecole Polytechnique Federale de Lausanne (EPFL) | Nanopore forming method and uses thereof |
RU2020100511A (en) | 2015-04-03 | 2020-06-26 | Эбботт Лэборетриз | DEVICES AND METHODS FOR SAMPLE ANALYSIS |
WO2016161402A1 (en) | 2015-04-03 | 2016-10-06 | Abbott Laboratories | Devices and methods for sample analysis |
GB201508669D0 (en) * | 2015-05-20 | 2015-07-01 | Oxford Nanopore Tech Ltd | Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown |
WO2017004463A1 (en) | 2015-07-01 | 2017-01-05 | Abbott Laboratories | Devices and methods for sample analysis |
JP2020502478A (en) | 2016-10-05 | 2020-01-23 | アボット・ラボラトリーズAbbott Laboratories | Device and method for sample analysis |
US20190256904A1 (en) * | 2016-10-12 | 2019-08-22 | Roche Sequencing Solutions, Inc. | Nanopore voltage methods |
JP6653767B2 (en) * | 2016-12-09 | 2020-02-26 | 株式会社日立ハイテクノロジーズ | Nanopore formation method, nanopore formation device, and biomolecule measurement device |
GB2573433B (en) * | 2017-01-10 | 2022-05-25 | Hitachi High Tech Corp | Current measurement device and current measurement method using nanopore |
EP3369474A1 (en) * | 2017-03-01 | 2018-09-05 | Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH | Isoporous block copolymer membranes in flat sheet geometry |
NO20170513A1 (en) * | 2017-03-29 | 2018-06-04 | Condalign As | A method for forming av body comprising at least one through-going passage |
US20200191767A1 (en) | 2017-04-28 | 2020-06-18 | The University Of Ottawa | Controlling Translocating Molecules Through A Nanopore |
WO2018209441A1 (en) * | 2017-05-17 | 2018-11-22 | The Royal Institution For The Advancement Of Learning / Mcgill University | Method and apparatus for making a nanopore in a membrane using an electric field applied via a conductive tip |
US10618805B2 (en) | 2017-09-22 | 2020-04-14 | Applied Materials, Inc. | Method to reduce pore diameter using atomic layer deposition and etching |
US10752496B2 (en) | 2017-09-22 | 2020-08-25 | Applied Materials, Inc. | Pore formation in a substrate |
US10830756B2 (en) | 2017-09-22 | 2020-11-10 | Applied Materials, Inc. | Method to create a free-standing membrane for biological applications |
JP6975609B2 (en) * | 2017-10-19 | 2021-12-01 | 株式会社日立製作所 | Hydrophilicity retaining substrate, measuring device, device and hydrophilicity retention method |
JP6959121B2 (en) * | 2017-12-05 | 2021-11-02 | 株式会社日立ハイテク | Hole forming method and hole forming device |
WO2019109253A1 (en) * | 2017-12-05 | 2019-06-13 | 清华大学 | Method for adjusting effective size of solid-state nanopore in solid-state nanopore system |
CN108279312B (en) * | 2018-03-08 | 2021-06-01 | 冯建东 | Nanopore-based proteomics analysis device, serum detection method and application |
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JP7174614B2 (en) * | 2018-12-12 | 2022-11-17 | 株式会社日立製作所 | Nanopore formation method and analysis method |
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WO2021260587A1 (en) * | 2020-06-23 | 2021-12-30 | The University Of Ottawa | Improved techniques for nanopore enlargement and formation |
WO2022024335A1 (en) * | 2020-07-31 | 2022-02-03 | 株式会社日立ハイテク | Biomolecule analysis method, biomolecule analyzing reagent, and biomolecule analysis device |
JP7440375B2 (en) | 2020-08-19 | 2024-02-28 | 株式会社日立製作所 | Hole forming method and hole forming device |
JP2022134179A (en) * | 2021-03-03 | 2022-09-15 | 株式会社日立製作所 | Method and device for forming pore |
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CA3116407C (en) | 2013-03-15 | 2023-02-07 | President And Fellows Of Harvard College | Surface wetting method |
-
2013
- 2013-05-07 AU AU2013257756A patent/AU2013257756B2/en not_active Ceased
- 2013-05-07 CN CN201380036310.2A patent/CN104411386B/en active Active
- 2013-05-07 CA CA2872602A patent/CA2872602C/en active Active
- 2013-05-07 EP EP13787360.0A patent/EP2846901B1/en active Active
- 2013-05-07 WO PCT/IB2013/000884 patent/WO2013167952A1/en active Application Filing
- 2013-05-07 WO PCT/IB2013/000891 patent/WO2013167955A1/en active Application Filing
- 2013-05-07 SG SG11201407252UA patent/SG11201407252UA/en unknown
- 2013-05-07 JP JP2015510884A patent/JP6298450B2/en active Active
- 2013-05-07 MX MX2014013412A patent/MX357200B/en active IP Right Grant
- 2013-05-07 KR KR1020147033950A patent/KR102065745B1/en active IP Right Grant
- 2013-05-07 US US14/399,071 patent/US9777389B2/en active Active
- 2013-05-07 CN CN201380036177.0A patent/CN104662209B/en active Active
- 2013-05-07 SG SG10201606334XA patent/SG10201606334XA/en unknown
- 2013-05-07 SG SG11201407249XA patent/SG11201407249XA/en unknown
- 2013-05-07 AU AU2013257759A patent/AU2013257759B2/en not_active Ceased
- 2013-05-07 JP JP2015510885A patent/JP6420236B2/en active Active
- 2013-05-07 US US14/399,091 patent/US9777390B2/en active Active
- 2013-05-07 EP EP13787530.8A patent/EP2847367B1/en active Active
- 2013-05-07 CA CA2872600A patent/CA2872600C/en active Active
- 2013-05-07 BR BR112014027829-6A patent/BR112014027829B1/en not_active IP Right Cessation
- 2013-05-07 KR KR1020147033949A patent/KR102065754B1/en active IP Right Grant
- 2013-05-07 ES ES13787530.8T patent/ES2630064T3/en active Active
- 2013-05-07 MX MX2014013410A patent/MX353370B/en active IP Right Grant
- 2013-05-07 BR BR112014027873A patent/BR112014027873B8/en not_active IP Right Cessation
- 2013-05-07 ES ES13787360.0T patent/ES2629952T3/en active Active
-
2018
- 2018-06-06 JP JP2018108930A patent/JP2018187626A/en active Pending
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