SG10202101478YA - Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells - Google Patents

Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells

Info

Publication number
SG10202101478YA
SG10202101478YA SG10202101478YA SG10202101478YA SG10202101478YA SG 10202101478Y A SG10202101478Y A SG 10202101478YA SG 10202101478Y A SG10202101478Y A SG 10202101478YA SG 10202101478Y A SG10202101478Y A SG 10202101478YA SG 10202101478Y A SG10202101478Y A SG 10202101478YA
Authority
SG
Singapore
Prior art keywords
proliferation
differentiation
generation
progenitor cells
hematopoietic stem
Prior art date
Application number
SG10202101478YA
Other languages
English (en)
Inventor
Sudipto Bari
Christina Li Lin Chai
Gigi Ngar Chee Chiu
William Ying Khee Hwang
Joo Leng Low
Qixing Zhong
Original Assignee
Nat Univ Singapore
Singapore Health Serv Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Univ Singapore, Singapore Health Serv Pte Ltd filed Critical Nat Univ Singapore
Publication of SG10202101478YA publication Critical patent/SG10202101478YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG10202101478YA 2016-08-18 2017-08-18 Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells SG10202101478YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SG10201606886V 2016-08-18

Publications (1)

Publication Number Publication Date
SG10202101478YA true SG10202101478YA (en) 2021-03-30

Family

ID=61562838

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201901199WA SG11201901199WA (en) 2016-08-18 2017-08-18 Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells
SG10202101478YA SG10202101478YA (en) 2016-08-18 2017-08-18 Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201901199WA SG11201901199WA (en) 2016-08-18 2017-08-18 Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells

Country Status (10)

Country Link
US (1) US20190359941A1 (ko)
EP (1) EP3500562B1 (ko)
JP (1) JP7168552B2 (ko)
KR (1) KR102522572B1 (ko)
CN (1) CN109890805B (ko)
AU (1) AU2017325511B2 (ko)
ES (1) ES2968146T3 (ko)
MY (1) MY197282A (ko)
SG (2) SG11201901199WA (ko)
WO (1) WO2018048346A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110511909B (zh) * 2019-07-29 2022-01-04 吉林大学 体外扩增造血干细胞的生长因子组合物及其应用
CN110904038B (zh) * 2019-12-13 2023-09-12 深圳市蓝思人工智能医学研究院 一种间充质干细胞及其应用
BR112022026762A2 (pt) * 2020-07-10 2023-01-24 Beckman Coulter Inc Plataforma automatizada de preparação de amostras para análise celular

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20100362A1 (es) * 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
WO2012141971A2 (en) 2011-04-05 2012-10-18 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for rejuvenation and expansion of stem cells
WO2013059357A1 (en) * 2011-10-19 2013-04-25 Stowers Institute For Medical Research Methods, kits, and compositions for stem cell self-renewal
EP2788475A1 (en) * 2011-12-05 2014-10-15 Primorigen Biosciences Inc. Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
WO2013086436A1 (en) * 2011-12-08 2013-06-13 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
WO2013110198A1 (en) * 2012-01-27 2013-08-01 Université de Montréal Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
KR20150030709A (ko) * 2012-06-14 2015-03-20 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 췌장 내분비 세포로의 분화
SG11201606427SA (en) * 2014-02-07 2016-09-29 Agency Science Tech & Res 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis
WO2015148716A1 (en) * 2014-03-26 2015-10-01 The Brigham And Women's Hospital, Inc. Compositions and methods for ex vivo expansion of human hematopoietic stem/progenitor cells
WO2015161373A1 (en) * 2014-04-22 2015-10-29 Université de Montréal Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells
CN105713879B (zh) * 2014-12-01 2020-05-08 顺昊细胞生物技术（天津）股份有限公司 一种用于脐带血造血干细胞扩增的培养体系及其应用
US20180325947A1 (en) 2015-10-27 2018-11-15 Children's Hospital Medical Center Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and/or genetic manipulation

Also Published As

Publication number Publication date
JP7168552B2 (ja) 2022-11-09
CN109890805A (zh) 2019-06-14
KR20190039988A (ko) 2019-04-16
KR102522572B1 (ko) 2023-04-17
EP3500562A1 (en) 2019-06-26
MY197282A (en) 2023-06-09
EP3500562A4 (en) 2020-03-18
US20190359941A1 (en) 2019-11-28
EP3500562B1 (en) 2023-11-15
SG11201901199WA (en) 2019-03-28
AU2017325511A1 (en) 2019-03-07
ES2968146T3 (es) 2024-05-08
WO2018048346A1 (en) 2018-03-15
JP2019528066A (ja) 2019-10-10
CN109890805B (zh) 2023-04-04
AU2017325511B2 (en) 2021-12-09

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