SG10202101478YA - Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells - Google Patents

Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells

Info

Publication number
SG10202101478YA
SG10202101478YA SG10202101478YA SG10202101478YA SG10202101478YA SG 10202101478Y A SG10202101478Y A SG 10202101478YA SG 10202101478Y A SG10202101478Y A SG 10202101478YA SG 10202101478Y A SG10202101478Y A SG 10202101478YA SG 10202101478Y A SG10202101478Y A SG 10202101478YA
Authority
SG
Singapore
Prior art keywords
proliferation
differentiation
generation
progenitor cells
hematopoietic stem
Prior art date
Application number
SG10202101478YA
Inventor
Sudipto Bari
Christina Li Lin Chai
Gigi Ngar Chee Chiu
William Ying Khee Hwang
Joo Leng Low
Qixing Zhong
Original Assignee
Nat Univ Singapore
Singapore Health Serv Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Univ Singapore, Singapore Health Serv Pte Ltd filed Critical Nat Univ Singapore
Publication of SG10202101478YA publication Critical patent/SG10202101478YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
SG10202101478YA 2016-08-18 2017-08-18 Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells SG10202101478YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SG10201606886V 2016-08-18

Publications (1)

Publication Number Publication Date
SG10202101478YA true SG10202101478YA (en) 2021-03-30

Family

ID=61562838

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202101478YA SG10202101478YA (en) 2016-08-18 2017-08-18 Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells
SG11201901199WA SG11201901199WA (en) 2016-08-18 2017-08-18 Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201901199WA SG11201901199WA (en) 2016-08-18 2017-08-18 Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells

Country Status (10)

Country Link
US (1) US20190359941A1 (en)
EP (1) EP3500562B1 (en)
JP (1) JP7168552B2 (en)
KR (1) KR102522572B1 (en)
CN (1) CN109890805B (en)
AU (1) AU2017325511B2 (en)
ES (1) ES2968146T3 (en)
MY (1) MY197282A (en)
SG (2) SG10202101478YA (en)
WO (1) WO2018048346A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110511909B (en) * 2019-07-29 2022-01-04 吉林大学 Growth factor composition for in vitro expansion of hematopoietic stem cells and application thereof
CN110904038B (en) * 2019-12-13 2023-09-12 深圳市蓝思人工智能医学研究院 Mesenchymal stem cells and application thereof
JP2023533948A (en) * 2020-07-10 2023-08-07 ベックマン コールター， インコーポレイテッド Automated sample preparation platform for cell analysis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20100362A1 (en) * 2008-10-30 2010-05-27 Irm Llc PURINE DERIVATIVES THAT EXPAND HEMATOPOYETIC STEM CELLS
US20120276064A1 (en) * 2011-04-05 2012-11-01 Blau Helen M Methods and compositions for rejuvenation and expansion of stem cells
US9896659B2 (en) 2011-10-19 2018-02-20 Stowers Institute For Medical Research Methods, kits, and compositions for stem cell self-renewal
WO2013086029A1 (en) 2011-12-05 2013-06-13 Primorigen Biosciences Inc. Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
WO2013086436A1 (en) * 2011-12-08 2013-06-13 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
WO2013110198A1 (en) * 2012-01-27 2013-08-01 Université de Montréal Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
BR112014031424A2 (en) * 2012-06-14 2017-06-27 Janssen Biotech Inc pluripotent cell treatment
ES2926931T3 (en) * 2014-02-07 2022-10-31 Agency Science Tech & Res Casein kinase 1 inhibitors based on 2,4,5-tri-substituted azoles as inducers of cardiomyogenesis
JP2017511132A (en) * 2014-03-26 2017-04-20 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． Compositions and methods for ex vivo expansion of human hematopoietic stem / progenitor cells
US10647718B2 (en) * 2014-04-22 2020-05-12 Universitéde Montréal Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells
CN105713879B (en) 2014-12-01 2020-05-08 顺昊细胞生物技术（天津）股份有限公司 Culture system for umbilical cord blood hematopoietic stem cell amplification and application thereof
CA3003433A1 (en) 2015-10-27 2017-05-04 Children's Hospital Medical Center Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and/or genetic manipulation

Also Published As

Publication number Publication date
AU2017325511B2 (en) 2021-12-09
ES2968146T3 (en) 2024-05-08
EP3500562A4 (en) 2020-03-18
SG11201901199WA (en) 2019-03-28
AU2017325511A1 (en) 2019-03-07
CN109890805B (en) 2023-04-04
CN109890805A (en) 2019-06-14
KR20190039988A (en) 2019-04-16
KR102522572B1 (en) 2023-04-17
WO2018048346A1 (en) 2018-03-15
EP3500562B1 (en) 2023-11-15
EP3500562A1 (en) 2019-06-26
US20190359941A1 (en) 2019-11-28
MY197282A (en) 2023-06-09
JP7168552B2 (en) 2022-11-09
JP2019528066A (en) 2019-10-10

Similar Documents

Publication Publication Date Title
HK1247245A1 (en) Methods and compositions for inducing hematopoietic cell differentiation
EP3371301A4 (en) Methods and compositions for inducing hematopoietic cell differentiation
EP3245289A4 (en) Differentiation of macrophages from pluripotent stem cells
EP3122181A4 (en) Compositions and methods for ex vivo expansion of human hematopoietic stem/progenitor cells
EP3280797A4 (en) Generation of functional cells from stem cells
IL249828A0 (en) Cultured mammalian limbal stem cells, methods for generating the same, and uses thereof
EP3440198A4 (en) Method for generating progenitor t cells from stem and/or progenitor cells and use of same
EP3455344A4 (en) Haematopoietic stem/progenitor cells
EP3472173A4 (en) Coatings for components of electrochemical cells
EP3384006A4 (en) Uses of expanded populations of hematopoietic stem/progenitor cells
EP3288569A4 (en) Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
EP3134409A4 (en) Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells
EP3223831A4 (en) Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
IL266251A (en) Immunosuppressive mesenchymal cells and methods for forming same
EP3286301A4 (en) Generation of muscle-lineage cells from stem cells
EP3383182A4 (en) Methods for generating functional hematopoietic stem cells
EP3442064A4 (en) Unit cell of fuel cell
IL279172A (en) Methods for generating hematopoietic stem cells
MX2017007117A (en) Aqueous coating composition and process thereof.
EP3419617A4 (en) Highly engraftable hematopoietic stem cells
EP3194569A4 (en) Differentiation of hepatocyte-like cells from stem cells
HK1247639A1 (en) Medium composition for culturing stem cells
EP3138767A4 (en) Fuel gas supply system of vessel
EP3452500A4 (en) Mesenchymal stem cell proliferation
SG10202101478YA (en) Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells