SG10202012205XA - Triterpene saponin analogues - Google Patents
Triterpene saponin analoguesInfo
- Publication number
- SG10202012205XA SG10202012205XA SG10202012205XA SG10202012205XA SG10202012205XA SG 10202012205X A SG10202012205X A SG 10202012205XA SG 10202012205X A SG10202012205X A SG 10202012205XA SG 10202012205X A SG10202012205X A SG 10202012205XA SG 10202012205X A SG10202012205X A SG 10202012205XA
- Authority
- SG
- Singapore
- Prior art keywords
- triterpene saponin
- saponin analogues
- analogues
- triterpene
- saponin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562252296P | 2015-11-06 | 2015-11-06 | |
US201562268837P | 2015-12-17 | 2015-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10202012205XA true SG10202012205XA (en) | 2021-01-28 |
Family
ID=58662549
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201803594TA SG11201803594TA (en) | 2015-11-06 | 2016-11-04 | Triterpene saponin analogues |
SG10202012205XA SG10202012205XA (en) | 2015-11-06 | 2016-11-04 | Triterpene saponin analogues |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201803594TA SG11201803594TA (en) | 2015-11-06 | 2016-11-04 | Triterpene saponin analogues |
Country Status (12)
Country | Link |
---|---|
US (4) | US20180327436A1 (fr) |
EP (2) | EP4001290A1 (fr) |
JP (3) | JP6900385B2 (fr) |
KR (1) | KR20180077180A (fr) |
CN (2) | CN108778289B (fr) |
AU (1) | AU2016349693B2 (fr) |
CA (1) | CA3003483C (fr) |
CL (1) | CL2018001192A1 (fr) |
IL (3) | IL286493B (fr) |
SG (2) | SG11201803594TA (fr) |
WO (1) | WO2017079582A1 (fr) |
ZA (1) | ZA201802891B (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112028951A (zh) * | 2014-05-30 | 2020-12-04 | 索隆-基特林癌症研究协会 | 微小皂苷类似物、合成及其用途 |
IL286493B (en) * | 2015-11-06 | 2022-07-01 | Memorial Sloan Kettering Cancer Center | Triterpene saponin analogs, methods for their production, preparations containing them and their uses |
KR20190137808A (ko) * | 2017-04-13 | 2019-12-11 | 아쥬반스 테크놀로지스 인코포레이티드 | 트리테르펜 사포닌, 중간체 및 보조제 배합물 |
CN110730666A (zh) * | 2017-04-25 | 2020-01-24 | 佐剂技术公司 | 三萜皂苷类似物 |
KR20190137827A (ko) * | 2017-04-25 | 2019-12-11 | 아쥬반스 테크놀로지스 인코포레이티드 | 트리테르펜 사포닌 유사체 |
CN111212846B (zh) | 2017-10-16 | 2023-05-26 | 佐剂技术公司 | 三萜皂苷类似物 |
WO2021195024A1 (fr) * | 2020-03-23 | 2021-09-30 | Adjuvance Technologies, Inc. | Composés adjuvants, formes salines et formulations |
CN115867304A (zh) | 2020-05-19 | 2023-03-28 | 欧萨尔普罗席纳有限公司 | 用于治疗阿兹海默症的多抗原决定基疫苗 |
WO2023056089A1 (fr) | 2021-10-03 | 2023-04-06 | Eisai R&D Management Co., Ltd. | Formulations d'adjuvants immunologiques comprenant un agoniste du tlr4 e6020 |
WO2023081505A1 (fr) * | 2021-11-08 | 2023-05-11 | Adjuvance Technologies, Inc. | Composés et formulations d'adjuvant |
EP4190359A1 (fr) | 2021-12-03 | 2023-06-07 | Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE | Adjuvants et vaccins à base de saponine |
WO2023139145A1 (fr) | 2022-01-19 | 2023-07-27 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | Adjuvants et vaccins à base de saponines |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5231112A (en) | 1984-04-12 | 1993-07-27 | The Liposome Company, Inc. | Compositions containing tris salt of cholesterol hemisuccinate and antifungal |
US5916588A (en) | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
US4684479A (en) | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
US6759057B1 (en) | 1986-06-12 | 2004-07-06 | The Liposome Company, Inc. | Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
IE60901B1 (en) | 1986-08-21 | 1994-08-24 | Vestar Inc | Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics |
US6406713B1 (en) | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
AU598958B2 (en) | 1987-11-12 | 1990-07-05 | Vestar, Inc. | Improved amphotericin b liposome preparation |
US5215680A (en) | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
CA2263455C (fr) | 1996-08-23 | 2002-10-29 | Sequus Pharmaceuticals, Inc. | Liposomes contenant un compose cisplatine |
WO1998016201A1 (fr) | 1996-10-11 | 1998-04-23 | Sequus Pharmaceuticals, Inc. | Composition de liposomes therapeutiques et procede |
US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
NZ336538A (en) | 1996-10-15 | 2001-11-30 | Liposome Co Inc | N-acyl phosphatidylethanolamine-mediated liposomal drug delivery |
US6080725A (en) * | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
AU5565599A (en) * | 1998-08-14 | 2000-03-06 | Dante J. Marciani | Chemically modified saponins and the use thereof as adjuvants |
AU7085400A (en) | 1999-09-02 | 2001-03-26 | Antigenics, Inc. | Compositions of immunostimulatory polymers and saponin adjuvants and uses thereof |
GB0401239D0 (en) | 2004-01-21 | 2004-02-25 | Molecularnature Ltd | Adjuvant compositions |
GB0504436D0 (en) | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
GB0700562D0 (en) * | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
AR066676A1 (es) | 2007-05-24 | 2009-09-02 | Glaxosmithkline Biolog Sa | Composicion antigenica liofilizada que contiene un agonista del receptor tipo toll |
WO2009080715A2 (fr) | 2007-12-21 | 2009-07-02 | Glaxosmithkline Biologicals S.A. | Vaccins anti-malaria |
US8283456B2 (en) * | 2008-04-08 | 2012-10-09 | Sloan-Kettering Institute For Cancer Research | Triterpene saponins, methods of synthesis, and uses thereof |
EP2271360B1 (fr) | 2008-04-16 | 2015-09-23 | GlaxoSmithKline Biologicals S.A. | Vaccin |
WO2012156391A1 (fr) | 2011-05-17 | 2012-11-22 | Glaxosmithkline Biologicals S.A. | Vaccin contre le streptococcus pneumoniae |
US20130309273A1 (en) | 2012-05-17 | 2013-11-21 | Kimberly Hassett | Thermostable Vaccine Compositions and Methods of Preparing Same |
US20150037374A1 (en) | 2013-07-31 | 2015-02-05 | Csl Limited | Anti-tumor compositions and uses thereof |
CN112028951A (zh) * | 2014-05-30 | 2020-12-04 | 索隆-基特林癌症研究协会 | 微小皂苷类似物、合成及其用途 |
IL286493B (en) * | 2015-11-06 | 2022-07-01 | Memorial Sloan Kettering Cancer Center | Triterpene saponin analogs, methods for their production, preparations containing them and their uses |
WO2017106836A1 (fr) | 2015-12-17 | 2017-06-22 | Memorial Sloan-Kettering Cancer Center | Variants de saponine triterpène, procédés de synthèse et leur utilisation |
-
2016
- 2016-11-04 IL IL286493A patent/IL286493B/en unknown
- 2016-11-04 AU AU2016349693A patent/AU2016349693B2/en active Active
- 2016-11-04 SG SG11201803594TA patent/SG11201803594TA/en unknown
- 2016-11-04 IL IL293848A patent/IL293848A/en unknown
- 2016-11-04 CN CN201680078068.9A patent/CN108778289B/zh active Active
- 2016-11-04 WO PCT/US2016/060564 patent/WO2017079582A1/fr active Application Filing
- 2016-11-04 JP JP2018543061A patent/JP6900385B2/ja active Active
- 2016-11-04 CN CN202011417416.5A patent/CN112812143A/zh active Pending
- 2016-11-04 CA CA3003483A patent/CA3003483C/fr active Active
- 2016-11-04 SG SG10202012205XA patent/SG10202012205XA/en unknown
- 2016-11-04 KR KR1020187012783A patent/KR20180077180A/ko not_active Application Discontinuation
- 2016-11-04 EP EP21210191.9A patent/EP4001290A1/fr active Pending
- 2016-11-04 EP EP16863057.2A patent/EP3370730A4/fr not_active Withdrawn
- 2016-11-04 US US15/774,081 patent/US20180327436A1/en not_active Abandoned
-
2018
- 2018-05-03 ZA ZA2018/02891A patent/ZA201802891B/en unknown
- 2018-05-03 IL IL259145A patent/IL259145B/en unknown
- 2018-05-03 CL CL2018001192A patent/CL2018001192A1/es unknown
-
2020
- 2020-03-23 US US16/827,220 patent/US10906926B2/en active Active
- 2020-08-27 US US17/005,110 patent/US20210002316A1/en not_active Abandoned
-
2021
- 2021-06-16 JP JP2021099839A patent/JP2021152043A/ja active Pending
-
2022
- 2022-11-02 JP JP2022176130A patent/JP2023012519A/ja active Pending
-
2023
- 2023-03-08 US US18/180,421 patent/US20230219991A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210002316A1 (en) | 2021-01-07 |
IL286493A (en) | 2021-10-31 |
WO2017079582A1 (fr) | 2017-05-11 |
SG11201803594TA (en) | 2018-05-30 |
KR20180077180A (ko) | 2018-07-06 |
CN108778289B (zh) | 2020-11-17 |
AU2016349693A1 (en) | 2018-05-17 |
JP2021152043A (ja) | 2021-09-30 |
IL286493B (en) | 2022-07-01 |
EP3370730A1 (fr) | 2018-09-12 |
US20200239509A1 (en) | 2020-07-30 |
ZA201802891B (en) | 2020-01-29 |
CA3003483C (fr) | 2022-09-13 |
JP2018537527A (ja) | 2018-12-20 |
IL259145A (en) | 2018-06-28 |
EP4001290A1 (fr) | 2022-05-25 |
EP3370730A4 (fr) | 2019-07-31 |
IL259145B (en) | 2021-09-30 |
CA3003483A1 (fr) | 2017-05-11 |
US20230219991A1 (en) | 2023-07-13 |
US10906926B2 (en) | 2021-02-02 |
CL2018001192A1 (es) | 2018-11-23 |
JP6900385B2 (ja) | 2021-07-07 |
CN112812143A (zh) | 2021-05-18 |
CN108778289A (zh) | 2018-11-09 |
US20180327436A1 (en) | 2018-11-15 |
IL293848A (en) | 2022-08-01 |
JP2023012519A (ja) | 2023-01-25 |
AU2016349693B2 (en) | 2022-08-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA201802891B (en) | Triterpene saponin analogues | |
IL256297B (en) | Regulators of nrf2 | |
HK1256199A1 (zh) | Nrf2調節劑 | |
GB201508138D0 (en) | Aircraft | |
HK1218410A1 (zh) | 旋翼升力航空器 | |
IL290897A (en) | Minimal saponin analogues, their synthesis and use | |
IL273691A (en) | Triterpene saponin analogs | |
GB201416842D0 (en) | Aircraft | |
IL253924A0 (en) | Amylin analogs | |
PL3177817T3 (pl) | Statek powietrzny | |
GB201616518D0 (en) | Aircraft | |
IL270182B (en) | Triterpene saponin analogs | |
EP3615039A4 (fr) | Analogues de saponine triterpénique | |
GB2543351B (en) | A parachute | |
GB201500996D0 (en) | An aircraft | |
PL3335983T3 (pl) | Statek powietrzny | |
GB201702133D0 (en) | Aircraft | |
HK1257366A1 (zh) | 包含三萜類的組合物 | |
ZA201607059B (en) | Omega-3 analogues | |
HK1257370A1 (zh) | 包含三萜類的組合物 | |
GB2549235B (en) | Turboprop | |
GB201619846D0 (en) | Saponin composition | |
GB201719843D0 (en) | Aircraft | |
GB201520684D0 (en) | Aeroplanes | |
ZA201500260B (en) | Aircraft |