SG10201811109PA - Methods of treating ttp with immunoglobulin single variable domains and uses thereof - Google Patents

Methods of treating ttp with immunoglobulin single variable domains and uses thereof

Info

Publication number
SG10201811109PA
SG10201811109PA SG10201811109PA SG10201811109PA SG10201811109PA SG 10201811109P A SG10201811109P A SG 10201811109PA SG 10201811109P A SG10201811109P A SG 10201811109PA SG 10201811109P A SG10201811109P A SG 10201811109PA SG 10201811109P A SG10201811109P A SG 10201811109PA
Authority
SG
Singapore
Prior art keywords
single variable
treating
variable domains
immunoglobulin single
methods
Prior art date
Application number
SG10201811109PA
Other languages
English (en)
Inventor
Christian Duby
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv filed Critical Ablynx Nv
Publication of SG10201811109PA publication Critical patent/SG10201811109PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG10201811109PA 2014-06-16 2015-06-16 Methods of treating ttp with immunoglobulin single variable domains and uses thereof SG10201811109PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2013007A NL2013007B1 (en) 2014-06-16 2014-06-16 Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
US201462030817P 2014-07-30 2014-07-30

Publications (1)

Publication Number Publication Date
SG10201811109PA true SG10201811109PA (en) 2019-01-30

Family

ID=51541255

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201811109PA SG10201811109PA (en) 2014-06-16 2015-06-16 Methods of treating ttp with immunoglobulin single variable domains and uses thereof
SG11201610488QA SG11201610488QA (en) 2014-06-16 2015-06-16 Methods of treating ttp with immunoglobulin single variable domains and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201610488QA SG11201610488QA (en) 2014-06-16 2015-06-16 Methods of treating ttp with immunoglobulin single variable domains and uses thereof

Country Status (15)

Country Link
US (5) US10858445B2 (https=)
EP (6) EP4059513A1 (https=)
JP (3) JP6688746B2 (https=)
KR (2) KR102568585B1 (https=)
CN (1) CN106559985A (https=)
AU (2) AU2015276237B2 (https=)
CA (1) CA2952103A1 (https=)
ES (5) ES2843642T3 (https=)
IL (1) IL249540B (https=)
NL (1) NL2013007B1 (https=)
PL (5) PL3332800T3 (https=)
PT (5) PT3154569T (https=)
RU (1) RU2704444C2 (https=)
SG (2) SG10201811109PA (https=)
WO (1) WO2015193326A1 (https=)

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NL2013007B1 (en) 2014-06-16 2016-07-05 Ablynx Nv Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
CN107340225B (zh) * 2017-07-13 2019-07-05 徐州医科大学 一种基于流式细胞术检测血小板受体GPIba胞外段酶切的方法
EP3749696A1 (en) * 2018-02-06 2020-12-16 Ablynx N.V. Methods of treating initial episode of ttp with immunoglobulin single variable domains
US20230405096A1 (en) * 2020-11-18 2023-12-21 Green Cross Corporation Adamts13 variant having increased escaping rate or activity against autoantibody
CA3232223A1 (en) 2021-09-17 2023-03-23 Ying Fu Synthetic humanized llama nanobody library and use thereof to identify sars-cov-2 neutralizing antibodies
CN118715246A (zh) * 2021-12-10 2024-09-27 李人浩 结合血管性血友病因子(vwf)a1结构域或自动抑制模块的多肽、变体及其用途

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Also Published As

Publication number Publication date
EP4059513A1 (en) 2022-09-21
ES2843642T3 (es) 2021-07-19
WO2015193326A1 (en) 2015-12-23
US12269893B2 (en) 2025-04-08
EP3335724A1 (en) 2018-06-20
EP3335723B1 (en) 2022-03-30
HK1258508A1 (en) 2019-11-15
PL3366305T3 (pl) 2021-06-14
ES2924199T3 (es) 2022-10-05
KR102403388B1 (ko) 2022-06-03
RU2019131713A (ru) 2019-11-11
JP6688746B2 (ja) 2020-04-28
HK1256730A1 (en) 2019-10-04
RU2704444C2 (ru) 2019-10-28
IL249540B (en) 2021-09-30
KR20170015513A (ko) 2017-02-08
US20180155440A1 (en) 2018-06-07
CN106559985A (zh) 2017-04-05
JP2022160431A (ja) 2022-10-19
US10919980B2 (en) 2021-02-16
US20180155441A1 (en) 2018-06-07
EP3335723A1 (en) 2018-06-20
PT3332800T (pt) 2020-11-19
JP2020097600A (ja) 2020-06-25
EP3335724B1 (en) 2022-06-22
US20180155442A1 (en) 2018-06-07
AU2021202747B2 (en) 2024-02-15
PT3154569T (pt) 2021-06-22
HK1256731A1 (en) 2019-10-04
PL3335723T3 (pl) 2022-07-18
PL3332800T3 (pl) 2021-04-19
PT3335723T (pt) 2022-05-20
EP3366305B1 (en) 2020-11-18
RU2017100077A3 (https=) 2018-12-25
ES2915473T3 (es) 2022-06-22
EP3332800B1 (en) 2020-08-26
EP3154569B1 (en) 2021-04-21
ES2831865T3 (es) 2021-06-09
US20170210822A1 (en) 2017-07-27
CA2952103A1 (en) 2015-12-23
JP7105260B2 (ja) 2022-07-22
KR102568585B1 (ko) 2023-08-18
EP3366305A1 (en) 2018-08-29
US20180155443A1 (en) 2018-06-07
PT3335724T (pt) 2022-08-02
AU2021202747A1 (en) 2021-05-27
SG11201610488QA (en) 2017-01-27
EP3154569A1 (en) 2017-04-19
US10858445B2 (en) 2020-12-08
AU2015276237B2 (en) 2021-02-25
AU2015276237A1 (en) 2017-01-19
KR20220053040A (ko) 2022-04-28
ES2881331T3 (es) 2021-11-29
EP3332800A1 (en) 2018-06-13
RU2017100077A (ru) 2018-07-12
NL2013007B1 (en) 2016-07-05
JP2017519762A (ja) 2017-07-20
PT3366305T (pt) 2020-12-21
IL249540A0 (en) 2017-02-28
PL3154569T3 (pl) 2021-11-02
PL3335724T3 (pl) 2022-09-19

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