SG10201509476RA - Antiviral therapy - Google Patents

Antiviral therapy

Info

Publication number
SG10201509476RA
SG10201509476RA SG10201509476RA SG10201509476RA SG10201509476RA SG 10201509476R A SG10201509476R A SG 10201509476RA SG 10201509476R A SG10201509476R A SG 10201509476RA SG 10201509476R A SG10201509476R A SG 10201509476RA SG 10201509476R A SG10201509476R A SG 10201509476RA
Authority
SG
Singapore
Prior art keywords
antiviral therapy
antiviral
therapy
Prior art date
Application number
SG10201509476RA
Inventor
Mark Richard Underwood
Original Assignee
Viiv Healthcare Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44319704&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201509476R(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Viiv Healthcare Co filed Critical Viiv Healthcare Co
Publication of SG10201509476RA publication Critical patent/SG10201509476RA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG10201509476RA 2010-01-27 2011-01-24 Antiviral therapy SG10201509476RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29858910P 2010-01-27 2010-01-27

Publications (1)

Publication Number Publication Date
SG10201509476RA true SG10201509476RA (en) 2015-12-30

Family

ID=44319704

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201509476RA SG10201509476RA (en) 2010-01-27 2011-01-24 Antiviral therapy
SG10201707183TA SG10201707183TA (en) 2010-01-27 2011-01-24 Antiviral therapy
SG2012053492A SG182614A1 (en) 2010-01-27 2011-01-24 Antiviral therapy

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG10201707183TA SG10201707183TA (en) 2010-01-27 2011-01-24 Antiviral therapy
SG2012053492A SG182614A1 (en) 2010-01-27 2011-01-24 Antiviral therapy

Country Status (45)

Country Link
US (12) US20120295898A1 (en)
EP (6) EP2932970B1 (en)
JP (8) JP2013518107A (en)
KR (4) KR101830715B1 (en)
CN (2) CN102791129B (en)
AP (1) AP3551A (en)
AU (1) AU2011209788C1 (en)
BR (1) BR112012018670A2 (en)
CA (4) CA3060290C (en)
CL (1) CL2012002080A1 (en)
CO (1) CO6602152A2 (en)
CR (1) CR20120423A (en)
CY (4) CY1116509T1 (en)
DK (4) DK3494972T3 (en)
DO (2) DOP2012000205A (en)
EA (4) EA202190473A3 (en)
EC (1) ECSP12012106A (en)
ES (4) ES2688925T3 (en)
FI (2) FI3494972T3 (en)
FR (1) FR18C1043I2 (en)
HK (3) HK1250335A1 (en)
HR (4) HRP20240168T1 (en)
HU (4) HUE040554T2 (en)
IL (5) IL221007A (en)
LT (4) LT2932970T (en)
LU (1) LUC00090I2 (en)
MA (1) MA34002B1 (en)
ME (2) ME02182B (en)
MX (4) MX2012008774A (en)
MY (1) MY188334A (en)
NO (2) NO2932970T3 (en)
NZ (4) NZ627826A (en)
PE (2) PE20121524A1 (en)
PH (2) PH12016500195A1 (en)
PL (4) PL2932970T3 (en)
PT (4) PT3494972T (en)
RS (4) RS65183B1 (en)
SG (3) SG10201509476RA (en)
SI (4) SI2932970T1 (en)
SM (1) SMT201500177B (en)
TN (1) TN2012000376A1 (en)
TR (1) TR201807704T4 (en)
UA (1) UA105556C2 (en)
WO (1) WO2011094150A1 (en)
ZA (1) ZA201205586B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2688925T3 (en) 2010-01-27 2018-11-07 Viiv Healthcare Company Antiviral treatment
CN104884063A (en) 2012-10-23 2015-09-02 西普拉有限公司 Pharmaceutical antiretroviral composition
KR102527797B1 (en) 2012-12-21 2023-05-03 길리애드 사이언시즈, 인코포레이티드 Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
EP2956123A1 (en) 2013-02-18 2015-12-23 ratiopharm GmbH Solid pharmaceutical dosage form of dolutegravir
EP2767272A1 (en) * 2013-02-18 2014-08-20 Ratiopharm GmbH Solid pharmaceutical dosage form of dolutegravir
CA2916993C (en) 2013-07-12 2019-01-15 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
NO2865735T3 (en) 2013-07-12 2018-07-21
EA030695B1 (en) 2013-09-27 2018-09-28 Мерк Шарп И Доум Корп. Substituted quinolizine derivatives useful as hiv integrase inhibitors
WO2015140569A1 (en) 2014-03-20 2015-09-24 Cipla Limited Pharmaceutical composition
CA2950911C (en) 2014-06-04 2023-10-10 Sanford-Burnham Medical Research Institute Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy
TWI744723B (en) 2014-06-20 2021-11-01 美商基利科學股份有限公司 Synthesis of polycyclic-carbamoylpyridone compounds
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
NO2717902T3 (en) 2014-06-20 2018-06-23
EP3177629B1 (en) 2014-07-29 2020-01-29 LEK Pharmaceuticals d.d. Novel hydrates of dolutegravir sodium
TWI695003B (en) 2014-12-23 2020-06-01 美商基利科學股份有限公司 Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
AU2016244035B2 (en) 2015-04-02 2018-11-01 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
WO2017029225A1 (en) * 2015-08-14 2017-02-23 Sandoz Ag Solid pharmaceutical composition of abacavir, lamivudine, and efavirenz
WO2017205585A1 (en) * 2016-05-27 2017-11-30 Viiv Healthcare Company Combinations and uses treatments thereof
WO2018028841A1 (en) * 2016-08-12 2018-02-15 Sandoz Ag Solid pharmaceutical composition of abacavir, lamivudine, and efavirenz
WO2018042332A1 (en) * 2016-08-31 2018-03-08 Glaxosmithkline Intellectual Property (No.2) Limited Combinations and uses and treatments thereof
US20200138845A1 (en) * 2017-07-18 2020-05-07 Viiv Healthcare Company Combination Drug Therapy
KR20200031658A (en) 2017-07-21 2020-03-24 비이브 헬쓰케어 컴퍼니 Therapy to treat HIB infection and AIDS
EP3654981A4 (en) * 2017-07-21 2021-04-21 VIIV Healthcare Company Regimens for treating hiv infections and aids
KR20200070246A (en) * 2017-10-13 2020-06-17 비이브 헬쓰케어 컴퍼니 Bilayer pharmaceutical tablet formulation
EP4122537A1 (en) 2019-03-22 2023-01-25 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
CN114901363A (en) * 2020-01-09 2022-08-12 华盛顿大学 Long-acting therapeutic compositions and methods thereof
US11697652B2 (en) 2020-02-24 2023-07-11 Gilead Sciences, Inc. Tetracyclic compounds and uses thereof
WO2022159387A1 (en) 2021-01-19 2022-07-28 Gilead Sciences, Inc. Substituted pyridotriazine compounds and uses thereof
WO2023164293A1 (en) * 2022-02-28 2023-08-31 Jericho Sciences, Llc Methods for viral infections

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US7119202B1 (en) 1989-02-08 2006-10-10 Glaxo Wellcome Inc. Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
GB8815265D0 (en) 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
GB9009861D0 (en) 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
ZA923640B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9111902D0 (en) 1991-06-03 1991-07-24 Glaxo Group Ltd Chemical compounds
GB9204015D0 (en) 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
US5519021A (en) 1992-08-07 1996-05-21 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
IL106507A (en) 1992-08-07 1997-11-20 Merck & Co Inc Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
GB9402161D0 (en) 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
IL113432A (en) 1994-04-23 2000-11-21 Glaxo Group Ltd Process for the diastereoselective synthesis of nucleoside analogues
UA49803C2 (en) 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Method for treatment of retrovirus infections
MY115461A (en) 1995-03-30 2003-06-30 Wellcome Found Synergistic combinations of zidovudine, 1592u89 and 3tc
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US5849911A (en) 1996-04-22 1998-12-15 Novartis Finance Corporation Antivirally active heterocyclic azahexane derivatives
HUP9903249A3 (en) * 1996-06-25 2001-04-28 Glaxo Group Ltd Combinations comprising vx478, zidovudine, ftc and/or 3tc for use in the treatment of hiv
US5922695A (en) 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
US5965729A (en) 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
GB9709945D0 (en) 1997-05-17 1997-07-09 Glaxo Group Ltd A novel salt
US5935946A (en) 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
GB9717928D0 (en) 1997-08-22 1997-10-29 Glaxo Group Ltd Process for the enatioselective hydrolysis of n-derivatised lactams
GB9721780D0 (en) 1997-10-14 1997-12-10 Glaxo Group Ltd Process for the synthesis of chloropurine intermediates
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
US6087383A (en) 1998-01-20 2000-07-11 Bristol-Myers Squibb Company Bisulfate salt of HIV protease inhibitor
GB9805898D0 (en) 1998-03-20 1998-05-13 Glaxo Group Ltd Process for the sythesis of hiv protease inhibitors
EP1063888A1 (en) 1998-03-27 2001-01-03 The Regents of the University of California Novel hiv integrase inhibitors and hiv therapy based on drug combinations including integrase inhibitors
UA72207C2 (en) 1998-04-07 2005-02-15 Брістол- Майєрс Сквібб Фарма Компані Pharmaceutical formulations of efavirenz and disintegrants providing for increasing dissolution rate and process of manufacturing such tablets or capsules
GB9809213D0 (en) * 1998-04-29 1998-07-01 Glaxo Group Ltd Pharmaceutical compositions
GB9815567D0 (en) 1998-07-18 1998-09-16 Glaxo Group Ltd Antiviral compound
ES2286097T7 (en) 2000-01-31 2009-11-05 Cook Biotech, Inc ENDOPROTESIS VALVES.
DE60219292T2 (en) 2001-04-10 2008-04-10 Pfizer Inc. PYRAZONE DERIVATIVES FOR THE TREATMENT OF HIV
JO3429B1 (en) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv Hiv inhibiting pyrimidines derivatives
US7638522B2 (en) * 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
AR040242A1 (en) * 2002-06-04 2005-03-23 Glaxo Group Ltd PHARMACEUTICAL COMPOSITIONS
PL373758A1 (en) * 2002-06-27 2005-09-05 Medivir Ab Synergistic interaction of abacavir and alovudine
US20040224917A1 (en) * 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
BRPI0507628A (en) * 2004-02-11 2007-07-03 Smithkline Beecham Corp pharmaceutically acceptable compound or salt thereof, method of treating a viral infection in a human, use of a compound pharmaceutical composition, and process for preparing a compound
ES2315922T3 (en) * 2004-04-14 2009-04-01 Gilead Sciences, Inc. PHOSPHONATE ANALOGS OF INHIBITING COMPOUNDS OF HIV INTEGRAS.
EP2229945A1 (en) * 2004-05-21 2010-09-22 Japan Tobacco, Inc. Combinations comprising a 4-isoquinolone derivative and anti-HIV agents
US7176196B2 (en) 2004-05-28 2007-02-13 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
CA2576659A1 (en) 2004-08-23 2006-03-02 Teva Pharmaceutical Industries Ltd. Solid and crystalline ibandronate sodium and processes for preparation thereof
PL1632232T6 (en) 2004-09-02 2022-06-27 Janssen Pharmaceutica Nv Salt of 4[[4-[[4-(2-Cyanoethenyl)-2,6-dimethylphenyl]amino]-2-Pyrimidinyl]amino]benzonitrile
RS50981B (en) 2004-09-17 2010-10-31 Idenix Pharmaceuticals Inc. Phosphoindoles as hiv inhibitors
EP1853604A4 (en) 2005-03-04 2010-02-24 Smithkline Beecham Corp Chemical compounds
WO2006116764A1 (en) * 2005-04-28 2006-11-02 Smithkline Beecham Corporation Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity
UA96568C2 (en) * 2005-04-28 2011-11-25 Глаксосмиткляйн Ллк Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor
EP2308490A1 (en) * 2005-12-30 2011-04-13 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
UA108605C2 (en) * 2005-12-30 2015-05-25 METHOD OF IMPROVING PHARMACOKINETICS OF HIV INTEGRASION INHIBITORS
TWI458483B (en) * 2006-01-20 2014-11-01 Tibotec Pharm Ltd Long term treatment of hiv infection
US20080039428A1 (en) 2006-06-29 2008-02-14 Panacos Pharmaceuticals, Inc. Antiretroviral combination therapy
CA2657936C (en) 2006-07-21 2017-01-10 Gilead Sciences, Inc. Antiviral protease inhibitors
US7960428B2 (en) 2006-09-29 2011-06-14 Idenix Pharmaceuticals, Inc. Enantiomerically pure phosphoindoles as HIV inhibitors
ES2603617T3 (en) 2007-02-23 2017-02-28 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
TW200835693A (en) 2007-02-23 2008-09-01 Auspex Pharmaceuticals Inc Preparation and utility of non-nucleoside reverse transcriptase inhibitors
KR20100041798A (en) 2007-06-29 2010-04-22 한국화학연구원 Novel hiv reverse transcriptase inhibitors
CA2692460A1 (en) 2007-06-29 2009-01-08 Korea Research Institute Of Chemical Technology Hiv reverse transcriptase inhibitors
JP5393665B2 (en) 2007-07-06 2014-01-22 ギリアード サイエンシーズ， インコーポレイテッド Modulator of pharmacokinetic properties of therapeutic agents
DK2175857T3 (en) * 2007-07-12 2013-12-02 Janssen R & D Ireland Crystalline Form of (E) 4 - [[4 - [[4- (2-CYANOETHENYL) -2,6-DIMETHYLPHENYL] AMINO] -2-PYRIMIDINYL] AMINO] BENZONITRIL
WO2009058923A1 (en) 2007-10-31 2009-05-07 Smithkline Beecham Corporation Ccr5 antagonists as therapeutic agents
JP2011502998A (en) 2007-11-01 2011-01-27 ザ ユーエイビー リサーチ ファウンデイション Treatment and prevention of viral infection
US8108055B2 (en) 2007-12-28 2012-01-31 Larry Wong Method, system and apparatus for controlling an electrical device
MX2010007375A (en) * 2008-01-03 2010-09-30 Virochem Pharma Inc Novel lupane derivatives.
EP2240504A1 (en) 2008-01-03 2010-10-20 Virochem Pharma Inc. Novel c-21-keto lupane derivatives preparation and use thereof
EP2231628B1 (en) 2008-01-04 2015-10-28 Gilead Sciences, Inc. Inhibitors of cytochrome p450
WO2009100532A1 (en) 2008-02-14 2009-08-20 Virochem Pharma Inc. NOVEL 17ß LUPANE DERIVATIVES
WO2009148600A2 (en) * 2008-06-06 2009-12-10 Concert Pharmaceuticals, Inc. Deuterated lysine-based compounds
PT2320908E (en) * 2008-07-25 2014-03-06 Shionogi & Co Dolutegravir prodrugs
MX2011006241A (en) * 2008-12-11 2011-06-28 Shionogi & Co Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates.
ES2964383T3 (en) 2008-12-11 2024-04-05 Viiv Healthcare Co Processes and intermediates for carbamoylpyridone HIV integrase inhibitors
ES2688925T3 (en) 2010-01-27 2018-11-07 Viiv Healthcare Company Antiviral treatment
GB201006038D0 (en) 2010-04-12 2010-05-26 Unilever Plc Improvements relating to antiviral compositions
CN103402516B (en) 2010-06-17 2018-01-30 富津世生物技术有限公司 Compound, composition and application method as antiviral drugs

Also Published As

Publication number Publication date
JP2019167371A (en) 2019-10-03
CA3003988C (en) 2020-01-07
EP3351249A1 (en) 2018-07-25
CN105311033B (en) 2019-05-07
WO2011094150A1 (en) 2011-08-04
HK1179522A1 (en) 2013-10-04
DK3494972T3 (en) 2024-01-29
KR101883750B1 (en) 2018-07-31
EA202190473A3 (en) 2021-12-31
CY1120457T1 (en) 2019-07-10
CA2787691C (en) 2018-07-17
JP2022071126A (en) 2022-05-13
NZ627824A (en) 2016-02-26
NZ601319A (en) 2014-08-29
IL281959A (en) 2021-05-31
CY1116509T1 (en) 2017-03-15
PT2932970T (en) 2018-06-08
EP3494972A1 (en) 2019-06-12
AU2011209788A1 (en) 2012-08-16
ME03058B (en) 2019-01-20
US20170119777A1 (en) 2017-05-04
US20180098992A1 (en) 2018-04-12
HUE037812T2 (en) 2018-09-28
FR18C1043I2 (en) 2019-10-11
TN2012000376A1 (en) 2014-01-30
RS54123B1 (en) 2015-12-31
EA025176B1 (en) 2016-11-30
US20170079982A1 (en) 2017-03-23
CO6602152A2 (en) 2013-01-18
US20170281636A1 (en) 2017-10-05
ES2969969T3 (en) 2024-05-23
ES2688925T3 (en) 2018-11-07
DK3127542T3 (en) 2018-11-12
MX367937B (en) 2019-09-12
IL267658B (en) 2021-04-29
MX356891B (en) 2018-06-19
DK2531027T3 (en) 2015-07-20
HUE026849T2 (en) 2016-08-29
HRP20180855T1 (en) 2018-06-29
PH12018502489A1 (en) 2020-06-15
EP4316599A2 (en) 2024-02-07
NZ627827A (en) 2016-02-26
KR101964923B1 (en) 2019-04-02
HK1250335A1 (en) 2018-12-14
NZ627826A (en) 2016-01-29
LTPA2018013I1 (en) 2018-11-12
EA202190473A2 (en) 2021-06-30
AU2011209788C1 (en) 2014-08-28
EA201690872A2 (en) 2016-08-31
SMT201500177B (en) 2015-09-07
SI2531027T1 (en) 2015-08-31
PT2531027E (en) 2015-09-16
CA3060290C (en) 2022-07-12
CN102791129B (en) 2015-09-30
RS57323B1 (en) 2018-08-31
SG182614A1 (en) 2012-08-30
JP2023085431A (en) 2023-06-20
KR20180078358A (en) 2018-07-09
US20160199379A1 (en) 2016-07-14
US20160339033A1 (en) 2016-11-24
IL245182A0 (en) 2016-06-30
CN105311033A (en) 2016-02-10
KR101830715B1 (en) 2018-04-04
HRP20181531T1 (en) 2018-11-16
US20120295898A1 (en) 2012-11-22
UA105556C2 (en) 2014-05-26
CA2787691A1 (en) 2011-08-04
EA032868B1 (en) 2019-07-31
US10426780B2 (en) 2019-10-01
SI3494972T1 (en) 2024-03-29
PH12016500195B1 (en) 2016-12-05
CY2018029I1 (en) 2019-07-10
PE20121524A1 (en) 2012-12-03
ES2670811T3 (en) 2018-06-01
EP2531027B1 (en) 2015-05-06
HUS1800042I1 (en) 2018-11-28
JP2013518107A (en) 2013-05-20
IL245182B (en) 2018-04-30
CY2018029I2 (en) 2019-07-10
HRP20240168T1 (en) 2024-04-26
IL221007A (en) 2016-06-30
LUC00090I2 (en) 2019-01-08
JP2017008087A (en) 2017-01-12
DK2932970T3 (en) 2018-05-28
PL3127542T3 (en) 2019-03-29
CA3003988A1 (en) 2011-08-04
IL257267A (en) 2018-03-29
ME02182B (en) 2015-10-20
KR20120128640A (en) 2012-11-27
US20180200254A1 (en) 2018-07-19
US11234985B2 (en) 2022-02-01
DOP2021000147A (en) 2022-01-16
PT3494972T (en) 2024-02-12
EP2531027A4 (en) 2013-07-03
US20170216284A1 (en) 2017-08-03
HK1209629A1 (en) 2016-04-08
HUE040554T2 (en) 2019-03-28
LT2932970T (en) 2018-06-25
IL257267B (en) 2019-08-29
KR20170078868A (en) 2017-07-07
KR20160111536A (en) 2016-09-26
RS57728B1 (en) 2018-12-31
IL281959B (en) 2021-12-01
PE20160180A1 (en) 2016-05-04
ZA201205586B (en) 2014-01-29
ECSP12012106A (en) 2013-05-31
EA201690872A3 (en) 2016-12-30
CA2967453A1 (en) 2011-08-04
DOP2012000205A (en) 2012-10-15
SI2932970T1 (en) 2018-07-31
TR201807704T4 (en) 2018-06-21
LTC2932970I2 (en) 2022-04-25
EA201892277A1 (en) 2019-03-29
EP4316599A3 (en) 2024-04-10
EP2932970A1 (en) 2015-10-21
FIC20240016I1 (en) 2024-05-31
PL2531027T3 (en) 2016-01-29
AP2012006445A0 (en) 2012-08-31
PT3127542T (en) 2018-11-26
CA3060290A1 (en) 2011-08-04
JP2016145204A (en) 2016-08-12
EA037601B1 (en) 2021-04-20
LT3494972T (en) 2024-03-12
EP2932970B1 (en) 2018-03-21
JP6268386B2 (en) 2018-01-31
CR20120423A (en) 2012-11-22
MX2012008774A (en) 2012-08-17
PL3494972T3 (en) 2024-05-27
EP3127542B1 (en) 2018-08-22
FR18C1043I1 (en) 2018-11-30
ES2543066T3 (en) 2015-08-14
HRP20150770T1 (en) 2015-08-28
NO2018036I1 (en) 2018-10-15
CN102791129A (en) 2012-11-21
CY1121040T1 (en) 2019-12-11
MY188334A (en) 2021-11-30
JP2018127473A (en) 2018-08-16
EP2531027A1 (en) 2012-12-12
PH12016500195A1 (en) 2016-12-05
AP3551A (en) 2016-01-18
IL221007A0 (en) 2012-09-24
AU2011209788B2 (en) 2014-02-06
US20210401850A1 (en) 2021-12-30
EP3494972B1 (en) 2023-12-13
MX367938B (en) 2019-09-12
EA201290583A1 (en) 2013-04-30
CL2012002080A1 (en) 2012-11-30
SG10201707183TA (en) 2017-10-30
MA34002B1 (en) 2013-02-01
NO2932970T3 (en) 2018-08-18
US20200230147A1 (en) 2020-07-23
BR112012018670A2 (en) 2018-02-06
SI3127542T1 (en) 2018-11-30
RS65183B1 (en) 2024-03-29
IL267658A (en) 2019-08-29
FI3494972T3 (en) 2024-03-01
EP3127542A1 (en) 2017-02-08
US20150238496A1 (en) 2015-08-27
CA2967453C (en) 2018-07-17
LT3127542T (en) 2018-11-26
JP2021091705A (en) 2021-06-17
PL2932970T3 (en) 2018-08-31

Similar Documents

Publication Publication Date Title
HUS1800042I1 (en) Antiviral therapy
HK1250162A1 (en) Antiviral compounds
IL222481A0 (en) Combination therapy
EP2552323A4 (en) Combination therapy
EP2663304A4 (en) Combination therapy
EP2726095A4 (en) Combination therapy
EP2585073A4 (en) Antiviral compounds
EP2701744A4 (en) Combination therapy
GB201005394D0 (en) Therapy
GB0905485D0 (en) Antiviral therapy
GB201016864D0 (en) Therapeutic methods
EP2629766A4 (en) Combination therapy
ZA201207199B (en) Immune therapy
GB0908952D0 (en) Antiviral therapy
GB201004674D0 (en) Novel therapy
GB201021708D0 (en) Novel Therapeutic use