SE9401709D0 - Improved alphavirus vectors for expression of heterologous DNA - Google Patents

Improved alphavirus vectors for expression of heterologous DNA

Info

Publication number
SE9401709D0
SE9401709D0 SE9401709A SE9401709A SE9401709D0 SE 9401709 D0 SE9401709 D0 SE 9401709D0 SE 9401709 A SE9401709 A SE 9401709A SE 9401709 A SE9401709 A SE 9401709A SE 9401709 D0 SE9401709 D0 SE 9401709D0
Authority
SE
Sweden
Prior art keywords
expression
alphavirus
heterologous dna
vectors
alphavirus vectors
Prior art date
Application number
SE9401709A
Other languages
English (en)
Swedish (sv)
Inventor
Mathilda Sjoeberg
Maarit Suomalainen
Henrik Garoff
Original Assignee
Mathilda Sjoeberg
Maarit Suomalainen
Henrik Garoff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mathilda Sjoeberg, Maarit Suomalainen, Henrik Garoff filed Critical Mathilda Sjoeberg
Priority to SE9401709A priority Critical patent/SE9401709D0/xx
Publication of SE9401709D0 publication Critical patent/SE9401709D0/xx
Priority to EP95920347A priority patent/EP0760000B1/de
Priority to AT95920347T priority patent/ATE352633T1/de
Priority to JP52958095A priority patent/JP3786956B2/ja
Priority to US08/737,608 priority patent/US6224879B1/en
Priority to PCT/SE1995/000558 priority patent/WO1995031565A1/en
Priority to DE69535376T priority patent/DE69535376T2/de
Priority to CA002188421A priority patent/CA2188421A1/en
Priority to AU25826/95A priority patent/AU698976B2/en
Priority to FI964577A priority patent/FI964577A/fi
Priority to US09/657,312 priority patent/US6692750B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/10—Vectors comprising a special translation-regulating system regulates levels of translation
    • C12N2840/105—Vectors comprising a special translation-regulating system regulates levels of translation enhancing translation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
SE9401709A 1994-05-18 1994-05-18 Improved alphavirus vectors for expression of heterologous DNA SE9401709D0 (sv)

Priority Applications (11)

Application Number Priority Date Filing Date Title
SE9401709A SE9401709D0 (sv) 1994-05-18 1994-05-18 Improved alphavirus vectors for expression of heterologous DNA
AU25826/95A AU698976B2 (en) 1994-05-18 1995-05-17 Alphavirus expression vector
US08/737,608 US6224879B1 (en) 1994-05-18 1995-05-17 Alphavirus expression vector
AT95920347T ATE352633T1 (de) 1994-05-18 1995-05-17 Expressionsvektor des alphavirus
JP52958095A JP3786956B2 (ja) 1994-05-18 1995-05-17 アルファウイルス発現ベクター
EP95920347A EP0760000B1 (de) 1994-05-18 1995-05-17 Expressionsvektor des alphavirus
PCT/SE1995/000558 WO1995031565A1 (en) 1994-05-18 1995-05-17 Alphavirus expression vector
DE69535376T DE69535376T2 (de) 1994-05-18 1995-05-17 Expressionsvektor des alphavirus
CA002188421A CA2188421A1 (en) 1994-05-18 1995-05-17 Alphavirus expression vector
FI964577A FI964577A (fi) 1994-05-18 1996-11-15 Alfavirusilmennysvektori
US09/657,312 US6692750B1 (en) 1994-05-18 2000-09-07 Alphavirus expression vector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9401709A SE9401709D0 (sv) 1994-05-18 1994-05-18 Improved alphavirus vectors for expression of heterologous DNA

Publications (1)

Publication Number Publication Date
SE9401709D0 true SE9401709D0 (sv) 1994-05-18

Family

ID=20394041

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9401709A SE9401709D0 (sv) 1994-05-18 1994-05-18 Improved alphavirus vectors for expression of heterologous DNA

Country Status (10)

Country Link
US (2) US6224879B1 (de)
EP (1) EP0760000B1 (de)
JP (1) JP3786956B2 (de)
AT (1) ATE352633T1 (de)
AU (1) AU698976B2 (de)
CA (1) CA2188421A1 (de)
DE (1) DE69535376T2 (de)
FI (1) FI964577A (de)
SE (1) SE9401709D0 (de)
WO (1) WO1995031565A1 (de)

Families Citing this family (43)

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US6015686A (en) * 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
US5792462A (en) * 1995-05-23 1998-08-11 University Of North Carolina At Chapel Hill Alphavirus RNA replicon systems
US6465634B1 (en) 1996-04-05 2002-10-15 Chiron Corporation Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
US6451592B1 (en) 1996-04-05 2002-09-17 Chiron Corporation Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
WO1998015636A1 (en) * 1996-10-10 1998-04-16 Henrik Garoff Alphavirus-retrovirus vectors
US5811407A (en) 1997-02-19 1998-09-22 The University Of North Carolina At Chapel Hill System for the in vivo delivery and expression of heterologous genes in the bone marrow
US6432699B1 (en) 1997-03-28 2002-08-13 New York University Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A
WO1998051810A1 (en) 1997-05-13 1998-11-19 University Of North Carolina At Chapel Hill Lentivirus-based gene transfer vectors
US8647864B2 (en) 1999-04-14 2014-02-11 Novartis Ag Compositions and methods for generating an immune response utilizing alphavirus-based vector systems
AU1013601A (en) 1999-10-22 2001-05-08 Aventis Pasteur Limited Method of inducing and/or enhancing an immune response to tumor antigens
DK1282702T3 (da) * 2000-05-10 2007-04-02 Sanofi Pasteur Ltd Immunogene polypeptider, som er kodet af KAGE-minigener, og anvendelser deraf
DE60135983D1 (de) 2000-05-31 2008-11-13 Novartis Vaccines & Diagnostic Verfahren zur reinigung von alphaviralen replikon partikeln
US6783939B2 (en) 2000-07-07 2004-08-31 Alphavax, Inc. Alphavirus vectors and virosomes with modified HIV genes for use in vaccines
AU2001290642A1 (en) * 2000-09-07 2002-03-22 University Of North Carolina At Chapel Hill Vectors derived from south african arbovirus no. 86
WO2002046372A1 (en) 2000-12-08 2002-06-13 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
AU2002258631B2 (en) * 2001-03-27 2007-05-17 New York University Tumor therapy with alphavirus-based and high affinity laminin receptor-targeted vectors
CA2460269C (en) 2001-09-06 2013-01-15 Alphavax, Inc. Alphavirus replicon vector systems
US6899507B2 (en) * 2002-02-08 2005-05-31 Asm Japan K.K. Semiconductor processing apparatus comprising chamber partitioned into reaction and transfer sections
US7786278B2 (en) 2002-04-09 2010-08-31 Sanofi Pasteur Limited Modified CEA nucleic acid and expression vectors
EP1386926A1 (de) * 2002-07-29 2004-02-04 Bioxtal Verfahren zur Herstellung von rekombinanten markierten Polypeptiden und ihre Anwendungen
JP4991108B2 (ja) * 2002-12-13 2012-08-01 アルファバックス，インコーポレイティド 多抗原性アルファウイルス・レプリコン粒子及び方法
ES2552687T3 (es) 2002-12-13 2015-12-01 Alphavax, Inc. Partículas alfavíricas y métodos de preparación
WO2004063342A2 (en) * 2003-01-09 2004-07-29 Invitrogen Corporation Cellular delivery and activation polypeptide-nucleic acid complexes
KR101518309B1 (ko) 2003-03-20 2015-05-08 알파벡스, 인크. 개선된 알파바이러스 레플리콘 및 헬퍼 구축물
AU2004257214B2 (en) * 2003-07-11 2010-04-22 Alphavax, Inc. Alphavirus-based cytomegalovirus vaccines
US7910093B2 (en) 2003-08-19 2011-03-22 New York University Method for detecting cancer cells and monitoring cancer therapy
CN101124327A (zh) * 2003-10-08 2008-02-13 圣诺菲·帕斯图尔公司 经修饰的cea/b7载体
WO2005118809A2 (en) * 2004-04-29 2005-12-15 The University Of North Carolina At Chapel Hill Methods and compositions for enhancing cell adhesion properties
ES2321212T3 (es) 2004-05-18 2009-06-03 Alphavax, Inc. Vectores alfavirus derivados de tc-83, particulas y metodos antecentes de la invencion.
WO2006085983A2 (en) 2004-07-09 2006-08-17 University Of North Carolina At Chapel Hill Viral adjuvants
US8486420B2 (en) * 2005-02-15 2013-07-16 The University Of North Carolina At Chapel Hill Live virus vaccines
US7303898B2 (en) * 2005-03-29 2007-12-04 New York University Defective sindbis viral vectors
US20100233209A1 (en) * 2005-08-11 2010-09-16 Higgs Stephen T Chikungunya virus infectious clones and uses therefor
WO2008127486A2 (en) * 2006-12-29 2008-10-23 Bacilligen, Inc. Replication-proficient dsrna capsids and uses thereof
US7850977B2 (en) 2007-06-21 2010-12-14 Alphavax, Inc. Promoterless cassettes for expression of alphavirus structural proteins
AU2009248735B2 (en) * 2008-05-23 2015-08-20 Fit Biotech Oy Expression vector encoding alphavirus replicase and the use thereof as immunological adjuvant
US10538786B2 (en) 2016-04-13 2020-01-21 Janssen Pharmaceuticals, Inc. Recombinant arterivirus replicon systems and uses thereof
KR20190082226A (ko) 2016-10-17 2019-07-09 신테틱 제노믹스, 인코포레이티드. 재조합 바이러스 레플리콘 시스템 및 그의 용도
BR112019011661A2 (pt) * 2016-12-05 2020-01-07 Synthetic Genomics, Inc. Composições e métodos para aumentar expressão de gene
US11020476B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV)
US11021692B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Hepatitis B virus (HBV) vaccines and uses thereof
EA202091517A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и устройство для доставки вакцин против вируса гепатита b (hbv)
WO2019143949A2 (en) 2018-01-19 2019-07-25 Synthetic Genomics, Inc. Induce and enhance immune responses using recombinant replicon systems

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091309A (en) 1986-01-16 1992-02-25 Washington University Sindbis virus vectors
US5217879A (en) 1989-01-12 1993-06-08 Washington University Infectious Sindbis virus vectors
SE9003978D0 (sv) * 1990-12-13 1990-12-13 Henrik Garoff Dna expressionssystem baserade paa ett virus replikon
GB9406498D0 (en) 1994-03-31 1994-05-25 Smithkline Beecham Biolog Novel compounds

Also Published As

Publication number Publication date
US6692750B1 (en) 2004-02-17
DE69535376D1 (de) 2007-03-15
FI964577A0 (fi) 1996-11-15
CA2188421A1 (en) 1995-11-23
JPH10500017A (ja) 1998-01-06
US6224879B1 (en) 2001-05-01
ATE352633T1 (de) 2007-02-15
AU698976B2 (en) 1998-11-12
WO1995031565A1 (en) 1995-11-23
AU2582695A (en) 1995-12-05
EP0760000B1 (de) 2007-01-24
FI964577A (fi) 1996-11-15
DE69535376T2 (de) 2007-11-08
JP3786956B2 (ja) 2006-06-21
EP0760000A1 (de) 1997-03-05

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