SE8702940L - PHARMACEUTICAL, N-ACETYL-CYSTEIN-CONTAINING, WATER-SOLUBLE COMPOSITION - Google Patents
PHARMACEUTICAL, N-ACETYL-CYSTEIN-CONTAINING, WATER-SOLUBLE COMPOSITIONInfo
- Publication number
- SE8702940L SE8702940L SE8702940A SE8702940A SE8702940L SE 8702940 L SE8702940 L SE 8702940L SE 8702940 A SE8702940 A SE 8702940A SE 8702940 A SE8702940 A SE 8702940A SE 8702940 L SE8702940 L SE 8702940L
- Authority
- SE
- Sweden
- Prior art keywords
- water
- pharmaceutical
- cystein
- acetyl
- soluble composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 2
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 2
- 108010011485 Aspartame Proteins 0.000 abstract 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
- 229960004308 acetylcysteine Drugs 0.000 abstract 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 abstract 1
- 229960003438 aspartame Drugs 0.000 abstract 1
- 235000010357 aspartame Nutrition 0.000 abstract 1
- 239000000605 aspartame Substances 0.000 abstract 1
- 230000001013 cariogenic effect Effects 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 230000000510 mucolytic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A pharmaceutical composition in the form of water-soluble effervescent granules or tablets comprises: N-Acetylcysteine 6-32% Citric acid 35-50% Sodium bicarbonate 26-37% Aspartame 1-1.5% Flavouring agent 5-7% The weight ratio of citric acid to sodium bicarbonate is from 1.2:1 to 1.4:1. The compositions have mucolytic activity, are non-cariogenic and are suitable for diabetics.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH2975/86A CH667590A5 (en) | 1986-07-24 | 1986-07-24 | WATER-SOLUBLE EFFERVESCENT PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYL-CISTEIN. . |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8702940D0 SE8702940D0 (en) | 1987-07-23 |
SE8702940L true SE8702940L (en) | 1988-01-25 |
SE500494C2 SE500494C2 (en) | 1994-07-04 |
Family
ID=4245841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8702940A SE500494C2 (en) | 1986-07-24 | 1987-07-23 | Pharmaceutical, water-soluble composition containing N-acetyl-cysteine and aspartame |
Country Status (8)
Country | Link |
---|---|
BE (1) | BE1000355A3 (en) |
CH (1) | CH667590A5 (en) |
DE (1) | DE3723735A1 (en) |
FR (1) | FR2601876B1 (en) |
GB (1) | GB2192790B (en) |
IT (1) | IT1222104B (en) |
NL (1) | NL194067C (en) |
SE (1) | SE500494C2 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1217445B (en) * | 1988-04-29 | 1990-03-22 | Altergon Sa | SOLUBLE PHARMACEUTICAL COMPOSITION CONTAINING ACETYLCISTEIN |
DE3822096A1 (en) * | 1988-06-30 | 1990-01-04 | Klinge Co Chem Pharm Fab | STABILIZED DRUG PREPARATION |
SE462779B (en) * | 1988-10-10 | 1990-09-03 | Lejus Medical Ab | PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYL CYSTEIN IN A CERNA COATED WITH HYDROXIPROPYLMETHYL CELLULOS AGREEMENT |
DE3909049A1 (en) * | 1989-03-18 | 1990-09-20 | Arthur Boskamp | PREPARATION AND THEIR USE |
IT1231012B (en) * | 1989-07-27 | 1991-11-08 | Zambon Spa | PHARMACEUTICAL COMPOSITION FOR ORAL USE CONTAINING NAC. |
DK0497724T3 (en) * | 1991-01-26 | 1996-04-29 | Senju Pharma Co | Means for the disintegration of gallstones |
DE4103360A1 (en) * | 1991-02-05 | 1992-08-06 | Koehler Peter | Use of acetyl-cysteine and isotonic sodium chloride (0.9 per cent) - for treating bronchial asthma and bronchitis-induced spasms |
US5296500A (en) * | 1991-08-30 | 1994-03-22 | The Procter & Gamble Company | Use of N-acetyl-cysteine and derivatives for regulating skin wrinkles and/or skin atrophy |
IT1256616B (en) * | 1992-12-02 | 1995-12-12 | Zambon Spa | SYRUP CONTAINING N-ACETYL-CISTEIN |
DE4406261C2 (en) * | 1993-08-31 | 1996-07-04 | Deutsches Krebsforsch | Use of thiol compounds to reduce body fat |
BE1007926A3 (en) * | 1994-01-31 | 1995-11-21 | Zambon Int Pharma | Pharmaceutical composition containing n-acetyl-cysteine. |
US5451405A (en) * | 1994-04-25 | 1995-09-19 | Chesebrough-Pond's Usa Co. | Skin treatment composition |
DE19509856C2 (en) * | 1995-03-17 | 1997-09-11 | Schwabe Willmar Gmbh & Co | Use of an effervescent composition with Ginkgo biloba dry extract for the treatment of peripheral and cerebral circulatory disorders |
WO2000018392A1 (en) | 1998-09-25 | 2000-04-06 | Glycox Corporation Limited | Fructosamine oxidase: antagonists and inhibitors |
AU772616B2 (en) | 1998-09-25 | 2004-05-06 | Protemix Corporation Limited | Fructosamine oxidase assay: methods and materials |
AU2003225442B2 (en) | 2002-03-08 | 2010-02-04 | Philera New Zealand Limited | Preventing and/or treating cardiovascular disease and/or associated heart failure |
EP1539129A4 (en) | 2002-08-20 | 2006-03-08 | Protemix Corp Ltd | Dosage forms and related therapies |
PT1778618E (en) | 2004-07-19 | 2014-03-04 | Philera New Zealand Ltd | Synthesis of triethylenetetramines |
TR200900881A2 (en) * | 2009-02-05 | 2010-08-23 | Bi̇lgi̇ç Mahmut | Stable pharmaceutical compositions masked by taste and odor |
TR200900882A2 (en) * | 2009-02-05 | 2010-08-23 | Bi̇lgi̇ç Mahmut | Pharmaceutical compositions with high bioavailability, masked by taste and odor. |
IT1399492B1 (en) * | 2010-04-13 | 2013-04-19 | Alpex Pharma Sa | EFFERVESCENT PHARMACEUTICAL COMPOSITIONS CONTAINING N-ACETYLCISTEIN. |
CN102233139B (en) * | 2010-04-21 | 2012-09-05 | 重庆健能医药开发有限公司 | Acetylcysteine effervescent tablet and preparation method and application thereof |
WO2011146031A1 (en) * | 2010-05-18 | 2011-11-24 | Bilgic Mahmut | Pharmaceutical composition comprising n- acetylcysteine and a xanthine |
CN101947211A (en) * | 2010-08-28 | 2011-01-19 | 浙江金华康恩贝生物制药有限公司 | Method for preparing acetylcysteine effervescent tablet |
TR201104738A2 (en) * | 2011-05-16 | 2012-12-21 | Bi̇lgi̇ç Mahmut | Pharmaceutical combination containing N-Acetylcysteine. |
US8747894B2 (en) * | 2012-05-08 | 2014-06-10 | Alpex Pharma S.A. | Effervescent compositions containing N-acetylcysteine |
WO2015117987A1 (en) * | 2014-02-05 | 2015-08-13 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Effervescent formulations comprising ibuprofen and n-acetylcystein |
CN113559078A (en) * | 2021-07-02 | 2021-10-29 | 安徽省先锋制药有限公司 | Preparation method of acetylcysteine effervescent tablets |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2470M (en) * | 1962-03-13 | 1964-04-20 | Mead Johnson & Co | Therapeutic composition. |
ZA723683B (en) * | 1971-07-12 | 1973-06-27 | Hoffmann La Roche | Improved effervescent preparations |
DE3317558A1 (en) * | 1983-05-13 | 1984-11-15 | Dietrich Dr.med. Sta. Eulalia Ibiza Reichert | Oral antisnoring composition |
DE3317530A1 (en) * | 1983-05-13 | 1984-11-15 | Dietrich Dr.med. Sta. Eulalia Ibiza Reichert | Antisnoring composition |
IT1170268B (en) * | 1983-12-21 | 1987-06-03 | Zambon Spa | USE OF ACETYLCISTEIN TO REDUCE THE INCREASE IN THE PROLIEFERATION OF THE BASAL CELLS OF THE RESPIRATORY THRACHEO-BRONCHIAL EPITHELIUM INDUCED BY TOBACCO SMOKE IN MAMMALS |
DE3514995A1 (en) * | 1985-04-25 | 1986-10-30 | Protopharma Ltd., 7831 Malterdingen | Use of sulfhydryl pharmaceuticals for combating damage to the gastric mucosa |
-
1986
- 1986-07-24 CH CH2975/86A patent/CH667590A5/en not_active IP Right Cessation
-
1987
- 1987-07-17 DE DE19873723735 patent/DE3723735A1/en active Granted
- 1987-07-22 FR FR878710368A patent/FR2601876B1/en not_active Expired
- 1987-07-23 SE SE8702940A patent/SE500494C2/en not_active IP Right Cessation
- 1987-07-23 BE BE8700816A patent/BE1000355A3/en not_active IP Right Cessation
- 1987-07-23 IT IT21411/87A patent/IT1222104B/en active
- 1987-07-23 NL NL8701743A patent/NL194067C/en not_active IP Right Cessation
- 1987-07-27 GB GB8717582A patent/GB2192790B/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FR2601876B1 (en) | 1989-10-13 |
NL8701743A (en) | 1988-02-16 |
IT1222104B (en) | 1990-08-31 |
DE3723735C2 (en) | 1992-05-21 |
NL194067B (en) | 2001-02-01 |
NL194067C (en) | 2001-06-05 |
GB2192790B (en) | 1990-01-31 |
DE3723735A1 (en) | 1988-02-04 |
SE500494C2 (en) | 1994-07-04 |
CH667590A5 (en) | 1988-10-31 |
BE1000355A3 (en) | 1988-11-08 |
SE8702940D0 (en) | 1987-07-23 |
FR2601876A1 (en) | 1988-01-29 |
GB8717582D0 (en) | 1987-09-03 |
GB2192790A (en) | 1988-01-27 |
IT8721411A0 (en) | 1987-07-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
NUG | Patent has lapsed |