SE8603486L - INACTIVATION OF BACTERY ENDOTOXINES - Google Patents
INACTIVATION OF BACTERY ENDOTOXINESInfo
- Publication number
- SE8603486L SE8603486L SE8603486A SE8603486A SE8603486L SE 8603486 L SE8603486 L SE 8603486L SE 8603486 A SE8603486 A SE 8603486A SE 8603486 A SE8603486 A SE 8603486A SE 8603486 L SE8603486 L SE 8603486L
- Authority
- SE
- Sweden
- Prior art keywords
- bactery
- endotoxines
- inactivation
- cytosylyl
- guanylyl
- Prior art date
Links
- 230000002779 inactivation Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 125000001572 5'-adenylyl group Chemical group C=12N=C([H])N=C(N([H])[H])C=1N=C([H])N2[C@@]1([H])[C@@](O[H])([H])[C@@](O[H])([H])[C@](C(OP(=O)(O[H])[*])([H])[H])([H])O1 0.000 abstract 1
- 125000001417 5'-guanylyl group Chemical group C=12N=C(N([H])[H])N([H])C(=O)C=1N=C([H])N2[C@@]1([H])[C@@](O[H])([H])[C@@](O[H])([H])[C@](C(OP(=O)(O[H])[*])([H])[H])([H])O1 0.000 abstract 1
- 208000006386 Bone Resorption Diseases 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 230000024279 bone resorption Effects 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 229910052718 tin Inorganic materials 0.000 abstract 1
- 239000011135 tin Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A non-toxic, water-soluble, pharmaceutically acceptable peroxydiphosphate compound is used to inhibit hypotensive shock and localised bone resorption caused by bacterial endotoxins. Preferred compounds are alkali metal, zinc, tin or quaternary ammonium salts or C1-12 alkyl, adenylyl, guanylyl, cytosylyl or thymylyl esters.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76839685A | 1985-08-22 | 1985-08-22 | |
| US85191586A | 1986-04-14 | 1986-04-14 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8603486D0 SE8603486D0 (en) | 1986-08-19 |
| SE8603486L true SE8603486L (en) | 1987-02-23 |
| SE468626B SE468626B (en) | 1993-02-22 |
Family
ID=27118049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8603486A SE468626B (en) | 1985-08-22 | 1986-08-19 | APPLICATION OF A PEROXIDIFOSPHATE PHOTO SOCIETY FOR INHIBITATION OF HYPOTENSIVE SHOCK AND LOCAL BENRESORPTION |
Country Status (12)
| Country | Link |
|---|---|
| BE (1) | BE905319A (en) |
| CA (1) | CA1282004C (en) |
| CH (1) | CH670046A5 (en) |
| DE (1) | DE3627759A1 (en) |
| DK (1) | DK168513B1 (en) |
| FR (1) | FR2586351B1 (en) |
| GB (1) | GB2180451B (en) |
| HK (1) | HK593A (en) |
| IT (1) | IT1196587B (en) |
| NL (1) | NL8602140A (en) |
| SE (1) | SE468626B (en) |
| SG (1) | SG108892G (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2586350B1 (en) * | 1985-08-22 | 1992-05-15 | Colgate Palmolive Co | PHARMACEUTICAL COMPOSITION BASED ON PEROXODIPHOSPHATE FOR INHIBITION OF SECRETION OF PARATHYROIDIAN HORMONE |
| DE4201858A1 (en) * | 1992-01-24 | 1993-07-29 | Renschler Aloys Dr Med | AGENT FOR TREATING MALIGNER CELLS |
| NO20024880L (en) * | 2002-03-19 | 2003-09-22 | Per Hamre | Composition containing phosphate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4041149A (en) * | 1976-01-12 | 1977-08-09 | Colgate-Palmolive Company | Composition and method of controlling and preventing mouth odor |
| US4430325A (en) * | 1981-12-23 | 1984-02-07 | Colgate-Palmolive Company | Topical treatment of skin lesions |
| US4975423A (en) * | 1984-06-27 | 1990-12-04 | Colgate-Palmolive Company | Inhibition of tumor development |
| DK168191B1 (en) * | 1984-06-27 | 1994-02-28 | Colgate Palmolive Co | Use of peroxydiphosphates for the preparation of pharmaceutical tablets or pharmaceutical aqueous solutions |
-
1986
- 1986-08-16 DE DE19863627759 patent/DE3627759A1/en not_active Ceased
- 1986-08-18 FR FR868611812A patent/FR2586351B1/en not_active Expired - Lifetime
- 1986-08-19 IT IT48389/86A patent/IT1196587B/en active
- 1986-08-19 SE SE8603486A patent/SE468626B/en not_active IP Right Cessation
- 1986-08-21 CA CA000516466A patent/CA1282004C/en not_active Expired - Lifetime
- 1986-08-22 NL NL8602140A patent/NL8602140A/en not_active Application Discontinuation
- 1986-08-22 BE BE0/217073A patent/BE905319A/en not_active IP Right Cessation
- 1986-08-22 GB GB8620482A patent/GB2180451B/en not_active Expired
- 1986-08-22 DK DK402086A patent/DK168513B1/en not_active IP Right Cessation
- 1986-08-22 CH CH3377/86A patent/CH670046A5/de not_active IP Right Cessation
-
1992
- 1992-10-14 SG SG1088/92A patent/SG108892G/en unknown
-
1993
- 1993-01-07 HK HK5/93A patent/HK593A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT8648389A0 (en) | 1986-08-19 |
| SG108892G (en) | 1992-12-24 |
| DK402086D0 (en) | 1986-08-22 |
| HK593A (en) | 1993-01-15 |
| CH670046A5 (en) | 1989-05-12 |
| IT1196587B (en) | 1988-11-16 |
| NL8602140A (en) | 1987-03-16 |
| GB2180451B (en) | 1989-10-18 |
| DK402086A (en) | 1987-02-23 |
| BE905319A (en) | 1987-02-23 |
| SE8603486D0 (en) | 1986-08-19 |
| CA1282004C (en) | 1991-03-26 |
| GB8620482D0 (en) | 1986-10-01 |
| GB2180451A (en) | 1987-04-01 |
| DK168513B1 (en) | 1994-04-11 |
| DE3627759A1 (en) | 1987-03-19 |
| SE468626B (en) | 1993-02-22 |
| FR2586351B1 (en) | 1991-10-18 |
| FR2586351A1 (en) | 1987-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAL | Patent in force |
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| NUG | Patent has lapsed |
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