SE8406450L - 5-PYRIMIDINE CARBOXAMIDES AND -TIOCHARBOXAMIDES AND TREATMENT OF LEUKEMIA AND TUMORS THEREOF - Google Patents

5-PYRIMIDINE CARBOXAMIDES AND -TIOCHARBOXAMIDES AND TREATMENT OF LEUKEMIA AND TUMORS THEREOF

Info

Publication number
SE8406450L
SE8406450L SE8406450A SE8406450A SE8406450L SE 8406450 L SE8406450 L SE 8406450L SE 8406450 A SE8406450 A SE 8406450A SE 8406450 A SE8406450 A SE 8406450A SE 8406450 L SE8406450 L SE 8406450L
Authority
SE
Sweden
Prior art keywords
leukemia
tumors
hydrogen
tiocharboxamides
treatment
Prior art date
Application number
SE8406450A
Other languages
Swedish (sv)
Other versions
SE8406450D0 (en
SE469171B (en
Inventor
A D Brewer
J A Minatelli
Original Assignee
Uniroyal Inc
Uniroyal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniroyal Inc, Uniroyal Ltd filed Critical Uniroyal Inc
Publication of SE8406450D0 publication Critical patent/SE8406450D0/en
Publication of SE8406450L publication Critical patent/SE8406450L/en
Publication of SE469171B publication Critical patent/SE469171B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/66—Thiobarbituric acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel 5-pyrimidinecarboxamides useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compounds have the formula: <IMAGE> wherein: R is hydrogen, 2- or 3-halo, 4-fluoro, 2-methyl, 2- or 4-alkoxy, or 2- or 4-trifluoromethyl, and R1 is hydrogen; or R is 2-fluoro and R1 is 4-fluoro; or R is 2-methoxy and R1 is 5-methyl; and R2 and R3 are hydrogen atoms or carbohydrate residues; and, with the exception of the compound wherein R is 4-methoxy and R1 is hydrogen, the pharmacologically acceptable acid-addition salts thereof.
SE8406450A 1983-12-19 1984-12-18 2-TIOXO-5-PYRIMIDINE CARBOXAMIDES, PHARMACEUTICAL COMPOSITION CONTAINING THESE, AND PROCEDURES FOR PREPARING THEREOF SE469171B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56269383A 1983-12-19 1983-12-19
US66520184A 1984-10-26 1984-10-26
US66526784A 1984-10-26 1984-10-26

Publications (3)

Publication Number Publication Date
SE8406450D0 SE8406450D0 (en) 1984-12-18
SE8406450L true SE8406450L (en) 1985-06-20
SE469171B SE469171B (en) 1993-05-24

Family

ID=27415896

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8406450A SE469171B (en) 1983-12-19 1984-12-18 2-TIOXO-5-PYRIMIDINE CARBOXAMIDES, PHARMACEUTICAL COMPOSITION CONTAINING THESE, AND PROCEDURES FOR PREPARING THEREOF

Country Status (19)

Country Link
US (1) US4634707A (en)
JP (1) JPH0660164B2 (en)
AT (1) AT394194B (en)
AU (1) AU580746B2 (en)
BE (1) BE901301A (en)
CH (1) CH671225A5 (en)
DE (1) DE3446371A1 (en)
DK (1) DK164055C (en)
ES (1) ES8606296A1 (en)
FR (1) FR2557108B1 (en)
GB (1) GB2152047B (en)
GR (1) GR82494B (en)
IE (1) IE57675B1 (en)
IL (1) IL73840A (en)
IT (1) IT1213257B (en)
LU (1) LU85696A1 (en)
NL (1) NL8403856A (en)
NZ (2) NZ220399A (en)
SE (1) SE469171B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2145087B (en) * 1983-08-19 1987-02-04 Ciba Geigy Ag Barbituric acid derivatives
EP0167491A3 (en) * 1984-07-06 1986-12-30 Ciba-Geigy Ag Thiobarbituric-acid derivatives
PH24423A (en) * 1985-02-15 1990-06-25 Ciba Geigy Ag 5-(azolyloxyphenylcarbamoyl)barbituric acid derivatives as anthelmintics
US4636508A (en) * 1985-04-22 1987-01-13 Uniroyal Chemical Company, Inc. 5-pyrimidinecarboxyamides and treatment of leukemia therewith
US4845217A (en) * 1985-05-17 1989-07-04 Uniroyal Chemical Ltd./Ltee Purification of 5-pyrimidinecarboxamides
EP0202823A3 (en) * 1985-05-17 1987-11-19 Uniroyal Limited Purification of 5-pyrimidinecarboxamides
US4880811A (en) * 1987-06-24 1989-11-14 Memorial Hospital For Cancer And Allied Diseases Use of C-5 mono-substituted barbiturates to treat disorders of uric acid metabolism
US4920126A (en) * 1988-05-10 1990-04-24 Uniroyal Chemical Ltd/Uniroyal Chemical Ltee Barbituric acid derivative and treatment of leukemia and tumors therewith
WO1991013623A1 (en) * 1990-03-09 1991-09-19 Memorial Hospital For Cancer And Allied Diseases C-5 mono-substituted barbiturates in combination with therapeutic agents and uses thereof
WO2001081319A2 (en) 2000-04-24 2001-11-01 Aryx Therapeutics Ultrashort acting hypnotic barbiturates
WO2015123003A1 (en) * 2014-02-14 2015-08-20 Warrell Raymond P Bifunctional compounds and use for reducing uric acid levels
CN107108526A (en) * 2015-01-22 2017-08-29 R·P·小沃勒尔 Dual-function compound and the purposes for reducing uric acid level
TWI772309B (en) 2016-06-30 2022-08-01 美商艾克奎斯特有限責任公司 Compounds and their use for reducing uric acid levels
KR102444538B1 (en) 2016-07-06 2022-09-16 애퀴스트 엘엘씨 Compounds and their use to reduce uric acid levels
IT201700028709A1 (en) 2017-03-15 2018-09-15 Fondazione St Italiano Tecnologia ACIDS-5-CARBOSSAMIDE-2-THIOBARBITURIS AND THEIR USE AS MEDICATIONS

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH602664A5 (en) * 1973-06-14 1978-07-31 Sandoz Ag 2-Tert. amino-alkylamino-pyrimidine derivs.
DE2405733C2 (en) * 1974-02-07 1984-12-13 Bayer Ag, 5090 Leverkusen Amidocarbonylthiobarbituric acid derivatives and their salts, processes for their preparation and their use for combating insects, mites and fungi
DE2405732A1 (en) * 1974-02-07 1975-08-21 Bayer Ag Agents against endo- and ecto-parasites - contg. 5-carbamoyl-2-thio-barbituric acid derivs
CH614944A5 (en) * 1974-04-16 1979-12-28 Sandoz Ag Process for the preparation of novel pyrimidine derivatives
PL103086B1 (en) * 1976-05-06 1979-05-31 Ciba Geigy Ag INSECTICIDE
CH616563A5 (en) * 1976-05-06 1980-04-15 Ciba Geigy Ag Pesticide containing a 5-phenylcarbamoylbarbituric acid as active ingredient
DE2624856A1 (en) * 1976-06-03 1977-12-22 Hoechst Ag Anthelmintic thio-barbituric acid derivs. - have (5)-benzyl-thiocarbamoyl substit. and are esp. useful for control of liver flukes
US4283444A (en) * 1978-09-12 1981-08-11 Ciba-Geigy Corporation Method of protecting keratinous material from attack by insects that feed on keratin by treatment with 5-phenylcarbamoylbarbituric acid compounds
US4349552A (en) * 1978-10-30 1982-09-14 Fujisawa Pharmaceutical Company, Ltd. 5-Fluorouracil derivatives, and their pharmaceutical compositions
EP0010941B1 (en) * 1978-10-30 1982-05-12 Fujisawa Pharmaceutical Co., Ltd. 5-fluorouracil derivatives, preparation thereof and their pharmaceutical compositions
CH654720A5 (en) * 1981-09-03 1986-03-14 Ciba Geigy Ag STORAGE-RESISTANT MOTH PROTECTION FORMULAS.
US4410524A (en) * 1982-06-01 1983-10-18 American Cyanamid Company Novel 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
CH658770A5 (en) * 1982-08-26 1986-12-15 Ciba Geigy Ag MUD AND COPPER PROTECTION AGENTS.
EP0102327A3 (en) * 1982-08-26 1985-05-15 Ciba-Geigy Ag Barbituric acid derivatives as anthelmintica
ZA849819B (en) * 1983-12-19 1985-07-31 Uniroyal Inc 5-pyrimidinecarboxamides and thiocarboxamides and treatment of leukemia and tumors therewith
EP0167491A3 (en) * 1984-07-06 1986-12-30 Ciba-Geigy Ag Thiobarbituric-acid derivatives
JPS641445A (en) 1987-06-22 1989-01-05 Toshiba Corp Manufacture of stator coil

Also Published As

Publication number Publication date
IE57675B1 (en) 1993-02-24
ATA402684A (en) 1991-08-15
IE843237L (en) 1985-06-19
FR2557108B1 (en) 1988-11-18
IT8424104A0 (en) 1984-12-18
GB8432112D0 (en) 1985-01-30
FR2557108A1 (en) 1985-06-28
DK609184A (en) 1985-06-20
IL73840A (en) 1988-11-15
US4634707A (en) 1987-01-06
DK164055B (en) 1992-05-04
DK164055C (en) 1992-09-28
SE8406450D0 (en) 1984-12-18
GB2152047A (en) 1985-07-31
AU3690884A (en) 1985-07-04
CH671225A5 (en) 1989-08-15
JPH0660164B2 (en) 1994-08-10
IT1213257B (en) 1989-12-14
JPS62174058A (en) 1987-07-30
DE3446371A1 (en) 1985-06-27
AU580746B2 (en) 1989-02-02
GR82494B (en) 1985-04-19
BE901301A (en) 1985-06-18
ES538829A0 (en) 1986-04-16
AT394194B (en) 1992-02-10
ES8606296A1 (en) 1986-04-16
NZ220399A (en) 1987-09-30
NL8403856A (en) 1985-07-16
GB2152047B (en) 1988-04-27
DK609184D0 (en) 1984-12-18
LU85696A1 (en) 1985-09-12
SE469171B (en) 1993-05-24
NZ210599A (en) 1987-09-30
DE3446371C2 (en) 1990-08-16
IL73840A0 (en) 1985-03-31

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