SE8303564D0 - N- (4-pyrazolidinyl) benzamides - Google Patents

N- (4-pyrazolidinyl) benzamides

Info

Publication number
SE8303564D0
SE8303564D0 SE8303564A SE8303564A SE8303564D0 SE 8303564 D0 SE8303564 D0 SE 8303564D0 SE 8303564 A SE8303564 A SE 8303564A SE 8303564 A SE8303564 A SE 8303564A SE 8303564 D0 SE8303564 D0 SE 8303564D0
Authority
SE
Sweden
Prior art keywords
alkyl
lower alkyl
phenyllower
benzamides
pyrazolidinyl
Prior art date
Application number
SE8303564A
Other languages
Swedish (sv)
Other versions
SE451723B (en
SE8303564L (en
Inventor
C D Lunsford
Jr A D Cale
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of SE8303564L publication Critical patent/SE8303564L/en
Publication of SE8303564D0 publication Critical patent/SE8303564D0/en
Publication of SE451723B publication Critical patent/SE451723B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Abstract

N-(4-Pyrazolidinyl) benzamides having the formula <IMAGE> wherein R represents lower alkyl, lower cycloalkyl or phenyllower-alkyl; R<1> represents lower alkyl, lower cycloalkyl, or phenyllower-alkyl; R<2> represents hydrogen, lower alkyl or phenyl; R<3> represents hydroxy, cyano, nitro, amino, fluoro, chloro, bromo, trifluoromethyl, lower alkyl, lower alkoxy, sulphamoyl or acetamido; and n is zero, 1, 2 or 3, pharmaceutically acceptable acid addition salts thereof, and compositions comprising such compounds or salts and a pharmaceutically acceptable carrier, are useful for treating warm blooded animals for emesis and for facilitating gastric emptying.
SE8303564A 1977-08-19 1983-06-21 4-AMINOPYRAZOLIDE INGREDIENTS USED AS INTERMEDIATES FOR THE PREPARATION OF N- (4-PYRAZOLIDINYL) BENZAMIDES SE451723B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82603177A 1977-08-19 1977-08-19
US90036978A 1978-04-26 1978-04-26
US93012578A 1978-08-01 1978-08-01

Publications (3)

Publication Number Publication Date
SE8303564L SE8303564L (en) 1983-06-21
SE8303564D0 true SE8303564D0 (en) 1983-06-21
SE451723B SE451723B (en) 1987-10-26

Family

ID=27420183

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7808694A SE444434B (en) 1977-08-19 1978-08-16 N- (4-pyrazolidinyl) benzamides
SE8303564A SE451723B (en) 1977-08-19 1983-06-21 4-AMINOPYRAZOLIDE INGREDIENTS USED AS INTERMEDIATES FOR THE PREPARATION OF N- (4-PYRAZOLIDINYL) BENZAMIDES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7808694A SE444434B (en) 1977-08-19 1978-08-16 N- (4-pyrazolidinyl) benzamides

Country Status (21)

Country Link
JP (1) JPS5441873A (en)
AU (1) AU521421B2 (en)
BR (1) BR7805288A (en)
CA (1) CA1105037A (en)
CH (2) CH639374A5 (en)
DE (1) DE2836062A1 (en)
DK (1) DK152361C (en)
ES (1) ES472686A1 (en)
FI (1) FI68044C (en)
FR (1) FR2400511A1 (en)
GB (2) GB2003153B (en)
HK (1) HK42282A (en)
IE (1) IE47430B1 (en)
MX (1) MX5469E (en)
NL (1) NL7808596A (en)
NO (1) NO149107C (en)
NZ (1) NZ188189A (en)
PH (1) PH13331A (en)
PT (1) PT68442A (en)
SE (2) SE444434B (en)
YU (1) YU41116B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309552A (en) * 1980-08-07 1982-01-05 A. H. Robins Company, Inc. Synthesis of 4-nitro-1,2-hydrocarbyl pyrazolidines and process for preparation thereof
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
JP3065506B2 (en) 1995-04-03 2000-07-17 株式会社資生堂 Pyrazolidine derivative and radical scavenger, cerebral infarction inhibitor, cerebral edema inhibitor
UY34104A (en) 2011-05-31 2013-01-03 Syngenta Participations Ag ? HETEROCYCLIC BENZAMID DERIVATIVE COMPOUNDS, PROCESSES AND INTERMEDIATES FOR PREPARATION, COMPOSITIONS AND METHODS FOR USE.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966957A (en) * 1972-04-03 1976-06-29 A. H. Robins Company, Incorporated Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides

Also Published As

Publication number Publication date
SE7808694L (en) 1979-02-20
SE451723B (en) 1987-10-26
FI782507A (en) 1979-02-20
CH645356A5 (en) 1984-09-28
DK152361C (en) 1988-07-25
HK42282A (en) 1982-10-08
SE8303564L (en) 1983-06-21
IE47430B1 (en) 1984-03-21
DK152361B (en) 1988-02-22
NZ188189A (en) 1984-07-06
DE2836062A1 (en) 1979-03-01
PT68442A (en) 1978-09-01
AU521421B2 (en) 1982-04-01
IE781682L (en) 1979-02-19
JPS6315273B2 (en) 1988-04-04
AU3906178A (en) 1980-02-21
CH639374A5 (en) 1983-11-15
NO782812L (en) 1979-02-20
PH13331A (en) 1980-03-13
MX5469E (en) 1983-08-16
CA1105037A (en) 1981-07-14
NO149107B (en) 1983-11-07
NL7808596A (en) 1979-02-21
NO149107C (en) 1984-02-22
GB2017678A (en) 1979-10-10
JPS5441873A (en) 1979-04-03
DK366978A (en) 1979-02-20
FI68044C (en) 1985-07-10
YU198678A (en) 1983-01-21
FR2400511A1 (en) 1979-03-16
GB2003153A (en) 1979-03-07
GB2003153B (en) 1982-02-24
BR7805288A (en) 1979-04-10
FR2400511B1 (en) 1981-09-04
ES472686A1 (en) 1979-03-16
YU41116B (en) 1986-12-31
GB2017678B (en) 1982-03-10
SE444434B (en) 1986-04-14
FI68044B (en) 1985-03-29

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