GB2003153A - N-(4-Pyrzaolidinyl) benzamides, and pharmaceutical compositions containing them - Google Patents

N-(4-Pyrzaolidinyl) benzamides, and pharmaceutical compositions containing them

Info

Publication number
GB2003153A
GB2003153A GB7833696A GB7833696A GB2003153A GB 2003153 A GB2003153 A GB 2003153A GB 7833696 A GB7833696 A GB 7833696A GB 7833696 A GB7833696 A GB 7833696A GB 2003153 A GB2003153 A GB 2003153A
Authority
GB
United Kingdom
Prior art keywords
alkyl
benzamides
lower alkyl
pyrzaolidinyl
phenyllower
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7833696A
Other versions
GB2003153B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of GB2003153A publication Critical patent/GB2003153A/en
Application granted granted Critical
Publication of GB2003153B publication Critical patent/GB2003153B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

N-(4-Pyrazolidinyl) benzamides having the formula <IMAGE> wherein R represents lower alkyl, lower cycloalkyl or phenyllower-alkyl; R<1> represents lower alkyl, lower cycloalkyl, or phenyllower-alkyl; R<2> represents hydrogen, lower alkyl or phenyl; R<3> represents hydroxy, cyano, nitro, amino, fluoro, chloro, bromo, trifluoromethyl, lower alkyl, lower alkoxy, sulphamoyl or acetamido; and n is zero, 1, 2 or 3, pharmaceutically acceptable acid addition salts thereof, and compositions comprising such compounds or salts and a pharmaceutically acceptable carrier, are useful for treating warm blooded animals for emesis and for facilitating gastric emptying.
GB7833696A 1977-08-19 1978-08-17 N-(4-pyrazolidinyl)benzamides and pharmaceutical compositions containing them Expired GB2003153B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82603177A 1977-08-19 1977-08-19
US90036978A 1978-04-26 1978-04-26
US93012578A 1978-08-01 1978-08-01

Publications (2)

Publication Number Publication Date
GB2003153A true GB2003153A (en) 1979-03-07
GB2003153B GB2003153B (en) 1982-02-24

Family

ID=27420183

Family Applications (2)

Application Number Title Priority Date Filing Date
GB7901821A Expired GB2017678B (en) 1977-08-19 1978-08-17 Substituted pyrazolidines
GB7833696A Expired GB2003153B (en) 1977-08-19 1978-08-17 N-(4-pyrazolidinyl)benzamides and pharmaceutical compositions containing them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB7901821A Expired GB2017678B (en) 1977-08-19 1978-08-17 Substituted pyrazolidines

Country Status (21)

Country Link
JP (1) JPS5441873A (en)
AU (1) AU521421B2 (en)
BR (1) BR7805288A (en)
CA (1) CA1105037A (en)
CH (2) CH639374A5 (en)
DE (1) DE2836062A1 (en)
DK (1) DK152361C (en)
ES (1) ES472686A1 (en)
FI (1) FI68044C (en)
FR (1) FR2400511A1 (en)
GB (2) GB2017678B (en)
HK (1) HK42282A (en)
IE (1) IE47430B1 (en)
MX (1) MX5469E (en)
NL (1) NL7808596A (en)
NO (1) NO149107C (en)
NZ (1) NZ188189A (en)
PH (1) PH13331A (en)
PT (1) PT68442A (en)
SE (2) SE444434B (en)
YU (1) YU41116B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309552A (en) * 1980-08-07 1982-01-05 A. H. Robins Company, Inc. Synthesis of 4-nitro-1,2-hydrocarbyl pyrazolidines and process for preparation thereof
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
JP3065506B2 (en) * 1995-04-03 2000-07-17 株式会社資生堂 Pyrazolidine derivative and radical scavenger, cerebral infarction inhibitor, cerebral edema inhibitor
AR086587A1 (en) 2011-05-31 2014-01-08 Syngenta Participations Ag INSECTICIDE COMPOUNDS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966957A (en) * 1972-04-03 1976-06-29 A. H. Robins Company, Incorporated Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides

Also Published As

Publication number Publication date
DK366978A (en) 1979-02-20
FR2400511A1 (en) 1979-03-16
GB2017678B (en) 1982-03-10
BR7805288A (en) 1979-04-10
YU198678A (en) 1983-01-21
SE444434B (en) 1986-04-14
GB2003153B (en) 1982-02-24
NO149107B (en) 1983-11-07
CA1105037A (en) 1981-07-14
NO782812L (en) 1979-02-20
DK152361C (en) 1988-07-25
YU41116B (en) 1986-12-31
ES472686A1 (en) 1979-03-16
FR2400511B1 (en) 1981-09-04
NO149107C (en) 1984-02-22
FI782507A (en) 1979-02-20
CH645356A5 (en) 1984-09-28
NL7808596A (en) 1979-02-21
PT68442A (en) 1978-09-01
FI68044C (en) 1985-07-10
GB2017678A (en) 1979-10-10
FI68044B (en) 1985-03-29
SE8303564D0 (en) 1983-06-21
AU521421B2 (en) 1982-04-01
IE47430B1 (en) 1984-03-21
HK42282A (en) 1982-10-08
DE2836062A1 (en) 1979-03-01
JPS6315273B2 (en) 1988-04-04
JPS5441873A (en) 1979-04-03
SE8303564L (en) 1983-06-21
SE7808694L (en) 1979-02-20
PH13331A (en) 1980-03-13
SE451723B (en) 1987-10-26
IE781682L (en) 1979-02-19
NZ188189A (en) 1984-07-06
DK152361B (en) 1988-02-22
CH639374A5 (en) 1983-11-15
AU3906178A (en) 1980-02-21
MX5469E (en) 1983-08-16

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19920817