SE8301039L - HETEROCYCLIC DERIVATIVES - Google Patents

HETEROCYCLIC DERIVATIVES

Info

Publication number
SE8301039L
SE8301039L SE8301039A SE8301039A SE8301039L SE 8301039 L SE8301039 L SE 8301039L SE 8301039 A SE8301039 A SE 8301039A SE 8301039 A SE8301039 A SE 8301039A SE 8301039 L SE8301039 L SE 8301039L
Authority
SE
Sweden
Prior art keywords
alkyl
group
substituted
oxygen
sulphur
Prior art date
Application number
SE8301039A
Other languages
Swedish (sv)
Other versions
SE8301039D0 (en
Inventor
J W Clitherow
B J Price
R Hayes
D E Bays
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SE8301039D0 publication Critical patent/SE8301039D0/en
Publication of SE8301039L publication Critical patent/SE8301039L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compounds of the formula (I):- <IMAGE> and physiologically acceptable salts, hydrates and bioprecursors thereof have been found to show pharmacological activity as selective histamine H2-antagonists. In formula (I> R1 represents hydrogen, C1-14 alkyl, cycloalkyl, alkenyl, aralkyl, heteroaralkyl, trifluoroalkyl or substituted alkyl; and R2 represents hydrogen or C1-4 alkyl; or R1 and R2 together complete an optionally substituted 5 to 10 membered ring; Alk represents C1-3 alkylene; Q represents a furan or thiophene bonded via the 2- and 5- positions, the furan or thiophene ring optionally bearing a further substituent R4 adjacent to the group R1R2N-Alk-; or Q represents a thiophene ring bonded via the 2- and 4- positions, the thiophene ring optionally bearing a further substituent R4 adjacent to the group R1R2NAlk with the proviso that when the group R1R2 NAlk is in the 4- position then the group R4 is in the 5-position; or Q represents a benzene ring bonded via the 1- and 3- or 1- and 4-positions; R4 represents halogen or C1-4 alkyl which may be substituted by hydroxy or C1-4 alkoxy; X represents oxygen, sulphur-, -NH-, methylene or a bond; Y represents oxygen, sulphur, methylene or a bond; n represents zero, 1, 2 or 3 and m is an integer from 2 to 5, with the provisos that (a) the total number of atoms in the chain X(CH2)nY(CH2)m is an integer from 3 to 8, (b) when X and Y represents oxygen or sulphur then n is 2 or 3, (c) when X represents -NH- then Q is a benzene ring and Y represents methylene or a bond, and (d) when Q represents a benzene ring, X represents oxygen, and n represents 1, then m may additionally represent 1 and Y may additionally represent -CHOR14 where R14 represents hydrogen or acyl; and R3 represents hydrogen, alkyl, alkenyl, aralkyl, or C2-6 alkyl substituted by hydroxy or alkoxy; either A represents N and B min represents CR5; or A represents CR5 and B represents N; and R5 represents one of various defined substituents.
SE8301039A 1982-02-24 1983-02-24 HETEROCYCLIC DERIVATIVES SE8301039L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8205431 1982-02-24
GB8205723 1982-02-26

Publications (2)

Publication Number Publication Date
SE8301039D0 SE8301039D0 (en) 1983-02-24
SE8301039L true SE8301039L (en) 1983-08-25

Family

ID=26282061

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8301039A SE8301039L (en) 1982-02-24 1983-02-24 HETEROCYCLIC DERIVATIVES

Country Status (18)

Country Link
JP (1) JPS58157772A (en)
AU (1) AU1180383A (en)
BE (1) BE896012A (en)
DE (1) DE3306503A1 (en)
DK (1) DK88283A (en)
ES (2) ES8407030A1 (en)
FI (1) FI830609L (en)
FR (1) FR2521993B1 (en)
GB (1) GB2116178B (en)
GR (1) GR77048B (en)
IL (1) IL67990A0 (en)
IT (1) IT1167622B (en)
LU (1) LU84659A1 (en)
NL (1) NL8300697A (en)
NO (1) NO830643L (en)
NZ (1) NZ203384A (en)
PT (1) PT76280A (en)
SE (1) SE8301039L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3336410A1 (en) * 1983-10-06 1985-04-18 Ludwig Heumann & Co GmbH, 8500 Nürnberg SULFEN AMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
FR2815346B1 (en) * 2000-10-13 2004-02-20 Servier Lab NOVEL AMINOTRIAZOLONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0016565B1 (en) * 1979-03-02 1984-05-23 Glaxo Group Limited 1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them
US4410523A (en) * 1979-10-22 1983-10-18 Glaxo Group Limited Heterocyclic derivatives
EP0029303B1 (en) * 1979-10-22 1985-01-30 Glaxo Group Limited 1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them
GB2064515B (en) * 1979-10-23 1983-06-29 Glaxo Group Ltd Heterocyclic derivatives processes for their production and pharmaceutical compositions containing them
FR2477150A1 (en) * 1980-02-28 1981-09-04 Glaxo Group Ltd NOVEL HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

Also Published As

Publication number Publication date
NL8300697A (en) 1983-09-16
ES526532A0 (en) 1985-11-16
DK88283A (en) 1983-08-25
FI830609A0 (en) 1983-02-24
NO830643L (en) 1983-08-25
LU84659A1 (en) 1984-11-08
FI830609L (en) 1983-08-25
ES520031A0 (en) 1984-04-01
FR2521993A1 (en) 1983-08-26
IL67990A0 (en) 1983-06-15
IT8347786A0 (en) 1983-02-24
GB2116178A (en) 1983-09-21
ES8407030A1 (en) 1984-04-01
ES8602702A1 (en) 1985-11-16
GR77048B (en) 1984-09-04
FR2521993B1 (en) 1988-09-16
GB2116178B (en) 1985-10-02
PT76280A (en) 1983-03-01
DE3306503A1 (en) 1983-09-01
BE896012A (en) 1983-08-24
AU1180383A (en) 1983-09-01
IT1167622B (en) 1987-05-13
JPS58157772A (en) 1983-09-19
GB8305147D0 (en) 1983-03-30
DK88283D0 (en) 1983-02-24
SE8301039D0 (en) 1983-02-24
NZ203384A (en) 1985-08-16

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